LaGuardia, James

Department/Division:			Email Address:
Neurology			jlaguardia@siumed.edu
Office Location:			Location of Laboratory:
751 N. Rutledge, 3rd floor Springfield			SCLF 2536
Office Phone Number:			Laboratory Phone Number:
217-545-8684			217-545-8532
Willing to mentor medical students and / or residents?		Yes
Research Interests:	Multiple sclerosis, proteomics, interferons, genotyping, Fragile X syndrome, neurovirology
Techniques and Methodologies:	[RT-]PCR, western blots, 2d electrophoresis, mass spectroscopy
Equipment:	RT-PCR Smart Cycler, microarray reader, 2d electrophoresis equipment, western blotting equipment, HPLC system
Current Collaborators:	M. Steven Evans, Mary McAsey, Gregory Brewer, Ko Watabe, Rod Curtis, Larry Hughes
Current and Pending Awards:
Neurological Proteomics: Two Pilot Studies (Principal Investigator). Central Research Committee grant, Southern Illinois University School of Medicine. 7/04 ˆ 6/05: $11,000 per year. Interferon-B Receptor Levels in Multiple Sclerosis Patients (Principal Investigator). Biogen-Idec 1/04 ˆ 12/04: $5,000 per year. AVONEX Combination Trial (ACT): A Multi-Center, Randomized, Blinded, Parallel-Group Study of AVONEX in Combination with Oral Methotrexate, Intravenous Methylprednisolone, or Both in Subjects with Relapsing-Remitting Multiple Sclerosis Who Have Breakthrough Disease on AVONEX Monotherapy. (Principal Investigator at SIU). Biogen-Idec and the Cleveland Clinic Foundation 7/04 ˆ approximately two years: imbursement per patient enrolled.
Publications:
Hamori E, Varga G, LaGuardia JJ: HYLAS: a program for generating H-curves (abstract three-dimensional representations of long DNA sequences). Computer Applications in the Biosciences 5(4):263-9, 1989. Vern BA, Leheta BJ, Juel VC, LaGuardia J, Graupe P, Schuette, WH: Interhemispheric synchrony of slow oscillations of cortical blood volume and cytochrome aa3 redox state in unanesthetized rabbits. Brain Research 775(1-2):233-9, 1997. Vern BA, Leheta BJ, Juel VC, LaGuardia J, Graupe P, Schuette, WH: Slow oscillations of cytochrome oxidase redox state and blood volume in unanesthetized cat and rabbit cortex. Interhemispheric synchrony. Advances in Experimental Medicine and Biology 454:561-70, 1998. Nordborg C, Nordborg E, Petursdottir V, LaGuardia J, Mahalingam R, Wellish M, Gilden DH: Search for varicella-zoster virus in giant cell arteritis. Annals of Neurology 44(3):413-4, 1998. LaGuardia JJ, Cohrs RJ, Gilden DH: Prevalence of varicella-zoster virus DNA in dissociated human trigeminal ganglia neurons and non-neuronal cells. Journal of Virology 73:8571-7, 1999. Gilden DH, Kleinschmidt-DeMasters BK, LaGuardia JJ, Mahalingam R, Cohrs RJ: Neurologic complications of varicella-zoster virus reactivation. NEJM 342:635-645, 2000. LaGuardia JJ, Cohrs RJ, Gilden DH: Numbers of neurons and non-neuronal cells in human trigeminal ganglia. Neurological Research 22:565-566, 2000. Gilden DH, Gesser R, Smith J, Wellish M, LaGuardia JJ, Cohrs RJ, Mahalingam R: Presence of VZV and HSV-1 DNA in human nodose and celiac ganglia. Virus Genes 23:145-147, 2001. LaGuardia JJ, Gilden DH: Varicella-zoster virus: a re-emerging infection. Journal of Investigative Dermatology 6:183-187, 2001. Curtis R, Freitag P, Thornton S, LaGuardia JJ, Markwell S, Vicari S: Spinal Cord Injury in People with Mental Retardation: Potentially One of Many Underdiagnosed Medical Conditions. Public Health Reports 119:396-400, 2004.
Optional-CV Web address: