Hughes CV

Southern Illinois University School of Medicine

CURRICULUM VITAE

LARRY F. HUGHES

Date of Birth: April 15, 1944

EDUCATION:

1962-1965
University of Illinois, Urbana Illinois. Major - Electrical Engineering

1966-1968
Southern Illinois University,
Carbondale, Illinois. B.A. in
Psychology, awarded June 1968

1968-1972 Graduate School, Tulane
University, New Orleans,
Louisiana. M.S. Experimental
Psychology, awarded December
1971. Ph.D. in Experimental
Psychology, awarded July 1972

PROFESSIONAL EXPERIENCE:

1972-1976 Assistant Professor
1976-1983 Associate Professor
1983-1986 Professor
Department of Otorhinolaryngology and Biocommunications, Kresge Hearing Research Laboratory of the South, Louisiana State University Medical Center New Orleans, Louisiana, with joint appointments in the Department of Audiology and Speech Pathology, School of Allied Health Professions, and the Department of Psychology, University of New Orleans, New Orleans, Louisiana.

1987-1989 Professor
Department of Psychology, MacMurray College, Jacksonville, Illinois with a joint appointment in the Department of Educational Administration, Sangamon State University, Springfield, Illinois.

1990-Present Research Professor
Southern Illinois University School of Medicine, Departments of Surgery/ Otolaryngology, Neurology, Psychiatry, and Center for Alzheimer Disease and Related Disorders with a joint appointment in the Psychology Department at the University of Illinois in, Springfield, Illinois and MacMurray College, Jacksonville, Illinois.

Elected Memberships:

Sigma Xi, The Scientific Research Society

Acoustical Society of America

New York Academy of Science

Psychonomic Society

Research Membership, American Speech-Language-Hearing Association.

Association for Research in Otolaryngology

Military service:

1965-1971 United States Marine Corps Active Reserve

Publications:

Dunlap, W.P., Hughes, L.F., O'Brien, T.J., Lewis J.H. and Dachowski, L. Goalbox activity as a measure of frustration in a single runway. Psychonomic Science, 23:327-328, 1971.

Berlin, C.I., Hughes, L.F. Lowe-Belle, S.S., and Berlin, H.L. Dichotic right ear advantage in children 5 to 13. Cortex,9(4):393-401, 1973.

Berlin, C.I., Porter R.J. Jr., Lowe-Belle, S.S., and Berlin, H.L., Thompson, C.L. and Hughes, L.F. Dichotic signs of the recognition of speech elements in normals, temporal lobectomies, and hemispherectomies. IEEE Transactions on Audio and Electroacoustics, AU-21(3):189-195, 1973.

Dunlap, L.F., Hughes, L.F., and O'Brien, T.J. Frustration effect and extent of instrumental response. Psychological Reports, 32:267-273, 1973.

Hughes, L.F. and Dachowski, L. The role of reinforcement and non- reinforcement in a operant frustration effect. Animal Learning and Behavior, 1:68-72, 1973.

Cullen, J.K., Jr., Thompson, C.I., Hughes, L.F., and Berlin, C.I. Information additivity in dichotic stop-vowel perception tasks. Proceedings of Speech Communication Seminar, John Wiley & Sons: New York, 31-37, 1974.

Cullen, J.K., Jr., Thompson, C.L. Hughes, L.F. Berlin C.I., and Samson, Diane. The effects of varied acoustic parameters on performance in dichotic speech perception tasks. Brain and Language, 1:307-322, 1974.

Hughes, L.F. Reward magnitude and partial reinforcement effects in a single runway. Journal of Comparative Physiological Psychology, 87:(3):563-570, 1974.

Dunlap, W.P., Hughes, L.F., Dachowski, L., and O'Brien, T.J. The Temporal course of the frustration effect. Journal of Learning & Motivation, 5:484-497, 1974.

Berlin, C.I., Cullen, J.K., Jr., Hughes, L.F., Berlin, H. L., Lowe-Bell, S.S., and Thompson, C.L. Dichotic processing of speech: Acoustic and phonetic variables (acoustic variables in dichotic listening). Proceedings of a Symposium on Central Auditory Processing Disorders, Pp. 36-46, January 1975.

Cullen, J.K., Jr., Berlin, C.I., Hughes, L.F., Thompson, C.L., and Samson, D.S. Speech information flow: A model. Proceedings of A Symposium on Central Auditory Processing Disorders, P. 108- 127, January 1975.

Hughes, L.F. Learning; Motivation. Two Chapters In: R.J. Porter, Jr.,R.A. Lewis, and C.W.Hill(Eds.), Instructor's Manual to Accompany an Introduction to Psychology by R.N. Haber and A.H.Fried. Holt, Rinehart, and Winston: New York, New York, Pp 59-75 and 98-113, 1975.

Hughes, L.F. Learning; Motivation. Two Chapters In: R.J. Porter, Jr., R.A. Lewis, and C.W. Hill (Eds.), Study Guide to Accompany an Introduction to Psychology by R.N. Haber and A.H. Fried. Holt, Rinehart, and Winston: New York, New York, Pg 59-75 and 98-113, 1975.

Riley, E.P., Dunlap, W.P., and Hughes, L.F. The kamin effect as a function of number of prior unsignalled inescapable shocks. Journal of Comparative & Physiological Psychology, 88: 565- 569, 1975.

Hughes, L.F. and Berlin, C.I. Physics of sound and the decibel. In: J. Northern (Ed.), Hearing Disorders. Little, Brown & Co.: Boston, Massachusetts, 1976.

