Research at SIU SOM
 
 
Research Profile - Rodger Elble  
   
Department/Division:     Email Address:
Neurology relble@siumed.edu
Office Location:     Location of Laboratory:
751 N. Rutledge, Springfield   801 N. Rutledge
Office Phone Number:     Laboratory Phone Number:
217-545-7182     217-545-0895
Willing to mentor medical students and / or residents? Yes
Research Interests: Physiologic and pathologic tremors
Pathophysiology and genetics of essential tremor
Quantification of pathologic tremors
Parkinson disease
dementia
Alzheimer disease
movement disorders
Techniques and Methodologies: Clinical trials
Biomechanics

Equipment:

Accelerometers
Torque motors
Digitizing tablets
Current Collaborators:
See CV
Current and Pending Awards: See CV

 

Publications:    


Papers in peer-reviewed journals:
1. Elble RJ, Randall JE.  1976.  Motor unit activity responsible for the 8- to 12-Hz component of human physiological finger tremor.  J Neurophysiol 39:370-383.

2. Elble RJ, Randall JE.  1978.  Mechanistic components of normal hand tremor. Electroenceph Clin Neurophysiol 44:72-82.

3. Kapila A, Elble R, Ratcheson RA, Burde R, Gado M.  1982.  Radiologic demonstration of the dorsal medullocervical spur in adult Chiari malformation.  J Clin Neuro-Ophthalmology 2:235-240.

4. Elble RJ, Schieber MH, Thach WT.  1984.  Activity of muscle spindles, motor cortex and cerebellar nuclei during action tremor.  Brain Res 323:330-334.


5. Elble RJ.  1986.  Physiologic and essential tremor. Neurology 36:225-231.

6. Elble RJ, Higgins C, Moody C.  1987.  Stretch reflex oscillations and essential tremor.  J Neurol Neurosurg Psychiat 50:691-698.

7. Elble RJ, Giacobini E, Scarsella GF.  1987.  Cholinesterases in cerebrospinal fluid: a longitudinal study in Alzheimer disease.  Arch Neurol 44:403-407.

8. Norfray JF, Couch JR, Elble RJ, Good DC, Manyam BV, Partick JL.  1988.  Visualization of brain iron by mid-field MR.  Am J Neuroradiol 9:77-82.

9. Becker R, Giacobini E, Elble R, McIlhany M, Sherman K.  1988.  Potential pharmacotherapy of Alzheimer disease: a comparison of various forms of physostigmine administration.  Acta Neurol Scandinav 77(suppl 116):19-29.

10. Elble RJ, Giacobini E, Higgins C.  1989.  Choline levels are increased in cerebral spinal fluid of Alzheimer patients.  Neurobiol of Aging 10:45-50.

11. Elble RJ, Moody C, Higgins C.  1990.  Primary writing tremor: a form of focal dystonia?  Movement Disorders 5:118-126.

12. Becker RE, Colliver J, Elble RJ, et al.  1990.  Effects of metrifonate, a long-acting cholinesterase inhibitor, in Alzheimer disease: a report of an open trial.  Drug Development Res 19:425-434.

13. Elble RJ, Sinha R, Higgins C.  1990.  Quantification of tremor with a digitizing tablet.  J Neurosci Methods 32:193-198.

14. [1]Elble RJ, Thomas SS, Higgins C, Colliver J.  1991.  Stride-dependent changes in gait of older people.  J Neurol 238:1-5.

15. Elble RJ.  1991.  Inhibition of forearm EMG by palatal myoclonus.  Mov Disord 6:324-329.

16. Elble RJ, Higgins C, Hughes L.  1992.  The syndrome of senile gait.  J Neurol 239:71-75.

17.  Elble RJ, Higgins C, Hughes L.  1992.  Longitudinal study of essential tremor.  Neurology 42:441-443.

18.  Elble RJ, Higgins C, Hughes L.  1992.  Phase resetting and frequency entrainment of essential tremor.  Exp Neurol 116:355-361.

