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| Research Profile - Sophia
Ran |
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| Department/Division: |
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Email
Address: |
| Medical
Microbiology & Immunology & Cell Biology |
sran@siumed.edu |
| Office
Location: |
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Location
of Laboratory: |
| 911
N. Rutledge Springfield room 1310C |
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911
N. Rutledge room 1348 |
| Office
Phone Number: |
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Laboratory
Phone Number: |
| (217)
545-7026 |
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(217)
545-7332 |
| Willing
to mentor medical students and / or residents? |
Yes |
| Research
Interests: |
angiogenesis,
lymphangiogenesis, breast cancer, metastasis, pre-clinical
animal models |
| Techniques
and Methodologies: |
Immunohistochemistry,
RT-PCR, real time PCR, cell proliferation, migration
assays, production of antibodies, analysis of tumor
& blood vessel growth in vivo |
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Equipment:
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fluorescent
microscope, inverted microscope, PCR machine |
Current
Collaborators:
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James
Malone, Tom Tarter, Don Torry, Vic Ramkumar, Daotai Nie, Yin Mo, Linda Toth, Rita Trammell |
| Current
and Pending Awards: |
Active Grants:
Ran, S. – Principal Investigator
NIH, 1R15CA125682-01-AREA; the title of the project is “Mechanism of VEGF-A regulated tumor lymphangiogenesis”. July 2007- June 2009
Ran, S. – Principal Investigator
McElroy Foundation, IL. “VEGF-A as a target for inhibition of lymphatic metastasis in breast cancer patients” ”. July 2007 – June 2009
Ran, S. – Mentor
American Cancer Society Institutional Research Grant (ACS-IRG)
Training grant for Brandt Whitehurst, second year medical student (MSII), for the project titled “Clinical relationship between angiopoietin-2 expression and patient prognosis in squamous cell carcinomas of the head and neck”. July 2007 – June 2008
Ran, S. – Mentor
DOD-BRCP program, pre-doctoral training award #BC073318 for the project “Regulatory role of the NF-kB pathway in lymphangiogenesis and breast cancer metastasis”. January 2008 – December 2011
Trammell, R. – PI; Ran, S. – co-PI
McElroy Foundation, IL. “Inflammation, Cancer and Sleep”. July 2006 – June 2008
Malone, J. – Principal Investigator; Ran, S. – co-PI
Central Research Committee Award, SIU School of Medicine, Springfield, IL. Project:”Ubc9 expression in head & neck cancer”. July 2007-June 2008
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| Publications 2004 - 2007:
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Whitehurst, B., Flister, M.J., Bagaitkar, J., Volk, L., Bivens, C.M., Pickett, B., Castro-Rivera, E., Brekken, R.A., Gerard, R.D. and Ran, S. (2007). Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model. Int. J. Cancer, 121(10):2181-2191.
Whitehurst, B., Eversgerd, C., Flister, M., Bivens, C.M., Pickett, B., Zawieja, D.C. and Ran, S. (2006). Molecular profile and proliferative responses of rat lymphatic endothelial cells in culture. Lymphatic Research and Biology, 4(3):119-142.
Ran, S., Mohamedali, K., Thorpe, P.E. and Rosenblum, M.G. (2005) VEGF121/rGel fusion toxin, a novel tumor vasculo-ablative agent, inhibits pulmonary metastases of MDA-MB-231 breast tumors in mice. Neoplasia, 7:486-496.
Ran, S., He, J., Huang, X., Soares, M., Scothorn, D. and Thorpe, P.E. (2005) Anti-Tumor Effects in Mice of a Monoclonal Antibody, 3G4, Directed Against Anionic Phospholipids. Clin. Cancer Res., 11(4):1551-1562.
Castro-Rivera, E., Ran, S., Thorpe, P.E. and Minna, J.D. (2004) Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer while VEGF165 antagonizes this effect. Proc. Natl. Acad. Sci. U.S.A., 101(31):11432-11437.
Bandyopadhyay, S., Pai, S.K., Hirota, S., Hosobe, S., Takano, Y., Saito, K., Piquemal, D., Commes, T., Watabe, M., Gross, S. C., Wang, Y., Ran, S. and Watabe, K. (2004) Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression. Oncogene, 22;23(33):5675-5681.
Pickering, W., Gray, E., Goodall, A.H., Ran, S., Thorpe, P.E., Barrowcliffe, T.W. (2004) Characterisation of the cell-surface procoagulant activity of T-lymphoblastoid cell lines. J. Throm. Haemostasis, 2(3): 459-467. |
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