A. Liberati, DVM, PhD, DABT, DACLAM
|Doctor of Veterinary Medicine||1988||The Ohio State University||Veterinary Medicine|
|PhD||1995||University of Rochester||Toxicology|
|Laboratory Animal Medicine|
|My laboratory studies pulmonary carcinogenesis caused by environmental exposure to toxicants and known carcinogens. In particular, we are interested in the innate response of the alveolar lung tissue and alterations in the alveolar cells cytokine/chemokine profiles following exposure to tobacco-source carcinogens, e-liquid components and particulate matter. Numerous factors, including cytokines, chemokines, growth factors and inflammatory regulators likely contribute to tumor initiation. Determining the role of these factors in conjunction with recognized molecular changes in the lung epithelial cells could support an earlier identification of tumors, improved prognostic indicators, or better risk analysis for patients. Mechanistic studies in the laboratory use cell lines and a lung slice tissue culture model. Our lung slice model allows for in vitro exposure of lung tissue from multiple sources to a variety of pulmonary toxicants. Recent work in our laboratory has examined the ability of caloric-restriction and obesity to modify the response of the lung to known pulmonary carcinogens. Understanding the possible mechanism behind the observed changes is a key focus. Newer studies in the laboratory are focused on the toxicological effects of e-liquid components on the cells of the alveolar region.|
|Current collaborations include examining inflammatory mediators and how they are altered by physical exercise in patients with pulmonary or cardiac inflammatory diseases. The laboratory also participates in collaborative clinical research by determining the inflammatory profiles of surgically resected tumor, biopsy specimens, and serum from individuals exposed to lung carcinogens, especially tobacco exposure, or with inflammatory lung disease.|
Gupta, A, Liberati, TA, Verhulst, SJ, Main, BJ, Roberts, MH, Potty, AGR, Pylawka, TK and El-Amin III, SF. Biocompatibility of Single Walled Carbon Nanotubes Composites for Bone Regeneration. Bone Joint Res May 4(50); 70-77, 2015.
Liberati, TA, Trammell, RA, Randle, MR, Barrett, S and Toth, LA. Cytokine and Chemokine Responses of Lung Exposed to Surrogate Viral and Bacterial Infections. Comp Med, 63(2); 1-13, 2013.
Trammell, RA, Liberati, TA and Toth, LA. Host genetic background and the innate inflammatory response of lung to influenza virus. Microbes Infection, 14; 50-58, 2012.
Masternak, MM, Bartke, A, Wang, F, Spong, A, Gesing, A, Fang, Y, Salmon, AB, Hughes, LF, Liberati, T, Boparai, R, Kopchick, JJ and Westbrook, R. Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell, 11: 73-81, 2012.
Liberati, TA, Randle, MR and Toth, LA. In vitro lung slices: a powerful approach for assessment of lung pathophysiology. Expert Rev Mol Diagn, 10(4); 501-508, 2010.
TA Liberati, MR Randle, O Arum, M Masternak and A Bartke. Caloric-restriction and diet-induced obesity effects in A/J mouse model of NNK-induced lung cancer. Society of Toxicology National Meeting. 2012.
TA Liberati and MR Randle. NNK-Induced Cytokine Alterations in Lung Slices from Lean and Diet-induced Obese C57BL/6J Mice. Society of Toxicology 50th Anniversary National Meeting, 2011.
P White, TA Liberati, PL Hopkins-Price, SJ Verhulst and JQ Henkle. Cytokine Changes in Clinically Normal and Cancerous Lung of Smokers. Mini-symposium at American Thoracic Society International Meeting. Am J Respir Crit Care Med, 181: A2524, 2010.
TA Liberati, MR Randle and RA Trammell. NNK-Induced Acute Toxicity and Cytokine Alterations in a Lung Slice Model. Society of Toxicology National Meeting, 2010. T Liberati, E Perkins, R Gairani and L Vermeulen. In Vitro Effects of a Novel Nanoparticle, Zirconium Phosphate. Society of Toxicology National Meeting, 2009.
A Gesing, MM Masternak, F Wang, R Boparai, T Liberati and A Bartke. Visceral Fat Removal Affects Insulin Signaling Pathway in Growth Hormone Receptor Knockout (GHRKO) Mice. 38th Annual Meeting of the American Aging Association and 23rd Annual Meeting of the American College of Clinical Gerontology, 2009.
MM Masternak, F Wang, A Spong, A Gesing, R Westbrook, T Liberati and A Bartke. The Impact of Growth Hormone Receptor Deficient Adipose Tissue on Insulin Signaling. 62nd Annual Scientific Meeting of the Gerontological Society of America, 2009.
MM Masternak, R Westbrook, A Gesing, F Wang, JA Pancicni, A Spong, T Liberati and A Bartke. Divergent effects of visceral fat removal on insulin signaling pathway in growth hormone receptor knockout (GHRKO) and normal mice. Nathan Shock Aging Center 2008 Conference on Aging, 2008.
N Mirza, P Hopkins-Price, T Liberati, R Trammell, S Markwell and M Johnson. Effect of Exercise and Physical Activity on Cytokines in Healthy and Cystic Fibrosis Patients. Amer J Resp Critical Care Med. 177; A1000, 2008.
MR Johnson, PL Hopkins-Price, TA Liberati, RA Trammell, SJ Markwell and N Mirza. Effect of Physical Activity on Cytokine Levels. Med Scien Sports Exer. 40:5, 2008.