19. Brilliant M, Elble RJ, Ghobrial M, Struble RG.  1992.  Distribution of amyloid in the brainstems of patients with Alzheimer disease.  Neurosci Lett 148:23-26.

20. Elble RJ, Moody C, Leffler K, Sinha R.  1994.  The initiation of normal walking.  Mov Disord 9:139-146.

21.  Elble RJ, Higgins C, Hughes L.  1994.  Essential tremor entrains rapid voluntary movements.  Exp Neurol 126:138-143.

22. Elble RJ, Higgins C, Leffler K, Hughes L. 1994.  Factors influencing the amplitude and frequency of essential tremor.  Mov Disord 9:589-596.

23. [2]Brilliant M, Hughes L, Anderson D, Ghobrial M, Elble R.  1995.  Rarefied white matter in patients with Alzheimer disease.  Alzheimer Disease Related Disorders 9:39-46.

24. Elble RJ, Brilliant M, Leffler K, Higgins C.  1996.  Quantification of essential tremor in writing and drawing.  Mov Disord 11:70-78.

25.  Qureshi F, Morales A, Elble RJ.  1996.  Tremor due to infarction in the ventrolateral thalamus.  Mov Disord 11:440-444.

26. Elble RJ, Cousins R, Leffler K, Hughes L.  1996.  Gait initiation by patients with lower-half parkinsonism.  Brain 119:101-112.

27. Brilliant MJ, Elble RJ, Ghobrial M, Struble RG.  1997.  Distribution of amyloid b–protein deposition in the corpus striatum of patients with Alzheimer’s disease.  Neuropath Applied Neurobiol 23:322-325.

28. Bashir K, Elble RJ, Ghobrial M, Struble RG, Brilliant M.  Hemianopsia in dementia with Lewy bodies. Arch Neurol 1998;55:1132-1135.

29. Elble RJ.  Tremor in ostensibly normal elderly people.  Mov Disord 1998;13:457-464.

30. Zec RF, Landreth ES, Belman J, Fritz S, Hasara A, Fraizer W, Wainman S, McCool M, Grames E, O’Connell C, Harris R, Robbs R, Elble R, Manyam B.  1999.  A comparison of phonemic, semantic, and alternating word fluency in Parkinson disease.  Arch Clin Neuropsychol 14:255-264.

31. [3]Henderson VW, Paganini-Hill A, Miller BL, Elble RJ, Reyes PF, Shoupe D, McCleary CA, Klein RA, Hake AM, Farlow MR.  2000.  Estrogen for Alzheimer’s disease in women: randomized, double-blind, placebo-controlled trial.  Neurology 54:295-301.

32. Elble RJ, Leffler K.  2000.  Pushing and pulling with the upper extremities while standing: the effects of mild Alzheimer dementia and Parkinson disease.  Mov Disord;15:255-268.
33. Elble RJ.  2000.  Essential tremor frequency decreases with time.  Neurology 55:1547-1551.

34. Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ.  2001.  Pentagon copying is more impaired in dementia with Lewy bodies than in Alzheimer's disease.  J Neurol Neurosurg Psychiatry 70:483-488.

35. Kovach MJ, Ruiz J, Kimonis K, Mueed S, Sinha S, Higgins C, Elble S, Elble R, Kimonis VE.  2001.  Genetic heterogeneity in autosomal dominant essential tremor.  Genetics Medicine 3:197-199.

36. Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ.  The Mini Mental State Exam may help in the differentiation of dementia with Lewy bodies and Alzheimer’s disease.  International Journal of Geriatric Psychiatry 2002;17:503-509.

37. Elble RJ.  Characteristics of physiologic tremor in young and elderly adults.  Clin Neurophysiol 2003;114:624

SEE CV for more journal publication, book chapters, etc.

Optional-CV Web address:
http://www.siumed.edu/neuro/index.html
     
     

 

 

 

 

 
 
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