Curriculum Vitae

Donald M. Caspary, Ph.D.
Department of Pharmacology
217-787-4335
801 N. Rutledge, P.O. Box 19230 
email: dcaspary@siumed.edu

EDUCATION

• B.A., June, 1965 University of Wisconsin, Zoology
• M.S., January, 1968
• M.S., January 1968 Syracuse University, Zoology / Sensory Communication
• Ph.D., June 1971 New York University, Biology/Neurobiology

PROFESSIONAL EXPERIENCE

Southern Illinois University School of Medicine, Springfield, IL, Distinguished Scholar and Professor of Pharmacology, 2004-present (Primary Appointment)
Southern Illinois University School of Medicine, Assistant Dean for Faculty Development
(10%-time) 1998-present
Southern Illinois University School of Medicine, Springfield, IL, Professor of Pharmacology and Surgery, 1989-2004
Southern Illinois Univ. Sch. of Med., Springfield, IL, Associate Professor of Pharmacology and Surgery, 1979-1989
Southern Illinois Univ. Sch. of Med., Springfield, IL, Assoc. Prof. Med. Sciences (Neurobiology), 1976-1979
Southern Illinois Univ. Sch. of Med., Springfield, IL, Assistant Prof., Dept. of Medical Sciences, 1973-1976
SUNY-Albany, Albany, New York, NINCDS (NIH) Postdoctoral Fellow, August, 1971 to Dec., 1972
New York University, Graduate Teaching Associate, Fall 1968 to Spring 1969
Syracuse University, Research Assistant, Laboratory of Sensory Communication, Fall 1967
Syracuse University, Graduate Teaching Assistant, 1966-1967

TEACHING EXPERIENCE

• Medical Courses:
  Medical Neuroscience
  Medical Pharmacology
  Electives: Advanced Therapeutics
  Anatomy and Physiology of Sensory System
  Research in Auditory Pharmacology
  
• Graduate Courses:
  550 - Advanced Pharmacology
  551 - Methods in Pharmacology
  574 - Neuropharmacology
  530 - Cell and Molecular Biology

Professional Service

Honors and Awards

Founders Day Award, New York University, New York
Certificate of Merit, American Speech and Hearing Association
Advisor to the Committee on Hearing and Bioacoustics, National Academy of Science
Claude Pepper Award from the National Institute on Deafness and Other Communicative Disorders
Council Member, Association for Research in Otolaryngology
Member, Board of Directors, Center for Neural Communication Technology-University of Michigan
Nineteenth Outstanding Scholar, Southern Illinois University, 2003
Distinguished Scholar, Southern Illinois University, 2004
Sigma Xi Kaplan Research Award, 2005
Scientific Advisory Committee, American Tinnitus Association- 3/2005 (4 Year term)
Board Member, Tinnitus Research Consortium- 2005-

Membership in Professional Associations:

ASPET - American Soc. for Pharm. and Exp. Therapeutics
Society for Neuroscience
Association for Research in Otolaryngology
Sigma Xi

Offices Held in Professional Associations:

1980 – 1981 Vice-president, Sangamon Chapter of Sigma Xi
1980 - 1981 Secretary/Treasurer, Sangamon Chapter of Sigma Xi
1984 - 1985 Organizer and host of 9th Annual Midwest Neurobiology Meeting
1986 - 1989 Member Long-Range Planning Committee, ARO
1986- 1992 Advisor, Committee on Hearing and Bioacoustics, National Academy of Science
1987 NIH, Workshop on the Pharmacology of Hearing, Bethesda, MD
1987 - 1988 Board Member, Springfield Neuroscience Chapter
1989 - 1990 President, Springfield Neuroscience Chapter
1988 - 1990 Council Member, Sigma Xi
1991 - 1992 Panel for Hearing and Hearing Impairment-Advisory Board of NIDCD
1993 - 1994 Organizer and host of 17th Annual Midwest Neurobiology Meeting
1994 - 1997 Council Member, Assn. for Research in Otolaryngology
1990 - 1998 Chair, Use of Animals in Research-Assn. for Res. in Otolaryngology (ARO)

Evaluation of Manuscripts for Journals: (subset)

• Hearing Research
• Journal of Neurophysiology
• Journal of Neuroscience
• Neuroscience
• Experimental Neurology
• Experimental Brain ResearcH
• Behavioral Neuroscience
• Journal of Comparative Neurology
• Journal of Biochemistry
• Journal of Biochemistry
• Journal of Biochemistry
• Neuroscience Letters
• Science
• Neuroscience Letters

Evaluation of Grant Proposals for Agencies:

National Institutes of Health (Ad Hoc Chair and member RO3 committee NIDCD; AUD
study section Ad Hoc member 2002 & 2004. Frequent ad hoc. Reviewer.
National Science Foundation (sensory review panel member, ad hoc. reviewer)
Scientific Advisory Committee, American Tinnitus Association- 3/2005 (4 Year term)

