SELECTED PUBLICATIONS:

Premkumar L. S. and Raisinghani M. (2006) Nociceptors in cardiovascular functions: Complex interplay as a result of cyclooxygenase inhibition. Mol. Pain (in press).

Premkumar L. S., Raisinghani M., Pingle S., Long C. and Pimentel, F. (2005) Downregulation of TRPM8 by protein kinase C mediated dephosphorylation. J. Neurosci. 25: 11322-11329.

Premkumar L. S. (2005) Block of calcium activated potassium channels by cocaine. J. Memb. Biol. 204: 129-36.

Raisinghani M., and Pabbidi, R., Premkumar L. S. (2005) Activation of TRPV1 by  Resiniferatoxin: Implications in chronic pain conditions. J. Physiol. 567: 771-786.

Van Buren J., Bhat S., Smith S., Pauza M., Premkumar L. S. (2005) Role of TRPV1 in diabetic peripheral neuropathy. Mol. Pain 1: 17.

Raisinghani M. and Premkumar L. S. (2004). Block of Native and Cloned Vanilloid Receptor 1 (TRPV1) by Aminoglycoside Antibiotics. Pain 113: 123-133.

Puntambekar P., Van Buren J., Raisinghani M., Premkumar L. S. and Ramkumar V. (2004) Direct interaction of Adenosine with the TRPV1 channel protein. J. Neurosci. 24: 3663-3671.

Premkumar L. S., Qi Z.H., Van Buren J. and Raisinghani M. (2004) Enhancement of potency and efficacy of NADA by PKC-mediated phosphorylation of vanilloid receptor.     J. Neurophysiol. 91:1442-1449.

Watanabe J., Beck C., Kuner T., Premkumar L. S. and Wollmuth L. P. (2003) DRPEER: A motif in the extracellular vestibule conferring high Ca2+ flux rates in NMDA receptor channels.     J. Neurosci. 22:10209-10216.

Ahern G. P. and Premkumar L. S. (2002). Voltage-dependent priming of vanilloid receptor:  effects of agonists and phosphorylation state.      J. Physiol. 545: 441-451.

Premkumar L. S., Agarwal S. and Steffen D. (2002). Single channel properties of native and cloned rat vanilloid receptors. J. Physiol. 545: 107-117.

Sasaki Y. F., Rothe T., Premkumar L. S., Das S., Cui J., Talantova M. V., Wong H. K., Gong X., Chan S. F., Zhang D., Nakanishi N., Sucher N. J. and Lipton S. A. (2002).      Characterization and comparison of the NR3A Subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J. Neurophysiol. 87:2052-2063.

Chatterton J. E., Awobuluyi M., Premkumar L. S., Takahashi H., Talantova M., Shin Y., Cui J., Tu S., Sevarino K. A., Nakanishi N., Tong G., Lipton S. A. and Zhang D. (2002).      Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.      Nature 415:793-798.

Premkumar L. S. (2001) Interaction between vanilloid receptors and purinergic metabotropic receptors: pain perception and beyond. Proc. Natl. Acad. Sci. U S A. 98:6537-6539.

Premkumar L. S. and Ahern G. P. (2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature 408:985-990.

Kuehl-Kovarik C.M., Partin, M., Premkumar L. S. and Magnusson, K. R. (2000) Electrophysiological analysis of NMDA receptor subunit changes in the aging mouse cortex.       Mech. Ageing Dev. 115:39-59.

Premkumar L. S. (1999) Selective potentiation of L-type calcium currents in cardiac myocyte and hippocampal neurons by cocaine. Mol. Pharmacol. 56:1138-1142.

Das D., Sasaki Y. F., Rothe T., Premkumar L. S., Takasu M., Crandall J. E., Dikkes P.,  Connor D. A., Rayudu P. V., Cheung W., Chen H-S.V., Lipton S. A. and Nakanishi N. (1998). Increased NMDA current and spine density in mice lacking a novel NMDAR subunit, NR3A.      Nature 393: 377-381.

Premkumar L. S. and Auerbach A. (1997) Stoichiometry of mouse recombinant NMDA receptor channels inferred from single-channel conductance patterns. J. Gen. Physiol. 110:485-502.

Premkumar L. S., Qin F. and Auerbach A. (1996) Subconductance states of a mutant NMDA receptor channel: kinetics and voltage-dependence. J. Gen. Physiol. 109: 1-9.

Premkumar L. S. and Auerbach A. (1996) Identification of a high affinity divalent binding site at the entrance of NMDA receptor channel. Neuron 16: 869-880.

BOOK CHAPTERS

Gage P. W., Premkumar L. S. and Chung S-H. (1993). Potassium channels in cultured mammalian neurons. Molecular and Cellular Biology of Pharmacological Targets. Chapter 7. Eds.Glossmann, H and Striessnig, J. Plenum Press, New York.

Gage P. W., Chung S-H., Moore J. B. and Premkumar L. S. (1990). Detection and interpretation of multiple conductance levels in ion channels in membranes. In exocrine Secretion II. Eds. P. Y. D. Wong and J. A. Young. United League Graphic and Printing Co. Ltd., Hong Kong.

Van Buren J. and Premkumar L. S. (2003). Modalities of nociception and the Underlying molecular mechanisms. Chapter 16. Eds. Flora, S. J. S., Romano, J, A., Baskin, S. I., and Sekhar, K. Narosa Publishing House, New Delhi.