Bottum, Kathy

Department/Division:			Email Address:
Internal Medicine/Psychiatry			kbottum@siumed.edu
Office Location:			Location of Laboratory:
lab at Univ. of IL, Urbana-Ch
Office Phone Number:			Laboratory Phone Number:
(217) 545-4234			333-3502
Willing to mentor medical students and / or residents?		Yes
Research Interests:	Glutamate Neurotoxicity Superchiasmatic Nucleus Cell Culture Brain Derived Neurotrophic Factor Major Depressive Disorder Neuroprotection Apoptosis Necrosis Caspase 3 NMDA receptors Circadian Rythms
Techniques and Methodologies:	Cell culture Immunocytochemistry Quantitative RT-PCR Western Blot ELISA Brain slice Flow Cytometry
Equipment:
Current Collaborators:	Dr. Shelley Tischkau at Univ. of IL, Urbana Champaign Dr. Martha Gillette at Univ. of IL, Urbana-Champaign
Current and Pending Awards:
Current Awards: 1) The Suprachiasmatic Nucelus as a Model for Neuroprotection, a Fellow to Faculty Transition Award from the American Heart Association. I am the primary recipient, Dr. Martha Gillette is the mentor 2) Brain Derived Neurotrophic Factor as a Marker for Major Depressive Disorder in Women. A grant from SIU, CRC. I am a co investigator with Dr. David Resch.
Publications:
These interests have not yet resulted in publication. Publications from other interests include: 1) Jonas, A, Bottum K, and Kezdy K. 1991. Transformations fo reconstituted high density lipoprotein subclasses as a function of temperature or LDL concentration. Biochim. Biophys. Act. 1085: 71-76. 2) Jonas A, Bottum K, Theret N, Duchateau P, and Castro G. 1994. Transfer of cholesterol from Ob 1771 cells or LDL to reconstituted, defined high density lipoproteins. J. Lipid Res. 35: 860n - 870. 3) Bottum K and jonas A. 1995. Cholesterol transfer from low density lipoproteins to reconstituted high density lipoproteins is determined by the properties and concentrations of both particles. Biochemistry. 34:7264-7270. 4) Swartz C, Bottum K and Salazar L. 2002. Suppression of signs resembling catatonia in nonconvulsive status epilepticus by lorazapam without seizure termination. Am J. Geriat. Psych. 10(3): 348-350 5) Wagle, R, Ede K, Craig J, Bottum K. An ethical dilemma: when the family wants the withdrawal of care. J. Psychiatr. Practice. 2004, in press
Optional-CV Web address: