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Kathleen C.M. Campbell, Ph.D.
Department of Surgery
Division of Otolaryngology - Head and Neck Surgery, Audiology Research
South Dakota State University B.A. 1973 Communication/Education
University of South Dakota M.A. 1977 Audiology
University of Iowa Ph.D. 1989 Audiology/Hearing Science
1977-1982 Audiologist II, British Columbia Ministry of Health
1983-1988 Audiologist II, Department of Otolaryngology, University of Iowa
1989-1992 Assistant Professor & Director of Audiology, Division of Otolaryngology, Department of Surgery, Southern Illinois University School of Medicine
1992-1996 Associate Professor & Director of Audiology, Division of Otolaryngology, Department of Surgery, Southern Illinois University School of Medicine
1996-2002 Professor & Director of Audiology, Division of Otolaryngology, Department of Surgery, Southern Illinois University School of Medicine
2003-Present Professor & Director of Audiology Research, Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, Southern Illinois University School of Medicine
- NIH Clinical Investigator Award (K08), 1990
- NIH James A. Shannon Directors Award, 1997
- Fellow of the American Speech Language Hearing Association, 2000
- American Academy of Audiology: Special Presidential Citation for Work Developing National
- Professional Practice Guidelines and Algorithms, 2001
- Elected to the National Board of Directors for the American Academy of Audiology, 2001
- Campbell, K.C.M "Letter to the Editor re: Tinnitus and Vertigo (Chole and Parker)
Archives of Otolaryngology 119, 474, April 1993.
- Campbell, K. Reply to Dr. Shea, Annals of Otology, Rhinology, & Laryngology. (Letter to the Editor) 102 (2). 77 January 1993. (Invited)
- Campbell, K. Electrocochleographic Findings in Perilymphatic Fistula Seminars in Hearing Vol. 15/1, 22-30. February 1994. (Invited)
- Campbell, K., Abbas, P. Electrocochleography with Postural Changes in Perilymphatic Fistula and Meniere's Disease. Journal of the AmericanAcademy of Audiology . Vol. 4. 376-383, November, 1993. (Invited).
- Campbell, K.C.M Letter to the Editor re: Tinnitus and Vertigo (Chole and Parker)
Archives of Otolaryngology 119, 474, April 1993.
- Campbell, K. Reply to Dr. Shea, Annals of Otology, Rhinology, & Laryngology. (Letter to the Editor) 102 (2). 77 January 1993. (Invited)
- Campbell, K. Electrocochleographic Findings in Perilymphatic Fistula Seminars in Hearing Vol. 15/1, 22-30. February 1994. (Invited)
- Campbell, K.C.M, Abbas, P.J. Electrocochleography with Postural Changes in Perilymphatic Fistula: Animal Studies. Annals of Otology, Rhinology, & Laryngology103:474-82. June 1994
- Laureano, A., McGrady, M., and Campbell, K. Comparison of Tympanic Membrane Electrocochleography and the Auditory Brainstem Response in Threshold Determination. The American Journal of Otolaryngology. 16 (2):209-215 March 1995. (Selected for Home Study Course, an AAO-HNS publication, section eight, "Otology and Neurotology".)
- Campbell, K.C.M. Audiology Curriculum Guidelines for Otolaryngologists. American Journal of Audiology. 4(1):35-36. March 1995.
- Campbell, K.C.M, Brady, B.A.. Comparison of 1000 Hz Toneburst and Click Stimuli in Otoneurologic ABR. American Journal of Audiology. 4:55-60. July 1995.
- Coburn, K.L., Campbell, K.C.M, Kuhn, M.J., and Moreno, M.A. Electrocorticaland Structural Abnormalities in a Long-term Survivor of Trisomy 13 (Patau's
Syndrome). American Journal of Audiology. 5(1):35-43. March 1996
- Campbell, K.C.M, Naritoku, D. K., Evans, M.S., Hughes, L F.and Rybak, L.P. Is
Valproic Acid Ototoxic? American Journal of Audiology. 5(3):7-10. November 1996.