UNIVERSITY SERVICE

Department Chairman's Advisory Committee; Medical Education Committee, Chairman
Committees:Search Committee for Assistant Professor, Chairman
Research Committee, Chairman; Graduate Education Committee, Chairman
Graduate Program Committee: Chairman's, Long-Range Planning Committee

College and University Committees and Councils:
Outstanding Scholar Award Selection Committee

Past Committees:

Faculty Council (elected) (President (twice), Vice President and Secretary)
Education Policy Committee (elected)
Information Technology Committee
Grievance Committee (Chairman) (elected)
Search Committee-Associate Dean for Information Resources
Promotion and Tenure Committee
Central Research Committee
Sophomore Education Committee
Internal Medicine & Psychiatry Departmental Review Committees
Executive Committee of the Medical School (as Faculty Council President)
Pharmacology Chairman Search Committee
Laboratory Animal Care and Use Committee (Chairman-5 years)

SERVICE

1974 - 1980 Evoked Response Audiometry Clinic
1992 - 1995 Director, Electron Microscopy Facility (1974-1980)
1984 - 1998 Music in elementary Schools
1990 - 1991 Director of Parents Group Campaign for Assn. for Retarded Citizens
1992 - 2004 Lectures/workshops on the use of Animals in Research (Children, Adults)
1998 - 2003 Lectures in Mini-Medical School and Brain Awareness Week.

Postdoctoral Fellows;
M. J. Moore
P.G. Finlayson
P.M. Backoff

Doctoral Students;
A. Raza
P.S. Palombi
J.C. Milbrandt

Masters Students
S.D. Abbott
H. Wang

RESEARCH

Research Interest and Specialties:
Age-Related Hearing Loss (drug therapy for age-related hearing loss)
Central Sensory Plasticity and Tinnitus
Sensory Pharmacology, Anatomy, Physiology, and Neurochemistry (Auditory System)

Current Research Projects:

Molecular neurochemistry of inhibitory neurotransmitters in Plasticity and Aging
Electrophysiology of the Aging Rat Auditory System
Molecular neurochemistry of inhibitory neurotransmitters and electrophysiology in Tinnitus models

Grants Received (Active):

Merck Pharmaceutical, Gaboxadol: A Possible Treatment for Tinnitus, $200,000, 1/1/07-12/30/08, (Principal Investigator).

National Institutes of Health NIDCD, 1R01DC008532-01A1- The Glycine Receptor in a Rat Tinnitus Model: A Possible Therapeutic Target, $1,500,000, 7/1/07-6/30/12, (Principal Investigator).

National Institutes of Health NIDCD, RO1 DC00151- Coding in Auditory Neurons: Effects of Amino Acids, $1,600,000, 7/1/02-6/30/07, (Principal Investigator) (Years 23-28).

American Tinnitus Association The Glycine Receptor in a Rat Tinnitus Model: A Possible Therapeutic Target, $290,000, 1/1/05-12/30/07, (Principal Investigator). Last six mos. Will be returned.

National Institutes of Health NIDCD R21 DC008357-01 - Development of a Rapid Behavioral Tinnitus Screen for Rats, $386,250, 7/1/06-6/30/08 (Co-PI).

Grants Received (Inactive):

Air Force Office of Scientific Research Awarded to Dr. George Moushegian, "Speech Processing in the Central Nervous System," 1/73-12/76 (Co-Investigator-Consultant).

Deafness Research Foundation - "Effects of Putative Amino Acid Transmitters on Neurons of the Cochlear Nuclei," $9,868, 1/78-12/79 (Principal Investigator).

National Institutes of Health, NS15640 - "Coding in Auditory Neurons: Effects of Amino Acids," $85,437, 7/79-6/82 (Principal Investigator).

National Institutes of Health - "On the Pharmacology of Convulsant Drugs," $102,326, 12/79-11/82 (Co-Investigator).

Deafness Research Foundation - "Ototoxicity of Furosemide: Electrophysiologic and Pharmacokinetic Correlations," $10,000, 1/82-12/84 (Co-Investigator).

Program Project Grant/SIU - "Pharmacology of the Auditory and the Vestibular Systems," $285,320, 10/83-9/86 (Program Director).

National Institutes of Health, NS 15640 - "Coding in Auditory Neurons: Effects of Amino Acids," $110,863, 7/83-6/86 (Principal Investigator).

Deafness Research Foundation Grant - "Neurotransmitters of the Superior Olivary Complex: A Microiontophoretic Study," $10,000, 1/83-12/83 (Principal Investigator).
Deafness Research Foundation - "Inferior Colliculus Neurotransmission: Microapplication Studies in Normal and Audiogenic Seizure Prone Animals," $20,000, 1/84-12/85 (Co-Investigator).

Deafness Research Foundation - "Aging in Brainstem Auditory Pathways: An Immunocytochemical Approach to Neural Presbycusis," $42,500, 1/86-12/88 (Principal Investigator).

