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| Research Profile - Mark
Francis |
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| Department/Division: |
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Email
Address: |
| Medicine
/ Rheumatology |
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| Office
Location: |
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Location
of Laboratory: |
| MMC
D402 Springfield |
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N/A |
| Office
Phone Number: |
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Laboratory
Phone Number: |
| 217-545-0184 |
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N/A |
| Willing
to mentor medical students and / or residents?
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Yes |
| Research
Interests: |
Rural
Health Care
Questionnaire Development and Design
Research with Large Databases
Health Care Outcomes Research
Design of Clinical Trials
Health Care Disparities
Regression Analysis
Epidemiology
Social Epidemiology |
| Techniques
and Methodologies: |
Questionnaire
Development and Design
Research with Large Databases
Health Care Outcomes Research
Design of Clinical Trials
Regression Analysis |
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Equipment:
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SAS
SPSS |
Current
Collaborators:
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Sebastian Schneesweiss
Garrett Fitzmaurice
Alexander Goehler |
| Current
and Pending Awards: |
Primary
Care Practice-Based Researach Network for
Central and Southern Illinois submitted to AHRQ (PI
with Bob Bussing, Maureen Francis, and David Resch as
co-investigators) |
| Publications:
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Francis,
ML; Moss, J; Fitz, TA; and Mond, JJ. (1990) cAMP-independent
effects of cholera toxin on B cell activation. I. A
possible role for cell surface ganglioside GMI in B
cell activation. J Immunol. 145: 3162-3169.
Brunswick, M; Bonvini, E; Francis, M; Felder, CC; Hoffman,
T; and Mond, J. (1990) Absence of demonstrable phospholipid
turnover in B cells stimulated by low mitogenic concentrations
of dextran-anti-immunoglobulin conjugates. Eur J Immunol.
20: 855-861.
Anastassiou, ED; Yamada, H; Francis, ML; Mond, JJ; and
Tsokos, GC. (1990) Effects of cholera toxin on human
B cells: cholera toxin induces B cell surface DR expression
while it inhibits anti- antibody-induced
cell proliferation. J Immunol. 145: 2375-2380.
Feuerstein, N; Lindsberg, ML; Tung, L; Francis, ML;
and Mond JJ. (1991) Identification of a pominent 85-kDa
cAMP-dependent phophoprotein associated with late G1
phase in mitogen-stimulated B lymphocytes. J Biol Chem.
266: 4746-4751.
Francis, ML; Ryan, J; Jobling, MG; Holmes, RK; Moss,
J; and Mond, JJ. (1992) Cyclic AMP-independent effects
of cholera toxin on B cell activation. II. The binding
of ganglioside GMI induces B cell activation. J Immunol.
148: 1999-2005.
Francis, ML; Meltzer, MS; and Gendelman, HE. (1992)
Interferons in the persistence, pathogenesis, and treatment
of human immunodeficiency virus infection. AIDS Res
Human Retroviruses. 8: 199-207.
Francis, ML and Meltzer, MS. (1993) Induction of IFN-
by HIV-1 in monocyte-enriched PBMC requires gp120-CD4
interaction but not virus replication. J Immunol. 151:
2208-2216.
Francis, ML; Okazaki, I; Moss, J; Kurosky, A; Pecanha,
LMT; and Mond, JJ. (1995) cAMP-independent effects of
cholera toxin on B cell activation. III. Cholera toxin
A subunit-mediated ADP-ribosylation acts synergistically
with ionomycin or I1-4 to induce B cell proliferation.
J Immunol. 154: 4956-4964.
Schwartz, GN; Kessler, SW; Szabo, JM; Burrell, LM; and
Francis, ML. (1995) Negative regulators may mediate
some of the inhibitory effects of HIV-1 infected stromal
cell layers on erythropoiesis and myelopoiesis in human
bone marrow long term cultures (LTC). J Leuk Biol. 57:
948-955.
Francis, ML; Fan, XS; and Meltzer, MS. (1996) Loss of
ability to produce IFN- in response to HIV-1
as monocytes differentiate into macrophages: Induction
via a mechanism independent of double-stranded RNA.
J Immunol. 156: 2481-2487.
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Optional-CV
Web address:
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Department
of Internal Medicine, SIU |
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