Southern Illinois University School of Medicine
February 6, 2004
1965-1969: Claremont Men's College
Claremont, California
B.A. Biology
1969-1970: California State University
Los Angeles, California
1970-1976: University of California
Riverside, California
M.A., Ph.D. Experimental Psychology (Physiological)
Alzheimer's Disease
Struble RG, Rosario ER, Kircher ML, Ludwig SM, McAdamis PJ, Watabe K, McAsey ME, Cady C, Nathan BP. Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiol. Exp Neurol. 2003 Oct;183(2):638-644.
Brewer GJ, Espinosa JA, Struble RG. Effect of Neuregen nutrient medium on survival of cortical neurons after aspiration lesion in rats. J Neurosurg. 2003 Jun;98(6):1291-1298.
Hughes LF, McAsey ME, Donathan CL, Smith T, Coney P, Struble RG. Effects of hormone replacement therapy on olfactory sensitivity: cross-sectional and longitudinal studies. Climacteric. 2002 Jun;5(2):140-150.
Nathan BP, Jiang Y, Wong GK, Shen F, Brewer GJ, Struble RG. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 2002 Feb 22;928(1-2):96-105.
Nathan BP, Nisar R, Randall S, Short J, Sherrow M, Wong GK, Struble RG. Apolipoprotein E is upregulated in olfactory bulb glia following peripheral receptor lesion in mice. Exp Neurol. 2001 Nov;172(1):128-136.
Struble RG, Beckman SL, Fesser E, Nathan BP. Volumetric and horseradish peroxidase tracing analysis of rat olfactory bulb following reversible olfactory nerve lesions. Chem Senses. 2001 Oct;26(8):971-981.
Hughes LF, Struble RG, Shaffer CL. Olfaction in elderly and patients with Alzheimer's disease: Differing feedback conditions.
J Alzheimers Dis. 2001 Aug;3(4):367-375.
Struble RG, Husain K, Somani SM. Response of the olfactory bulb antioxidant system following diethyldithiocarbamate (DDTC) administration in rats. J Appl Toxicol. 1999 Jul-Aug;19(4):221-228.
Struble RG, Short J, Ghobrial M, Nathan BP. Apolipoprotein E immunoreactivity in human and mouse olfactory bulb. Neurosci Lett. 1999 May 28;267(2):137-140.
Bashir K, Elble RJ, Ghobrial M, Struble RG. Hemianopsia in dementia with Lewy bodies. Arch Neurol. 1998 Aug;55(8):1132-1135.
Struble RG, Ghobrial M. Cancer treatment and growth cone-associated protein in human olfactory bulb glomeruli. Arch Otolaryngol Head Neck Surg. 1998 Aug;124(8):867-870.
Struble RG, Dhanraj DN, Mei Y, Wilson M, Wang R, Ramkumar V. Beta-amyloid precursor protein-like immunoreactivity is upregulated during olfactory nerve regeneration in adult rats. Brain Res. 1998 Jan 5;780(1):129-137.
Brilliant MJ, Elble RJ, Ghobrial M, Struble RG. The distribution of amyloid beta protein deposition in the corpus striatum
of patients with Alzheimer's disease. Neuropathol Appl Neurobiol. 1997 Aug;23(4):322-325.
Ravi R, Krall, A, Rybak LP, Struble RG: Olfactory mucosal damage following subcutaneous diethyl dithiocarbamate (DDTC). J Neurotoxicol;18(1):123-128, 1997
Brilliant M, Elble RJ, Ghobrial M, Struble, RG: Distribution of amyloid in the brainstem of patients with Alzheimer disease. Neurosci Let;148:23-26, 1992
Ogane N, Giacobini E, Struble RG: Differential inhibition of acetylcholinesterase in normal and Alzheimer brain. Brain Res;589:307-312, 1992
Struble RG, Clark HB: Olfactory bulb lesions in Alzheimer's disease. Neurobiol Aging;13:469-473, 1992
Schröder H, Giacobini E, Struble RG, Zilles K, Maelicke A, Luiten PG, Strosberg AD: Cellular distribution and expression of cortical acetylcholine receptors in aging and Alzheimer's disease. Ann N Y Acad Sci; 640:189-192, 1991
Struble RG, Polinsky RJ, Hedreen JC, Nee LE, Frommelt P, Feldman RG, Price DL: Hippocampal lesions in dominantly inherited Alzheimer's disease. J. Neuropathol Exp Neurol 50:82-94, 1991
Schröder H, Giacobini E, Struble RG, Zilles K, Maelicke A: Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease. Neurobiol Aging 12:259-262, 1991
Schröder H, Giacobini E, Struble RG, Luiten PGM, Van Der Zee EA, Zilles K, Strosberg AD: Muscarinic cholinoceptive neurons in the frontal cortex in Alzheimer's disease. Brain Res Bull;27:631-636 1991
Struble RG, Clark HB: Plaques, tangles and amyloid: What do they tell us about Alzheimer's disease? In: Alzheimer Disease. Current Research in Early Diagnosis. RE Becker and E Giacobini (eds). Taylor and Francis, New York. 1990 pps 253-278.
