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| Research
Profile - Louis S. Premkumar |
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| Department/Division: |
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Email
Address: |
| Pharmacology |
lpremkumar@siumed.edu |
| Office
Location: |
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Location
of Laboratory: |
| 801
North Rutledge street rm. 3325 Springfield, Illinois |
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801
North Rutledge street rm. 3219 Springfield, Illinois |
| Office
Phone Number: |
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Laboratory
Phone Number: |
| (217)
545-2179 |
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(217) 545-7006 |
| Willing
to mentor medical students and / or residents?
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Yes |
| Research
Interests: |
Molecular Mechanims
of Pain Perception: Modulation of ion channels and synaptic
transmission |
| Techniques
and Methodologies: |
Electrophysiology,
Molecular biology, immunocytochemistry, radioligand,
ELISA, Ca2+ imaging, double electrode voltage clamp,
patch clamp |
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Equipment:
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Five Electrophysiology
rigs, Ca2+ imaging setup |
Current
Collaborators:
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Mary Pauza
Romesh Khardori |
| Current
and Pending Awards: |
Current RO1 NINDS
Current RO1 NIDDK |
| Publications:
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1.
Raisinghani, M., Long C and Premkumar L. S (2004) Gabapentin:
A TRPV1 antagonist.
Mol. Pharmacol. (in press).
2. Raisinghani, M and Premkumar, L. S. (2004). Block
of Native and Cloned Vanilloid Receptor 1 (TRPV1) by
Aminoglycoside Antibiotics. Pain (in press).
3. Van Buren J., Bhat S., Smith S., Pauza M., Premkumar
L. S. Role of TRPV1 in diabetic peripheral neuropathy.
Submitted to J. Neurosci. (under consideration).
4. Puntambekar, P., Van Buren, J., Raisinghani, M.,
Premkumar, L. S. and Ramkumar V. (2004) Direct interaction
of Adenosine with the TRPV1 channel protein. J.Neurosci.
24: 3663-3671.
5. Premkumar, L. S., Qi, Z.H., Van Buren, J. and Raisinghani,
M. (2004) Enhancement of potency and efficacy of NADA
by PKC-mediated phosphorylation of vanilloid receptor.
J.Neurophys. 91:1442-1449.
6. Watanabe J., Beck C., Kuner T., Premkumar L. S. and
Wollmuth L. P. (2003) DRPEER: A motif in the extracellular
vestibule conferring high Ca2+ flux rates in NMDA receptor
channels. (2002) J. Neurosci. 22:10209-10216.
7. Ahern G. P. and Premkumar L. S. (2002). Voltage-dependent
priming of vanilloid receptor: effects of agonists and
phosphorylation state. J. Physiol. 545: 441-451.
8. Premkumar L. S., Agarwal S. and Steffen D. (2002).
Single channel properties of native and cloned rat vanilloid
receptors. J. Physiol. 545: 1070117.
9. Chatterton J. E., Awobuluyi M., Premkumar L. S.,
Takahashi H., Talantova M., Shin Y., Cui J., Tu S.,
Sevarino K. A., Nakanishi N., Tong G., Lipton S. A.
and Zhang D. (2002). Excitatory glycine receptors containing
the NR3 family of NMDA receptor subunits. Nature 415:793-798.
10. Premkumar L. S. (2001) Interaction between vanilloid
receptors and purinergic metabotropic receptors: pain
perception and beyond. Proc. Natl. Acad. Sci. U S A.
98:6537-6539.
11. Premkumar L. S. and Ahern G. P. (2000). Induction
of vanilloid receptor channel activity by protein kinase
C. Nature 408:985-990.
12. Kuehl-Kovarik C.M., Partin, M., Premkumar L. S.
and Magnusson, K. R. (2000). Electrophysiological analysis
of NMDA receptor subunit changes in the aging mouse
cortex. Mech. Ageing Dev. 115:39-59.
13. Premkumar L. S. (1999) Selective potentiation of
L-type calcium currents in cardiac myocytes and hippocampal
neurons by cocaine. Mol. Pharmacol. 56:1138-1142.
14. Das D., Sasaki Y. F., Rothe T., Premkumar L. S.,
Takasu M., Crandall J. E., Dikkes P., Connor D. A.,
Rayudu P. V., Cheung W., Chen H-S.V., Lipton S. A. and
Nakanishi N. (1998). Increased NMDA current and spine
density in mice lacking a novel NMDAR subunit, NR3A.
Nature 393: 377-381.
15. Premkumar L. S. and Auerbach A. (1997). Stoichiometry
of mouse recombinant NMDA receptor channels inferred
from single-channel conductance patterns. J. Gen. Physiol.
110: 485-502.
16. Premkumar L. S., Qin F. and Auerbach, A (1996).
Subconductance states of a mutant NMDA receptor channel:
kinetics and voltage-dependence. J. Gen. Physiol. 109:
1-9.
17. Premkumar L. S. and Auerbach A. (1996). Identification
of a high affinity divalent binding site at the entrance
of NMDA receptor channel. Neuron 16: 869-880. |
Optional-CV
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