Research at SIU SOM
 
 
Research Profile - Don Caspary  
   
Department/Division:     Email Address:
Pharmacology dcaspary@siumed.edu
Office Location:     Location of Laboratory:
801 N. Rutledge rm.3261, Springfield   801 N. Rutledge, rm.3234 
Office Phone Number:     Laboratory Phone Number:
217-545-2195     217-545-7009 
Willing to mentor medical students and / or residents? Yes
Research Interests: plasticity and neuroscinece of the auditory neuraxis. neurotransmitters coding and aging. GABA, glycine. molecular neurochemistry
Techniques and Methodologies: auditory neurophysiology, immunocytochemistry, neurochemistry including in situ hybridization, receptor binding, western blotting.

Equipment:

auditory neurophysiology set-up. cryostat  
Current Collaborators:
Drs. Turner, Hughes, Bauer, Brozoski and Helfert. 
Current and Pending Awards:

NIH/NIDCD Coding in Auditory Neurons: Effects of Amino Acids
PI: Donald M. Caspary 641,550 7/1/02-6/30/07

NIH/NIA Age-related synaptic changes in the auditory brainstem
PI: Jeremy Turner 126,378 7/1/04-6/30/06


SIU- EAM Age-related and Acoustic Coding across Layers of Auditory Cortex
PI: Larry Hughes 40,000 1/1/04-12/31/04 

Publications:    


Caspary, D.M, P.S. Palombi, L.F. Hughes: GABAergic Inputs Shape Responses to Sinusoidally Amplitude Modulated Stimuli in the Chinchilla Inferior Colliculus. Hearing Res. 168:163-173, 2002.

Turner, J.G., L.F. Hughes, D.M. Caspary: Divergent Response Properties of Layer V Neurons in Rat Primary Auditory Cortex. Hearing Res. 202:129-140, 2005.

Turner, J.G., J. Parrish, L.F. Hughes, L.A. Toth, D.M. Caspary: Hearing in Laboratory Animals: Strain Differences and Non-Auditory Affects of Noise. Comparative Medicine 55:12-23, 2005.

Ling, L.L., L.F. Hughes, D.M. Caspary: Aged-Related Loss of the GABA Synthetic Enzyme in Rat Primary Auditory Cortex. Neurosci. 132:1103-1113, 2005.

Turner, J.G., L.F. Hughes, D.M. Caspary: Effects of Aging on Receptive Fields in Rat Primary Auditory Cortex Layer V Neurons. J.Neurophysiol. 94:2738-2747, 2005.

Brozoski, T.J., D.M. Caspary, C.A. Bauer: Marking multi-channel silicon-substrate electrode recording sites using radiofrequency lesions. J. Neurosci. Methods 150:185-91, 2005.

Caspary, D.M., T.A. Schatteman, L.F. Hughes: Age-Related Loss of Response Inhibition in Rat Dorsal Cochlear Nucleus. J Neurosci. 23;25(47):10952-10959, 2005.

Turner, J.G., T.J. Brozoski, C.A. Bauer, J.L. Parrish, K. Myers, L.F. Hughes, D.M. Caspary: Rapid Tinnitus Screening in Rats. Behavioral Neurosci. 120:188-95. 2006

Caspary DM, Palombi PS, Hughes LF.
GABAergic inputs shape responses to amplitude modulated stimuli in the inferior
colliculus. Hear Res. 2002 Jun;168(1-2):163-73.
PMID: 12117518 [PubMed - indexed for MEDLINE]

Brozoski TJ, Bauer CA, Caspary DM.
Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas
with psychophysical evidence of tinnitus.
J Neurosci. 2002 Mar 15;22(6):2383-90.
PMID: 11896177 [PubMed - indexed for MEDLINE]

Shaddock Palombi P, Backoff PM, Caspary DM.
Responses of young and aged rat inferior colliculus neurons to sinusoidally
amplitude modulated stimuli.
Hear Res. 2001 Mar;153(1-2):174-80.
PMID: 11223307 [PubMed - indexed for MEDLINE]

Milbrandt JC, Holder TM, Wilson MC, Salvi RJ, Caspary DM.
GAD levels and muscimol binding in rat inferior colliculus following acoustic
trauma.
Hear Res. 2000 Sep;147(1-2):251-60.
PMID: 10962189 [PubMed - indexed for MEDLINE]

Bauer CA, Brozoski TJ, Holder TM, Caspary DM.
Effects of chronic salicylate on GABAergic activity in rat inferior colliculus.
Hear Res. 2000 Sep;147(1-2):175-82.
PMID: 10962183 [PubMed - indexed for MEDLINE]

Wang J, Caspary D, Salvi RJ.
GABA-A antagonist causes dramatic expansion of tuning in primary auditory
cortex.
Neuroreport. 2000 Apr 7;11(5):1137-40.
PMID: 10790896 [PubMed - indexed for MEDLINE]

Abbott SD, Hughes LF, Bauer CA, Salvi R, Caspary DM.
Detection of glutamate decarboxylase isoforms in rat inferior colliculus
following acoustic exposure.
Neuroscience. 1999;93(4):1375-81.
PMID: 10501462 [PubMed - indexed for MEDLINE]

Caspary DM, Holder TM, Hughes LF, Milbrandt JC, McKernan RM, Naritoku DK.
Age-related changes in GABA(A) receptor subunit composition and function in rat
auditory system.
Neuroscience. 1999;93(1):307-12.
PMID: 10430494 [PubMed - indexed for MEDLINE]

Milbrandt JC, Hunter C, Caspary DM.
Alterations of GABAA receptor subunit mRNA levels in the aging Fischer 344 rat
inferior colliculus.
J Comp Neurol. 1997 Mar 17;379(3):455-65.
PMID: 9067836 [PubMed - indexed for MEDLINE]

Optional-CV Web address:
 
     
     

 

 

 

 

 
 
SIU-SM | Research Homepage | Aspects Magazine | Library/Information Resources | Maps/Directions | Multimedia
Copyright © 2008, Board of Trustees, Southern Illinois University
Privacy Policy Last Updated January 10, 2008