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| Research Profile - Kathleen
C.M. Campbell, PhD |
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| Department/Division: |
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Email
Address: |
| Surgery/Otolaryngology |
kcampbell@siumed.edu |
| Office
Location: |
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Location
of Laboratory: |
| 801
N. Rutledge, Rm #3341, Springfield |
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801
N. Rutledge, #3365 and 3375 |
| Office
Phone Number: |
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Laboratory
Phone Number: |
| (217)
545-7310 |
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(217)
545-6774 |
| Willing
to mentor medical students and / or residents?
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Yes |
| Research
Interests: |
ototoxicity,
otoprotective agents, anti-oxidants, drug development,
clinical trials |
| Techniques
and Methodologies: |
electrophysiology,
light microscopy, SEM, TEM, HPLC, spectrophotometry |
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Equipment:
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See
techniques and methods |
Current
Collaborators:
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Robert
Meech, Larry Hughes, Len Rybak, Morris Cooper, PhD, Nancy Khardori, MD |
| Current
and Pending Awards: |
Current:
2007-2012 R01 DC008412-01A1 NIH/NIDCD "Developing D-methionine as an Aminoglycoside Otoprotectant".R01.PI Kathleen Campbell, PhD Co investigators: M. Cooper PhD, L. Rybak, MD, PhD, L. Hughes, PhD, N. Khardori, MD. Mohamed El-Azizi June 1, 2007-May 31, 2012 ($1,941,684)
2007-211 U01 DC008423-01A2/NIDCD "Micronutrient Intervention to Reduce Noise-Induced Hearing Loss" PI Joseph Miller, PhD, Co-Is: Colleen LePrell, PhD, Patrick Antonelli, MD, Kathleen Campbell, PhD, Julio Carbayo Herencia, MD, Luis Angel Gonzalez Fernadez MD, Kenneth Guire MA, Glen Green MD , Bjorn Hagerman MD, James Hall III, PhD, Jose Juiz MD, PhD,,Ann-Catherine Lindblad, MSc , Roderick Little PhD, Ulf Rosenhall, MD ($2,274,644.00) 2008-2012
2004 MPEE grant with Todd Gerberi MSI for "Oral D-methionine Dosing for Cisplatin"
2003 "Dosing Strategies for Rescue from Noise-Induced
Hearing Loss (NIHL)" $15,000 SIU Central Research
Committee, P.I. Kathleen Campbell, PhD, Larry Hughes,
PhD co-investigator ($15,000)
2003 "D-met Rescue from Noise-induced Hearing Loss
(NIHL)": Post-Administration Intervals PI Kathleen
Campbell, PhD, Larry Hughes, PhD co-investigator Excellence
in Academic Medicine ($50,000)
2003 "Aging and Oxidative Stress in the Inferior
Colliculus." PI Robert Helfert, Ph.D., Kathleen
Campbell, Ph.D., Surgery, Larry Hughes, Ph.D., Vickram
Ramkumar, Ph.D., Excellence in Academic Medicine ($40,000)
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| Publications:
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Selected publications 2002-2007
Kimonis, V.E., Kovach, M, Campbell, K., Herman, K., Waggoner, B., Gelber, D., and Hughes, L. Anticipation in a Unique Family with Charcot-Marie-Tooth Syndrome and Deafness: Delineation of the Clinical Features and Review of the Literature. American Journal of Medical Genetics, 108:295-303 (2002).
Donnersberger, David R., Campbell, Kathleen C. M., Meech, Robert P., Rybak, Leonard P., Hughes, Larry F., Nanavati, P. J. A Model for Marked Radiation-Induced Hearing Loss. Journal of Burns, (journalofburns.com) 2002
Campbell, Kathleen C.M. Developing Otoprotective Agents for Ototoxic and Noise-Induced Hearing Loss: D-methionine and other compounds. NHCA Spectrum 19(2):12-14, 2002
Korver, K.D., Rybak, L.P., Whitworth, C., & Campbell, K.C. Round Window Application of D-Methionine Provides Complete Cisplatin Otoprotection. Otolaryngology-Head and Neck Surgery, 126:683-689, 2002.
