Research at SIU SOM
 
 
Research Profile - Yin-Yuan MO  
   
Department/Division:     Email Address:
MMI&CB ymo@siumed.edu
Office Location:     Location of Laboratory:
913 N. Rutledge #1213, Springfield   911 N. Rutledge #1337, Springfield
Office Phone Number:     Laboratory Phone Number:
(217) 545-8508     545-7374
Willing to mentor medical students and / or residents? Yes
Research Interests: tumor cell biology; posttranslation modifications; Ubc9; sumoylation; microRNA; breast cancer; molecular biology
Techniques and Methodologies: Molecular cloning; Gene silencing; real time PCR
Immuno-histochemistry

Equipment:

 
Current Collaborators:
 
Current and Pending Awards:

Ubc9 as a novel target for cancer therapy?
Principal Investigator: Yin-Yuan Mo, Ph.D.
Agency: NIH NCI
Type: RO1 CA102630; Period 8/01/03-7/31/07
The major goal of this project is to dissect the molecular mechanism of Ubc9-mediated tumorigenesis and analyze Ubc9 regulation in normal and tumor tissue. The ultimate goal is to identify and develop Ubc9-based anticancer agents.

?Dysregulation of RNA interference in breast cancer?
Principal Investigator: Yin-Yuan Mo, Ph.D.
Agency: DOD
Type: Concept Award, BC045418; period: 7/2005-6/2006
This proposal is to test a novel idea that dysregulation of RNA interfering pathway could lead to development of breast cancer.

?MicroRNA target genes in breast cancer?
Principal Investigator: Yin-Yuan Mo, Ph.D.
Agency: DOD
Type: Concept Award, BC052294; period: 7/2006-6/2007
This proposal is to develop a high throughput method for identification of miRNA target genes in breast cancer.

Publications:    

Mo Y-Y, Yu Y, Shen Z, Beck WT. 2002. Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein. J Biol Chem.277:2958-64.

Tavormina PA, Come MG, Hudson JR, Mo Y-Y, Beck WT, Gorbsky GJ. 2002. Rapid exchange of mammalian topoisomerase II{alpha}at kinetochores and chromosome arms in mitosis. J. Cell Biol. 158:23-29.

Rallabhandi P, Hashimoto K, Mo YY, Beck WT, Moitra PK, D'Arpa P. 2002. Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin. J Biol Chem. 277:40020-40026.

Mo, Y-Y, Yu Y, Ee P.P., Beck, W.T. 2004. Overexpression of a dominant negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs, Cancer Research, 64(8):2793-8

Mo, Y-Y, Yu Y, Theodosio E., Ee P.P., Beck, W.T. 2005. A role for Ubc9 in tumorigenesis. Oncogene. 24:2677-83.

Anh Dinh, Mo, Y-Y. 2005. An alternative approach to generating shRNAs from cDNAs. Biotechniques. 38:629-632.

Mo, Y-Y., Moschos, S. 2005. Targeting Ubc9 for cancer therapy. Expert Opinion on Therapeutic Targets. 9:1203-16.

Lu Z, Wu H, Mo YY. 2006. Regulation of bcl-2 expression by Ubc9. Experimental Cell Research. 2006 Mar 25; [Epub ahead of print]

Wu F, Mo, Y-Y. 2006. Ubiquitin-like protein modifications in prostate and breast cancer. Frontier in Bioscience. In press. Moschos SJ, Mo YY 2006. Role of Ubc9 in DNA damage repair and tumorigenesis. J Mol Histol. Jun 7; [Epub ahead of print]. 3. Dinh, A., Mo, Y-Y. 2005. An alternative approach to generating shRNAs from cDNAs. Biotechniques. 38:629-632.

Mo, Y-Y, Yu Y, Theodosio E., Ee P.P., Beck, W.T. 2005. A role for Ubc9 in tumorigenesis. Oncogene. 24:2677-83.

Mo, Y-Y, Yu Y, Ee P.P., Beck, W.T. 2004. Overexpression of a dominant negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs, Cancer Research, 64(8):2793-8

Rallabhandi P, Hashimoto K, Mo Y-Y, Beck WT, Moitra PK, D'Arpa P. 2002. Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin. J Biol Chem. 277:40020-6.

Tavormina PA, Come MG, Hudson JR, Mo Y-Y, Beck WT, 2002. Gorbsky GJ. Rapid exchange of mammalian topoisomerase II{alpha}at kinetochores and chromosome arms in mitosis. J. Cell Biol. 158:23-29.

Mo, Y-Y, Yu, Y-N, Shen, Z. and Beck, W.T. 2002. Sumoylation of topoisomerase I in response to topotecan is associated with its nucleolar delocalization J. Biol. Chem. 277:2958-2964.

Zhang, JH, Barr VA, Mo, Y-Y, Rojkova, AM, Liu, S, Simonds, WF. 2001. Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain. J. Biol. Chem. 276:10284-10289.

Mo, Y-Y, Wang C., and Beck, W.T. 2000. A novel nuclear localization sequence in human DNA topoisomerase I. J. Biol. Chem. 275:41107-41113

Yu R, Chen C, Mo Y-Y, Hebbar V, Owuor ED, Tan TH, and Kong AN. 2000. Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via Nrf2-dependent Mechanism. J. Biol. Chem. 275:39907-39913

Mo, Y-Y., Wang, P., and Beck, W.T. 2000. Functional expression of human topoisomerase I fused to enhanced green fluorescent protein in mammalian cells. Exp. Cell. Res. 256:480-490.

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