Janak Koirala, MD, MPH, FACP, FIDSA
Department of Internal Medicine
Division of Infectious Diseases
Associate Professor of Medicine
Assistant Professor (Adjunct Faculty), University of Illinois at Springfield School of Public Health

Dr. Koirala is involved in several clinical and laboratory research projects including the following projects for which he is the principal investigator.

Current Laboratory Research Projects:
1. Interferon-gamma to improve macrophage functions against MAC (Mycobacterium avium complex) infection in HIV-infected patients
2. In vitro MAC (Mycobacterium avium complex) antigen assay to screen for MAC infection
3. In vitro antimicrobial susceptibility test for Multidrug Resistant Acinetobacter baumanii

Current Clinical Research Projects:

1. HIV/AIDS Education and Prevention in Central Illinois
2. Prevention and Self-Treatment of Diarrhea in International Travelers
3. An International, Multicenter, Prospective Observational Study of the Safety of Maraviroc Used With Optimized Background Therapy in Treatment Experienced HIV-1 Infected Patients (Pfizer Protocol # A4001067)
4. A Phase IV, Multi-center, Cross-Sectional Study to Evaluate the I50L Substitution among Subjects Experiencing Virologic Failure on a HAART regimen containing Atazanavir

1. Diagnosis and management of all infectious diseases
2. Travel Medicine and immunization

Current Laboratory and Clinical Research since 2008:

1. Prevention and Self-Treatment of Diarrhea in International Travelers (Principal Investigator)
2. An International, Multicenter, Prospective Observational Study of the Safety of Maraviroc Used With Optimized Background Therapy in Treatment Experienced HIV-1 Infected Patients: Pfizer Protocol # A4001067. (Principal Investigator)
3. A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg versus Comparator (Vancomycin or Teicoplanin) in the Treatment of Subjects Undergoing Surgical Standard of Care for Osteomyelitis Associated with an Infected Prosthetic Hip or Knee Joint caused by Methicillin-resistant Staphylococcus aureus and/or Coagulase- negative staphylococci. Cubist Pharmaceuticals, Inc. Protocol DAP-OST-06-02. (Co- Investigator; PI- Gordon Allan)
4. Protocol Based Management of Diabetic Ketoacidosis in Pediatric ICU. (Co- Investigator and statistical advisor; PI- Sangita Basnet)
5. Interferon-gamma to improve macrophage functions against MAC infection in HIV- infected patients- supported by ALA Grant (Principal Investigator)
6. In vitro MAC antigen assay to screen for MAC infection (Principal Investigator)
7. In vitro antimicrobial synergy and mechanism of resistance for Multidrug Resistant Acinetobacter baumanii (Principal Investigator)

Articles Published – Beginning 2008

1. Emergencies in Infectious diseases: From Head To Toe Edited by Khardori, NM, and Wattal, C. 2010. Sinusitis. Mucormycosis. Koirala, J, Speil, C and Khardori, N.
2. Emergencies in Infectious diseases: From Head To Toe Edited by Khardori, NM, and Wattal, C. 2010. Sinusitis. Mucormycosis. Discussion. Koirala, J,
3. Emergencies in Infectious diseases: From Head To Toe Edited by Khardori, NM, and Wattal, C. 2010. Infective Endocarditis: S. aureus infective
   endocarditis and brain abscess. Koirala, J, and.Speil, C.
4. Emergencies in Infectious diseases: From Head To Toe Edited by Khardori, NM, and Wattal, C. 2010. Infective Endocarditis: S. aureus infective
   endocarditis and brain abscess. Discussion. Koirala, J.
5. B. M. Pokhrel, J. Koirala, S. K. Mishra, R.K. Dahal, P.K. Khadga, N.R. Tuladhar. Prevalence of Multi-Drug Resistant (MDR) and ESBL Producing Salmonella enterica serotypes typhi and paratyphi A in Nepal. Int J Infect Dis. 2006 Sep;10(5): 434-438. (Received journal’s award for the top 10 articles cited for 2006-2008 period).
6. Strategies for Management of Antiretroviral Therapy (SMART) Study Group (includes J Koirala), Lundgren JD, Babiker A, El-Sadr W, Emery S, Grund B, Neaton JD, Neuhaus J, Phillips AN. Inferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: role of CD4+ Cell counts and HIV RNA levels during follow-up. J Infect Dis. 2008 Apr 15;197(8):1145-55.
7. Strategies for Management of Antiretroviral Therapy (SMART) Study Group (includes J Koirala), Emery S, Neuhaus JA, Phillips AN, Babiker A, Cohen CJ, Gatell JM, Girard PM, Grund B, Law M, Losso MH, Palfreeman A, Wood R. Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study. J Infect Dis. 2008 Apr 15;197(8):1133-44.
8. Koirala J, Adamski A, Koch L, Stueber D, El-Azizi M, Khardori NM, Ghassemi M, Novak RM. Interferon-Gamma Receptors in HIV-1 Infection. AIDS Res Hum Retroviruses. 2008 Aug;24(8):1097-102.
9. Htwe TH, Bergman S, Koirala J. Famciclovir substitution for patients with acyclovir-associated renal toxicity. J Infect. 2008 Jul: 57:266-268.
10. Strategies for Management of Antiretroviral Therapy (SMART) Study Group (includes J Koirala), El-Sadr WM, Grund B, Neuhaus J, Babiker A, Cohen CJ, Darbyshire J, Emery S, Lundgren JD, Phillips A, Neaton JD. Risk for opportunistic disease and death after reinitiating continuous antiretroviral therapy in patients with HIV previously receiving episodic therapy: a randomized trial. Ann Intern Med. 2008 Sep 2;149(5):289-99.
11. Fox Z, Phillips A, Cohen C, Neuhaus J, Baxter J, Emery S, Hirschel B, Hullsiek KH, Stephan C, Lundgren J; SMART Study Group (includes J Koirala). Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen. AIDS. 2008 Nov 12;22(17):2279-89.
12. Mocroft A, Wyatt C, Szczech L, Neuhaus J, El-Sadr W, Tracy R, Kuller L, Shlipak M, Angus B, Klinker H, Ross M; INSIGHT SMART Study Group (includes J Koirala).Interruption of antiretroviral therapy is associated with increased plasma cystatin C. AIDS. 2009 Jan 2;23(1):71-82.