Kopke, R.D., Coleman, J.K.M., Liu, J., Campbell, K.C.M., and Riffenburgh, R.H. Enhancing Intrinsic Cochlear Stress Defenses to Reduce Noise-Induced Hearing Loss. The Laryngoscope 112:1515-1532, 2002
Klemens, James J., Campbell, Kathleen C. M., Meech, Robert P., Hughes, Larry F., and Somani, Satu. Anti-oxidant Levels Inversely Co-vary with Hearing Loss After Amikacin Treatment. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):134-143.2003
Campbell, Kathleen C.M., Larsen, Deb L., Meech, Robert P., Rybak, Leonard P., and Hughes, Larry F. Glutathione Ester But Not Glutathione Protects Against Cisplatin-Induced Ototoxicity in a Rat Model. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):124-133.2003
Campbell, Kathleen CM, Kelly, Ellen, Targovnik, Nan, Hughes, Larry F., Van Saders, Claudia, Gottleib, Alice B., Dorr, Mary Beth, Leighton, Anton. Audiologic Monitoring for Potential Ototoxicity in a Phase I Clinical Trial of a New Glycopeptide Antibiotic. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):157-169. 2003
Campbell, Kathleen CM. Introduction to Oxidative Processes. (brief tutorial) Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):121-123.2003
Campbell, Kathleen CM, Meech, Robert P., Rybak, Leonard P., Hughes, Larry F., 2003 The Effect of D-Methionine on Cochlear Oxidative State with and without Cisplatin Administration: Mechanisms of Otoprotection. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):144-156.2003
Leighton, A, Gottlieb, AB, Dorr, MB, Jabes, D, Mosconi, G, VanSaders, C, Mroszczak, EJ, Campbell, KCM, Kelly, E. Tolerability, Pharmacokinetics and Serum Bacterial Activity of Intravenous Dalbavancin in Healthy Volunteers. Antimicrobial Agents and Chemotherapy. 48(3):940-945, March 2004
Campbell, Kathleen CM, Bromate Induced Ototoxicity. (2006) Toxicology. 221(2-3):205-211
Doolittle, Nancy D.; Peereboom, David; M. Christoforidis, Gregory A.; Hall, Walter A.; Pamieri, Diane; Brock, Penelope R.; Campbell, Kathleen C.M.; Dickey, D. Thomas; Muldoon, Leslie L, O'Neill, Brian P; Peterson, Darryl R.; Pollock, Brad; Smith, Quentin; Sousain, Carole; Tyson, Rose Marie; Neuwelt, Edward "Delivery of Chemotherapy and Antibodies Across the Blood Brain Barrier and the Role of Chemoprotection, in Primary and Metastatic Brain Tumors: Report of the Eleventh Annual Blood-Brain Barrier Consortium Meeting. Journal of Neuro-Oncology (2007) Journal of Neurooncology Jan;81(1):81-91 (e-pub Jul 21, 2006)
Campbell, Kathleen C.M., Meech, Robert P., Klemens, James J., Gerberi, Michael. T., Dyrstad Sara S.W., Larsen Deb. L, Mitchell, Diana L., El-Azizi, Mohammed, Verhulst, Steven J., Hughes, Larry F. "Prevention of Noise- and Drug-Induced Hearing Loss with D-methionine" Hearing Research (2007) Apr; 226(1-2):92-103 (e-pub Jan 16, 2007)
Bullarayasamudram, S.B., Hamstra, D.A., Khanna, D., Hamilton C.A., Campbell K.C.M., Sunkara, P, Ross, B.D, and Rehemtulla, A. "Evaluation of a D-Methionine as a Novel Oral Radioprotector for Prevention of Mucositis" In press: Clinical Cancer Research
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CV
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