|Brandon Cox, Ph.D.
Hearing loss is primarily caused by damage to specialized cells (called hair cells) that detect sound waves traveling through the cochlea of the inner ear. Non-mammalian vertebrates, such as birds, fish, and amphibians, can regenerate their hair cells after damage, while damage to auditory hair cells in mammals is currently thought to be permanent. We have recently developed a genetic method to damage hair cells in the neonatal mouse in vivo and discovered that, in contrast to common belief, the mouse cochlea does have the capacity to regenerate its hair cells
Montgomery SC and Cox, BC (2016) Whole mount dissection and immunofluorescence of the adult mouse cochlea. J Vis Exp 107:e53561.
Walters BJ*, Liu Z*, Crabtree M*, Coak E, Cox, BC, and Zuo J. (2014) Auditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing. J Neurosci, 34:15751-15763.
*authors contributed equally
Cox, BC, Dearman JA, Brancheck J, Zindy F, Roussel MF, and Zuo J. (2014) Generation of Atoh1-rtTA transgenic mice: a tool for inducible gene expression in hair cells of the inner ear. Sci Rep 4:6885.
Cox BC*, Chai R*, Lenoir A, Liu Z, Zhang L, Nguyen D, Chalasani K, Steigelman KA, Fang J, Rubel EW, Cheng AG, and Zuo J. (2014) Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. Development 141:816-829.
*authors contributed equally
Mellado Lagarde, MM, Cox BC, Fang J, Taylor R, Forge A and Zuo J. (2013) Selective ablation of pillar and Deiters’ cells severely affects cochlear postnatal development and hearing function in mice. J Neurosci 33:1564-1576.
Liu Z, Walters BJ, Owen T, Brimble MA, Steigelman KA, Zhang L, Mellado Lagarde MM, Valentine MB, Yu Y, Cox BC and Zuo J. (2012) Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium. J Neurosci 32:10530-10540.
Burns J*, Cox BC*, Thiede BR, Zuo J and Corwin JT. (2012) In vivo proliferative regeneration of balance hair cells in newborn mice. J Neurosci 32:6570-6577.
Cox BC, Liu Z, Mellado Lagarde MM and Zuo J. (2012) Conditional gene expression in the mouse inner ear using Cre-loxP. J Assoc Res Otolaryngol 13:295-322.
Liu Z, Dearman JA, Cox BC, Walters BJ, Zhang L, Ayrault O, Zindy F, Gan L, Roussel M, and Zuo J. (2012) Age-dependent in vivo conversion of mouse cochlear pillar and Dieters’ cells to immature hair cells by Atoh1 ectopic expression. J Neurosci 32: 6600-6610.
Yu Y, Weber T, Yamashita Y, Liu Z, Valentine MB, Cox BC and Zuo J. (2010) In vivo proliferation of postmitotic cochlear supporting cells by acute ablation of the retinoblastoma protein in neonatal mice. J Neurosci 30: 5927-5936.
Cox BC, Marritt AM, Perry DC and Kellar KJ. (2008) Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: High densities of receptors containing α6 and β3 subunits. J Neurochem 105: 1924-1938.
Marritt AM, Cox BC, Yasuda RP, McIntosh JM, Xiao Y, Wolfe BB and Kellar KJ. (2005) Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Mol Pharmacol 68: 1656-1668.
Kingsley RJ, Affif E, Cox BC, Kothari S, Kriechbaum K, Kuchinsky K, Neill AT, Puri AF and Kish VM. (2003) Expression of heat shock and cold shock proteins in the gorgonian Leptogorgia virgulata. J Exp Zoolog A Comp Exp Biol 296: 98-107.