Research Interests
Elucidation of the cellular and molecular mechanisms controlling proliferation and differentiation of epithelial cells and determine how defects in such mechanisms could lead to malignant transformation. Focus is on 1), Ligand/receptor function and its intracellular signal transduction mechanisms; and 2), cellular adhesions such as cell-cell and cell-matrix adhesions. Chemoprevention of cancer and cancer biomarkers is another focus of this laboratory.

Selected Publications
Wang, H., Radjendirane, V., Wary, K.K., and Chakrabarty, S . Transforming growth factor b regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells. Oncogene, 23, 5558-5561, 2004.
Pub Med

Chakrabarty, S., and Wang, H. Cellular adhesion and control of colon epithelial cell growth and differentiation.: Role of transforming growth factor b and the calcium sensing receptor. J. Clin. Ligand Assay. 27: no.2 , 104-111, 2004.

Wang, H., and Chakrabarty, S. Lipids and lipid-like molecules in cellular proliferation and differentiation, potential in cancer chemoprevention and treatment. J. Clin. Ligand Assay. 27, no. 2, 118-132, 2004.

 Chakrabarty, S., Wang, H., Canaff, L., Hendy, G.N., Appelman, H., and Varani, J. Calcium Sensing Receptor in Human Colon Carcinoma: Interaction with Ca 2+ and 1,25-dihydroxyvitamin D 3. Cancer Res., 65, 493-398, 2005.

Bghagavathula, N., Kelley, E.A., Reddy, M., Nerusu, K.C., Leonard, C., Fay, K., Chakrabarty, S., and Varani, J. Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signaling in the regulation of growth and differentiation in colon carcinoma. Br. J. Cancer, 93, 1364-1371, 2005. Pub Med