Southern Illinois University School of Medicine

Current academic appointments at SIU

• Associate Professor of Neurology and Pharmacology
  
• Associate Chair, Department of Neurology
  
• Director, Clinical Neurophysiology and Epilepsy fellowship
  
• Director, SIU Office of Therapeutics Research
  
• Graduate School faculty
  

Other appointments

• Visiting adjunct associate professor of Clinical Pharmacology, Univ of IL College of Med., Peoria IL
  
• Director of Clinical Neurophysiology laboratory and Epilepsy Program, Memorial Medical Center, Springfield, IL
  
• Faculty and Advisory Board Member, J. Kiffin Penry Minifellowship Programs, Bowman-Gray School of Medicine, Winston-Salem, NC.

Honors and Awards

1975 Phi Eta Sigma Honor Society
1985-1986 USPHS Postdoctoral Fellow (5-T-32-NS07205-04)
1986-1987 Seay Neuropharmacology Fellowship
1989 American Epilepsy Society, Young Investigator Travel Award
1989 Moderator, Experimental Seizure Scientific Session, American Epilepsy Society; Boston MA.
1991 Special Recognition Award, Epilepsy Assn. of Lincoln Land

Education and training

• B.A. in biochemistry and molecular biology, Northwestern University, Evanston, IL
  
• M.D., Chicago Medical School, Chicago, IL
  
• Internship in Internal Medicine, University of IL, Chicago, IL
  
• Residency in Neurology, Washington University, St. Louis, MO
  
• Fellowship in Neuropharmacology and Epilepsy, Washington University, St. Louis, MO (under James A. Ferrendelli, M.D.)

Certifications

• Neurology; American Board of Psychiatry and Neurology
  
• Clinical Neurophysiology; American Board of Psychiatry and Neurology
  
• Clinical Pharmacology; American Board of Clinical Pharmacology

Clinical Interests

Research Interests

Publications

Original Articles

1. Naritoku DK, Levine JA, Covey D and Ferrendelli JA. Effects of anticonvulsant gamma butyrolactones and thiobutyrolactones on GABA-dependent chloride uptake, Biochem. Pharmacol., 1987; 36:797-800.
   
2. Holland KD, Naritoku DK, McKeon AC, Ferrendelli JA and Covey DF: Convulsant and anticonvulsant cyclopentanones and cyclohexanones. Mol. Pharmacol. 1990; 37:98-103.
   
3. Naritoku DK, Mecozzi LB, Stryker MT, and Faingold CL. Repetition of audiogenic seizures in genetically epilepsy-prone rats induces cortical epileptiform activity and additional seizure behaviors. Exp. Neurol. 1992;115:317-324.
   
4. Naritoku DK, Morales A, Pencek TL and Winkler D. Chronic Vagus Nerve Stimulation Increases the Latency of the Thalamocortical Somatosensory Evoked Potential. Pacing and Clin. Elecrophysiol. 1992; 15 (II): 1572-1578.
   
5. Faingold CL, Naritoku DK, Copley CA, Randall MR, Riaz A, Boersma-Anderson CA, and Arneric SP. Glutamate in the Inferior Colliculus Plays a Critical Role in Audiogenic Seizure Initiation. Epilepsy Res. 1992; 13:95-105.
   
6. Matsuoka Y, Rakonczay A, Giacobini E, Naritoku D. L-Beta-methylamino-alanine-induced behavioral changes in rat. Pharmacol. Biochem. Behav., 1993; 44:727-734.
   
7. Faingold CL, Randall ME, Naritoku DK and Boersma-Anderson, CA. Non-Competitive and Competitive NMDA Antagonists Exert Anticonvulsant Effects by Actions on Different Sites Within the Neuronal Network for Audiogenic Seizures Exp. Neurol., 1993, 119:198-204.
   
8. Summers, K.L., Cuadra, G., Naritoku, D. and Giacobini, E. Effects of Nicotine on Levels of Acetylcholine and Biogenic Amines in Rat Cortex. Drug Devel. Res., 1994, 31:108-119.
   
9. Ramsay R.E., Augustinsson L.E., Naritoku D.K., Willis J.K., Treig T., Wernicke J.F. and First International Vagal Stimulation Study Group. Vagal Stimulation as Treatment for Partial Epilepsy: 2. Clinical and Pharmacological Correlates of Efficacy. Epilepsia , 1994, 35:627-636.
   
10. Naritoku DK, Terry WJ, and Helfert, RH. Regional induction of fos immunoractivity in the brain by anticonvulsant stimulation of the vagus nerve. Epilepsy Res., 1995, 22:53-62.
    
11. Patel J and Naritoku, DK. Gabapentin for the treatment of hemifacial spasm. Clin. Neuropharmacol., 1996, 19:185-188.
    
12. Evans, M.S., Naritoku, D.K., Ghobrial, M., Couch, J.R. Dihydroergotamine (DHE)-induced stroke in a patient with saggital sinus thrombosis. Clin. Neuropharmacol., 1996, 19:177-184.
    