Hughes, L.F. Effects of varied response modes upon dichotic consonant-vowel identification latency. Brain and Language, 5:301-309, 1978.

Jones, J.W., Ochsner, J.L., Mill, N.L., and Hughes, L.F. Impact of multiple variables on operative and extended survival following coronary artery surgery. Transactions of the Society for Vascular Surgery, 85(1):20-26, 1978.

Jones, J.W., Ochsner, J.L. Mills, N.L., and Hughes, L.F. The internal mammary bypass graft: A superior second coronary artery. Journal of Thoracic and Cardiovascular Surgery, 75 (4):625-631, 1978.
Mouney, D.F., Berlin, C.I., Cullen, J.K.,Jr., and Hughes, L.F. Changes in human eighth nerve action potential as a function of stimulation rate. Archives of Otolaryngology, 104:551-554, 1978.

Mirabile, P.J., Porter, R.J., Jr., Hughes, L.F., and Berlin, C.I. Dichotic lag effect in children 7 to 15. Developmental Psychology, 14(3):277-285, 1979.

Hughes, L.F. and Holtzapple, P. Temporal-order judgments of speech and noise stimuli by normal and brain-injured subjects. In: J.J. Wolf and D.H. Klatt (Eds.), Speech Communication Papers.
Acoustical Society of America: New York, New York, Pp 583- 586, 1979.

Jones, J.W., Ochsner, J.L. Mills, N.L., and Hughes, L.F. Clinical comparison between patients with saphenous vein and internal mammary artery as a coronary graft. Journal of Thoracic and Cardiovascular Surgery,80 (3):334-341, 1980.

Jones, W.P., Ochsner, J.L., Mills, N.L. and Hughes, L.F. Long-term results of myocardial revascularization in early-onset arteriosclerosis. Surgery 88(6):760-765, 1980.

Porter, R.J., Jr. and Hughes, L.F. Dichotic Listening to CV's: Method, interpretation and application In: Helige, Joseph (Ed.), Cerebral Hemisphere, Asymmetry: Method, Theory and Application, Praeger Scientific Publishers, University of Southern Calif. Press, 1983.

Hughes, L.F., Tobey, E.A., and Miller, C.J. Temporal aspects of dichotic listening in brain-damaged subjects. Ear Hear., 4: 306-310, 1984.

Hughes, L.F., and Miller, C.J. The measurement of Performance Asymmetries with Dichotic Stimulus Presentation. Ear Hear.,5 (3):175-177, 1984.

Meyers, S.C., Hughes, L.F., and Zahrl, S.G. Temporal-phonemic processing skills in adult stutterers and nonstutterers. Journal of Speech and Hearing Research, 32:274-280, 1989.

May, J.G., and Hughes, L.F. A Posterior filtering to reduce signal-averaging of steady-state evoked potentials. Optometry and Vision Science, 69(2):117-121, 1992.

Elble, R.J., Hughes, L.F., Higgins, C. The syndrome of senile gait. Journal of Neurology, 239: 71-75, 1992.

Elble, R.J., Higgins, C., Hughes, L.F. Longitudinal study of essential tremor. Neurology, 42: 441-443, 1992.

Elble, R.J., Higgins, C., Hughes, L.F. Phase resetting and frequency entrainment of essential tremor. Exp. Neurol. 116: 355-361, 1992.

Santos, P.M., Hall, R.A., Hughes, L.F., Snyder, J.M., Dobie, R.A. Diuretic and Diet effect on Meniere's Disease, evaluated by the 1985 Committee on Hearing and Equilibrium Guidelines. Otolaryngology - Head and Neck Surgery, 109(4): 680-689, 1993.

Elble, R.J., Higgins, C., Leffler, K., Hughes, L.F. Factors influencing the amplitude and frequency of essential tremor. Movement Disorders, 9,(6): 589-596, l994.

Elble, R.J., Higgins, C., Hughes, L.F. Essential tremor entrains rapid voluntary movements. Exp. Neurol. 126: 138-143, 1994.

Struble, R.G., Ghobrial, M., Hughes, L.F., Olfactory Bulb Involvement in AD: An Early Change? In: Giacobini,E. and Becker, R. (Eds.) Alzheimer Disease: Therapeutic Strategies, Birkhasser, Boston, MA., 1994.

McManus, D.Q., Harris, R., Hughes, L.F. Validation of Informant Based Cognitive Assessment for Use in Autopsy In: Giacobini,E. and Becker, R. (Eds.) Alzheimer Disease: Therapeutic Strategies, Birkhasser, Boston, MA., 1994.

Brilliant, M., Hughes L.F., Anderson D., Ghobrial M., Elble R. Rarefied White Matter in patients with Alzheimer Disease. Alzheimer Disease and Associated Disorders 9(1): 39-46, 1995.

Struble, R.G., Hughes, L.F., and Clark, B.R. Olfactory Bulb Degeneration in Aging and Alzheimer Disease. In: Development Growth and Senescence in the Chemical Senses. 1996.

Wortsman, J., and Hughes, L.F. Olfactory Function in a Fertile Eunuch with Kallmann Syndrome. American Journal of the Medical Sciences. 311:(3),1996.

Selz, P.A., Girardi, M., Konrad, H.R., Hughes, L.F. Vestibular Deficits in Deaf Children. Otolaryngology Head and Neck Surgery 115, 70-77,1996.

