Kathy Bottum, MD, PhD  

Kathy Bottum, MD, PhD
Department of Internal Medicine
Division of Medicine Psychiatry
Assistant Professor of Medicine

Office Location: 751 N. Rutledge, Room 1700
Springfield, Illinois 62702
Appointments: 217-545-0182



Degree Year Institution Area
BA 1985 Grand Valley State University Chemistry and Russian Studies
PhD 1995 University of Illinois - Urbana-Champaign Biochemistry
MD 1997 University of Illinois - Urbana-Champaign Medicine
Residency 2002 Southern Illinois University School of Medicine Medicine/Psychiatry
 
Board Certifications
Internal Medicine
Psychiatry
Psychosomatic Medicine
 
Academic Interests
Resistance to Excitotoxicity in Suprachiasmatic Nucleus Neurons
Brain Derived Neurotrophic Factor in Major Depressive Disorder
Role of AhR in Diabetes
 
Clinical Interests
Consult liaison psychiatry
Medical care of the psychiatrically ill
 
Representative Publications
  1. Tischkau S., Cohen J., Stark J., Gross D., Bottum K. 2007. Time-of-day affects expression of hippocampal markers for ischemic damage induced by global ischemia. Exp. Neurology. 208: 314-322.
  2. Bottum K, Poon E., Comiskey M., Haley B. and Tischkau S.A. 2008. Suprachiasmatic Nucleus Neurons Display Endogenous Resistance to Excitotoxicity. Neurotox Res. In revision.
  3. Wagle R.K., Ede K., Craig J., and Bottum K. 2004. An ethical dilemma: when the family wants the withdrawal of care. J Psychiatr. Pract. 10(5): 334-6.
  4. Swartz C.M., Bottum K.M., and Salazar L.S. Jr. 2002. Suppression of catatonia-like symptoms by lorazepam in nonconvulsive status epilepticus without seizure termination. Am. J. Geriatr. Psychiatry. 10 (3): 348-350.
  5. Bottum K. and Jonas A. 1995. Cholesterol transfer from low density lipoproteins to reconstituted high density lipoproteins is determined by the properties and concentrations of both particles. Biochemistry. 34: 7264-7270.
  6. Jonas A., Bottum K., Theret N., Duchateau P., and Castro G. 1994. Transfer of cholesterol from Ob1771 cells or LDL to reconstituted, defined high density lipoproteins. J. Lipid Res. 35: 860-870.
  7. Jonas A., Bottum K., and Kezdy K. 1991. Transformations of reconstituted high density lipoprotein subclasses as a function of temperature or LDL concentration. Biochim. Biophys. Acta. 1085: 71-76.
  8. Karmarkar SW, Bottum KM, Krager SL, Tischkau SA. ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells. PLoS One 2011; 6(8) e23493.
  9. Wang C, Xu C, Krager SL, Bottum KM, Liao DF, Tischkau SA. Aryl Hydrocarbon Receptor Deficiency Enhances Insulin Sensitivity and Reduces PPAR-α Pathway Activity in Mice. Environ Health Perspect 2011, Aug 17.
  10. Karmarkar SW, Bottum KM, Tischkau SA. Considerations for the use of anesthetics in neurotoxicity studies. Comp Med 2010 Aug; 60(4): 256-62. Review.
  11. Bottum K, Poon E, Haley B., Karmarkar S., and Tischkau S.  Suprachiasmatic nucleus neurons display endogenous resistance to excitotoxicity.  Exp Bio Med 2010 Feb; 235(2):237-46.

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