13. Takaya M, Terry WJ and Naritoku DK. Vagus nerve stimulation induces a persistent anticonvulsant effect. Epilepsia, 1996, 37:1111-1116.
    
14. Campbell KCM, Naritoku DK, Evans MS, Hughes LF and Rybak LP. Is valproic acid ototoxic? Am. J. Audiology., 5:7-10.
    

Publications Resulting From Multicenter Studies

1. Ben-Menachem E, Hufnagel, Wilder, Stefan, Mirza and First International Vagal Stimulation Study Group. Vagal Stimulation as Treatment for Partial Epilepsy: 1. Effect on Seizures in a Controlled Study. Epilepsia, 1994, 616-626.
   
2. George R, Salinsky M, Kuzniecky R, Rosenfeld W, Bergen D, Tarver WB, Wernicke JFand First International Vagus Nerve Stimulation Study Group. Vagus nerve stimulation for treatment of partial seizures: 3. Long-term follow-up on first 67 patients exiting a controlled study. Epilepsia, 1994, 35(3):637-43.
   
3. Salinski, Manon, Kuzniecki, Rosenfeld and First International Vagal Stimulation Study Group. Vagal Stimulation as Treatment for Partial Epilepsy: 4. Long-Term Effects and Quality of Life. Epilepsia, in press.
   
4. Faught E, Wilder BJ, Ramsay RE, Reife RA, Kramer LD, Pledger GW, Karim RM and Topiramate YD Study Group. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Neurology. 46(6):1684-90.
   
5. Devinsky O, Leppik I, Willmore LJ, Pellock JM, Dean C, Gates J, Ramsay RE Safety of intravenous valproate. Ann Neurol., 1995, 38(4):670-4.

Reviews

1. Dailey JW and Naritoku DK. Antidepressants and seizures: clinical anectdotes overshadow neuroscience. Biochem. Pharmacol., 1996, 52:1323-1329.
   
2. Hernandez TD and Naritoku DK. Seizures, epilepsy and functional recovery following traumatic brain injury: a reappraisal. Neurology, 1997, 48:803-806.

Book Chapters

1. Faingold CL and Naritoku DK. Genetically epilepsy-prone rat: neuronal networks and amino acid transmitters. In: Drugs for Control of Epilepsy: Actions on Neuronal Networks Involved in Seizure Disorders, Faingold CL and Fromm GL (eds). Boca Raton, Florida: CRC Press, 1991, pp. 277-308.
   
2. Naritoku DK and Hernandez, T.D. Posttraumatic Epilepsy and Neurorehabilitation. In: Traumatic Brain Injury Rehabilitation:(Ashley MJ and Krych DK eds). Boca Raton, Florida: CRC Press, 1995, pp. 43-65.

Recent Presentations

"EEG of epilepsy," "Epilepsy in the elderly," "Indications for referral for epilepsy surgery," and "Epilepsy surgery." Epilepsy Minifellowship, Bowman Gray School of Medicine, Winston-Salem, NC. 1/23-1/25/94.

"Subcortical mechanisms in epilepsy: developing new strategies for therapy." University of Miami, Miami FL. 1/11/94.

"EEG of epilepsy," "Indications for referral for epilepsy surgery," and "Epilepsy surgery." Epilepsy Minifellowship, Bowman Gray School of Medicine, Winston-Salem, NC. 3/14-3/15/94.

"Models of epilepsy," "Epilepsy in the multiply handicapped," and "Geriatric epilepsy." Epilepsy Minifellowship, Bowman Gray School of Medicine, Winston-Salem, NC. , 4/20-4/21/94.

"Intermittent vagus nerve stimulation acitvates brainstem noradrenergic nuclei." European Congress of Epileptology, Oporto, PORTUGAL; 9/6/94.

"Vagus nerve stimulation: insights into mechanisms of action." Dept. of Neurology, Caen, FRANCE; Service de Neurolgie, Hopital de la Salpetriere, Paris, FRANCE; The Center for Epilepsy, Maudsley Hospital, London, UK; Div. Neurologica e Centro per l'Epilepsia, Opedale San Martino, Genoa, ITALY.

Grants

Primary Investigator

1. McNeil Pharmaceutical: Double-Blind Parallel Comparison of Three Doses of Topiramate (Low to Mid Range) and Placebo in Refractory Partial Epilepsy (YD). 3/88 - present.

2. SIU-CRC (23-89): Functional Anatomy of Progressive Seizure Severity and Electroencephalographic Spike-Wave Activity Following Repeated Audiogenic Seizures in the Genetically Epilepsy Prone Rat (GEPR). 7/1/88‚6/30/89.

3. McNeil Pharmaceutical : Long Term Effectiveness of Topiramate on Refractory Partial Seizures Topiramate (YK-P and YKP). 4/89 - present.

4. McNeil Pharmaceutical: A Double-blind, Placebo-Controlled, Parallel, Efficacy and Safety Study of Topiramate in Patients with Partial Epilepsy followed by Topiramate Single Therapy as Accomplished by the Reduction of concomitant Tegretol (or Dilantin) (YF and YG). 4/89 - present.