Campbell, K.C.M., Naritoku, D.K., Evans, M.S., Hughes, L.F., Rybak, L.P. Is valproic acid ototoxic? American Journal of Audiology,5,7-10,1996.

Campbell, K.C.M., Rybak, L.P., Meech, R.P., Hughes, L.F., D-Methionine Provides Excellent Protection from Cisplatin Ototoxicity in the Rat. Hearing Research ,102,90-98,1996.

Elble, R., J., Cousins, R., Leffler, K., Hughes, L. Gait Initiation by Patients with Lower-Half Parkinsonism. Brain, 119,1705-1716,1996.

Krenning, J., Hughes, L., Caspary, D., Helfert, R., (1998). Age- Related Glycine Receptor Subunit Changes in the Cochlear Nucleus of Fischer-344 Rats. The Laryngoscope , 108: 26-31.

Meech, R.P., Campbell, K.C.M., Hughes, L.F., Rybak, L.P., (1998). A Semiquantitative Analysis of the Effects of Cisplatin on the Rat Stria Vascularis. Hearing Research , 124: 44-59.

Helfert, R.H., Sommer, T.J., Meeks, J., Hofstetter, P., Hughes, L.F., (1999). Age-Related Synaptic Changes in the Central Nucleus of the Inferior Colliculus of Fischer-344 Rats. Journal of Comparative Neurology, 406:285-298.

Caspary, D.M., Holder, T., Hughes, L.F., Milbrant, J., McKernan, R., Naritoku, D.K., (1999). Age-related changes in GABAA receptor subunit composition and function in the rat auditory system. Neuroscience, 93:307-312.

Abbot,S., Hughes, L.F., Bauer, C.A., Salvi, R., Caspary, D.M., (1999) Detection of glutamate decarboxylase isoforms in rat inferior colliculus following acoustic exposure. Neuroscience, 93:1375-1381.

Campbell, K.C.M., Meech, R.P., Rybak, L.P., Hughes, L.F. (1999) D-Methionine protects against cisplatin damage to the stria vascularis. Hearing Research, 138:13-28.

Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. (2001) Pentagon copying is more impaired in dementia with Lewy bodies than in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 70(4):483-8.

Sato T, Wilson TS, Hughes LF, Konrad HR, Nakayama M, Helfert RH. (2001) Age-related changes in levels of tyrosine kinase B receptor and fibroblast growth factor receptor 2 in the rat inferior colliculus: implications for neural senescence. Neuroscience 103,(3):695-702.

Hughes, Larry F., Struble, Robert G., Shaffer, Carla L. (2001) Olfaction in elderly and Alzheimer patients: differing feedback conditions. Journal of Alzheimer's Disease 3,(4):367-375.

Girardi M, Konrad HR, Amin M, Hughes LF. (2001) Predicting fall risks in an elderly population: computer dynamic posturography versus electronystagmography test results. Laryngoscope.;111(9):1528-32.

Donnersberger, D.R., Campbell, K.C.M., Meech, R.P., Rybak, L.P., Hughes, L.F. and Nanavati, P.J. (2001) A Model for Acute Marked Radiation-Induced Hearing Loss. Journal of Burns, Volume 1, 2001-2002.

Kovach MJ,Campbell K,Herman K,Waggoner B,Gelber D,Hughes LF, Kimonis VE.(2002) Anticipation in a Unique Family with Charcot-Marie-Tooth Syndrome and Deafness: Delineation of the Clinical Features and Review of the Literature. American Journal of Medical Genetics;108:295-303.

Lange R, Donathan CL, Hughes LF. (2002) Assessing Olfactory Abilities with the University of Pennsylvania Smell Identification Test: A Rasch Scaling Approach. Journal of Alzheimer's Disease;4(2):77-91.

Hughes LF, Donathan CL, Smith T, McAsey ME, Conney PJ, Struble RG. (2002) Effects of HRT on olfactory sensitivity: cross-sectional and longitudinal studies. Climacteric;5:122-134.

Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. (2002) The Mini-Mental State exam helps in the differentiation of Alzheimer and Lewy body dementias. International Journal of Geratrics and Psychiatry;17:503-509.

Amin M, Girardi M, Konrad HR, Hughes LF. (2002) A comparison of Electronystagmography results with posturography findings from the Balance Trak 500TM. The American Journal of Otology & Neurotology 23:488-493.

Caspary DM, Palombi PS, Hughes LF. (2002) GABAergic inputs shape responses to sinusoidally amplitude modulated stimuli in the chinchilla inferior colliculus. Hearing Research 168(1-2):163-73.

Helfert RH, Glatz FR III, Wilson TS, Ramkumar V, Hughes LF. (2002) Hsp70 in the Inferior Colliculus of Fisher-344 Rats: Effects of Age and Noise Exposure. Hearing Research (In Press)

Girardi M, Amin M, Konrad HR, Hughes LF, Hock L, and Jones K (2002) "Medical Profile of a Group of elderly Fallers," Otology and Neurotology, (Accepted ).

Perkins K, Wright BD, Westrick H, Hughes LF. (2002) Using a Rasch scale to chacterize the clinical features of patients with a clinical diagnosis of uncertain, probable, or possible Alzheimer disease at intake. Medical Care (Accepted pending revisions)

Le Prell CG, Shore SE, Hughes LF, Bledsoe, SC Jr. (2002) Disruption of lateral efferent pathways: Functional changes in auditory evoked responses. Journal of the Association for Research in Otolaryngology (Accepted)

Published Abstracts:

Hannah, J.E., Thompson, C.L., Cullen, J.K., Jr., Hughes, L.F., and Berlin, C.I. Size of the dichotic right-ear effect as a function of alignment criteria. Journal of the Acoustical Society of America, 50(1):130, 1971.

