Equipment:

Names and institutions of people outside SIU with whom I have collaborated in research during the past three years.

Colleen Le Prell, Ph.D.
University of Michigan Medical School, Ann Arbor, MI.

Susan Shore, Ph.D.
University of Michigan Medical School, Ann Arbor, MI.

Sanford Bledsoe, Jr., Ph.D.
University of Michigan Medical School, Ann Arbor, MI.

Kyle Perkins, Ph.D.
Florida International University, Miami, FL.

Manali Amin, M.D.
University of Nebraska Medical Center, Omaha, NE.

Rense Lange, Ph.D.
Illinois Department of Education, Springfield, IL.

Tatsu Sato, M.D.
Aichi Medical University, Aichi-ken, Japan.

Michael Thalbourne, Ph.D.
University of Adelaide, Adelaide, South Australia.

Peter Delin, Ph.D.
University of Adelaide, Adelaide, South Australia.

James Houran,
Ph.D. University of Adelaide, Adelaide, South Australia.

Benjamin D. Wright,
Ph.D. University of Chicago, Chicago, IL

C. Research Support
Ongoing Research Support
R01 DC00151 Caspary (PI) 7/1/02 - 6/30/07

NIH/NIDCD Coding in Auditory Neurons: Effects of Amino Acids
The objectives of this project are to determine how inhibitory amino acids function within known brainstem auditory circuits to encode acoustic information, and the impact of aging on inhibitory amino acid neurotransmission in the auditory brainstem.
Role: Co-Investigator
R01 DC00151 Rybak (PI) 4/1/99 - 3/31/04

NIH/NIDCD Endogenous Modulation of Cisplatin Ototoxicity
The objectives of this project are to determine the impact of endogenous antioxidants upon ototoxicity in the cochlea.
Role: Co-Investigator
R01 NS-40220 Toth (PI) 5/1/02 - 4/30/07

NIH Influenza induced changes in Somnolence
The objectives of this project are to identify the gene(s) that effect influenza induced changes in the pattern of sleep in genetically inbred strains of mice.
Role: Co-Investigator
Excellence in Academic
Medicine Award Hughes (PI) 01/01/04 ˆ 12/31/05

IDPH Aging and Acoustic Coding across layers of Auditory Cortex.
The objectives of this project are to characterize age-related layer-specific changes in response properties of the auditory cortex.
Role: Principal Investigator

22. Hughes, Larry F., Struble, Robert G., Shaffer, Carla L. (2001) Olfaction in elderly and Alzheimer patients: differing feedback conditions. Journal of Alzheimer‚s Disease 3,(4):367-375.

23. Caspary DM, Palombi PS, Hughes LF. (2002) GABAergic inputs shape responses to sinusoidally amplitude modulated stimuli in the chinchilla inferior colliculus. Hearing Research 168(1-2):163-73.

24. Lange R, Donathan CL, Hughes LF. (2002) Assessing Olfactory Abilities with the University of Pennsylvania Smell Identification Test: A Rasch Scaling Approach. Journal of Alzheimer‚s Disease;4(2):77-91.

25. Hughes LF, Donathan CL, Smith T, McAsey ME, Conney PJ, Struble RG. (2002) Effects of HRT on olfactory sensitivity: cross-sectional and longitudinal studies. Climacteric;5:122-134.

26. Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. (2002) The Mini-Mental State exam helps in the differentiation of Alzheimer and Lewy body dementias. International Journal of Geratrics and Psychiatry;17:503-509.

27. Helfert RH, Glatz FR III, Wilson TS, Ramkumar V, Hughes LF. (2002) Hsp70 in the Inferior Colliculus of Fisher-344 Rats: Effects of Age and Noise Exposure. Hearing Research; 170(1-2):155-65.

28. Le Prell CG, Shore SE, Hughes LF, Bledsoe, SC Jr. Disruption of lateral efferent pathways: Functional changes in auditory evoked responses. Journal of the Association for Research in Otolaryngology 2003;4(2):276-290.

29. Klemens JJ, Campbell KCM, Meech RP, Hughes LF, Somani S. Anti-oxidant Levels Inversely Co-vary with HearingLoss After Amikacin Treatment. Journal of the AmericanAcademy of Audiology: Special Edition on Ototoxicity 2003;14(3):134-143.

30. Campbell KCM, Larsen DL, Meech RP, Rybak LP, Hughes LF. Glutathione Ester But Not Glutathione Protects Against Cisplatin-Induced Ototoxicity in a Rat Model. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 2003;14(3):124-133.

31. Campbell KCM, Kelly E, Targovnik N, Hughes LF, Van Saders C, Gottleib AB, Dorr MB, Leighton A. Audiologic Monitoring for Potential Ototoxicity in a Phase I Clinical Trial of a New Glycopeptide Antibiotic. Journal of theAmerican Academy of Audiology: Special Edition on Ototoxicity 2003;14(3):157-169.

32. Campbell KCM, Meech RP, Rybak LP, Hughes LF. The Effect of D-Methionine on Cochlear Oxidative State with and without Cisplatin Administration: Mechanisms of Otoprotection. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 2003;14(3):144-156.

33. Helfert R, Krenning J, Wilson TS, Hughes LF. Age-related synaptic changes in the anteroventral cochlearnucleus of Fischer-344 rats. Hearing Research 2003;183(1-2):18-28.

34. Krishna S, Hughes LF, Lin SY. Postoperative Hemorrhage With Nonsteroidal Anti-inflammatory Drug Use After Tonsillectomy: A Meta-analysis. Arch Otolaryngol Head Neck Surg. 2003;129(10):1086-9.

35. Hughes LF, Perkins K, Wright BD, Westrick H. Using a Rasch scale to characterize the clinical features of patients with a clinical diagnosis of uncertain, probable, or possible Alzheimer disease at intake. Journal of Alzheimer‚s Disease 2003;5(5):367-373.

36. Ramkumar V, Whitworth CA, Pingle SC, Hughes LF, Rybak LP. Noise induces A(1) adenosine receptor expression in the chinchilla cochlea. Hear Res. 2004 Feb;188(1-2):47-56.