Reproductive Biology, Cancer Biology
The major research interest of our lab is to understand and discover key cellular and molecular mechanisms regulating uterine development and ovarian cancer. Fundamental findings from our studies will provide the information useful for prevention and clinical treatment of infertility and pregnancy loss involving uterine dysgenesis, dysplasia, and dysfunction, as well as develop knowledge essential for rational design of therapies for ovarian cancer patients through improvement of the diagnosis of ovarian tumorigenesis and metastasis. 
Current research projects are to study: 1) the impact of Wnt11 and Wnt16 deletion on postnatal uterine morphogenesis and function by ablating the expression of Wnt11 and Wnt16, and 2) the functional role of WNT7A in ovarian cancer.  Specifically to investigate WNT7A regulation of known metastatic inducing factors and determine whether WNT7A can serve as a clinical marker for the early detection of ovarian cancer for which there are currently few.
The experimental program in our lab integrates cellular and molecular biology, mammalian cell culture as well as gene targeting to produce gene knockout mice.