- Ferraro, J.A., Durrant, J.D., Sininger, Y. S. and Campbell, K. Recommended Guidelines for Reporting AEP Specifications. American Journal of Audiology. 5(3):35-37. November 1996.
- Campbell, K.C.M, Rybak, L.P. Sensorineural Hearing Loss and Dyslipidemia. American Journal of Audiology. 5(3):11-14. November 1996.
- Campbell, K.C.M, Rybak, L. P., Meech, R. P., and Hughes, L. D-Methionine Provides Excellent Protection from Cisplatin Ototoxicity in the Rat. Hearing Research. 102:90-December 1996.
- Meech, Robert P., Campbell, Kathleen C. M., Hughes, Larry P., and Rybak, Leonard P. A Semiquantitative Analysis of the Effects of Cisplatin on the Rat Stria Vascularis. Hearing Research 124:44-59 June 1998.
- Campbell, K.C.M Essential Audiology for Physicians (1998) Singular Publishing, San Diego (single author text book)
- Campbell, K.C.M, Meech, R.P., Rybak, L.P., Hughes, L.P. D-Methionine Protects Against Cisplatin Damage to the Stria Vascularis. Hearing Research 138:13-28, 1999.
- Kovach, Margaret J., Lin, Jing-Ping, Boyadjiev, Simeon, Campbell, Kathleen, Mazzeo, Larry, Herman, Kristin, Rimer, Lisa A., Frank, William, Llewellyn, Barbara, Jabs, Ethylin Wang, Gelber, David and Kimonis, Virginia E. A Unique Point Mutation in the PMP22 Gene is Associated with Charcot-Marie Tooth Disease and Deafness. American Journal of Human Genetics, Vol. 64, May, 1999.
- Campbell, K.C.M and Klemens, J. Sudden Hearing Loss and Autoimmune Inner Ear Disease. Journal of the American Academy of Audiology, 11:361-367, 2000 (invited)
- Cloven, Noelle Gillette, Re, Alesandra, McHale, Michael, Burger, Robert, DiSala, Philip, Rose, Scott, Campbell, Kathleen C.M., Fan, Hung. Evaluation of D-Methionine as a Cytoprotectant in Cisplatin Treatment of an Animal Model for Ovarian Cancer. AntiCancer Research, 20:4205-4210, 2000
- Campbell, Kathleen C.M., Kalkanis, James and Glatz, F. Robert. Ototoxicity: mechanisms, protective agents, and monitoring. Current Opinion in Otolaryngology & Head and Neck Surgery, 8:436-440, 2000 (invited).
- Bratt, G., Campbell, K., Cherow, E., Grimes, A. Haskell, G., Higdon, L., McCarthy, P., Noffsinger, D. Center for Hearing and Balanceal Practice Algorithms and Statements. Audiology Today Special Issue, August 2000, pp3-19.
- Hatzopoulos, Stavros, Di Stefano, M., Campbell, K.C.M, Falgione, D., Ricci, D., Rosignoli, M., Finesso, M., Albertin, A., Previati, M., Capitani, S. and Martini, A. Cisplatin Ototoxicity in the Sprague Dawley Rat Evaluated by Distortion Product Otoacoustic Emissions. Audiology, 40:253-264, 2001.
- Kimonis, V.E., Kovach, M, Campbell, K., Herman, K., Waggoner, B., Gelber, D., and Hughes, L. Anticipation in a Unique Family with Charcot-Marie-Tooth Syndrome and Deafness: Delineation of the Clinical Features and Review of the Literature. American Journal of Medical Genetics, 108:295-303 (2002).
