Wang CV

Southern Illinois University School of Medicine

Zeng Y. Wang, M.D., Ph.D.
Updated: October 1, 2007

SIU Department of Neurology
P.O. Box 19637
Springfield , IL 62794-9637
Appointments: (217) 545-8417
Office Phone: (217) 545-8486
Fax: (217) 545-8039
E-mail: zwang@siumed.edu

ACADEMIC APPOINTMENTS
Assistant Professor of Clinical Neurology
Clinical Co-Director, MDA/ALS Clinics
Director, Electrodiagnostic Medicine (EMG) Laboratories

PROFESSIONAL QUALIFICATIONS
Diplomate of the American Board of Psychiatry and Neurology, a Member Board of the American Board of Medical Specialties
Diplomate of Clinical Neurophysiology, a Subspecialty Board of the American Board of Psychiatry and Neurology
Diplomate of the American Board of Electrodiagnostic Medicine

EDUCATION
M.D., Hunan Medical University, Changsha, Hunan, China
Ph.D. in Neuroimmunology, Karolinska Institute, Stockholm, Sweden

CLINICAL TRAINING
Clinical Fellowship in Neuromuscular Disease and Clinical Neurophysiology, Washington University School of Medicine, St. Louis, Missouri
Residency in Neurology, SIU School of Medicine (Chief Resident 2003-04)
Internship in Internal Medicine, SIU School of Medicine

RESEARCH TRAINING
Postdoctoral Associate, Department of Biochemistry, University of Minnesota, Minneapolis-St. Paul, Minnesota
Research Assistant, Department of Neurology, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden

PROFESSIONAL MEMBERSHIPS
American Academy of Neurology
American Association of Neuromuscular and Electrodiagnostic Medicine
American College of Physicians-American Society of Internal Medicine
American Association for the Advancement of Science
New York Academy of Sciences

SCHOLARSHIP AND FELLOWSHIP AWARDS
Annual Meeting Resident Scholarship, American Academy of Neurology (2003)
Postdoctoral Research Fellowship, Muscular Dystrophy Association (1994-96)
Scholarship, Swedish Medical Society, Stockholm, Sweden (1992-93)
Scholarship, Karolinska Institute, Stockholm, Sweden (1991-92)

