Experimental Therapeutics/Prevention Program Publications

2004

1. Pickering W, Gray E, Goodall AH, Ran S, Thorpe PE, Barrowcliffe TW. (2004). Characterisation of the cell-surface procoagulant activity of T-lymphoblastoid cell lines. J. Throm. Haemostasis, 2(3): 459-467.

2. Bandyopadhyay S, Pai SK, Hirota S, Hosobe S, Takano Y, Saito K, Piquemal D, Commes T, Watabe M, Gross S C, Wang Y, Ran S, Watabe K. (2004). Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression. Oncogene, in press.

3. Arai AC, Xia Y-F, Suzuki E. (2004). Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus. Neuroscience. 123: 1011-1024.

4. Ramkumar V, Whitworth CA, Pingle SC, Hughes LF, Rybak LP. (2004). Noise induces A(1) adenosine receptor expression in the chinchilla cochlea. Hear Res. 188(1-2):47-56.

5. Mitchell D, Rybak LP, Glatz FR. (2004). Hyperparathyroid crisis in a pediatric patient. Int J Pediatr Otorhinolaryngol. 68(2):237-41.

6. Nathan BP, Barsukova AG, Shen F, McAsey M, Struble RG. (2004). Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons. Endocrinology.

7. Leighton A, Gottlieb AB, Dorr MB, Jabes D, Mosconi G, VanSaders C, Mroszczak EJ, Campbell KCM, Kelly E. (2004). Tolerability, Pharmacokinetics and Serum Bacterial Activity of Intravenous Dalbavancin in Healthy Volunteers. Antimicrobial Agents and Chemotherapy. 48(3):940-945.

8. Murphy LL. (2004). Cannabinoids and the neuroendocrine system. Recent Advances in Pharmacology and Physiology of Cannabinoids.

9. Hou Y, Meyers CY. (2004). Stereochemistry of Reactions Involving Rotationally Restricted, Sterically Hindered, Cations, Radicals and Anions. 9-Fluorenyl Systems. J. Org. Chem., 69, in press.

2003

1. Mason RP, Constantinescu A, Ran S, Thorpe PE. (2003). Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody directed infarction. Adv. Exp. Med. Biol. 530:197-204.

2. Zhao D, Ran S, Constantinescu A, Hahn EW, Mason RP. (2003). Tumor oxygen dynamics: correlation of in vivo MRI with histological findings. Neoplasia, 5(4): 308-318.

3. Ran S, Huang X, Downes A, Thorpe PE. (2003). Evaluation of anti-mouse VEGFR2 antibodies as potential anti-angiogenic or vascular targeting agents for tumor therapy. Neoplasia, 5(4): 297-307.

4. Rao K, Bryant E, McDougall JK. (2003). Production of spindle cell carcinoma by transduction of H-Ras 61L into immortalized primary human mammary epithelial cells. Cancer Letters, 201: 79-88.

5. Lin B, Arai AC, Lynch G, Gall CM. (2003). Integrins regulate NMDA receptor-mediated synaptic currents. J. Neurophysiol. 89: 2874-2878.

6.Pingle SC, Sanchez JF, Hallam DM, Williamson AL, Maggirwar SB, Ramkumar V. (2003). Hypertonicity inhibits lipopolysaccharide-induced nitric oxide synthase expression in smooth muscle cells by inhibiting nuclear factor kappaB. Mol Pharmacol. 63(6):1238-47.

7. Struble RG, Rosario ER, Kircher ML, Ludwig SM, McAdamis PJ, Watabe K, McAsey ME, Cady C, Nathan BP. (2003). Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiol. Exp Neurol. 183(2):638-44.

8. Klemens JJ, Campbell KCM, Meech RP, Hughes LF, Somani S. (2003). Anti-oxidant Levels Inversely Co-vary with Hearing Loss After Amikacin Treatment. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):134-143.

9. Campbell KCM, Larsen DL, Meech RP, Rybak LP, Hughes LF. (2003). Glutathione Ester But Not Glutathione Protects Against Cisplatin-Induced Ototoxicity in a Rat Model. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):124-133.

10. Campbell KCM, Kelly E, Targovnik N, Hughes LF, Van Saders C, Gottleib AB, Dorr MB, Leighton A. (2003). Audiologic Monitoring for Potential Ototoxicity in a Phase I Clinical Trial of a New Glycopeptide Antibiotic. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):157-169.

11. Campbell, Kathleen CM. (2003) Introduction to Oxidative Processes. (brief tutorial) Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):121-123.