Struble RG, Polinsky RJ, Hedreen JC, Nee LE, Frommelt P, Feldman RG, Price DL: Hippocampal lesions in dominantly inherited Alzheimer's disease. J. Neuropathol Exp Neurol;50:82-94 1991
Price DL, Whitehouse PJ, Struble, RG, Hedreen JC, Uhl GR: Transmitter systems in selected types of dementia. In: An Introduction to Neurotransmission in Health and Disease. Riederer P, Kopp N, Pearson J. (eds). Oxford University Press, Oxford. pps 349-357. 1990
Struble RG, Kitt CA, Hedreen JC, Whitehouse PJ, Walker LC, Price DL: The basal forebrain cholinergic system in primates. In: An Introduction to Neurotransmission in Health and Disease. Riederer P, Kopp N, Pearson J. (eds). Oxford University Press, Oxford. pps 343-348. 1990
Walker LC, Kitt CA, Struble RG, Wagster MV, Price DL and Cork LC: The neural basis of memory decline in aged monkeys. Neurobiol. Aging 9: 657-666, 1988.
Cork LC, Struble RG, Gold BG, DiCarlo C, Fahnestock KE, Griffin JW and Price DL: Changes in the size of motor axons in Hereditary Canine Spinal Muscular Atrophy. Lab Invest;61:333-342 1989
Grigoriadis DE, Struble RG, Price DL and De Souza EB: Normal pa tern of labeling of cerebral cortical corticotropin-releasing factor (CRF) receptors in Alzheimer's disease: evidence from chemical cross-linking studies. Neuropharmacol. 28:761-764. 1989
Wenk GL, Pierce DJ, Struble RG, Price DL and Cork LC: Age-related changes in multiple neurotransmitter systems in the monkey brain. Neurobiol. Aging 10: 11-19, 1989
Casanova MF, Struble RG, Whitehouse PJ and Price DL: A historical perspective on the neuropathology of dementia with emphasis on the senile plaque. Boletin-Asociacion Medica De Puerto Rico. 80:424-428. 1988
Hedreen JC, Raskin LS, Struble RG and Price DL: Selective silver impregnation of senile plaques: A method useful for computer imaging. J. Neurosci Meth. 25:151-158, 1988
Herrick-Davis, Titeler M, Struble RG and Price DL: Serotonin 5HT1D receptors in human prefrontal cortex and caudate: interaction with a GTP binding protein. J. Neurochem. 51:1906-1912, 1988
Powers RE, Struble RG, Casanova MF, O'Connor DT, Kitt CA and Price DL: Innervation of human hippocampus by noradrenergic systems: normal anatomy and structural abnormalities in aging and in Alzheimer's disease. Neuroscience 25:401-417, 1988
Walker LC, Kitt CA, Cork LC, Struble RG, Dellovade TL and Price DL: Multiple transmitter systems contribute neurites to individual senile plaques. J. Neuropathol. Exp. Neurol. 47:138-144, 1988
Aigner TG, Mitchell SJ, Aggleton JP, DeLong MR, Struble RG, Price DL, Wenk GL and Mishkin M: Effects of scopolamine and physostigmine on recognition memory in monkeys with ibotenic acid-induced lesions of the nucleus basalis of Meynert. Psychopharmacology 92:292-300, 1987
Powers RE, Walker LC, DeSouza EB, Vale WW, Struble RG, Whitehouse PJ and Price DL: Immunohistochemical study of neurons containing corticotropin-releasing factor in Alzheimer's disease. Synapse 1: 405-410, 1987
Presty SK, Bachevalier J, Walker LC, Struble RG, Price DL, Mishkin M and Cork LC: Age differences in recognition memory of the rhesus monkey (Macaca mulatta). Neurobiol. Aging 8:435-440, 1987
Struble RG, Powers RE, Casanova MF, Kitt CA, Brown EC and Price DL: Neuropeptidergic systems in plaques of Alzheimer's disease. J. Neuropath. Exp. Neurol. 46:567-584, 1987
Aigner TG, Mitchell SJ, Aggleton JP, DeLong MR, Struble RG, Price DL, Wenk GL and Mishkin M: The effects of physostigmine and scopolamine on recognition memory in monkeys. Behav. Neural Biol. 45:81-87, 1986
