Research at SIU SOM
 
 
Research Profile - Mary Pauza  
   
Department/Division:     Email Address:
MMICB mpauza@siumed.edu
Office Location:     Location of Laboratory:
825 North Rutledge, SCLFII room 2630   825 North Rutledge, SCLFII room 2637
Office Phone Number:     Laboratory Phone Number:
(217) 545-4334     (217) 545-2217
Willing to mentor medical students and / or residents? Yes
Research Interests: Autoimmunity, type 1 diabetes, T cells, immune function, molecular biology
Techniques and Methodologies: PCR, RT-PCR, Real-time PCR, cloning, chemotaxis assays, chromatin immunoprecipitation assays, western blots, flow cytometry, genotyping, FRET assays

Equipment:

Cryostat, BioRad real-time thermocycler, scintillation counter
Current Collaborators:
Ko Watabe, Louis Premkumar, Linda Toth, Nancy Johnston
Current and Pending Awards:
Current:
Title: Understanding chemokine synergism in type 1 diabetes.
Principal Investigator: Mary Pauza
Agency: NIH 1 R15 DK67086-01

Title: c-Maf function in T cells as a surrogate marker for type 1 diabetes in mice
Principal Investigator: Mary Pauza
Agency: ADA
Publications:    

Rhode A, Pauza ME, Rodrigo E, Oldstone MBA, von Herrath MG, Christen U: Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development. J Immunol 15:3516-3524, 2005.

Bandyopadhyay S, Pai SK, Watabe M, Gross SC, Hirota S, Hosobe S, Tsukada T, Miura K, Saito K, Markwell SJ, Wang Y, Pauza ME, Huggenvik J, Watabe K: FAS expression inversely correlates with PTEN level in prostate cancer and an Akt inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene 24:5389-5395, 2005.

Van Buren JJ, Bhat S, Rotello R, Pauza ME, Premkumar LS: Sensitization and translocation of TRPV1 by insulin and IGF-1. Molecular Pain 1:17, 2005.

Smith S, Patterson T, Pauza ME: Transgenic Ly-49A Inhibits Antigen-Driven T Cell Activation and Delays Diabetes. J Immunol 174: 3897-3905, 2005.


Pauza ME, Dobbs C, Patterson T, Wagner S, Anobile B, Bradley B, Lo D, Haskins K: Absence of Autoantigen in a T cell Receptor Transgenic NOD Mouse: A Flexible Model of Type 1 Diabetes. Diabetes 53:978-988, 2004.

Pauza ME, Nguyen A, Wolfe T, Ho I-C, Glimcher LH, von Herrath M, and Lo D: Variable effects of transgenic c-Maf on autoimmune diabetes. Diabetes 50:39-46, 2001.


Pauza ME, Smith KM, Neal H, Reilly C, Lanier LL, Lo D: Transgenic expression of Ly-49A in thymocytes alters repertoire selection. J Immunol 164:884-892, 2000.

Pauza ME, Neal H, Hagenbaugh A, Cheroutre H, Lo D: T cell production of an inducible IL-10 transgene provides limited protection from autoimmune diabetes. Diabetes 48:1948-1953, 1999.

Xia Y, Pauza ME, Feng L, Lo D: RelB regulation of chemokine expression modulates local inflammation. Am J Path 151:375-387, 1997.

Pauza ME, Doumbia SO, Pennell CA: Construction and characterization of CD7 specific single chain Fv immunotoxins. J Immunol 158:3259-3269, 1997.


Eldin P, Pauza ME, Hieda Y, Lin G, Murtaugh MP, Pentel PR, Pennell CA: High-level secretion of two antibody single chain Fv fragments by Pichia pastoris. J Immunol Methods 201:67-75, 1997.

Pauza ME, Rehmann JA, LeBien TW: Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: human B cells can simultaneously express cell surface  and  light chains. J Exp Med 178:139-149, 1993.

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