12. Campbell KCM, Meech RP, Rybak LP, Hughes LF. (2003). The Effect of D-Methionine on Cochlear Oxidative State with and without Cisplatin Administration: Mechanisms of Otoprotection. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):144-156.

13. Brewer GJ, Espinosa JA, Struble RG. (2003). Neuregentm nutrient medium promotes survival of cortical neurons after aspiration lesion, J. Neurosurgery 98:1291-1298.

14. Patel JR, Brewer GJ. (2003). Age-related changes in neuronal glucose uptake to glutamate and beta-amyloid, J. Neurosci. Res. 72:527-536.

15. Murphy LL. (2003). American ginseng in cancer therapeutics. Proceedings of the International Ginseng Society.

16. Meyers CY, Chan-Yu-King R, Hua DH, Kolb VM, Matthews WS, Parady TE, Horii T, Sandrock PB, Hou Y, Xie S. (2003). Unexpected Differences in the ?-Halogenation and Related Reactivity of Sulfones with Perhaloalkanes in KOH-t-BuOH. J. Org. Chem.68, 500-511.

17. Xie S, Hou Y, Meyers CY, Robinson PD. (2003). (±)-5-Ethyl-endo-4-(4-methoxyphenyl)-2,2,anti-8-trimethyl-6-oxabicyclo[3.2.1]octan-7-one, a bicyclic ?-lactone. Acta Crystallographica, Section E: Structure Reports Online, E59, o406-o407.

18. Xie S, Hou Y, Meyers CY, Robinson PD. (2003). (?)-anti-7-Ethyl-1-(4-methoxyphenyl)-5,5,syn-8-trimethyl-2-oxabicyclo[2.2.2]octan-3-one, a bicyclic ?-lactone. Acta Crystallographica, Section E: Structure Reports Online, E59, o403-o405.

19. MacDonald J, Ketchum J, Williams RG, Rogers LQ. (2003). A lay person versus a trained endoscopist: can the preop endoscopy simulator detect a difference? Surg Endosc. 17(6):896-8.

2002
1. Mason RP, Ran S, Thorpe P.E. (2002). Quantitative assessment of tumor oxygen dynamics: a key to prognostic radiology. J. Cell. Biochem. 39: 45-53.

2. Zhang W*, Ran S*, Sambade M, Huang X, Thorpe PE. (2002). A monoclonal antibody that blocks VEGF binding to VEGF-R2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model. Angiogenesis, 5: 35-44. (** Both authors contributed equally to this study).

3. Ran S, Rosenblum MG, Thorpe PE. (2002). Ligand-directed destruction of tumor vasculature. Book chapter contribution to “Biomedical Aspects of Drug Targeting”, pp.229-248. Eds., V. R. Muzykantov, V. P. Torchilin; Kluwer Academic Publishers, MA, USA.

4. Ran S, Thorpe PE. (2002). Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy. International J. of Radiation Oncology Biology Physics, 54 (5): 1479-1484.

5. Ran S, Downes A, Thorpe PE. (2002). Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res. 62:6132-6140.

6. Thorpe PE, Ran S. (2002). Mapping zip codes in human vasculature. Pharmacogenomics J., 2 (4): 205-206.

7. Veenendaal LM, Jin H, Ran S, Cheung L, Navone N, Marks JW, Waltenberger J, Thorpe PE, Rosenblum MG. (2002). In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors. Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7866-7871.

8. Schwarz RE, Hillebrand G, Peralta EA, Chu DZ, Weiss LM. (2002). Long-term survival after radical operations for cancer treatment-induced sarcomas: how two survivors invite reflection on oncologic treatment concepts. Am J Clin Oncol. 25(3):244-7.

9. Phillips D, Sonnenberg J, Arai AC, Vaswani R, Krutzik PO, Kleisli T, Kessler M, Granger R, Lynch G, Chamberlin R (2002). R. 5'-Alkyl-benzothiadiazides: A new subgroup of AMPA receptor modulators with improved affinity. J. Bioorganic Medicinal Chemistry. 10: 1229-1248.

10. Lin B, Brucher FA, Coligin LL, Arai AC, Lynch G. (2002). Interactions between recording technique and AMPA receptor modulators. Brain Res. 955: 164-173.

11. Lin SHS, Arai AC, Espana RA, Berridge CQ, Leslie F, Huguenard JR, Vergnes M, Civelli, O. (2002). Prolactin Releasing Peptide (PrRP) promotes waking and suppresses absence seizures in rats. Neuroscience. 114: 229-238.

