Evans, Miles Steven

Department/Division:			Email Address:
Neurology			mevans@siumed.edu
Office Location:			Location of Laboratory:
Room 3514, 751 N. Rutledge			Room 4361, 801 N. Rutledge
Office Phone Number:			Laboratory Phone Number:
217 545-5175			217 545-2714
Willing to mentor medical students and / or residents?		Yes
Research Interests:	epilepsy, seizures, ion channels, electrophysiology, memory, LTP, synaptic transmission
Techniques and Methodologies:	Patch clamp recording in cultured neurons and acute brain slices. Neuronal cell culture. Sharp electrode intracellular recording. Extracellular recording from hippocampal brain slices.
Equipment:	1. Patch clamp recording apparatus with inverted microscope, for cultured neurons. 2. Patch clamp recording apparatus with upright microscope and IR-DIC optics, for brain slices. 3. Extracellular recording apparatus. 4. Cell culture system.
Current Collaborators:	Carl L. Faingold, Tony J-F Lee, Gregory G. Brewer, James J. Laguardia, Dean K. Naritoku
Current and Pending Awards: Current Brief Epileptic Seizures and GABAA Receptor Plasticity (PI, SIU-EAM) Comparison of Cognitive Effects of Antiepileptics (PI, Glaxo) Cerebral Vascular Nitric Oxidergic Innervation (Co-I, NIH, T J-F Lee PI) Pending Brief Epileptic Seizures and GABAA Receptor Plasticity (PI, NINDS)

Publications:
Liu J, Evans MS, Brewer GJ, Lee TJ-F: N-type Ca2+ channels in cultured rat sphenopalatine ganglion neurons: an immunohistochemical and electrophysiological study. J. of Cerebral Blood Flow and Metabolism 20:183-91, 2000. PMID 10616807 Evans MS, Li Y, Faingold CL: Inferior colliculus intracellular response abnormalities in vitro associated with susceptibility to ethanol withdrawal seizures. Alcohol Clin. Exp. Res. 24:1180-6, 2000. PMID 10968655 Faingold C, Li Y, Evans MS: Decreased GABA and increased glutamate receptor-mediated activity on inferior colliculus neurons in vitro are associated with susceptibility to ethanol withdrawal seizures. Brain Research 868:287-95, 2000. PMID 10854581 Lee TJF, Liu J, Evans MS: Cholinergic-nitrergic transmitter mechanisms in the cerebral circulation. Microscopy Research and Technique 53(2), p119-28, 2001. Cady C, Evans MS, Brewer GJ: Age-related differences in NMDA responses in cultured rat hippocampal neurons. Brain Research 921:1-11, 2001. PMID 11720706 Liu J, Evans MS, Lee TJ: Presynaptic muscarinic M(2)-receptor-mediated inhibition of N-type Ca(2+) channels in cultured sphenopalatine ganglion: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation. J. of Pharmacology and Experimental Therapeutics 302:397-405, 2002. PMID 12065743 Yang L, Long C, Evans MS, Faingold C: Ethanol withdrawal results in aberrant membrane properties and synaptic responses in periaqueductal gray neurons associated with seizure susceptibility. Brain Research 957(1):99-108, 2002. PMID 12443985 Hord ED, Evans MS, Mueed S, Adamolekun B, Naritoku DK: The effect of vagus nerve stimulation on migraines. J Pain 4:530-4, 2003. PMID 14636821 Evans MS, Verma-Ahuja S, Naritoku DK, Espinosa JA: Intraoperative human vagus nerve compound action potentials. Acta Neurologica Scandinavica 110:232-8, 2004. PMID 15355486 Sun LY, Evans MS, Hsieh J, Panici J, Bartke A: Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. Endocrinology, in press 2004. PMID 15564324
Optional-CV Web address:		http://www.msevans.com/cv.htm