Department of Neurology

Neuroscience Research - Current Studies

For more information on any study, please contact Senior Clinical Research Coordinator Barbara Lokaitis, BA, CCRP.

Email: blokaitis@siumed.edu
Phone: 217.545.9737

Dr. Ala

A Prospective, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Efficacy and Safety Study of Oral ELND005 for Treatment of Agitation and Aggression in Patients With Moderate to Severe Alzheimer’s Disease.
A 12-Week Safety Extension Study of Oral ELND005 for Treatment of Agitation and Aggression in Patients With Moderate to Severe Alzheimer’s Disease.
A Phase 11b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of MK-7622 as an Adjunctive Therapy to Donepezi for Symptomatic Treatment in Subjects with Alzheimer's Disease.
A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of [18F]NAV4694 PET for Detection of Cerebral β-Amyloid When Compared With Postmortem Histopathology.
Beta-amyloid Imaging With [18F]NAV4694 Positron Emission Tomography (PET) in Predicting Progression to Alzheimer’s Disease (AD) in Subjects with Mild Cognitive Impairment (MCI).
Consistency of Resting state networks in Healthy Adult and Elderly Subjects.

Dr. Cozzens

Reclaim Deep Brain Stimulation HDE # H050003.
A Phase 1 and 2 Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain.
National Neurosurgery Quality and Outcomes Database: A Prospective Registry for Quality Reporting.

Dr. Elble

Neuromuscular Control in Action Tremor.

Dr. Gilchrist

International GBS Outcome Study.

Dr. Hascup

The role of extracellular glutamate in Alzheimer's disease progression and its use as an early biomarker.
High-fat diet and Alzheimer's disease progression.

Dr. Kale

Randomized Evaluation of Recurrent Stroke comparing PFO Closure to Established Current Standard of Care Treatment.
Codman Enterprise Vascular Reconstruction Device and Delivery System, Humanitarian Use Device (HDE).
H020002 Supplement Neuroform Microdelivery Stent System, Neuroform EZ Stent System.
H050001 Wingspan® Stent System with Gateway® PTA Balloon Catheter, a Humanitarian Use Device (HUD).
The Randomized, Concurrent Controlled Trial to Assess the Penumbra System’s Safety and effectiveness in the Treatment of Acute Stroke (THERAPY).

Dr. Peng

A randomized, double-blind, placebo-controlled, parallel group, multi-center trial of pregabalin as adjunctive therapy in pediatric and adult subjects with primary generalized tonic-clonic seizures.
A Multicenter, Open-label Extension Trial to Assess the Long-term Use of Lacosamide Monotherapy and Safety of Lacosamide Monotherapy and Adjunctive Therapy in Subjects with Partial Seizures.
Long-Term Eslicarbazepine Acetate Extension Study.
Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) as Adjunctive Therapy for Refractory Partial Seizures in a Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicentre Clinical Trial.
1358: A randomized, double-blind, placebo-controlled, multi-center, parallel-group study to evaluate the effectiveness and safety of brivaracetam in subjects (≥ 16 to 80 years old) with partial onset seizures.
1379: An open label, multi-center, follow-up study to evaluate the safety and effectiveness of brivaracetam used as adjunctive treatment in subjects aged 16 years and older with partial onset seizures.

Dr. Siddiqui

Platelet-Oriented Inhibition in New TIA (POINT).

Dr. Zec

Diagnosis of Dementia: Sensitivity of Neuropsychological Tests.