Cork LC, Sternberger NH, Sternberger LA, Casanova MF, Struble RG and Price DL: Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 45:56-64, 1986
Price DL, Altschuler RJ, Struble RG, Casanova MF, Cork LC and Murphy DB: Sequestration of tubulin in neurons in Alzheimer's disease. Brain Res. 385:305-310, 1986
Struble RG, Lehmann J, Mitchell SJ, McKinney M, Price DL, Coyle JT and DeLong MR: Basal forebrain neurons provide major cholinergic innervation of primate neocortex. Neurosci. Lett. 66:215-220, 1986
Wenk GL, Engisch KL, McCall LD, Mitchell SJ, Aigner TG, Struble RL, Price DL and Olton DS: [ H]Ketanserin binding increases in monkey cortex following basal forebrain lesions with ibotenic acid. Neurochem. Int. 9: 557-562, 1986
Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH and Price DL: Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience 16:691-699, 1985
Price DL, Kitt CA, Struble RG, Whitehouse PJ, Cork LC and Walker LC: Neurobiological studies of transmitter systems in aging and in Alzheimer-type dementia. Ann. N. Y. Acad. Sci. 457:35-51, 1985
Price DL, Struble RG, Whitehouse PJ, Kitt CA and Cork LC: Neuropathological processes in Alzheimer's disease. Drug Dev. Res. 5: 59-68, 1985
Struble RG, Price DL Jr, Cork LC and Price DL: Senile plaques in cortex of aged normal monkeys. Brain Res. 361:267-275, 1985
Walker LC, Kitt CA, Struble RG, Schmechel DE, Oertel WH, Cork LC and Price DL: Glutamic acid decarboxylase-like immunoreactivite neurites in senile plaques. Neurosci. Lett. 59:165-169, 1985
Hedreen JC, Struble RG, Whitehouse PJ and Price DL: Topography of the magnocellular basal forebrain system in human brain. J. Neuropathol. Exp. Neurol. 43:1-21, 1984
Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW and Mobley WC: Evidence for cholinergic neurites in senile plaques. Science 226: 1443-1445, 1984
Lehmann J, Struble RG, Antuono PG, Coyle JT, Cork LC and Price DL: Regional heterogeneity of choline acetyltransferase activity in primate neocortex. Brain Res. 322:361-364, 1984
Struble RG, Hedreen JC, Cork LC and Price DL: Acetylcholinesterase activity in senile plaques of aged macaques. Neurobiol. Aging 5: 191-198, 1984
Struble RG, Kitt CA, Walker LC, Cork LC and Price DL: Somatostatinergic neurites in senile plaques of aged non-human primates. Brain Res. 324: 394-396, 1984
Whitehouse PJ, Struble RG, Hedreen JC, Clark AW, White CL III, Parhad IM and Price DL: Neuroanatomical evidence for a cholinergic deficit in Alzheimer's disease. Psychopharmacol. Bull. 19:437-443, 1983
Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT and DeLong MR: Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215:1237-1239, 1982
Struble RG, Cork LC, Whitehouse PJ and Price DL: Cholinergic innervation in neuritic plaques. Science 216:413-415, 1982
Struble RG and Walters CP: Light microscopic differentiation of two populations of rat olfactory bulb granule cells. Brain Res. 236: 237-251, 1982
Whitehouse PJ, Struble RG, Clark AW and Price DL: Alzheimer disease: plaques, tangles, and the basal forebrain. Letter to the Editor. Ann. Neurol. 12:494, 1982
McKinney M, Struble RG, Price DL and Coyle JT: Monkey nucleus basalis is enriched with choline acetyltransferase. J. Neurosci. 7:2363-2368, 1982
Struble RG and Riesen AH: Changes in cortical dendritic branching subsequent to partial social isolation in stumptailed monkeys. Dev. Psychobiol. 11:479-486, 1978.