12. Arai AC, Xia Y-F, Rogers G, Lynch G, Kessler M. (2002). Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J. Pharm. Exp. Ther. 303: 1075-1085.

13. Arai AC, Kessler M, Xia Y-F, Phillips D, Granger R, Chamberlin R, Lynch G. (2002). Effects of newly developed benzothiadiazide compounds on AMPA receptor mediated currents and synaptic responses. Mol. Pharmacol. 62: 566-577.

14. Helfert RH, Glatz FR, Wilson TS, Ramkumar V, Hughes LF. (2002). Hsp70 in the inferior colliculus of Fischer-344 rats: effects of age and acoustic stress. Hear Res. 170(1-2):155-65.

15. Bhat SG, Mishra S, Mei Y, Nie Z, Whitworth CA, Rybak LP, Ramkumar V. (2002). Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney. Eur J Pharmacol. 10; 442(3):251-64.

16. Helfert RH, Glatz FR, Wilson TS, Ramkumar V, Hughes LF. (2002). Hsp70 in the inferior colliculus of Fischer-344 rats: effects of age and acoustic stress. Hear Res. 170(1-2):155-65.

17. Korver K, Rybak LP, Whitworth C, Campbell KCM. (2002). Round window application of D-methionine provides complete cisplatin otoprotection. Otolaryngol Head Neck Surg 126:683-689.

18. Husain K, Jagannathan R, Zeshan H, Trammel GL, Rybak LP, Hazelrigg SR, Somani SM. (2002). Dose Response of Carboplatin-induced nephrotoxicity in rats. Phamacol x Toxicol 91:83-89.

19. Hughes LF, McAsey ME, Donathan CL, Smith T, Coney P, Struble RG. (2002). Effects of hormone replacement therapy on olfactory sensitivity: cross-sectional and longitudinal studies. Climacteric 5(2):140-50.

20. Kimonis VE, Kovach M, Campbell K, Herman K, Waggoner B, Gelber D, Hughes L. (2002). Anticipation in a Unique Family with Charcot-Marie-Tooth Syndrome and Deafness: Delineation of the Clinical Features and Review of the Literature. American Journal of Medical Genetics, 108:295-303.

21. Blakley BW, Cohen JI, Doolittle ND, Muldoon LL, Campbell KC, Dickey T, Neuwelt EA. (2002). Strategies for Prevention of Toxicity Caused by Platinum Based Chemotherapy: Review and Summary of the Annual Meeting of the Blood-Brain Barrier Disruption Program, Gleneden Beach, Oregon, March 12, 2001. Laryngoscope 112: pp 1997-2001.

22. Donnersberger DR, Campbell KCM, Meech RP, Rybak LP, Hughes LF, Nanavati PJ. (2002). A Model for Marked Radiation-Induced Hearing Loss. Journal of Burns, (journalofburns.com).

23. Campbell KCM. (2002). Developing Otoprotective Agents for Ototoxic and Noise-Induced Hearing Loss: D-methionine and other compounds. NHCA Spectrum 19(2):12-14.

24. Korver KD, Rybak LP, Whitworth C, Campbell KC. (2002). Round Window Application of D-Methionine Provides Complete Cisplatin Otoprotection. Otolaryngology-Head and Neck Surgery, 126:683-689.

25. Kopke RD, Coleman JKM, Liu J, Campbell KCM, Riffenburgh RH. (2002). Enhancing Intrinsic Cochlear Stress Defenses to Reduce Noise-Induced Hearing Loss. The Laryngoscope 112:1515-1532.

26. Nathan BP, Jiang Y, Wong GK, Shen F, Brewer G, Struble RG. (2002). Apolipoprotein E4 inhibits and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 928:96-105.

27. Malone JP, Levin RJ. (2002). Second malignant tumors after treatment of nasopharyngeal carcinoma: four case reports and literature review. Skull Base 12: 87-92.

28. Schuller DE, Grecula J, Agrawal A, Rhoades C, Orr D, Young D, Malone JP, Merz M. (2002). Multimodal intensification therapy for previously untreated advanced resectable squamous cell carcinoma of the oral cavity, oropharynx, or hypopharynx. Cancer 94:3169-3178.

29. Lang J, Borchers J, Danahey D, Smith S, Stover D, Agrawal A, Malone JP, Schuller D, Weghorst C, Holinga A, Lingam K, Patel C. (2002). Mutational status of overexpressed p16 in head and neck cancer: evidence for germline mutation of p16/p14ARF. Int J Oncol 21:401-408.