e-Publications Beginning 2008:

1. Koirala J. Mycobacterium Kansasii. eMedicine from WebMD 2001; 2(12). (Updated: April 2006; March 18, 2009).
   Available at: http://www.emedicine.com/med/topic1537.htm
2. Koirala J, Harley WB. Mycobacterium avium intracellulare. eMedicine Journal 2006; 2(12). An on-line medical reference; published by eMedicine inc. (Revisions: May 2008)
   Available at: http://www.emedicine.com/med/topic1532.htm
3. Koirala J, Htwe TH, Speil C. Lyme Disease. BMJ Point of Care; published by: BMJ Group and epocrates inc., 2008.
   Available at: http://bmj-preview.epocrates.com
4. Bharat M Pokhrel, Rajendra Karmacharya, Shyam K Mishra and Janak Koirala. Distribution of Antibody Titer against Salmonella enterica among Healthy Individuals in Nepal. Annals of Clinical Microbiology and Antimicrobials. Annals of Clinical Microbiology and Antimicrobials 2009, 8:1
5. Janak Koirala, Nancy Khardori. Global Swine Influenza A (H1N1) Outbreak, Spring 2009 (Commentary). eClips Consult; published by: Elsevier Inc., 2009. Available at: http://eclipsconsult.com/eclips
6. Koirala J, Sundareshan V, Basnet S. Bartonellosis. BMJ Point of Care. Editors: BMJ Group. Publishers: ePocrates inc., 2009.
   Available at: https://online.epocrates.com/u/29111152/Bartonella+infection

Abstracts Beginning 2008

1. Katherine Thompson, Janak Koirala. Longitudinal Assessment of Treatment Efficacy for Travelers' Diarrhea. SIU Mentored Professional Enrichment Experiences (MPEE) Students’ Presentation, Sep. 12, 2008.
2. Bharat M. Pokhrel, Janak Koirala, Rajan Kumar Dahal, Prem Kumar Khadga, Basista Prasad Rijal, Nhuchhe Ratna Tuladhar. Retrospective study of antibiotic resistance among Salmonella enterica isolates from 2005- 2007. Poster presentation at 57th ASTMH Annual Meeting, December 7-11, 2008, New Orleans [Abstract No. 66]
   
3. Swapna Devanna, MD; Lokesh Shahani, MD; Samih Mawari, MD; Cristian Speil, MD; Vidya Sundareshan, MD; Janak Koirala, MD. CMV Infection Complicating Crohn’s Disease with Extraintestinal Manifestation. Poster presented at ACP Downstate Conference, October 2009.
4. M Ahmed, J Koirala, N Khardori. Necrotizing fasciitis: A 10 year review of the spectrum of clinical presentation, microbiology and outcome. Poster presentation at the 47th Annual Meeting of the Infectious Diseases Society of America (IDSA), Philadelphia, Pennsylvania, October 29–November 1, 2009 (Presentation no. 928)
5. Sangita Basnet, Catherine Kottukapally, Rabia Akbar, Nobin J. Kottukapally, Gurpreet Mander, and Janak Koirala. Protocol Based Management in the Care of Children Admitted with Diabetic Ketoacidosis. SCCM Annual Congress. January 9-13, 2010 , Miami Beach, Florida. (SCCM Abstract no. 1056)
6. I. Tyagi, J. Koirala. Clinical characterization of patients with carbapenem- resistant versus carbapenem-susceptible Acinetobacter baumannii infections. Poster presentation at 14th International Congress on Infectious Diseases. March 9-12, 2010. Miami, Florida. (Abstract number: 2268)
7. J. Koirala, I. Tyagi, V. Sundareshan, S. Bergman, J. Lawhorn, C. Drake, C. Speil. Carbapenem hydrolyzing multidrug resistant Acinetobacter baumannii. Poster presentation at 14th International Congress on Infectious Diseases. March 9-12, 2010. Miami, Florida. (Abstract number: 1311)
8. Basnet S, Mander G, Andoh J, Koirala J. Early initiation of noninvasive positive pressure ventilation in the management of children with status asthmaticus. Pediatric Critical Care Colloquium, May 15-17th, 2010, Pittsburg, PA