laboratory studies pulmonary carcinogenesis caused by environmental exposure
to toxicants and carcinogens. In particular, we are evaluating the role
of chronic inflammation as a precursor and modulator of lung tumors. Numerous
factors, including cytokines, chemokines, growth factors, etc. may contribute
to tumor initiation and progression. Determining the role of these factors
in conjunction with recognized molecular changes in the gene expression
profile of lung epithelial cells may support earlier identification of lung
tumors and an improved ability to determine prognosis. Mechanistic studies
in the laboratory use cell lines and a lung slice tissue culture model.
The lung slice model allows in vitro exposure of lung tissue from various
species, including humans, to a variety of pulmonary toxicants, including
cigarette smoke derivatives, nanoparticles, chemicals, etc.
- Effect of Exercise and Activity
on Cytokines in Healthy and Cystic Fibrosis Patients. N Mirza, P Hopkins-Price,
T Liberati, R Trammel, S Markwell and M Johnson. Southern Illinois University
School of Medicine, Springfield, IL.
- Effect of Physical Activity
on Cytokine Levels. Mark R. Johnson, Patricia L. Hopkins-Price, Teresa
A. Liberati, Rita A. Trammell, Steven J. Markwell and Nureain Mirza.
Southern Illinois University School of Medicine, Springfield, IL.
- Alveolar Type II Cell Response
To Crocidolite Asbestos In Vitro TA Liberati, JN Finkelstein and G Oberdoerster.
Dept. of Environmental Medicine, U. of Rochester, Rochester, NY 14642.
- Proliferating Cell Nuclear
Antigen As A Marker Of Alveolar Type II Cell Proliferation In Vitro
Teresa A. Liberati, Jacob N. Finkelstein and Raymond B.Baggs . Depts.
of Environmental Medicine, Pathology and Division of Laboratory Animal
Medicine, U. of Rochester, Rochester, NY 14642.
- Effects Of Silicon Dioxide
On The Production Of Vasoregulatory Mediators By Rat Alveolar Type II
Epithelial Cells. DE Heck, DL Laskin, JD Laskin, J Finkelstein, T Liberati,
and G Oberdoerster. UMDNJ-Robert Wood Johnson Medical School and Rutgers
University, Piscataway, NJ and University of Rochester, Rochester, NY.
- Alterations by Fibrous and
Nonfibrous Particles on the Synthesis of Platelet-derived Growth Factor
by Primary Alveolar Type II Cells and the L2 Cell LineIn Vitro. TA Liberati,
CJ Johnston, G Oberdoerster and JN Finkelstein. Depts. of Environmental
Medicine and Pediatrics, University of Rochester, School of Medicine
and Dentistry, Rochester, New York.
- Use of Lung Tissue Slice
Cultures in the Study of Particle Effects on Gene Expression. TA Liberati,
RJ Jaramillo and NF Johnson. Molecular and Cellular Toxicology, Inhalation
Toxicology Research Institute, Albuquerque, NM.
- Neil F. Johnson, Thomas
R. Carpenter, Richard J. Jaramillo and Teresa A. Liberati. DNA Damage-Inducible
Genes as Biomarkers for Exposures to Environmental Agents. Environ.Health
Perspec. 1997, 105 (Suppl. 4), pages 913-917.