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 Elizabeth A. Peralta, MD, FACS
Assistant Professor, Division of General Surgery
E-mail: eperalta@siumed.edu
- Breast cancer
- Pancreatic tumors
- Soft tissue sarcomas
Dr. Elizabeth Peralta is an Associate Professor in the Division of General Surgery, Department of Surgery at the Southern Illinois University School of Medicine.
Dr. Peralta received her medical degree from the University of California in Irvine. She completed her general surgery residency at Virginia Mason Medical Center in Seattle and then a surgical oncology fellowship at the City of Hope National Medical Center in California.
Dr. Peralta is board certified in General Surgery. She is a Fellow of the American College of Surgeons and a member of the Society of Surgical Oncologists. She has been on the faculty of the Breast Center at SIU since 2000 and continues to treat breast cancer as well as gastrointestinal tumors and melanoma at the Simmons Cooper Cancer Institute at SIU.
She has received regional and national awards for research and presentations. Dr. Peralta has authored several scientific articles on the treatment and prevention of breast cancer.
For more information or to schedule an appointment with Dr. Peralta, please call SIU Physicians and Surgeons at 217-545-7234.
- 1978-1980 Massachusetts Institute of Technology, Cambridge, Massachusetts
- 1980-1987 University of California, Berkeley, California
Bachelor of Arts in Physiology
- 1988-1992 University of California, California College of Medicine, Irvine, California
Doctor of Medicine
- 1997-2000 City of Hope National Medical Center, Duarte, California
Surgical Oncology Fellow.
- 1992-1997 Virginia Mason Medical Center, Seattle, Washington General Surgery Resident
- September 1997 Society of Surgical Oncology Advanced Laparoscopic Skills
- June 1998 American Association of Immunology Advanced Course in Immunology
- July 1998 Berlex Cancer Foundation Biostatistics
- February 1999 City of Hope Clinical Cancer Genetics Emerging Genetic Technologies in Gastrointestinal Cancers: A Multidisciplinary Approach for the Clinician
American Board of Surgery -- June 9, 1998
POSITIONS AND HONORS:
Positions and Employment
07/2000-06/2008 Assistant Professor of Surgery, Southern Illinois University School of Medicine, Springfield, IL
07/1/2008-present Associate Professor of Surgery, Southern Illinois University School of Medicine, Springfield,IL
Other Experience and Professional Memberships
National:
Association for Academic Surgery, Issues Committee Apr 2008- present
State:
Medical Advisor, Illinois Breast and Cervical Cancer Program, Illinois Department of Public Health Jan 2006 to present.
Regional:
Cancer Liaison, Memorial Medical Center Cancer Committee, Springfield, IL, October 2003 to present.
Vice President, American Cancer Society Central Illinois, October 2006 to present
Medical Advisory Committee, Y-ME Illinois Affiliate, Y-ME National Breast Cancer Organization April 2006 to present
Institutional/Local:
Executive Committee, Simmons-Cooper Cancer Institute, July 2005 to present
Central Research Committee, SIU School of Medicine, July 2005 to present
Medical Advisory Committee, Central Illinois Blood Bank, Jan 2004 to present
Physicians Advisory Committee, Carol Jo Vecchie Women’s Services at St. John’s Hospital, June 2006 to present
Springfield Committee on Research in Human Subjects, July 2001 to present
Laboratory Animal Care and Use Committee, SIU School of Medicine, Jan 2001 to Dec 2004.
Transfusion Services Committee, St. John’s Hospital, Springfield, IL, Jan 2001 to 2004
Honors and Awards:
American Medical Association, Physician’s Recognition Award with Commendation, Jan 1, 2008 – Jan 1, 2011
AAMC/ Pfizer National finalist Humanism in Medicine Award Nov 7, 2005
Leonard Tow Humanism in Medicine Award from Healthcare Foundation of New Jersey, May 17, 2004.