Extra Curriculum
Compliance Committee, SIU Physician & Surgeon
House Staff Board of Directors, SIU School of Medicine
PUBLICATIONS
1. Link H, Xu Z, Melms A, Kalbacher H, Sun JB, Wang ZY, Fredrikson S, Olsson T: The T cell repertoire in myasthenia gravis involved multiple cholinergic receptor epitopes. Scand J Immunol 36: 405-414, 1992.
2. Fredrikson S, Michelsberg J, Hillert J, Wang ZY, Sun J, Olerup O, Olsson T, Link H: Conjugal multiple sclerosis: Immunogenetic characterization and analysis of T and B cell reactivity to myelin proteins. Neurology 42: 577-582, 1992.
3. Link H, Sun JB, Wang ZY, Xu Z, Löve A, Fredrikson S, Olsson T: Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis. J Neuroimmunol 38: 63-74, 1992.
4. Sun JB, Harcout G, Wang ZY, Hawke S, Olsson T, Fredrikson S, Link H: T and B cell responses to human recombinant acetylcholine receptor α-subunit in myasthenia gravis and controls. Eur J Immunol 22:1553-1559, 1992.
5. Wang ZY, Hansen K, Siden Å, Cruz M: Intrathecal synthesis of anti-Borrelia burgdorferi antibodies in neuroborreliosis: a study with special emphasis on oligoclonal IgM antibody bands. Scand J Immunol. 37: 369-376, 1993.
6. Wang ZY, Link H, Huang WX: T cell immunity to acetylcholine receptor and its subunits in Lewis rats over the course of experimental autoimmune myasthenia gravis. Scand J Immunol 37: 615-622, 1993.
7. Wang ZY, Link H, Qiao J, Olsson T, Huang WX: B cell autoimmunity to acetylcholine receptor and its subunits in Lewis rats over the course of experimental autoimmune myasthenia gravis. J Neuroimmunol 45: 103-112, 1993.
8. Wang ZY, Qiao J, Link H: Suppression of experimental autoimmune myasthenia gravis by oral administration of acetylcholine receptor. J Neuroimmunol 44: 209-214, 1993.
9. Wang ZY, Qiao J, Melms A, Link H: T cell reactivity to acetylcholine receptor in rats orally tolerized against experimental autoimmune myasthenia gravis. Cell Immunol 152: 394-404, 1993.
10. Qiao J, Wang ZY, Link H: ß-bungarotoxin binding protein is immunogenic but lacks myasthenogenicity in rats. J Neurol Sci 121: 190-193, 1994.
11. Wang ZY, Link H, Ljundahl Å, Höjeberg B, Link J, He B, Qiao J, Melms A, Olsson T: Induction of interferon-γ, interleukin-4 and transforming growth factor-ß in rats orally tolerized against experimental autoimmune myasthenia gravis. Cell Immunol 157: 353-368, 1994.
12. Link J, Söderström M, Ljungdahl Å, Höjeberg B, Olsson T, Xu Z, Fredrikson S, Wang ZY, Link H: Organ-specific autoantigens induce interferon-γ and interleukin-4 mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Neurology 44: 728-734, 1994.
13. Söderström M, Link H, Sun JB, Fredrikson S, Wang ZY, Huang WX: The autoimmune T cell repertoire in optic neuritis and multiple sclerosis: T cells recognizing multiple myelin proteins are accumulated in cerebrospinal fluid. J Neurol Neurosurg Psych 57: 544-551, 1994.
14. Wang ZY, Qiao J, Link H: Induction of oral tolerance to experimental autoimmune myasthenia gravis by oral administration of acetylcholine receptor. Shanghai J Immunol 14: 129-133, 1994.
15. Link H, Wang ZY, Olsson T: Cytokine differentiation in relation to human myasthenia gravis and experimental autoimmune myasthenia gravis. Neurology 44 (Suppl 4): A189, 1994.
16. Wang ZY, Huang J, Olsson T, He B, Link H: B cell responses to acetylcholine receptor in rats orally tolerized against experimental autoimmune myasthenia gravis. J Neurol Sci 128: 167-174, 1995.
17. Wang ZY, He B, Qiao J, Link H: Suppression of experimental autoimmune myasthenia gravis and experimental allergic encephalomyelitis by oral administration of acetylcholine receptor and myelin basic protein: Double tolerance. J Neuroimmunol 63: 79-86, 1995.
18. Wang ZY, He B, Qiao J, Link H: Antigen-induced cytokine patterns in double mucosal tolerance to EAE and EAMG. J Neuroimmunol (Suppl 1): 42, 1995.
19. Ma CG, Zhang GX, Xiao BG, Wang ZY, Link J, Olsson T, Link H: Mucosal tolerance to experimental autoimmune myasthenia gravis is associated with down-regulation of AChR-specific IFN-g-expressing Th1-like cells and up-regulation of TGF-b mRNA in mononuclear cells. Ann NY Acad Sci 778: 273-287, 1996.
20. Wang ZY, Okita DK, Howard Jr JF, Conti-Fine BM: Th1 epitope repertoire on the a subunit of human acetylcholine receptor in myasthenia gravis. Neurology 48:1643-1653, 1997.
21. Wang ZY, Okita DK, Howard Jr JF, Conti-Fine BM: T cell recognition of the human muscle acetylcholine receptor subunits in generalized and ocular myasthenia gravis. Neurology 50: 1045-1054, 1998.
22. Wang ZY, Okita DK, Howard Jr JF, Conti-Fine BM: CD4+ T cell repertoire on the e subunit of muscle acetylcholine receptor in myasthenia gravis. J Neuroimmunol: 91: 33-42, 1998.
23. Wang ZY, Okita DK, Howard Jr JF, Conti-Fine BM: CD4+ epitope spreading and differential T cell recognition of muscle acetylcholine receptor subunits in myasthenia. Ann NY Acad Sci 841: 283-308, 1998.
24. Wang ZY, Okita DK, Howard Jr JF, Conti-Fine BM: Th1 cells of myasthenia gravis patients recognize multiple on the muscle acetylcholine receptor a subunit. Ann NY Acad Sci 841: 329-333, 1998.
25. Conti-Fine BM, Navaneetham D, Karachunski PI, Raju R, Diethelm-Okita B, Okita DK, Howard Jr JF, Wang ZY: T cell recognition of the acetylcholine receptor in myasthenia gravis. Ann NY Acad Sci 841: 334-337, 1998.
26. Wang ZY, Karachunski PI, Howard Jr JF, Conti-Fine BM: Myasthenia in SCID mice grafted with myasthenic patient lymphocytes: Role of CD4+ and CD8+ cells. Neurology 52: 484-497, 1999.
27. Wang ZY, Karachunski PI, Howard Jr JF, Conti-Fine BM: Passive myasthenia gravis induced in SCID mice by transfer of blood lymphocytes from myasthenic patients. In: P. Christadoss ed. Myasthenia gravis: Disease Mechanisms and Immunointervention. Narosa Publishing House, New Delhi, India, 1999.
28. Conti-Fine BM, Wang ZY, Raju R, Howard Jr JF, Navaneetham D: Anti-acetylcholine receptor CD4+ T cells in myasthenia gravis: epitope repertoire and TCR gene usage. In: P. Christadoss ed. Myasthenia gravis: Disease Mechanisms and Immunointervention. Narosa Publishing House, New Delhi, India, 1999.
29. Wang ZY, Diethelm-Okita B, Okita DK, Karachunski PI, Howard Jr JF, Conti-Fine BM: T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis. J Neuroimmunol 108 (1-2): 29-39, 2000.
30. Ala TA, Wang ZY, Kuhn M: There may be a dissociation between clinical brain death and cerebral perfusion: A case report. Neurology 58 (Suppl 3): A136, 2002.
31. Wang ZY, Al-Lozi M, Pestronk A: Uniform nerve conduction slowing in acquired chronic demyelinating neuropathy. Manuscript.