30. Murphy LL, Lee TJ-F. (2002). Ginseng, sex behavior and nitric oxide. Annals New York Academy of Sciences 962: 372-377.

31. Wilson T, March H, Banz WJ, Hou Y, Adler S, Meyers CY , Winters TA, Maher MA. (2002). Antioxidant Effects of Phyto- and Synthetic Estrogens on Cupric-Ion Induced Oxidation of Human Low-Density Lipoproteins In Vitro. Life Sciences, 2287-2298.

32. Xie S, Hou Y, Meyers CY, Robinson PD. (2002). 2-cis-3-trans-3-Ethyl-2,6,6-trimethyl-4-oxocyclohexanecarboxylic acid: an intermediate in the synthesis of a highly potent estrogen. Acta Crystallogr. C58, o159-o161.

33. Xie S, Hou Y, Meyers CY, Robinson PD. (2002). 2(S),6(R)-Dimethyl-4-(4-methoxyphenyl)-5(R)-ethyl-3-cyclohexene-1(S)-carboxylic acid and its enantiomer: potential therapeutic agents for prostate cancer. Acta Crystallographica, E58, o1460-o1462.

34. Meyers CY, Hou Y, Winters TA, Banz WJ, Adler S. (2002). Activities of a non-classical estrogen, Z-bis-dehydrodoisynolic acid, with ER? and ER? J. Steroid Biochem. Molec. Biol., 82, 33-44.

35. Rogers LQ, Gutin B, Humphries M. (2002). Assessing physical activity determinants and preferences among patients with arthritis to enhance future intervention design. Medicine and Science in Sports and Exercise. 34(5):S38. (Abstract)

36. Rogers LQ, Macera CA, Hootman JM, Ainsworth BE, Blair SN. (2002). The association between joint stress from physical activity and self-reported osteoarthritis: an analysis of the Cooper Clinic data. Osteoarthrits and Cartilage. 10: 617-622.

37. Rogers LQ, Bailey JE, Gutin B, Johnson KC, Levine MA, Milan F, Seelig CB, Sherman SE. (2002). Teaching Resident Physicians to Provide Exercise Counseling: A Needs Assessment. Academic Medicine. 77 (8): 841-844.

2001
1. Morgan BR, Tarter TH. (2001). Serum heterophile antibodies interfere with prostate specific antigen test and result in over treatment in a patient with prostate cancer. J Urol. 166(6):2311-2.

2. Arai AC. (2001). GYKI 52466 has positive modulatory effects on AMPA receptors. Brain Res. 892: 396-400.

3. Lin SHS, Arai AC, Wang Z, Nothacker HP, Civelli O. (2001). The carboxyl terminus of the prolactin releasing peptide (PrRP) receptor interacts with PDZ domain proteins involved in AMPA receptor clustering. Mol. Pharmacol. 60: 916-924.

4. Hardiek K, Katholi RE, Ramkumar V, Deitrick C. (2001). Proximal tubule cell response to radiographic contrast media. Am. J. Physiol. Renal Physiol. 280(1):F61-70.

5. Ramkumar V, Hallam DM, Nie Z. (2001). Adenosine, oxidative stress and cytoprotection. Jap. J. Pharmacol. 86(3):265-74.

6. Whitworth CA, Rybak LP, Kemp R, Spence S. (2001). Pharmacological antagonism of the slow-rectifying potassium channel (IKS) has no effect on the cochlear structure and function in vivo. Pharmacol x Toxicol 88; 45-50.

7. Husain K, Scott RB, Whitworth C, Somani SM, Rybak LP. (2001). Dose-response of carboplatin-induced hearing loss in rats: Antioxidant system. Hear Res 151:71-78.

8. Armour G, Mhaskar Y, Rybak LP, Dunaway G. (2001). Alteration of 6-phosphofructo-1-kinase subunits during maturation of the rat cochlear cells. Hear Res 151:149-156.

9. Husain K, Whitworth C, Somani S, Rybak LP. (2001). Carboplatin-induced oxidative stress in rat cochlea. Hear Res 158:14-22.