Alpha Omega Alpha Honor Medical Society, elected 5/13/91
American College of Surgeons, Washington State Chapter, Henry N. Harkins Resident Paper Competition,
First place 6/17/96
James Ewing Foundation Trainee Grant 3/26/98
Selected peer-reviewed publications (in chronological order).
1. Peralta E.A. and Yarington C.T. Malignant Melanoma of the Head and Neck: Effect of Treatment on Survival. Laryngoscope 1998; 108 (2):200-203.
2. Traverso L.W., Peralta E.A., Ryan J.R., Kozarek RA. Intraductal Neoplasms of the Pancreas. Am. J. Surg. 1998 175 (5):426-432.
3. McCarty, T.M., Liu X., Sun J., Peralta E.A., Diamond D. J., and Ellenhorn J.D.I. Targeting p53 for Adoptive T Cell Immunotherapy. Cancer Res. 1998 58 (12):2601-2605.
4. Peralta E.A., McCarty T.M., Liu X.P., Wilson, T.G., Diamond D.J., and Ellenhorn J.D.I. Immunotherapy of Bladder Cancer Targeting p53. J.Urol. 1999 162(5):1806-11.
5. Schwarz, R.E., McCarty T.M., Peralta E.A., Ellenhorn J.D.I. An Orthotopic in vivo model of Human Pancreatic Cancer. Surgery, 1999 126:562-567.
6. Liu, X.P., Peralta E.A., Ellenhorn, J.D.I., Diamond, D.J. Targeting of Human p53 Over-Expressing Tumor Cells by an HLA A*0201-Restricted Murine T-Cell Receptor Expressed in Jurkat T Cells. Cancer Res. 2000 60:693- 701.
7. Peralta E.A., Ellenhorn, JDI, Wagman L.D., Andersen, J.D., Chu, D.Z. Contralateral Prophylactic Mastectomy Improves the Outcome of Selected Patients with Breast Cancer. Am J Surg 2000; 180:439-445.
8. Schwarz RE, Hillebrand G, Peralta E.A., Chu DZ, Weiss LM. Long-term survival after radical operations for cancer treatment-induced sarcomas: how two survivors invite reflection on oncologic treatment concepts. Am J Clin Oncol. 2002 Jun; 25(3):244-7.
9. Quin J, Engle D, Litwiller A, Peralta E, Grasch A, Boley T, Hazelrigg S. Vitamin E succinate decreases lung cancer tumor growth in mice. J Surg Res. 2005 Aug; 127(2):139-43.
10. Peralta E.A., Viegas M.L., Louis, S., Engle, D.L. Dunnington, G.L. Effect of Vitamin E on Tamoxifen-Treated Breast Cancer Cells. Surgery. 2006 Oct. 140(4):607-14.
11. Peralta E.A., Brewer A.T., Louis, S., and Dunnington, G.L. Vitamin E Increases Biomarkers of Estrogen Stimulation When Taken With Tamoxifen. J Surg Res 2008 Apr 22. [Epub ahead of print]
Book Chapters:
Benign Diseases of the Breast, Essentials of General Surgery 4th Edition, PF Lawrence, ed., Lippincott Williams & Wilkins, 2004.
Treatment of Breast Cancer, Essentials of General Surgery 4th Edition, PF Lawrence, ed., Lippincott Williams & Wilkins, 2004.
Best Work (Summary of Two Publications):
Contralateral Prophylactic Mastectomy Improves the Outcome of Selected Patients with Breast Cancer. Am J Surg 2000; 180:439-445.
This retrospective study was one of the first to examine the efficacy of contralateral prophylactic mastectomy (CPM) in women matched for age, stage, surgery, chemotherapy, and hormonal therapy. We found that the CPM group had a disease-free survival at 15 years of 55% versus 28% in the control group (p=0.01). The overall survival at 15 years was 64% versus 48% (p=0.26). Other relevant findings were that the control group, being matched to women who opted for CPM, had a higher than average rate of contralateral breast cancer (1.8%/year compared to historical rate of 0.7%/year), thus suggesting a profile for whom CPM may be beneficial. This profile included young age, multifocal primary tumor, 1st-degree relative with breast cancer, and dense breasts. Since this paper was published, there has been an actual rise in the percentage of patients opting for CPM, and this paper has been cited in several review articles.
