Research at SIU SOM
 
 
Research Profile - Ronald A. Browning  
   
Department/Division:     Email Address:
Physiology rbrowning@siumed.edu
Office Location:     Location of Laboratory:
Life Sciences III, 2076 Carbondale   LS III, Rooms 2010 & 2002
Office Phone Number:     Laboratory Phone Number:
618-453-7164     618-453-157
Willing to mentor medical students and / or residents? Yes
Research Interests: Seizure networks; Neurotransmitters & seizures; Post-traumatic brain injury; Vagus nerve stimulation; recovery of function
Techniques and Methodologies: Models of Epilepsy (audiogenic, MES, PTZ, Bicuculline). HPLC; Microdialysis. Stereotaxic surgery. Receptor binding.

Equipment:

HPLC, Microdialysis, stereotaxic equipment, EEG. Cell harvester.
Current Collaborators:
Rich Clough, Doug Smith, Rob Jensen, Peter Patrylo, Carl Faingold, Michael Collard.
Current and Pending Awards:
CURRENT:
Recovery of Function & Vagus Nerve Stimulation. (C0-Invest.) NIH Begining Yr. 3 of a 5yr. grant.
PENDING:
Genetics and Preservation of an Endangered Rat Resource. (Co-Invest). NIH.
Publications:    

Eells, J.B., Clough, R.W., Browning, R.A., and Jobe, P.C. Fos in locus ceoruleus following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol. Neuroscience Lett. 233: 21 - 24, 1997.

Clough, R.W., Peterson, B.R., Steenberger, J.L., Jobe, P.C., Eells, J.B., Browning, R.A., and Mishra, P.K. Neurite extension of developing noradrenergic neurons is impaired in genetically epilepsy prone rats (GEPR-3s): an invitro study on the locus coeruleus. Epilepsy Res. 29: 1135-1146, 1998.

Clark, K.B., Smith, D.C., Hassert, D.L., Browning, R.A., Naritoku, D.K. and Jensen, R.A. Post-training electrical stimulation of vagal afferents with concomitant vagal efferent inactivation enhances memory storage processes in the rat. Neurobiology of Learning and Memory 70: 364-373, 1998.

Krahl, S.E., Clark, K.B., Smith, D.C. and Browning, R.A. Locus Coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. Epilepsia 39: 704-714, 1998.

Eells, J.B., Clouth, R.W. and Browning, R.A. Expression of Fos in the superior lateral subdivision of the lateral parbrachial (LPBsl) area after generalized tonic seizures in rats. Brain Res. Bull. 47: 155-161, 1998.

Clark, K.B., Naritoku, D.K., Smith, D.C., Browning, R.A. and Jensen, R.A. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nature Neuroscience 2: 94-98, 1999.

Browning, R.A., Wang, C., Nelson, D.K. and Jobe, P.C. Effect of precollicular transection on audiogenic seizures in genetically epilepsy prone rats. Exp. Neurol. 155: 295-301, 1999.

Ryu, J.R., Jobe, P.C., Mildbant, J.C., Mishra, P.K., Clough, R.W., Browning, R.A., Dailey, J.W., Seo, O.D., and Ko, K.H. Morphological deficits in noradrenergic neurons in GEPR-9s stem from abnormalities in both the locus coeruleus and its target tissues. Exp. Neurol. 156: 84-91, 1999.

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