Thompson, C.L., Hughes, L.F. Effects of stimulus intensity in competing message tasks: I. Equal intensity dichotic stimuli. American Speech & Hearing Association, 14,(9):469, 1972.

Thompson, C.L., Stafford, M., Cullen, J.K., Jr., Hughes, L.F., Lowe-Bell, S., and Berlin, C.I. Interaural intensity differences in dichotic speech perception. Journal of the Acoustical Society of America, 52(1):174, 1972.

Berlin, C.I., Hughes, L.F., Thompson, C.L., Cullen, J.K., Jr., and Hannah, J.E. The effect of varying syllable microstructure on voiceless preponderance in dichotic listening. Journal of the Acoustical Society of America, 54:286, 1973.

Berlin, C.I., Hughes, L.F., Thompson, C.L., Cullen, J.K., Jr., and Lowe-Bell, Sena S. Phonetic errors in dichotic listening to simultaneous and time-staggered CV's. Journal of the Acoustical Society of America, 53(1):368, 1973.

Thompson, C.L., Sampson, Diane, Cullen, J.K., Jr., and Hughes, L.F. The effect of varied bandwidth, signal-to-noise ratio and intensity on the perception of consonant-vowels in a dichotic context: Additivity of central processing. Journal of the Acoustical Society of America, 55(2):435, 1974

Berlin, C.I., Berlin, H.L., Cullen, J.K., Jr., and Hughes, L.F. Dichotic lag effect and intensity. Journal of the Acoustical Society of America, 57(1):S51, 1975.

Berlin, C.I., Hughes, L.F., Berlin, H.L., and Cullen, J.K., Jr. Dichotic right ear advantages with "bleats". Journal of the Acoustical Society of America, 57(1):S51, 1975.

Cullen, J.K., Jr., Tobey, E.A., Hughes, L.F., and Berlin, C.I. Dichotic performance for temporally altered consonant-vowel tokens. Journal of the Acoustical Society of America,57(1): S52, 1975.

Hughes, L.F. and Hartson, C.M. Effect of varied response mode upon reaction times in a dichotic target-challenge paradigm. Journal of the Acoustical Society of America, 58(1):S76, 1975.

Berlin, C.I., Berlin, H.L., Hughes, L.F., and Dermody, P. Dichotic vs. monotic masking functions may reveal central organization for speech identification. Journal of the Acoustical Society of America, 59(1):S5, 1976.

Mirabile, P.J., Porter, R.J., Jr., Hughes, L.F., and Berlin, C.I. Dichotic lag effect and right-ear advantage in children 7 to 15. Journal of the Acoustical Society of America, 60(1):S119, 1976.

Hughes, L.F., Holtsapple, R., and Berlin, R.I. Effect of onset asymmetry upon the perceived onset of a CV during dichotic presentation. Journal of the Acoustical Society of America, 62:S1, 1977.

Jones, J.W., Ochsner, J.L., Mills, N.L., and Hughes, L.F. Impact of multiple variables on operative and extended survival following coronary artery surgery. The Society for Vascular Surgery, Pp 38, 1977

Hughes, L. F. and Holtzapple, P. Temporal-order judgments of speech and noise stimuli by normal and brain-injured subjects. Journal of the Acoustical Society of America, 65, Suppl. 1:S134, 1979.

Jones, J.W., Ochsner, J.L., Mills, N.L., and Hughes, L.F. Clinical comparison between patients with saphenous vein and internal mammary artery as a coronary graft. Proceedings of the American Association for Thoracic Surgery, Boston, Massachusetts, P. 18, April 30,1979.

Hughes, L.F., Miller, C.J., and Rafferty, E. Dichotic temporal order judgement for long duration stimuli differing in stimulus microstructure and intensity. Journal of the Acoustical Society of America, 73:S43, 1983.

Hood, L.J., Berlin, C.I., and Hughes, L.F. Binaural interaction in the middle latency response. Journal of the Acoustical Society of America, 73:S79, 1983.

Rafferty, E., Hughes, L.F., and Miller, C.J. Stop CV duration and dichotic temporal order judgment. Journal of the Acoustical Society of America, 75:S66, 1984.

Harris, R.B., Hughes, L.F., Elble, R.J., Manyam, B.V. Parkinson Disease: Factors of importance in rehabilitation. 10th International Symposium of Parkinson's Disease. Tokyo October 1991.

Struble, R.G., Hughes, L.F., Clark, B.R. Olfactory Bulb Degeneration in Aging and Alzheimer Disease. NIDCD. Washington D.C., March 1992.

Faloon, K.M., Campbell, K.C.M., Hughes, L.F. The effects of Aging on gap detection. American Speech-Language-Hearing. San Antonio, Texas, November 1992.

Campbell, K.C.M., Evans, M.S., Naritoku, D.K., Hughes, L.F. Is Valproic acid ototoxic. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February 1993.

Herrmann, D.B., Good, D.C., Young, R.A., Hughes, L.F. Gait predictors in acute stroke patients:Preliminary results. Arch Phys Med Rehabil Vol 74: June 1993.