10. Campbell, KCM. (2001). Preventing Ototoxic Hearing Loss. In Dennis, K. (Ed.) Hearing Impairment. Veterans Health Initiative. Washington, DC: Veterans Health Administration, Department of Veterans Affairs. (Required reading for all VA Primary Care Physicians)

11. Campbell, KCM, Chandler D, Dennis K. (2001). Preventing Noise-induced Hearing Loss. In Dennis, K. (ed.) Hearing Impairment. Veterans Health Initiative, Washington, DC: Veterans Health Administration, Department of Veterans Affairs. (Required Reading for all VA Primary Care Physicians).

12. Brewer GJ, Price PJ. (2001). Culture Medium for maintaining neural cells in ambient atmosphere, U.S. Patent 6,180,404.

13. Viel JJ, McMannus DJ, Brewer GJ. (2001). Temperature and time interval for culture of post mortem neurons from adult rat cortex, J. Neurosci. Res. 64:311-321.

14. Branch DW, Wheeler BC, Brewer GJ, Leckband DE. (2001). Long-term stability of microstamped substrates of polylysine and grafted polyethylene glycol in cell culture conditions, Biomaterials 22:1035-1047.

15. Viel JJ, McManus DJ, Smith SH, Brewer GJ. (2001). Age and concentration-dependent neuroprotection and toxicity by TNF in cortical neurons from beta-amyloid, J. Neurosci. Res. 64:454-465.

16. Brewer GJ, Espinosa J, McIlhaney MP, Pencek TP, Kesslak JP, Cotman C, Viel JJ, McManus DC. (2001). Culture and regeneration of human neurons after brain surgery, J. Neurosci. Meth. 107:15-23.

17. Cady C, Evans MS, Brewer GJ. (2001). Age-related differences in NMDA responses in cultured rat hippocampal neurons. Brain Res. 921:1-11.

18. Chang JC, Brewer GJ, Wheeler BC. (2001). Modulation of neural network activity by patterning. Biosensors x Bioelec., 16:527-533.

19.Malone JP, Agrawal A, Schuller DE. (2001). The safety and efficacy of transcervical resection of parapharyngeal space neoplasms. Ann Otol Rhinol Laryngol 110(12):1093-1098.

20. Murphy LL. (2001). Hormonal System and Reproduction. In: Cannabis and Cannabinoids- Pharmacology, Toxicology and Therapeutic Potential (F. Grotenhermen, ed.), Haworth Publishers, New York and Huber-Verlag, Bern, pp. 315-323, 2001. (published in English and German)

21. Murphy LL, Rice JA, Zong W. (2001). Ginsenosides Rc and Rh2 inhibit MCF-7 cell proliferation through distinctly different mechanisms. Molecular Biology of the Cell (suppl) 12: 764.

22. Robinson PD, Lutfi HG, Hou Y, Meyers CY. (2001). 9-(1-Acetoxy- ethylidene)fluorene ("Diacetylfluorene"), a Biproduct from the Acetylation of 9-Fluorenyllithium. Acta Crystallog. C57, 428-430.

23. Meyers CY, Lutfi HG, Hou Y, Robinson PD. (2001). 1,1-Di-9-fluorenylethanol, a Byproduct from the Acetylation of 9-Fluorenyllithium. Acta Crystallog. C57, 580-581.

24. Robinson PD, Lutfi HG, Hou Y, Meyers CY. (2001). 1,1-Di-9-fluorenylethyl Acetate, a Byproduct from the Acetylation of 9-Fluorenyllithium. Acta Crystallogr. C57, 582-584.

25. Chan-Yu-King R, Hou Y, Sandrock PB, Meyers CY, Robinson PD. (2001). 2-Bromo-2-propyl Mesityl Sulfone, Acta Crystallogr. E57, o449-450.

26. Meyers CY, Hua DH, Hou Y, Meyers CY, Robinson PD. (2001). 2-Chloro-2-propyl Mesityl Sulfone, Acta Crystallogr. E57, o587-589.

27. Robinson PD, Parady TE, Hou Y, Sandrock, Meyers CY. (2001). 2-Bromo-2-propyl Phenyl Sulfone, Acta Crystallogr. E57, o584-586.

28. Hootman JM, Macera CA, FACSM; Rogers LQ, Blair SN, FACSM. (2001). Walking Versus running: The long-term impact on the development of hip/knee osteoarthritis. Medicine and Science in Sports and Exercise. 33(5):S258. (Abstract)

29. Rogers LQ, Humphries MC, Gutin B, FACSM; Lemmon, C. (2001). Effect of a physician fitness program on fitness, behavior, and attitudes toward physical activity. Medicine and Science in Sports and Exercise. 33(5):S23.(Abstract)