Research at SIU SOM
 
 
Research Profile - Janak Koirala, MD, MPH, FACP  
   
Department/Division:     Email Address:
Medicine/ Infectious Disease jkoirala@siumed.edu
Office Location:     Location of Laboratory:
701 North Rutledge, Springfield   SCLF, Room #2528 
Office Phone Number:     Laboratory Phone Number:
217-545-9148     217-545-6865
Willing to mentor medical students and / or residents? Yes
Research Interests: HIV immunology and immune reconstitution, mycobacteria, MDR Salmonella
Techniques and Methodologies: flow cytometry; ELISA; cell culture; bacterial, viral and mycobacterial culture, viral cultures

Equipment:

 
Current Collaborators:
 
Current and Pending Awards:
Current Grants:
1. Principal Investigator, American Lung Association Research Award for: Interferon-gamma to improve macrophage functions against Mycobacterium Avium Complex infection in HIV-infected patients ($ 35000.00 per year for two years, 2004-2006)
2. Principal Investigator: Strategies for Management of Antiretroviral Therapy (SMART) Study: A NIH/NIAID Community Programs for Clinical Research on AIDS (CPCRA) study
3. Principal Investigator: Linezolid vs. vancomycin/ oxacillin/ dicloxacillin in the treatment of catheter-related gram-positive bloodstream infections
Publications:    

Novak RM, Koirala J, Sirdar ML, Laghi N, Moreira L, Pitrak DL, Ghassemi M. Lymphoproliferative Responses to Mitogens and Prepared Antigens of M. Avium Complex in Patients with HIV Infection. J Clin Immunol 2000; 20(1):62-67.

Koirala J. Mycobacterium kansasii. eMedicine Journal 2001; 2(12). An on-line medical reference; published by Emedicine inc. http://www.emedicine.com/med/

Temesgen Z, Cainelli F, Warnke D, Koirala J. Initial Atiretroviral Therapy in Chronically-infected HIV-Positive Adults. Expert Opin Pharmacother 2004 Mar; 5(3):595-612.
Koirala J, Basnet S. Botulism, Botulinum Toxin, and Bioterrorism: Review and Update. Infect Med 2004 Jun; 21:284-290.

Koirala J. Trimethoprim-Sulfamethoxazole Induced Methemoglobinemia in an HIV-infected patient. Mayo Clin Proc 2004 Jun; 79(6):829-30.

Koirala J, Ghassemi M, Novak RM. Use of lymphoproliferative Assay to Predict Opportunistic Infections in HIV-infected Patients. Poster presentation in the 36th Annual Meeting of Infectious Diseases Society of America, Denver, Colorado, November 1998.

Novak RM, Diaz-Linares M, Koirala J, Sofronici R, Kokoski P. Effect of Change From TID to BID Nelfinavir on Viral Load and CD4 Count. Poster presentation in the International Conference on the Discovery and Clinical Development of Antiretroviral Therapies, St. Thomas, West Indies, December 1998.

D'Alfonso-Laghi N, Koirala J, Ghassemi M, Pitrak DL, Novak R: Does Highly Active Antiretroviral Therapy Improve the Lymphoproliferative Response to Microbial Antigens and Phytohemagglutinin? Oral Presentation in CHEST 2000: Annual Meeting of the American College of Chest Physicians and Clinical World Congress on Diseases of the Chest, San Francisco, California, October 22-26, 2000.

Starks S, Spiker C, Koirala J, Kanchanapoom T, Khardori N. Bactericidal Activity of Newer Agents Against Gram-Positive Pathogens. Poster presentation in 101st General Meeting of the American Society of Microbiology, Orlando, Florida, May 2001.

Herr L, Koirala J, Campbell K, Starks S, Khardori N. D-Methionine Does Not Interfere with Antimicrobial Effectiveness. Poster presented in the 39th Annual Meeting of Infectious Diseases Society of America, San Francisco, California, October 2001.

J. Koirala, C. Powless, P. Luis-Jacques, B. Ryan, N. Khardori. Self-Treatment of Diarrhea in International Travelers. 8th Conference of the International Society of Travel Medicine, New York, USA, May 7-11, 2003.

J. Koirala, L. Koch. Interferon-Gamma and Interferon-Gamma R1 in HIV Infection. 11th International Congress on Infectious Diseases, Cancun, Mexico, March 4-7, 2004. (Poster no. 12-012)

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