Girardi, M.A., Konrad, H.R., Hughes, L.F. Normative data for gaze fixation and caloric tests in subjects over age 50. American Academy of Otolaryngology. Minneapolis, Minnesota, October 1993.

Helfert R.H., Sommer T.J., Jeffery C., Hughes. L.F., Caspary, D.M. Age-related changes in the synaptic organization of the inferior colliculus of the fischer 344 rat. Society for Neuroscience Washington D.C., November 1993.

Hughes, L.F., Shaffer, C.L., Struble, R.G. Olfactory discrimination and identification functions in elderly normal and Alzheimer subjects. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February 1994.

Helfert, R.H., Sommer, T.J., Hughes, L.F., Jeffery, C.M., Caspary, D.M. Age-related changes in the synaptic organization of the inferior colliculus of the fischer 344 rat. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February 1994.

Girardi, M., Konrad, H.R., Bauer, G.P. Hughes L.F. Normal changes due to aging in electronystagmography results of Dix-Hallpike and supine positional tests in human subjects. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February 1994.

Helfert, R.H., Sommer, T.J., Hughes, L.F., Jeffery, C.M., Caspary, D.M. Age-related changes in the synaptic organization of the inferior colliculus of the fischer 344 rat. Midwest Neurobiologists. Springfield, Illinois. April 1994.

Girardi, M., Konrad, H.R., Bauer, G.P. Hughes L.F. Normative data for Computer-Assisted Electronystagmography (ENG) tests in subjects over age 50. Midwest Neurobiologists. Springfield, Illinois. April 1994.

Girardi, M., Konrad, H.R., Nakayama, M., and Hughes, L.F. A Comparison of Caloric and Rotational Chair Test Results in Patients with a Variety of Vestibular Disorders. 98th Annual AAO/HNS Meeting, San Diego, CA., September 1994.

Struble, R.G., Clark, B., Hughes, L.F., Ghobrial, M., Murphy, B. Olfactory Bulb Involvement in AD: An Early Change? Third International Springfield Symposium On Advances In Alzheimer Therapy Springfield, Illinois. May 1994.

McManus, D.Q., Harris, R., Hughes, L.F. Validation of Informant Based Cognitive Assessment for Use in Autopsy Third International Springfield Symposium On Advances In Alzheimer Therapy Springfield, Illinois. May 1994.

Selz, P.A., Girardi, M., Konrad, H.R., Kelly, D.P., Hughes, L.F. ENG eye-tracking and positional testing in normal children and children with acquired and congenital deafness. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February 1995.

Campbell, K.C., and Hughes, L.F A comparison of contralateral suppression of otoacoustic emissions in Alzheimer Disease and matched control subjects. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February 1995.

Hughes,L.F., and Wortsman, J. Dissociation Between the Severity of the Gonadal and Olfactory Dysfunctions of Kallmann Syndrome. Midwest Neurobiologists. Milwaukee, Wisconsin, April 1995.

Campbell, K.C., Hughes, L.F., A comparison of contralateral suppression of otoacoustic emissions in Alzheimer disease and matched control subjects. International Evoked Response Audiometry Study Group, Lyon, France, August, 1995.

Girardi, M.A., Konrad, H.R., Bauer, G.P., Hughes, L.F. Electronystagmography Normative Data for Subjects Over Age 50. American Academy of Otolaryngology. New Orleans, Louisiana, September 1995.

Selz, P.A., Girardi, M.A., Konrad, H.R., Hughes, L.F. Vestibular Deficits in Deaf Children. American Academy of Otolaryngology. New Orleans, Louisiana, September, 1995.

Krenning, J., Blomquist, T.S., Hughes, L., Helfert, R.H. Age- related Changes in the Presynaptic Organization of the Anteroventral Cochlear Nucles in Fisher-344 Rats. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February 1996.

Girardi, M.A., Konrad, H.R., Turner, B., M., Hughes, L.F. Age- related Changes in Rotational Chair Test. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February, 1997.

Krenning, J., Helfert, R.H., Blomquist, T.S., Hughes, L.F., Age- related changes in the cochlear nucleus of Fisher-344 rats. Triological Society . Kansas City, Missouri, January, 1997

Krenning, J., Girardi, M., Konrad, H.R., Turner, B.M., and Hughes, L.F. Effects of corrective lenses on ENG ocular motor tests. American Academy of Otolaryngology - Head & Neck Surgery Foundation, San Francisco, CA, September 1997.

Campbell, K.C., Rybak, L.P., Meech, R.P., and Hughes, Larry.The Effect of Cisplatin On The Stria Vascularis In Rats. ASHA Annual Convention, Boston, MA, November 1997.

Korver, K.D., Rybak, L.P., Whitworth, C.A., Hughes, L.F., Campbell, K.M. Round window application of D-methionine provides cisplatin otoprotection. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February, 1998.

Campbell, K.C.M., Meech, R.P., Rybak, L.P.,Hughes, L.F. D- methionine provides protection against cisplatin damage in the rat stria vascularis: A semi-quantitative analysis. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February, 1998.

Nakayama, M., Nakayama, Y., Hughes, L.F., Helfert, R.H. Age- Related Changes in the Synaptic Organization of the Medial Vestibular Nucleus in Fischer-344 Rats. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February, 1998.

Campbell, K.C.M., Meech, R.P., Hughes, L.F., Rybak, L.P. The Discovery of D-methionine as a Cisplatin Otoprotective Agent: Correlations between Electrophysiologic and Histologic Findings. Ototoxicity: Basic Research and Clinical Applications, Bari, Italy, June 18-20, 1998.

