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| Research
Profile - Amy C. Arai, Ph.D. |
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| Department/Division: |
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Email
Address: |
| Pharmacology |
aarai@siumed.edu |
| Office
Location: |
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Location
of Laboratory: |
| 801
N. Rutledge, Springfield |
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801
N. Rutledge, Springfield |
| Office
Phone Number: |
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Laboratory
Phone Number: |
| 217-545-0228 |
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217-545-2204 |
| Willing
to mentor medical students and / or residents?
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Yes |
| Research
Interests: |
Molecular
and Pharmacological Modulation of AMPA-type Glutamate
Receptors and its impact on synaptic physiology |
| Techniques
and Methodologies: |
Electrophysiology,
Whole-cell recording, Field recording, Multielectrode
recording, Brain slice, Organotypic slice culture, Primary
cell culture, Microisland culture, Molecular biology,
Ligand binding, Western blot, Immunocytochemistry
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Equipment:
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Fluorescence
microscope, PCR, Scintillation counter |
Current
Collaborators:
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Markus
Kessler, Ph.D.(Department of Pharmacology),
Michael Pranzatelli, M.D. (Department of Neurology),
Olivier Civelli, Ph.D. (University of California Irvine) |
| Current
and Pending Awards: |
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NIH R01 "Differences in synaptic
and nonsynaptic AMPA receptors", PI |
| Publications:
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Arai
AC, Xia Y-F, Suzuki E (2004) Modulation of AMPA receptor
kinetics differentially influences formation of synaptic
plasticity in the hippocampus. Neuroscience 123: 1011-1024.
Xia Y-F, Arai AC (2004) Positive AMPA receptor modulators
have differential impact on synaptic transmission
in the thalamus and hippocampus. J. Pharmacol. Exp.
Ther.,in press.
Suzuki E, Kessler M, Montgomery K, Arai AC (2004)
Divergent effects of the purinoceptor antagonists
suramin and PPNDS on AMPA receptors. Mol. Pharmacol.
in press.
Suzuki E, Kessler M, Arai AC (2004) Kinetic properties
of C-terminally truncated GluR1 receptors, Mol. Cell.
Neurosci. in press.
Arai AC, Xia Y-F, Rogers G, Lynch G, Kessler M (2002)
Benzamide-type AMPA receptor modulators form two subfamilies
with distinct modes of action. J. Pharmacol. Exp.
Ther. 303: 1075-1085.
Lin SHS, Arai AC, Espana RA, Berridge CQ, Leslie F,
Huguenard JR, Vergnes M, Civelli O. (2002) Prolactin
Releasing Peptide (PrRP) promotes waking and suppresses
absence seizures in rats. Neuroscience 114: 229-238.
Lin SHS, Arai AC, Wang Z, Nothacker HP, Civelli O
(2001) The carboxyl terminus of the prolactin releasing
peptide (PrRP) receptor interacts with PDZ domain
proteins involved in AMPA receptor clustering. Mol.
Pharmacol. 60: 916-924.
Arai AC, Kessler M, Rogers G, Lynch G (2000) Effects
of the potent ampakine CX614 on hippocampal and recombinant
AMPA receptors: interactions with cyclothiazide and
GYKI 52466. Mol. Pharmacol. 58: 802-813.
Arai A, Kessler M, Rogers G, Lynch G (1996) Effects
of a memory enhancing drug on AMPA receptor currents
and synaptic transmission in hippocampus. J. Pharmacol.
Exp. Ther. 278: 627-638.
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Optional-CV
Web address:
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