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| Research
Profile - Mary McAsey, Ph.D. |
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| Department/Division: |
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Email
Address: |
| Obstetrics and Gynocolgy |
mmcasey@siumed.edu |
| Office
Location: |
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Location
of Laboratory: |
913 N. Rutledge, Springfield,
Room 1032 |
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911 N. Rutledge, Room 329 |
| Office
Phone Number: |
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Laboratory
Phone Number: |
| 217-545-4692 |
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217-545-2173 |
| Willing
to mentor medical students and / or residents?
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Yes |
| Research
Interests: |
1)
Mechanisms of action of estrogen, progesterone
and apolipoprotein
e in the brain
2) Induction of apoptotic cell death by vitamin e
succinate
in ovarian and cervical cancer
3) Role of placental hormones in diseases of pregnancy
4) Influence of apolipoprotein e genotype on development
in infants
5) Therapeutic uses of adult and umbilical cord
blood stem cells
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| Techniques
and Methodologies: |
radioimmunoassay,
ELISA, Western analysis, northern analysis, in situ
hybridization, immunocytochemistry, protein extraction,
cell and tissue culture, microscopy, flow cytometry,
estrous cycle monitoring of rodents, Stem cell isolation and culture |
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Equipment:
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Microtiter
plate reader, electrophoresis equipment, homogenizer,
sonicator, laminar flow hood, CO2 incubator, inverted
and compound microscopes |
Current
Collaborators:
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Robert
Struble, PhD, Kofi Amankwah, MD, Larry Hughes, PhD,
Dennis Crouse, MD, Don Torry, PhD, Glen Aylward, PhD,
Thomas Tarter, MD, Sophia Ran, PhD, James LaGuardia,
MD, Erica Nelson, MD, Victoria Nichols-Johnson, MD,
Britto Nathan, PhD (Eastern IL Univ.), Craig Cady, PhD
(Bradley Univ.), Bo Rueda, PhD (Mass. Gen. Hosp., Harvard
Univ.), Marta Crispens, MD (Vanderbilt Univ.) Kathy Bottum MD, Michael Beckmann DO |
| Current
and Pending Awards: |
Current:
1) Models of Ovarian Senescence and Brain function: The Role of Estrogen
Replacement. Excellence in Academic Medicine, State of Illinois,
January 2006- December 2006, Co-investigator
2) The Role of Estrogen on Lipid Internalization in Neurons, Illinois Department
of Public Health Alzheimer's Disease Research Fund,
July 2006-June 2007,co-investigator
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| Publications:
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Struble RG, Nathan BP, Cady C, Cheng X, McAsey M. Estradiol regulation of astroglia and apolipoprotein E: An important role in neuronal regeneration. Exp Gerontol. 2006 Jul 10 [Epub ahead of print]
Struble RG, Afridi S, Beckman-Randall S, Li M, Cady C, Nathan B, McAsey M. Neocortical and hippocampal glial fibrillary acidic protein (GFAP) density shows regional specific variation during the mouse estrous cycle. Neuroendocrinology (in press).
Welch, P, Amankwah K, Miller P, McAsey M, Torry DS. Correlation of placental perfusion and PlGF protein expression in early human pregnancy. American Journal of Obstetrics and Gynecology. 2006; 194:1625-1629.
McAsey ME, Cady C, Jackson LM, Li M, Randall S, Nathan BP, Struble RG. Time course of response to estradiol replacement in ovariectomized mice: Brain apolipoprotein e and synaptophysin transiently increase and glial fibrillary acidic protein is suppressed. Exp Neurol. 2006; 197:197-205.
Nathan
BP, Barsukova AG, Shen F, McAsey M, Struble RG. Estrogen
facilitates neurite extension via apolipotrotein E
in cultured adult mouse cortical neurons, Endocrinology.
2004; 145:3065-3073.
Struble RG, Rosario E, Kircher M, Ludwig S, McAdamis
PJ, Watabe K, McAsey M, Cady C, Nathan BP. Regional
specific brain apolipoprotein E modulation during
the estrus cycle and by exogenous 17_ estradiol in
the mouse. J Exp Neurol. 2003; 183:638-44.
Hughes LF, McAsey ME, Donathan CL, Smith T, Coney
PJ, Struble RG. The effects of hormone replacement
therapy on olfactory sensitivity: cross-sectional
and longitudinal studies. Climacteric. 2002; 5:140-150. |
Optional-CV
Web address:
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