Brewer, Gregory

Department/Division:			Email Address:
Departments of Neurology and Medical Microbiology, Immunology and Cell Biology			gbrewer@siumed.edu
Office Location:			Location of Laboratory:
801 N. Rutledge, SCLF2, Room 2640 Springfield			801 N. Rutledge, SCLF2, Rooms 2638, 2632, 2668
Office Phone Number:			Laboratory Phone Number:
217-545-5230			217-545-5731
Willing to mentor medical students and / or residents?		Yes
Research Interests:	Alzheimer disease, aging, cell biology, biochemistry, neuroscience, synaptogenesis, neuron cell culture, cell adhesion, neuronal networks
Techniques and Methodologies:	cell fluorescence analysis, mitochondrial and cellular respiration, electrode array analysis
Equipment:	Fluorescence Microscopes, Scintillation counter, Fluorescence plate reader,Centrifuges, Oxygraph respirometer, Culture shaker, Biosafety Hoods
Current Collaborators:	Robert Stuble, Ph.D.Alz. Ctr. Bruce Wheeler, Ph.D., Univ Illinois, Bioengineering Steve Dewirth, Ph.D.,Georgia Tech, Dept. Bioengineerng Peter LeRoux,M.D.,Univ Penn. Dept. Neurosurgery James Laguardia, M.D., Dept. Neurology Jose Espinosa, M.D., Division of Neurosurgery
Current and Pending Awards:
CURRENT: "Age-related responses of hippocampal neurons to stress", PI, Alzheimer Assoc. "Information Processing in Designed Neural Circuits", co-PI, NSF. "Age-dependent response of hippocampal neurons to stress", PI, NIH. "A 3-D Microfluidic/electronic NeuralInterfacing System" Subcontract for Stephen DeWeerth, P.I.-Georgia Tech. "Treatment of glioblastoma with neuropreservation", PI,Southern Illinois Univ.
Publications:
Brewer, G.J., Lim, A., Capps, N.G., Torricelli, J.R. 2005. Age-related calcium changes, oxyradical damage, caspase activation and nuclear condensation in hippocampal neurons in response to glutamate and beta-amyloid, Exp. Gerontol., 40:426-437. PM:15919595 Brewer, G.J.: Reichensperger, J.D.; Brinton, R.D. 2006. Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons, Neurobiology of Aging 27:306-317. PM:15961189 Vogt, A.K., Brewer, G.J., Decker, T., Boecker-Meffert, S., Jacobsen, V., Kreiter, M., Knoll, W., Offenhausser, A. 2005. Independence of synaptic specificity from neuritic guidance. Neuroscience., 134:783-790. PM:16009499 Vogt, A.K., Brewer, G.J., Offenhausser, A. 2005. Connectivity patterns in neuronal networks of experimentally defined geometry. Tissue Engineering, 11:1757-67. Brewer G.J., Espinosa, J., McIlhaney, R., Pencek, T, Kesslak, J.P., Cotman, C.W., Viel, J.J., and McManus, D.Q. 2001. Culture and regeneration of human neurons after brain surgery. J. Neurosci. Meth. 107:15-23. Chang, J.C., Wheeler, B.C. and Brewer, G.J. 2001. Microelectrode array recordings of patterned hippocampal neurons for four weeks. Biomedical Microdevices 2:245-253. Chang, J.C., Brewer, G.J. and Wheeler, B.C. 2001. Modulation of neural network activity by patterning. Biosensors & Bioelec. 16:527-533. Cady, C., Evans, M.S. and Brewer, G.J. 2001. Age-related differences in NMDA responses in cultured rat hippocampal neurons. Brain Res, 921:1-11. Nathan, B.P., Jiang, Y., Wong, G.K., Shen, F., Brewer, G. and Struble, R.G. 2002. Apolipoprotein E4 inhibits and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 928:96-105. Brewer, G.J., Espinosa,J.A., Struble, R.G. 2003. Neuregentmnutrient medium promotes survival of cortical neurons after aspiration lesion, J. Neurosurgery 98:1291-1298. Patel, J.R., Brewer, G.J. 2003. Age-related changes in neuronal glucose uptake to glutamate and beta-amyloid, J. Neurosci. Res.72:527-536. Chang, J.C., Brewer, G.J., Wheeler, B.C. 2003. A Modified Microstamping Technique Enhances Polylysine Transfer and Neuronal Cell Patterning. Biomaterials 24: 2863-2870. Nam, Y., Chang, J.C., Wheeler, B.C., Brewer, G.J. 2004. Gold-coated microelectrode array with thiol linked self-assembled monolayers for engineering neuronal circuits. IEEE Trans. Biomed. Eng. 51: 158-165. Viel, J.J., McMannus, D.J. and Brewer, G.J. 2004. Postmortem adult neuron culture: effect of pentobarbitol anaesthetic, Brain Res. 1009:219-222.
Optional-CV Web address:		http://www.siumed.edu/mmi/phdpages/gbpage2.htm