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January 15, 2003

SIU Med School Recruiting Patients with Leg Circulation Problems

Patients are being recruited by the Division of Vascular Surgery at Southern Illinois University School of Medicine as part of a national clinical trial for the treatment of severe peripheral artery disease.  This study, being conducted at 29 sites in the United States, will be evaluating the efficacy and safety of a new drug, Circulase, in treating critical limb ischemia where blood circulation has severely decreased.

“Severe peripheral artery disease is a condition whereby the arteries in the legs are blocked.  The condition can effect up to ten percent of people over the age of 70, “ said Dr. Robert McLafferty, assistant professor of vascular surgery at SIU, who is directing the study.  “This trial is testing a possibly therapy in which the drug dilates the blood vessels thus providing more blood flow.  At this point, its use is for an add-on therapy only.”

To be eligible for the study, patients must be more than 40 years old and have pain in their legs while at rest or a non-healing ulcer on their lower legs or feet.  Patients will received the new drug or a placebo and will be evaluated over a period of nine weeks with 40 visits.  Each participant will receive a physical examination and other tests before beginning.  There is no charge to the participants for the tests and medications related to the study, which is sponsored by Catalyst Pharmaceutical Research LLC.  Results will be shared with the participant’s personal physician.

If you are interested in participating in the study, call Catalyst’s toll free number, 1-888-216-4620, for initial screening.

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thern Illinois University School of Medicine Office of Public Affairs News Releases P.O. Box 19621, Springfield IL 62794-9621, 217-545-2155