5. Parke-Davis Pharmaceutical: Gabapentin: An Open-Label Multicenter Study of the Safety and Efficacy of Gabapentin as Monotherapy or Add-on Therapy in the Long-term Treatment of Epileptic Seizures. 5/89 - present.

6. SIU-CRC (7-90): Functional Anatomy of Progressive Seizure Severity and Electroencephalographic Spike-Wave Activity Following Repeated Audiogenic Seizures in the Genetically Epilepsy Prone Rat (GEPR). 7/1/89‚6/30/90.

7. Epilepsy Foundation of America: Studies on GABA in Progressive Seizure Severity and Cortical Epileptiform Activity in the Genetically Epilepsy-Prone Rat; 4/1/90 - 3/31/91.

8. SIU-CRC (26-91): Studies on Glycine in Audiogenic Seizures in the Genetically Epilepsy-Prone Rat (GEPR-9). 7/1/90‚6/30/91

9. Cyberonics, Inc: Vagus Nerve Stimulation for Intractable Partial Epilepsy. 11/90 present.

10. Abbott Laboratories: Safety of Intravenous Valproate. 6/1/92-present.

11. SIU-CRC (17-92): Studies on Glycine in Audiogenic Seizures in the Genetically Epilepsy-Prone Rat (GEPR-9). 7/1/91‚6/30/92

12. SIU-CRC (23-93): Studies on c-fos Expression in the Forebrain During Audiogenic Seizure Repetition. 7/1/92‚6/30/93.

13. Abbott Laboratories: Safety and Efficacy of B.I.D. and Q.I.D. Dosing with Tiagabine HCl Versus Placebo as Adjunctive treatment for Partial Seizures. 7/1/92‚present.

14. SIU Program Project: Mechanisms of Seizure Susceptibility - Reductions in GABA Efficacy in the Genetically Epilepsy-Prone Rat. 12/1/92-11/30/94.

15. Parke-Davis Pharmaceutical: Conversion from Marketed Antiepileptic Drug Therapy to Gabapentin (CI-945) Monotherapy in Patients with Complex Partial or Secondarily Generalized Seizures: A Double-Blind, Dose-Controlled , Multicenter Study. (945-082) 5/93 - present.

16. Cyberonics, Inc: Functional Anatomy of Vagus Nerve Stimulation. 7/1/93 - present.

17. Dainippon Pharmaceuticals: Baseline Controlled Safety and Efficacy of Zonisamide in the Treatment of Seizures in Medically Refractory Patients (810-920). 8/93 - present.

18. Dainippon Pharmaceuticals: Long-term Safety and Efficacy Evaluation of Zonisamide in the Treatment of Seizures in Medically Refractory Patients and Efficacy Evaluation of Zonisamide Monotherapy (810-921). 8/93 - present.

19. SIU Program Project: Studies on GABAA receptor function during aging, 3/94-2/96.

20. Schwabe Pharmaceuticals: Losigamone study. 8/94-7/96.

21. Cyberonics, Inc.: E05: Assessment of vagus nerve stimulation (VNS) for adjunctive treatment of epilepsy patients who have refractory partial onset seizures with alteration of consciousness. 4/95-3/97.

22. NIH (R15 NS34142): Antiepileptic Mechanisms of Vagus Nerve Stimulation. 6/1/95 5/31/98.

23. Cyberonics, Inc: „Studies on the role of brain monoamines in the anticonvulsant effect of vagus nerve stimulation (VNS).¾ (co-principle investigator with R. Browning) 7/1/75 6/30/97.

Coinvestigator

1. NIH (R01 NS 21281): Neurotransmitter Seizure Mechanisms; Principal Investigator: Carl L. Faingold; 9/1/88-8/31/91

2. Wallace Laboratories: Monotherapy Comparison of Felbamate and Valproate in Partial Seizures. Principal Investigator - M. Steven Evans; 12/89 - present.

3. Wallace Laboratories: A Multicenter, Open-Label, Long-Term Evaluation of the Safety of Felbamate in Subjects with Epilepsy. Principal Investigator - M. Steven Evans;12/89 - present.

4. Wallace Laboratories: Open-Label, Follow-On, Long-Term Felbamate Therapy in Adult Subjects. Principal Investigator - M. Steve Evans; 12/89 - present.

5. NIAAA (AA08591): Neuronal and Neurotransmitter Actions of Ethanol; Principal Investigator Carl L. Faingold; 2/1/92- 1/31/95.

6. NIH (R01 NS 21281): Neurotransmitter Seizure Mechanisms; Principal Investigator: Carl L. Faingold; 4/1/92-3/31/95.

7. Cyberonics: „Studies on the enhancement of memory storage processed by vagus nerve stimulation (VNS).¾ Priniciple investigators: R. Jensen 7/1/95-6/30/95.

Patents

Naritoku DK, Jensen RA, Browning RA, Clark KA and Smith D. Methods of modulating aspects of brain neural plasticity. (US patent pending)

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