Reproductive Biology

Homeobox genes encode transcription factors that determine the identity of cells and tissues in the developing embryo. While the embryonic function of homeobox genes is well established, their function in regulating postnatal events has only begun to be examined. The long term goal of my research is to characterize the role of the Rhox homeobox gene cluster in establishing and supporting reproduction. The recently discovered Rhox genes are selectively expressed in ovary, testis, epididymis, and placenta and are therefore good candidates to regulate fertility. We have begun to identify the downstream targets of the Rhox genes and examine how changes in their expression influence germ cell survival. The experimental program in my laboratory integrates traditional biochemistry, molecular biology, mammalian cell culture, and evolutionary analysis.