Research at SIU SOM
 
 
Research Profile - Tom Ala  
   
Department/Division:     Email Address:
Neurology/Alzheimer's tala@siumed.edu
Office Location:     Location of Laboratory:
751 Rutledge Springfield, Mail code 9643    
Office Phone Number:     Laboratory Phone Number:
217-545-7200      
Willing to mentor medical students and / or residents? Yes
Research Interests: Clinical aspects of dementia
Techniques and Methodologies: Resources include patients being seen in the SIU Memory Disorder Clinic and the SIU Alzheimer Center database and brain bank.

Equipment:

 
Current Collaborators:
 
Current and Pending Awards:
 
Publications:    

Ala T. With difficult patients, a less definitive diagnosis can be helpful. (Guest Editorial). Am J Alzheimers Dis Other Demen. 2004;19:79-80.

Ala TA, Mattson MD, Frey WH II. The clinical diagnosis of Alzheimer's disease without the use of head imaging studies. A cliniconeuropathological study. J Alzheimers Disease. 2003;5:463-465.

Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. The Mini-Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer's disease. Research and Practice in Alzheimer's Disease. 2003;7:231-235.

Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. The Mini-Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry. 2002;17:503-509.

Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. Pentagon copying is more impaired in dementia with Lewy bodies than in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001;70:483-488.


Ala TA, Yang K-H, Sung JH, Frey WH II. Inconsistency between severe substantia nigra degeneration with Lewy bodies and clinical parkinsonism in dementia patients. Acta Neuropathol (Berl). 2000;99:511-516.


Ala TA, Beh GO, Frey WH II. Pure hippocampal sclerosis. A rare cause of dementia mimicking Alzheimer‚s disease. Neurology. 2000;54:843-848.


Ala TA, Yang K-H, Sung JH, Frey WH II. Clinical parkinsonism in dementia patients with substantia nigra Lewy bodies. J Neural Transm. 1999;106:46-57.


Chen X-Q, Fawcett JR, Rahman Y-E, Ala TA, Frey WH II. Delivery of nerve growth factor to the brain via the olfactory pathway. J Alzheimers Disease. 1998;1:35-44.


Kjome JR, Swenson KA, Johnson MN, Bordayo EZ, Anderson LE, Klevan LC, Fraticelli AI, Aldrich SL, Fawcett JR, Venters HD Jr, Ala TA, Frey WH II. Inhibition of antagonist and agonist binding to the human brain muscarinic receptor by arachidonic acid. J Mol Neurosci. 1998;10:209-218.


Ala TA, Yang K-H, Sung JH, Frey WH II. Hallucinations and signs of parkinsonism help distinguish patients with dementia and cortical Lewy bodies from patients with Alzheimer‚s disease at time of presentation: a clinicopathologic study. J Neurol Neurosurg Psychiatry. 1997;62:16-21.

Frey WH II, Liu J, Chen X, Thorne RG, Ala TA, Rahman Y-E. Delivery of 125I-NGF to the brain via the olfactory route. Drug Delivery. 1997;4:87-92.

Venters HD Jr, Ala TA, Frey WH II. Inhibition of antagonist binding to the human brain muscarinic receptor by vanadium compounds. Recep Signal Transduct. 1997;7:137-142.


Venters HD Jr, Bonilla LE, Jensen T, Garner HP, Bordayo EZ, Najarian MN, Ala TA, Mason RP, Frey WH II. Heme from Alzheimer‚s brain inhibits muscarinic receptor binding via thiyl radical generation. Brain Res. 1997;764:93-100.


Frey WH II, Najarian MM, Kumar KS, Emory CR, Menning PM, Frank JC, Johnson MN, Ala TA. Endogenous Alzheimer‚s brain factor and oxidized glutathione inhibit antagonist binding to the muscarinic receptor. Brain Res. 1996;714:87-94.

Ala TA, Frey WH II. Validation of the NINCDS-ADRDA criteria regarding gait in the clinical diagnosis of Alzheimer's disease: a clinicopathologic study. Alzheimer Dis Assoc Disord. 1995;9:152-9.

Thorne RG, Emory CR, Ala TA, Frey WH II. Quantitative assessment of protein transport to the rat olfactory bulb following intranasal administration: implications for drug delivery. Brain Res. 1995;692:278-82.


Ala TA, Perfetti PA, Frey WH II. Two cases of acute anti-GM1 antibody elevations in response to exogenous GM1 without neurologic symptoms. J Neuroimmunol. 1994;53:109-13.

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