Struble RG, Desmond NL and Levy WB: Anatomical evidence for interlamellar inhibition in the fascia dentata. Brain Res. 152:580-585, 1978
Sieck MH, Turner J, Gordon BL and Struble RG: Some quantitative measures of activity and reactivity in rats after selective olfactory lesions. Physiol. Behav. 11:71-79, 1973
Ravi R, Krall, A, Rybak LP, Struble RG: Olfactory mucosal damage following subcutaneous diethyl dithiocarbamate (DDTC). J Neurotoxicol;18(1):123-128, 1997
Brilliant M, Elble RJ, Ghobrial M, Struble, RG: Distribution of amyloid in the brainstem of patients with Alzheimer disease. Neurosci Let;148:23-26. 1992
Ogane N, Giacobini E, Struble RG: Differential inhibition of acetylcholinesterase in normal and Alzheimer brain. Brain Res;589:307-312 1992
Struble RG, Clark HB: Olfactory bulb lesions in Alzheimer's disease. Neurobiol Aging,;13:469-73 1992
Schröder H, Giacobini E, Struble RG, Luitten PGM, van der Zee EA, Zilles K, Strosberg AD: Muscarinic cholinceptive neurons in the frontal cortex in Alzheimer's disease. Brain Res Bull;27:631-636 1991
Struble RG, Polinsky RJ, Hedreen JC, Nee LE, Frommelt P, Feldman RG, Price DL: Hippocampal lesions in dominantly inherited Alzheimer's disease. J. Neuropathol Exp Neurol 50:82-94, 1991
Schröder H, Giacobini E, Struble RG, Zilles K, Maelicke A: Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease. Neurobiol Aging 12:259-262, 1991
Schröder H, Giacobini E, Struble RG, Luiten PGM, Van Der Zee EA, Zilles K, Strosberg AD: Muscarinic cholinoceptive neurons in the frontal cortex in Alzheimer's disease. Brain Res Bull;27:631-636 1991
Schröder H, Giacobini E, Struble RG, Zilles K, Maelicke A: Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease. Neurobiol Aging;12:259-262. 1991
Schröder H, Giacobini E, Struble RG, Luitten PGM, van der Zee EA, Zilles K, Strosberg AD: Muscarinic cholinceptive neurons in the frontal cortex in Alzheimer's disease. Brain Res Bull 1991;27:631-636
Struble RG, Clark HB: Plaques, tangles and amyloid: What do they tell us about Alzheimer's disease? In: Alzheimer Disease. Current Research in Early Diagnosis. RE Becker and E Giacobini (eds). Taylor and Francis, New York. 1990 pps 253-278.
Struble RG, Polinsky RJ, Hedreen JC, Nee LE, Frommelt P, Feldman RG, Price DL: Hippocampal lesions in dominantly inherited Alzheimer's disease. J. Neuropathol Exp Neurol;50:82-94 1991
Price DL, Whitehouse PJ, Struble, RG, Hedreen JC, Uhl GR: Transmitter systems in selected types of dementia. In: An Introduction to Neurotransmission in Health and Disease. Riederer P, Kopp N, Pearson J. (eds). Oxford University Press, Oxford. pps 349-357. 1990
Struble RG, Kitt CA, Hedreen JC, Whitehouse PJ, Walker LC, Price DL: The basal forebrain cholinergic system in primates. In: An Introduction to Neurotransmission in Health and Disease. Riederer P, Kopp N, Pearson J. (eds). Oxford University Press, Oxford. pps 343-348. 1990
The rat olfactory bulb as a model of control of Alzheimer disease-associated proteins. Department of Pharmacology Stritch School of Medicine, Loyola University, Chicago, October, 1995
The olfactory bulb as a model of Alzheimer disease degeneration. Department of Neurobiology, University of Tennessee, Memphis Mar 1994
Olfactory bulb involvement in AD: An early change? Third Annual Springfield Symposium on Alzheimer Disease, April 1994.
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