Sommer, T.J., Hughes, L.F., Helfert, R.H. Age-related changes associated with NMDA receptor subunits in the Inferior Colliculus of Fischer-344 rats. Association for Research in Otolaryngology. St. Petersburg Beach, Florida, February, 1998.
Kittrell, A.E.P., Girardi, M., Neill, M., Konrad, H., Hughes, L.F. Balance and Vestibular Deficits in Deaf Children. AAO-HNS San Antonio, Texas, September 1998.

Schatteman, T. S., Hughes, L.F., Hancock, K.E., Larsen, D.L., Caspary, D.M. SAM coding in DCN output neurons of young adult FBN1 rats: Effects of different modulation depths and backround noise. Association for Research in Otolaryngology, February 13-18,1999, St. Petersburg Beach, Florida.

Campbell, K.C.M., Larsen, D.L., Meech, R.P., Hughes, L.F., Rybak, L.P. Glutathione ethyl ester protects against cisplatin- induced ototoxicity in the rat. Association for Research in Otolaryngology, February 13-18, 1999, St. Petersburg Beach, Florida.

Donnersberger, D.R., Campbell, K.C.M., Meech, R.P., Rybak, L.P., Hughes, L.F. A 24 hour model of marked radiation-induced hearing loss in the rat. Association for Research in Otolaryngology, February 13-18, 1999, St. Petersburg Beach, Florida.

Campbell, K.C.M., Mazzeo, L.P., Hughes, L.F., Kimonis, V.E. Audiologic findings in a large family with Charcot Marie Tooth Disease with Deafness. Association for Research in Otolaryngology, February 13-18, 1999, St. Petersburg Beach, Florida.

Rabinowitz, E., Girardi, M., Neill, M.E., Malkin, M.J., Hughes, L.F., and Konrad, H.R. Vestibular and Balance Deficits and Sensation Seeking in College Students with Attention Deficit Disorder. Association for Research in Otolaryngology, February 13-18, 1999, St. Petersburg Beach, Florida.

Amin, M., Girardi, M., Neill, M.E., Hughes, L.F. and Konrad, H.R. Effects of Exercise on Prevention of Recurrence of BPPV Symptoms. Association for Research in Otolaryngology, February 13-18, 1999, St. Petersburg Beach, Florida.

Campbell, K.C.M., Mazzeo, L.P., Hughes, L.F., Kimonis, V.E. Audiologic Findings in a Large Family with Charcot Marie Tooth Disease with Deafness. International Evoked Response Audiometry Study Group, XVI Biennial Symposium, Tromso, Norway, June 3.

Campbell, K., Meech, R., Rybak, L., Hughes, L. The Effect of D-Methionine on Cochlear Oxidative State With and Without Cisplatin Administration: Mechanisms of Otoprotection. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 20, 2000.

Klemens, J., Campbell, K., Meech, R., Hughes, L., Somani, S. Changes in Cochlear Anti-Oxidant Status Correlate with Amikacin-Induced Ototoxicity. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 21, 2000.

Caspary, DM., Holder, TM.., Hughes, LF., Schatteman, TA,. Leroy, SA,. Browning, RA. Aging-related changes in thresholds and GABA neurochemistry: Comparison between two rat Strains Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 21, 2000.

Holder, TM., Hughes,LF., Caspary, DM. Benzodiazepine modulation of GABA-mediated chloride uptake with age. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 21, 2000.

Amin, M., Girardi, M., Hughes, LF., Konrad, H. Clinical Application of the Balance Track 500 TM. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 21, 2000.

Klemens, J., Campbell, K., Meech, R., Hughes, LF., Somani, S. Changes in cochlear anti-oxidants status correlate with amikacin-induced ototoxicity. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 21, 2000.

Campbell, K.C.M., Derrick, G., Mazzeo, L.P., Hughes, L.F., Kimonis, V.E. Auditory assessment of a large family with Charcot-Marie-Tooth disease with deafness. 6th International Congress of Parkinson's Disease and Movement Disorders, Barcelona, Spain, June 2000.

Sato, T., Hughes, LF., Wilson, T., Helfert, R. Age-related changes in growth factor receptor levels in the inferior colliculus of Fisher-344 rats. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 21, 2000.

Glatz, F., Sommer, T., Hughes, LF., Ramkumar, V., Helfert, R. Heat shock protein levels, aging and organ specific stressors in the auditory system of fisher-344 rats. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 21, 2000.

Amin, M., Girardi, M., Konrad, H.R. and Hughes, L.F. A comparison of ENG results with posturographyfindings from the Balance Trak 500. American Otological Society Meeting, Orlando, FL, May 13-14, 2000.

Amin, M., Girardi, M., Konrad, H.R. and Hughes, L.F. Normative Data for the Balance Trak 500. American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, Washington, DC, Sept. 24-27, 2000.

Amin, M., Girardi, M., Neill, M.E., Konrad, H.R. and Hughes, L.F. Electronystagmography testing: a comparison of electro-oculography and infra-red video. American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, Washington, DC, Sept. 24-27, 2000.

Girardi M, Konrad HR, Amin M and Hughes LF. Predicting Falls Risks in an Elderly Population: Computer Dynamic Posturography vs. Electronystagmography Test Results. Middle Section of the Triological Society, Chicago, IL, January, 2000.

Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. The Mini-Mental State exam may help in the differentiation of Alzheimer and Lewy body dementias. In: Ageing Myths, Realities & Management of Alzheimer's Disease. An International (Mini)Symposium to the Millennium 52nd Indian Pharmaceutical Congress. Hyderabad, India: Indian Pharmaceutical Association; 2000:3 (Abstract).

Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. Patients with Lewy body dementia draw the interlocking pentagons on the Mini-Mental State examination less accurately than patients with Alzheimer disease: a cliniconeuropathological study. Neurobiol Aging. 2000;21:S83 (Washington DC).

Girardi M, Amin M, Konrad HR, Hughes LF. Can a sport that requires balance skills (sail boarding) improve equilibrium for older adults? Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 4, 2001.

Girardi M, Amin M, Konrad HR and Hughes LF. Medical Profile of a Group of Elderly Fallers. American Otological Society, Palm Dessert, CA, May 2001.

Amin M, Krishna S, Girardi M, Konrad HR and Hughes LF. CDP-Determined falls risks for patients with BPPV. American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, Denver, CO, Sept 2001.

Young JA, Campbell KC, Meech R, Hughes LF, Rybak LP. A rat model for carboplatin-induced ototoxicity. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 4, 2001.

Ramkumar V, Whitworth CA, Hughes LF, Rybak LP. Noise conditioning and A1 adenosine receptor regulation in the chinchilla inferior colliculus. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 4, 2001.

Schatteman TA, Hughes LF, Caspary DM. Aging alters DCN neuronal responses to sinusoidally amplitude modulated stimuli. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, February 4, 2001.

Lange R, Hughes LF. Rasch scaling the UPSIT: Using smell recognition to identify Alzheimer's Disease. International Conference on Objective Measurement: Focus on Health Care. Chicago IL, October 2001.

Caspary DM, Ling L, Hughes LF. Age-Related Changes in the Subunit Makup of the GABAa Receptor in Rat Primary Auditory Cortex. Association for Research in Otolaryngology Mid-Winter Meeting, St. Petersburg Beach, Florida, January 2002.

Hughes LF, Perkins K, Wright BD, Westrick H. Using a Rasch scale to characterize the clinical features of patients with a diagnosis of uncertain, probable, or possible Alzheimer disease at intake, 7th International Geneva / Springfield Symposium on Advances in Alzheimer Therapy. Geneva, Switzerland, April 2002.

INVITED LECTURES, SYMPOSIA AND COLLOQUIA:

Hughes, L.F. An apparent frustration effect in an operant situation. Colloquium given by the Department of Psychology, Louisiana State University in New Orleans, New Orleans, Louisiana, April 1970.

Hughes, L.F. The effect of reward magnitude on partial reinforcement effects in a single runway. Colloquium given by the Department of Psychology, Louisiana State University in New Orleans, New Orleans, Louisiana, October 1972.

Hughes, L.F. The use of a time-sharing computer system. Seminar Tulane University, New Orleans, Louisiana, October 1973.

Hughes, L.F. What dichotic listening tells us about levels of speech and language. Lecture - Fourth Annual Conference on Clinical Aphasiology, New Orleans, Louisiana, April 24, 1974.

Berlin, C.I., Cullen, J.K., Jr., Hughes, L.F., and Berlin, H.L. Dichotic signs of "speech mode" listening. Symposium on Dynamic Aspects of Speech Perception,Institute for Perception Research, Eindhoven, Holland, August 4-6, 1975

Hughes, L.F. Guidelines and usage of programmed-instructional materials. Invited lecture--New Orleans Dietetic Association Meeting, Louisiana State University School of Dentistry, New Orleans, Louisiana, May 16, 1977.

Hughes, L.F. Assessment of laterality indexes. Southern Society for Philosophy & Psychology 1981 Annual Meeting, Louisville, Kentucky, April 16-18, 1981.

Hughes, L.F. Dichotic Temporal Order Judgements: The Effects of Intensity and Duration. VA Symposium - Current Topics in Audiology, Irvine, California, August 23-24, 1984.

Hughes, L.F., Struble, R.G., and Shaffer, C.L. Aging and OLDtimers disease in the OLDfactory system. Midwest Neurobiologists Symposium - Aging Neural systems, Springfield, Illinois, April 8-10, 1994.

Hughes, L.F., Effects of Hormone Replacement Therapy on the Central Nervous System, 1999 Illinois Women's Health Conference, Springfield, Illinois, November 2-3, 1999.
Educational Workshops:

Berlin, C.I., Hughes, L.F., and Decker, G.O. First Self- Instructional Materials Program (SIMP) Workshop held for the Louisiana State University Medical Center, Chateau LeMoyne Hotel, New Orleans, Louisiana, May 8-9, 1974.

Berlin, C.I., Hughes, L.F., and Decker, G.O. Second Self-Instructional Materials Program (SIMP) Workshop held for the Louisiana State University Medical Center, Louisiana State University School of Medicine, Rooms 503A and 503B, New Orleans, Louisiana, July 11-12, 1974.

Berlin, C.I., Hughes, L.F., and Decker, G.O. Fourth Self-Instructional Materials Program (SIMP) Workshop held for the Louisiana State University Medical Center, Fontainebleau Motor Hotel, New Orleans, Louisiana, December 2-3, 1975.