- Donnersberger, David R., Campbell, Kathleen C. M., Meech, Robert P., Rybak, Leonard P., Hughes, Larry F., Nanavati, P. J. A Model for Marked Radiation-Induced Hearing Loss. Journal of Burns, (journalofburns.com)
- Campbell, Kathleen C.M. Developing Otoprotective Agents for Ototoxic and Noise-Induced Hearing Loss: D-methionine and other compounds. NHCA Spectrum 19(2):12-14, 2002
- Blakley, BW, Cohen, JI, Doolittle, ND, Muldoon, LL, Campbell, KC, Dickey, T, Neuwelt, EA. Strategies for Prevention of Toxicity Caused by Platinum Based Chemotherapy: Review and Summary of the Annual Meeting of the Blood-Brain Barrier Disruption Program, Gleneden Beach, Oregon, March 12, 2001. Laryngoscope 112: pp 1997-2001.2002.
- Korver, K.D., Rybak, L.P., Whitworth, C., & Campbell, K.C. Round Window Application of D-Methionine Provides Complete Cisplatin Otoprotection. Otolaryngology-Head and Neck Surgery, 126:683-689, 2002.
- Kopke, R.D., Coleman, J.K.M., Liu, J., Campbell, K.C.M, and Riffenburgh, R.H. Enhancing Intrinsic Cochlear Stress Defenses to Reduce Noise-Induced Hearing Loss. The Laryngoscope 112:1515-1532, 2002
- Klemens, James J., Campbell, Kathleen C. M., Meech, Robert P., Hughes, Larry F., and Somani, Satu. Anti-oxidant Levels Inversely Co-vary with Hearing Loss After Amikacin Treatment. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):134-143.2003.
- Campbell, Kathleen C.M., Larsen, Deb L., Meech, Robert P., Rybak, Leonard P., and Hughes, Larry F. Glutathione Ester But Not Glutathione Protects Against Cisplatin-Induced Ototoxicity in a Rat Model. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):124-133.2003.
- Campbell, Kathleen CM, Kelly, Ellen, Targovnik, Nan, Hughes, Larry F., Van Saders, Claudia, Gottleib, Alice B., Dorr, Mary Beth, Leighton, Anton. Audiologic Monitoring for Potential Ototoxicity in a Phase I Clinical Trial of a New Glycopeptide Antibiotic. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):157-169.2003.
- Campbell, Kathleen CM. Introduction to Oxidative Processes. (brief tutorial) Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):121-123.2003.
- Campbell, Kathleen CM, Meech, Robert P., Rybak, Leonard P., Hughes, Larry F., The Effect of D-Methionine on Cochlear Oxidative State with and without Cisplatin Administration: Mechanisms of Otoprotection. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 14(3):144-156.2003
- Leighton, A, Gottlieb, AB, Dorr, MB, Jabes, D, Mosconi, G, VanSaders, C, Mroszczak, EJ, Campbell, KCM, Kelly, E. Tolerability, Pharmacokinetics and Serum Bacterial Activity of Intravenous Dalbavancin in Healthy Volunteers._Antimicrobial Agents and Chemotherapy._48(3):940-945, March 2004
- Campbell, Kathleen CM, Bromate Induced Ototoxicity. (2006) _Toxicology._ 221(2-3):205-211
- Doolittle, Nancy D.; Peereboom, David; M. Christoforidis, Gregory A.; Hall, Walter A.; Pamieri, Diane; Brock, Penelope R.; Campbell, Kathleen C.M.; Dickey, D. Thomas; Muldoon, Leslie L, O’Neill, Brian P; Peterson, Darryl R.; Pollock, Brad; Smith, Quentin; Sousain, Carole; Tyson, Rose Marie; Neuwelt, Edward “Delivery of Chemotherapy and Antibodies Across the Blood Brain Barrier and the Role of Chemoprotection, in Primary and Metastatic Brain Tumors: Report of the Eleventh Annual Blood-Brain Barrier Consortium Meeting. Journal of Neuro-Oncology (2007) Journal of Neurooncology Jan;81(1):81-91 (e-pub Jul 21, 2006)