Vitamin E Increases Biomarkers of Estrogen Stimulation When Taken With Tamoxifen. J Surg Res 2008 Apr 22. [Epub ahead of print]
This prospective study was presented at the most recent Academic Surgical Congress and represents translation of my previous bench research into clinical relevance. In cultured breast cancer cells, supplemental vitamin E abrogates the apoptotic response to tamoxifen. Because many breast cancer patients take supplemental vitamin E while taking tamoxifen, I studied whether there were biomarkers of tamoxifen resistance present when the subjects were taking supplemental vitamin E. I found that activated phospho-ERK and estrogen receptor staining increased with vitamin E and serum tamoxifen levels decreased with vitamin E supplementation. This study, while small, indicates the importance of recognizing complementary or alternative medicine as potential harm.
Research Support:
Current
William E. McElroy Foundation, ($19,500) FY 2009 “Role of GPR30 in Triple Negative Breast Cancer”
Principal Investigator.
Excellence in Academic Medicine, SIUSM ($35,000) 1/1/08-12/31/08
"Toxicology of the complementary use of water-extracted Ginseng during Doxorubicin therapy
Principal Investigator.
SIU Breast Cancer Research Fund ($62,857) FY 2008 -covers lab overhead, publication costs, and part of researcher salary, .25 of Dr. Peralta’s salary
SIU Breast Cancer Research Fund ($63,000) FY 2009 -covers lab overhead, publication costs, and part of researcher salary, .25 of Dr. Peralta’s salary
Completed
Illinois Department of Public Health, Communities of Color Initiative, ($25,000) July 2006-June 2007 Role of GPR30 in Young and Minority Women with Breast Cancer. This project studied the prevalence of a new estrogen receptor, GPR30, in triple-negative breast cancer. Principal Investigator.
SIU Cancer Institute ($15,000) Vitamin E Analogue in Breast Cancer Treatment 03/15/04- 02/28/05
This project studied a non-hydrolyzable analogue of vitamin E in the treatment of ER-negative breast cancer xenografts. Principal Investigator.
The Breast Center at SIU, Denim and Diamonds Fund Interaction of Vitamin E and Tamoxifen in the Adjuvant Treatment of Breast Cancer 02/01/04-06/01/05
This project studied the effect of supplemental vitamin E on the estrogen receptor blockade with tamoxifen in women with a history of estrogen receptor positive breast cancer. Principal Investigator.
Central Research Committee Award ($25,000): Treatment of Tamoxifen-Resistant Breast Cancer with Vitamin E Succinate, July 1, 2002-June 30, 2004
The goal of this study is to evaluate the efficacy of vitamin E succinate in the treatment of tamoxifen-resistant, estrogen receptor-positive breast cancer in murine models, Principal Investigator.
llinois Department of Public Health Penny Severns Breast and Cervical Cancer Research Fund ($93,000) July 1, 2001-June 30, 2003. Interaction of vitamin E succinate and tamoxifen in the modulation of angiogenesis in breast cancer, Principal Investigator.
Illinois Division, American Cancer Society: Assessment of therapeutic benefits of nanoparticle paclitaxel and anti-VEGF-A antibody in metastatic breast cancer models,Co-Investigator
Excellence in Academic Medicine Award: January 1-December 30, 2004. The Roles of Drg-1 Gene in Breast Cancer Progression. Co-investigator.
Excellence in Academic Medicine Award: January 1-December 20, 2004. Defining In Vivo Functions of Chemokines Relevant to Type I Diabetes. Co-investigator.
SIU Surgery Subspecialty – Family Practice Telehealth Collaboration ($30,000): January 2002.
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