Teresa A. Liberati, DVM, PhD  

Teresa A. Liberati, DVM, PhD
Department of Internal Medicine
Division of Pulmonary & Critical Care Medicine and DLAM

Research Assistant Professor
Director, DLAM and RIF

Office Location: 825 N. Rutledge Street
Springfield, Illinois 62702

Degree Year Institution Area
Doctor of Veterinary Medicine 1988 The Ohio State University Veterinary Medicine
PhD 1995 University of Rochester Toxicology
 
Board Certifications
Toxicology
Laboratory Animal Medicine
 
Academic Interests
My laboratory studies pulmonary carcinogenesis caused by environmental exposure to toxicants and carcinogens. In particular, we are evaluating the role of chronic inflammation as a precursor and modulator of lung tumors. Numerous factors, including cytokines, chemokines, growth factors, etc. may contribute to tumor initiation and progression. Determining the role of these factors in conjunction with recognized molecular changes in the gene expression profile of lung epithelial cells may support earlier identification of lung tumors and an improved ability to determine prognosis. Mechanistic studies in the laboratory use cell lines and a lung slice tissue culture model. The lung slice model allows in vitro exposure of lung tissue from various species, including humans, to a variety of pulmonary toxicants, including cigarette smoke derivatives, nanoparticles, chemicals, etc.
 
Clinical Interests
Current collaborations include examining inflammatory mediators and how they are altered by physical exercise in patients with pulmonary or cardiac inflammatory diseases. The laboratory also participates in collaborative clinical research by determining the inflammatory profiles of surgically resected tumor, biopsy specimens, and serum from individuals exposed to lung carcinogens, especially tobacco exposure, or with inflammatory lung disease.
 
Representative Publications
  1. Effect of Exercise and Activity on Cytokines in Healthy and Cystic Fibrosis Patients. N Mirza, P Hopkins-Price, T Liberati, R Trammel, S Markwell and M Johnson. Southern Illinois University School of Medicine, Springfield, IL.
  2. Effect of Physical Activity on Cytokine Levels. Mark R. Johnson, Patricia L. Hopkins-Price, Teresa A. Liberati, Rita A. Trammell, Steven J. Markwell and Nureain Mirza. Southern Illinois University School of Medicine, Springfield, IL.
  3. Alveolar Type II Cell Response To Crocidolite Asbestos In Vitro TA Liberati, JN Finkelstein and G Oberdoerster. Dept. of Environmental Medicine, U. of Rochester, Rochester, NY 14642.
  4. Proliferating Cell Nuclear Antigen As A Marker Of Alveolar Type II Cell Proliferation In Vitro Teresa A. Liberati, Jacob N. Finkelstein and Raymond B.Baggs . Depts. of Environmental Medicine, Pathology and Division of Laboratory Animal Medicine, U. of Rochester, Rochester, NY 14642.
  5. Effects Of Silicon Dioxide On The Production Of Vasoregulatory Mediators By Rat Alveolar Type II Epithelial Cells. DE Heck, DL Laskin, JD Laskin, J Finkelstein, T Liberati, and G Oberdoerster. UMDNJ-Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ and University of Rochester, Rochester, NY.
  6. Alterations by Fibrous and Nonfibrous Particles on the Synthesis of Platelet-derived Growth Factor by Primary Alveolar Type II Cells and the L2 Cell LineIn Vitro. TA Liberati, CJ Johnston, G Oberdoerster and JN Finkelstein. Depts. of Environmental Medicine and Pediatrics, University of Rochester, School of Medicine and Dentistry, Rochester, New York.
  7. Use of Lung Tissue Slice Cultures in the Study of Particle Effects on Gene Expression. TA Liberati, RJ Jaramillo and NF Johnson. Molecular and Cellular Toxicology, Inhalation Toxicology Research Institute, Albuquerque, NM.
  8. Neil F. Johnson, Thomas R. Carpenter, Richard J. Jaramillo and Teresa A. Liberati. DNA Damage-Inducible Genes as Biomarkers for Exposures to Environmental Agents. Environ.Health Perspec. 1997, 105 (Suppl. 4), pages 913-917.

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