Andrzej Bartke, PhD  

Andrzej Bartke, PhD
Department of Internal Medicine
Division of Geriatric Research

Professor and Director of Geriatric Medicine, Departments of Internal Medicine and Physiology

Office Location: 801 N. Rutledge, Room 4389
Appointments: 217-545-7962
Lab visits welcome; please call first.
Degree Year Institution Area
Magister (equivalent MS) 1962 Jagiellonian University, Krakow, Poland Biology (Zoology)
PhD 1965 University of Kansas Zoology (Genetics)
 
Academic Interests

Our laboratory is exploring the genetic control of aging in mammals and endocrine mechanisms responsible for the effects of longevity genes. We reported the first evidence that mutation of a single gene can significantly extend lifespan in a mammal, and have extensively characterized the phenotype of long-lived Ames dwarf (Prop1df) mice, identifying several mechanisms that are likely to explain or contribute to their delayed aging and greatly prolonged longevity. We have performed similar studies of long-lived growth hormone receptor knockout (GHR-KO or “Laron dwarf”) mice and demonstrated numerous similarities in the characteristics related to aging and longevity in the two mutant animals. Our findings, along with results from other laboratories, firmly establish the physiological role of the somatotropic axis (GH and IGF-1) in the control of aging in mammals.

We are also examining interactions of mouse longevity genes with calorie restriction.  We have demonstrated that a 30% dietary reduction leads to further, significant extension of the average and maximal lifespan in Ames dwarf mice, but has little if any effect on the longevity of GHR-KO animals. Studies of the expression of genes related to GH, IGF-1 and insulin signaling, as well as analysis of broad profiles of gene expression, suggest that Prop1df and GHR-KO animals have prolonged lives by mechanisms that are overlapping but definitely not identical to the effects of caloric restriction.

 
Representative Publications
  1. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A.  Dwarf mice and the ageing process. Nature 384:33, 1996.
  2. Bartke A, Wright JC, Mattison J, Ingram DK, Miller RA, Roth GS.  Longevity: Extending the lifespan of long-lived mice.  Nature 414:412, 2001.
  3. Kinney BA, Coschigano KT, Kopchick JJ, Steger RW, Bartke, A.  Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice.  Physiology & Behavior 72:653-660, 2001.
  4. Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A. Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: correlation to extended longevity. Journal of Gerontology, A Biol. Sci. Med. Sci. 58A: 291-296, 2003.
  5. Tatar M, Bartke A, Antebi A.  The endocrine regulation of aging by insulin-like signals. Science 299:1346-1351, 2003.
  6. Masternak M, Al-Regaiey K, Bonkowski M, Panici J, Sun L, Wang J, Przybylski GK, Bartke A.  Divergent effects of caloric restriction on gene expression in normal and long-lived mice.  Journal of Gerontology. A Biol. Sci. Med. Sci.  59:784-788, 2004.
  7. Sun LY, Al-Regaiey K, Masternak MM, Wang J, Bartke A. Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiology of Aging 26:929-937, 2005.
  8. Bartke A. Minireview: Role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146:3718-3723, 2005.
  9. Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor 1/insulin signaling and caloric restriction. Endocrinology 146:851-860, 2005.
  10. Bonkowski MS, Rocha JS, Masternak MM, Al-Regaiey KA, Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proceedings of the National Academy of Sciences 103:7901-7905, 2006.
  11. Sun LY, Bartke A.  Adult neurogenesis in the hippocampus of long-lived mice during aging.  J Gerontol A Biol Sci Med Sci 62:117-125, 2007.
  12. Chandrashekar V, Dawson CR, Martin ER, Rocha JS, Bartke A, Kopchick JJ.  Age-related alterations in pituitary and testicular functions in long-lived growth hormone receptor gene-disrupted mice.  Endocrinology 148:6019-6025, 2007.
  13. Giani JF, Bonkowski MS, Munoz MC, Masternak MM, Turyn D, Bartke A, Dominici FP. Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice:  effects of calorie restriction.  J Gerontol A Biol Sci Med Sci 63:788-797, 2008.
  14. Westbrook R, Bonkowski MS, Strader AD, Bartke A.  Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice.  J Gerontol A Biol Sci Med Sci 64:443-451, 2009.
  15. Bonkowski MS, Dominici FP, Arum O, Rocha JS, Al Regaiey KA, Westbrook R, Spong A, Panici J, Masternak MM, Kopchick JJ, Bartke A.  Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity.  PLoS ONE 4:e4567, 2009.
  16. Ikeno Y, Hubbard GB, Lee S, Cortez LA, Lew CM, Webb CR, Berryman DE, List EO, Kopchick JJ, Bartke A.  Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice.  J Gerontol A Biol Sci Med Sci 64:522-529, 2009.
  17. Arum O, Bonkowski MS, Rocha JS, Bartke A.  The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet.  Aging Cell 8:756-60, 2009.
  18. Bates DJ, Li N, Liang R, Sarojini H, An J, Masternak MM, Bartke A, Wang E.  MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging.  Aging Cell 9:1-18, 2010. 

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