Post-Doctoral, Chemistry, University of Pennsylvania, 1992-1994
Medical School, Doctor of Medicine, University of Pittsburgh, 1994-1998
Internship, Obstetrics & Gynecology, Women & Infants Hospital, 1998-1999
Residency, Obstetrics & Gynecology, Women & Infants Hospital, 1999-2002
Fellowship, Gynecologic Oncology, Women & Infants Hospital, 2002-2005
Research Fellow, Gynecologic Oncology, Brown University, 2002-2003
Teaching Fellow, Gynecologic Oncology, Brown University, 2003-2005
Experience
Assistant Instructor, Brown University, 2001-2002
Physician, Women & Infants Hospital of Rhode Island, 2005-2010
Assistant Professor, Alpert Medical School of Brown University, 2005-2010
Associate Professor of Obstetrics & Gynecology, Southern Illinois University School of Medicine, 2010-Present
Board Certifications
Obstetrics & Gynecology, 2006-Present
Publications
Saulnier Sholler G, Bergendahl G, Brard L, Singh AP, Heath B, Bingham P, AshikagaT, Kamen B, Homans A, Ferguson W. A Phase I Study of Nifurtimox in Patients with Relapsed/Refractory Neuroblastoma. J Pediatr Hematol Oncol. 33(1): 25-30 (2011). Epub 2010 Nov 8. PMID: 21063221.
Singh R, Lange TS, Kim KK, Brard L*. A coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells. Invest New Drugs. 2009 Oct 29. [Epub ahead of print].
Lange TS, Zou Y, Singh R, Kim K, Kristjansdottir K, Saulnier-Sholler GL, Brard L*. Chemotherapeutic Effect of Calcidiol Derivative B3CD in a Neuroblastoma Xenograft Model. Chem Biol Drug Des. 76(2): 164-73 (2010). Epub 2010 May 11.
Kim K, Lange TS, Singh R, Brard L*. Lipophilic aroylhydrazone chelator HNTMB and its multiple effects in
ovarian cancer cells. BMC Cancer. 10:72 (2010).
Lange TS, Stuckey AR, Robison K, Kim KK, Singh RK, Raker CA, Brard L*. Effect of a Vitamin D3 derivative (B3CD) with postulated anti-cancer activity in an ovarian cancer animal model. Invest New Drugs. 28(5): 543-53 (2010). Epub 2009 Jul 7.
McCourt C, Dessie S, Bradley AM, Schwartz J, Brard L, Dizon DS. Is there a taxane-free interval that predicts response to taxanes as a later-line treatment of recurrent ovarian or primary peritoneal cancer? Int J Gynecol Cancer. 19(3): 343-347 (2009).
Saulnier Sholler GL, Brard L, Straub JA, Dorf L, Illyene S, Kalkunte S, Bosenberg M, Ashikaga N, Nishi R.
Nifurtimox Induces Apoptosis of Neuroblastoma Cells in Vitro and in Vivo. J Pediatr Hematol Oncol. 31(3):187-193 (2009).
Singh AP, Singh RK, Kim KK, Kalkunte SS, Nussbaum R, Kim KK, Torres M, Brard L*, Vorsa N. Cranberry
Proanthocyanidins are Cytotoxic to Human Cancer Cells and Sensitize Platinum-Resistant Ovarian Cancer Cells to Paraplatin. Phytother Res. 23(8): 1066-74 (2009).
Lange TS, McCourt C, Singh RK, Kim KK, Singh AP, Luisi BS, Alpturk O, Strongin R, Brard L*. Apoptotic and chemotherapeutic properties of Iron(III)-salophene in an ovarian cancer animal model. Drug Design,
Development and Therapy:3 17-26 (2009).
Singh RK, Lange TS, Kim KK, Singh AP, Vorsa N, Brard L*. Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signaling and cell cycle regression in ovarian cancer cells. Br J Cancer 99(11):1823-1831 (2008). Epub 2008 Nov 11.
Singh RK, Lange TS, Kim K, Singh AP, Hopson R, Vorsa N, Brard L* ChemInform Abstract: Synthesis of Bicyclic Aryl Thiazolines with Selective Antiproliferative Effects on Human Cancer Cell Lines. ChemInform 39(28), (July 8) (2008).
Lange TS, Kim KK, Singh RK, Strongin RM, McCourt CK, Brard L*. Iron(III)-salophene: An organometallic
compound with selective cytotoxic and anti-proliferative properties in platinum-resistant ovarian cancer cells.
PLoS ONE. 3(5):e2303 (2008).
Singh RK, Lange TS, Kim K, Shaw S, Brard L*. A Novel Indole Ethyl Isothiocyanate (7Me-IEITC) with Antiproliferative and Pro-apoptotic Effects on Platinum-resistant Human Ovarian Cancer Cells. Gynecol Oncol. 109(2):240-249 (2008).
Moore RG, Robison K, Brown AK, Disilvestro P, Steinhoff M, Noto R, Brard L, Granai CO. Isolated sentinel
lymph node dissection with conservative management in patients with squamous cell carcinoma of the vulva: A prospective trial. Gynecol Oncol. 109(1):65-70 (2008).
Brard L*, Singh RK, Kim KK, Lange TS, Saulier Sholler GL. Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-Butyl Carbamoyl, 7-Methyl-Indole-3-Ethyl Isothiocyanate (NB7M) in nervous system cancer cells. Drug Design, Development and Therapy 2:61–69 (2008).
Singh RK, Lange TS, Kim K, Singh AP, Hopson R, Vorsa N, Brard L*. Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines. Letters in Organic Chemistry 5(2):103-109 (2008).
McCourt C, Dessie S, Dizon DS, Young M, Brard L, Legare R, Sakr B, DiSilvestro P. Platinum-free, taxane-free, or treatment-free interval: Which predicts response to taxane therapy as third- or later-line treatment? Gynecol Oncol 108 (2008) S134 (abstract).
Robison K, Kim KK, Singh R, Lange T, Granai CO, Brard L*. The use of a vitamin D derivative in a mouse
xenograft ovarian cancer model. Gynecol Oncol 108 (2008) S68 (abstract).
Dizon DS, Restivo A, Lomme M, Charbonneau N, Brard L, Hughes T, Weitzen S, Legare R, Granai CO,
DiSilvestro P. For women receiving chemotherapy for clinically apparent early ovarian cancer, is there a benefit to surgical staging? Am J Clin Oncol. 31(1):39-42 (2008).
Dr. Laurent Brard and the Division of Gynecologic Oncology are located at both the
Carol Jo Vecchie Women's Center
415 N. 9th Street
Springfield, Illinois
And
Simmons Cancer Institute
315 W. Carpenter Street
Springfield, Illinois