Berlin, C.I., Hughes, L.F. Rasmussen, R., and Decker, G.O. Fifth Self-Instruction Materials Program (SIMP) Workshop held for the Louisiana State University Medical Center, Delta Towers Motor Hotel, New Orleans, Louisiana, July 29-30, 1976

Consultantships:

1970-1971 Consultant for Statistical and Computer Analysis, Kresge Hearing Research Laboratory of the South, Department of Otorhinolaryngology & Biocommunication, Louisiana State University Medical Center New Orleans, Louisiana.

1973 Statistical Consultant for Epileptic Research Grant, Edgar G. Schlieder Educational Foundation, New Orleans, Louisiana (No. 67242, C. Allen Roberts, Principal Investigator).

1974 Statistical Consultant for Study on the Incidence of Complications Following Myocardial Contusions. Joint Study conducted by Tulane University Medical School and Charity Hospital of Louisiana
in New Orleans, New Orleans, Louisiana (Dr. Robert Hewitt, Coordinator).

1975 Computer Configuration Consultant, Houston Speech and Hearing Institute,
University of Texas Health Sciences Center, Houston, Texas.

1976 Statistical Consultant, Callier Center for Communication Disorders, University of Texas, Dallas, Texas.

1976 Forensic Consultation for the firm of Michael X. St. Martin, Houma, Louisiana.

1976-l985 Statistical Consultant, Ochsner Foundation, Department of Cardiovascular Surgery, Ochsner Foundation Hospital, New Orleans, Louisiana.

1977 Consultant, New York State Psychiatric Institute, Department of Mental Hygiene, Columbia Presbyterian Medical Center, New York, New York.

1987 Statistical Consultant, Southern Regional Education Board (Nursing Research Development Project).

1978-79 Statistical Consultant for the firm of Davis, Thomas, and Douglas, New Orleans, Louisiana.

1978 Statistical Consultant, Tulane University School of Medicine, Department of Orthopaedic Surgery,
New Orleans, Louisiana.

1978-79 Statistical Consultant for Paul Brian Spurlock, Attorney at Law, New Orleans, Louisiana.

1980-82 Computer Consultant, Tulane University Medical Center, Department of Surgery.

1982 Statistical Consultant, Steven Lemoine Attorney at Law, New Orleans, Louisiana.

1982 Statistical Consultant, American Heart Association of Louisiana, Inc., New Orleans, Louisiana.

Courses Taught:

L.S.U. Medical Center (Department of Otorhinolaryngology)

ENT Residents Training Neural Sciences Labs

L.S.U. School of Allied Health Professions (Department of Speech Pathology and Audiology)

Math Concepts Instrumentation

University of New Orleans (Department of Psychology)

Introductory Psychology
Statistics
Child Psychology
Experimental Design
Motivation

L.S.U., Baton Rouge (Department of Speech)

Acoustics

MacMurray College (Department of Psychology)

Introductory Psychology
Statistics
Experimental Design
Abnormal Psychology
Sensation and Perception
History and Systems

University of Illinois, Springfield (Department of Education Administration)

Research Methods
Statistics

University of Illinois, Springfield (Department of Psychology)

Statistics

Southern Illinois University Medical School

Resident training courses in the departments of Otolaryngology, Neurology, and Psychiatry

Supervision of Resident and Student Research Projects:

Ph.D. Dissertations:

Rafferty, E., Stop CV duration and dichotic temporal order judgment. Dept Psychology, Tulane University, Ph.D. awarded 1984 (major advisor)

Palombi, P., Physiology of the Aging Fischer 344 Rat Inferior Colliculus. Dept. Pharmacology, Southern Illinois University School of Medicine, 1995.

Vost, K., Executive Function in Early Alzheimer's Disease. The Adler School of Professional Psychology, 1997.

Masters Theses:

Mirabile, P.J., Dichotic lag effect and right-ear advantage in children 7 to 15. Dept. Psychology, University of New Orleans, M.A. awarded 1975 ( thesis committee)

Faloon, K., Gap Detection and Speech Discrimination in Young and Elderly Adults. Dept. Gerontology, Sangamon State University, 1992.

Wolfson, B., The MMPI-2 TRT Scale: An Exploratory Study of Its Validity in an Outpatient Setting. University of Illinois at Springfield, 1995.

Moriearty P. I Guess We Have To Prove We're Doing A Good Job: Considerations for Implementation of an Outcomes Assessment Program for an Academic Department of Psychiatry. University of Illinois at Springfield, 1997.

Medical Residents:

Laureano, B., A Comparison of Standard and Electrocautery Procedures on Tonsillectomy, 1992.

Bauer, G.P., Normal changes due to aging in electronystagmography results of Dix-Hallpike and supine positional tests in human subjects, 1993.

Russell, R., Nerve-muscle Pedicle and Hyperbaric Oxygen, 1993

Selz, P.A., ENG eye-tracking and positional testing in normal children and children with acquired and congenital deafness, 1994.

Medical Students:

Thiele, J. Gaba Mediated Deficiency in the Inferior Colliculus and Its Relationship to Age Related Hearing Changes in the Fisher 344 Rat. Southern Illinois University School of Medicine, 3rd Yr. Elective project, 1994.

Shirley, D., BDNF and Nerve Regeneration, 1995

Green, K. Signal Detection of Amplitude Modulation in the Fisher 344 Rat. Southern Illinois University School of Medicine, Problem-Based Learning Curriculum Honors Thesis, 1995.

Undergraduate Internships:

Gustus, J. Animal Learning, Dept. Psychology, MacMurray College, Fall 1994.

Cherry, M. Audiology, Dept. Psychology, University of Illinois at Springfield, Spring 1995.