- Campbell, Kathleen C.M., Meech, Robert P.,Klemens, James J., Gerberi, Michael. T.,Dyrstad Sara S.W.,Larsen Deb. L,Mitchell, Diana L., ^El-Azizi, Mohammed, Verhulst, Steven J., Hughes, Larry F “Prevention of Noise- and Drug-Induced Hearing Loss with D-methionine” Hearing Research (2007) Apr; 226(1-2):92-103 (e-pub Jan 16, 2007)
- Vuyyuri, S.B., Hamstra, D.A., Khanna, D., Hamilton C.A., Marwart SM, Campbell K.C.M., Sunkara, P, Ross, B.D, and Rehemtulla, A.**(2008)*“*Evaluation of a D-Methionine as a Novel Oral Radiation Protector for Prevention of Mucositis” Clinical Cancer Research (2008) April 1;14(7): 2161-70
- Durrant, J. Campbell. K., Fausti, S. Guthrie, O., Jacobson, G., Lonsbury-Martin, B.. and Poling, G. American Academy of Audiology Position Statement and Clinical Practice Guidelines October 2009, Audiology.org pgs. 1-25
- Daniel Hamstra, Avraham Eisbruch, Maddireddy Naidu, Gogula Ramana, Prasad Sunkara, Kathleen Campbell, Brian Ross, Alnawaz Rehemtulla. Pharmacokinetic Analysis and Phase 1 Study of MRX-1024 in Patients Treated with Radiation Therapy with or without Cisplatinum for Head and NeckCancer. Clinical Cancer Research 2010 May 1:16(9):266-76 Epub April 13, 2010
- Le Prell, C. G., Hensley BN, Campbell, K. C, Hall, J. W. 3^rd and Guire, K. Hearing outcomes in a “normally-hearing” college-student population: Evidence of hearing loss Int J Audiol. 2011 Mar;50 Suppl 1:S21-31
- Campbell, Kathleen, LePrell, Colleen “Potential Therapeutic Agents” Seminars in Hearing. 2012: Vol. 33L1_ epub ahead of print
- Lorito G, Hatzopoulos S, Laurell G, Campbell KC, Petruccelli J, Giordano P, Kochanek K, Sliwa L, Martini A, Skarzynski H.”Dose-dependent protection on cisplatin-induced ototoxicity - an electrophysiological study on the effect of three antioxidants in the Sprague-Dawley rat animal model. Med Sci Monit. 2011 Aug 1;17(8):BR179-186.
- Campbell, Kathleen “Ototoxicity Monitoring” Seminars in Hearing. Vol 32:2, 196-202, 2011
- Campbell, Kathleen; Claussen, Alex;Meech, Robert, Verhulst, Steven; Fox, Daniel; Hughes, Larry “D-Methionine (D-met) Significantly Rescues Noise Induced Hearing Loss: Timing Studies” Hearing Research (Web release September, 2011)Volume 282, Issues 1-2 December 2011, Pages 138-144
- Le Prell C, Johnson, A., Skjonsberg A., Ulfendahl M., Guire K. Green G., Campbell K. Miller J. “Dietary nutrients and protection against noise insult: A first translation from bench to bedside” In press. Noise and Health
- Penelope Brock, *Kristin Knight, David Freyer, Kathleen Campbell, Peter S. Steyger, Brian W. Blakley, S. Rod Rassekh, Kay W. Chang, Brian Fligor, Michael Sullivan, Edward A. Neuwelt “Platinum-induced ototoxicity in children: a consensus review on ototoxicity, otoprotection and monitoring” In press Journal of Clinical Oncology (JCO)
- Le Prell, C.G., Johnson, A.-C., Lindblad, A.-C., Ulfendahl, M., Campbell, K.C.M., Kujawa, S.G., Green, G.E., Miller, J.M., Guire, K. 2011. Increased vitamin plasma levels in Swedish military personnel treated with nutrients prior to automatic weapon training Noise Health, 13:55 pp 432-43
- Gopal, KV; Wu C. Shreshta, B. Campbell, KCM; Moore EJ, Gross, GW D-Methionine Protectsagainst Cisplatin-induced Neurotoxicity in Cortical Networks Submitted for Publication
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