Interstitial Lung Disease in a Hot Tub User
Senior fellow, Division of Pulmonary and Critical Care Medicine
Southern Illinois University School of Medicine, Springfield, Illinois, USA
Central Illinois Allergy and Respiratory Services Ltd., Springfield, Illinois, USA
Associate Pathologist Ltd., Springfield, Illinois, USA
A 46 year old immunocompetent Caucasian female presented with a 2 week history of right sided chest discomfort, nonproductive cough, shortness of breath, and myalgias. Her shortness of breath was worse with activity and when lying down. She had no fever, chills, skin rash, or weight loss, and she denied any other complaints.
Her past medical history was significant for iron deficiency anemia, migraine headaches, eczema of bilateral hands, and an episode of severe acute bronchitis thirty years ago. There was no history of preexisting pulmonary disorders. Her medications included oral contraceptives and albuterol metered dose inhaler to be used as needed (the latter was given to her for a presumptive diagnosis of asthma since the onset of her symptoms). She denied cigarette smoking and illicit drug use, and had minimal alcohol use. She worked as a legal assistant and denied any unusual hobbies or occupational exposures. She kept two parakeets at home which were both healthy. She used an indoor hot tub at her home on a near daily basis for the last four years and had changed the water in the hot tub once or twice a year. Her family history was significant for coronary artery disease in her mother.
Her physical examination revealed a slender woman who did not appear ill with stable vital signs. She was in no obvious respiratory distress. She had fine bilateral inspiratory and expiratory crackles diffusely present in all lung fields on auscultation. In addition, she had mild scoliosis and eczema involving dorsa of bilateral hands.
Her chest radiograph showed bilateral interstitial infiltrates without any mediastinal or hilar lymphadenopathy. Her laboratory evaluation revealed a normal complete blood count, chemistry panel, B- type natriuretic peptide level, cardiac isoenzymes, and erythrocyte sedimentation rate. Her antinuclear antibody levels were normal. Her purified protein derivative (PPD) skin test showed less than 5 mm induration at 48 hours. Hypersensitivity pneumonitis screen was negative for the following antigens: Aspergillus fumigatus, Micropolyspora faeni, pigeon serum, thermophilic actinomycetes, and Saccharomonospora viridans. A spiral computerized tomography scan of her chest ruled out pulmonary embolism and revealed bilateral ground glass opacities with diffuse micro-nodular appearance (figure 1).
Her pulmonary function tests (Table 1) showed a mild obstructive defect with air trapping and moderate decrease in CO diffusion capacity (51% of predicted).
Table 1: Pulmonary function test (PFT) on presentation
|Pulmonary function test||Measured||Predicted *||Percent predicted|
* Predicted values were obtained using the Knudson’s reference equation.
Her clinical and radiologic picture did not improve even after the two parakeets were removed from her home. A subsequent bronchoscopy with bronchoalveolar lavage and transbronchial biopsy was done. The lavage revealed 75% lymphocytes and an unrevealing gram stain, GMS and acid fast bacillus (AFB) stain. Two weeks after the bronchoscopy, the lavage grew Mycobacterium avium complex (MAC). The transbronchial biopsy of the right upper lobe is shown in figure 2.
Figure 2: Lung, right upper lobe (H&E, 10 X and 40 X original magnification in Figures 2a and 2b respectively). The transbronchial biopsy of the right upper lobe showed several non-caseating granulomas (white arrows in Figure 2a) with multinucleated giant cells (black arrow in Figure 2b). No acid fast bacilli or fungal organism were identified on AFB and GMS stains respectively.
Given the clinical history, which ONE of the following is the most likely diagnosis?
Inhalation of water contaminated with all of the following may cause hypersensitivity pneumonitis-like picture EXCEPT:
All of the following are clinicopathologic patterns of MAC infection EXCEPT:
Which ONE of the following is the NEXT step in the management of this patient?
Which ONE of the following is true about the natural course of the disease?
in Respiratory Infections Online: Aksamit TR. Hot tub lung: infection,
inflammation, or both? (Requires paid access)
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