National Institutes of Health Shared Instrumentation Grant - "Electron Microscope with X-Ray Analysis," $200,000, 2/89 (Co-Investigator).

National Institutes of Health - "On the Pharmacology of Convulsant Drugs," $161,995, 12/85-8/89 (Co-Investigator).

National Institutes of Health, NS 15640-09 - "Coding in Auditory Neurons: Effects of Amino Acids," $281,699, 7/86-6/90 (Principal Investigator).

National Institutes of Health - "Development of Synapse Function in the Caudal CN," $168,717, 12/6-11/89 (Co-Investigator).

American Federation for Aging Research - "Age-Related Changes in A Central Auditory Structure: A Key to Presbycusis," $24,200, 7/89-6/90 (Principal Investigator).

Deafness Research Foundation - "Role in Inhibition in Coding Amplitude-Modulated Signals," $30,000, 01/93-12/94 (Co-Investigator; Pat Backoff, Principal Investigator).

Deafness Research Foundation - "Neural Mechanisms of Sound Localization: Descending Control of the Lateral Superior Olive," $45,000, 01/92-12/4 (Co-Investigator; Robert Helfert, Principal Investigator).

National Institutes of Health, R01 NS21281-06 - "Neurotransmitter Mechanisms in Epilepsy," $73,649, 9/90-8/96 (Co-Investigator; C.L. Faingold, Principal Investigator).

Program Project Grant - SIU/Bayer - "Age-Related Auditory Changes: Cell and Molecular Approaches," $149,999, 1/94 - 12/96 (Program Project Director - 4 Projects).

National Institutes of Health, R01 DC 00151-11 - "Coding in Auditory Neurons: Effects of Amino Acids,", $811,030, 7/90-6/97, (Principal Investigator), Claude Pepper Award.

American Acad. Otolaryngology Percy Award - A Behavioral Model of Chronic Tinnitus in Rats,@ $29,974, 7/1/96-6/30/97, (Co-Investigator) (Principal Investigator: Carol Bauer).

National Institute of Health, NIDCD - AA Behavioral Model of Chronic Tinnitus in Animals,@ $99,907, 1/1/97-12/31/98 (extension)(Co-Investigator) (Principal Investigator: Carol Bauer)

Deafness Research Foundation Age Related Changes in the GABA System of the Auditory Cortex, $20,000 1/1/00-12/31/00, (Principal Investigator)

National Institutes of Health, NIDCD, RO1 DC02247 - Age-Related Synaptic Changes in the Auditory Brainstem, $100,946, 5/96-4/01, (Co-Investigator) (Principal Investigator: Robert Helfert).

Merck Age-Related Changes in GABAA Receptor Sensitivity of Inferior Colliculus Neurons: In Vivo
Iontophoretic Studies, $50,000, 3/99-2/01, (Principal Investigator).

National Institutes of Health NIDCD, RO1 DC00151-20 - Coding in Auditory Neurons: Effects of Amino Acids, $1,070,855, 7/1/97-6/30/02, (Principal Investigator).

National Institutes of Health NIA, R03 AG023910, Auditory Plasticity in the Aged Mouse, $140,000, 7/1/04-6/30/06, (Co-Investigator).

Merck Pharmaceutical, Role of a4 and d GABAA Receptor Subunits in Tinnitus, $13,000, 1/05/12/30/05, (Principal Investigator).

PUBLICATIONS

Articles in Professional Journals:

Caspary, D.M.: Classification of Subpopulations of Neurons in the Cochlear Nuclei of the Kangaroo Rat. Exp. Neurol., 37:131-151, 1972.

Faingold, C.L. and D.M. Caspary: Changes in Reticular Formation Unit Response Patterns Associated with Pentylenetetrazol-Induced Enhancement of Sensory Evoked Responses. Neuropharmacology, 16:143-147, 1977.

Rupert, A.L., D.M. Caspary and G. Moushegian: Response Characteristics of Cochlear Neurons to Vowel Sounds. Ann. Otol. Rhinol. Laryngol., 63:37-49, 1977.

Caspary, D.M., A.L. Rupert and G. Moushegian: Neuronal Coding of Vowel Sounds in the Cochlear Nuclei. Exp. Neurol., 54:414-431, 1977.

Faingold, C.L. and D.M. Caspary: Frequency Following Responses in Primary Auditory and Reticular Formation Structures: Alteration of Response Components with Masking and Pentobarbital. Electroenceph. Clin. Neurophysiol., 47:12-20, 1979.

Caspary, D.M., D.C. Havey and C.L. Faingold: Effects of Microintophoretically Applied Glycine and GABA on Neuronal Response Patterns in the Cochlear Nuclei. Brain Res., 172:179-185, 1979.

Havey, D.C. and D.M. Caspary: A Simple Technique for Constructing "Piggy-Back" Multibarrel Microelectrodes. Electroenceph. Clin. Neurophysiol., 48:249-251, 1980.

Caspary, D.M., D.C. Havey and C.L. Faingold: Glutamate and Aspartate: Alteration in Threshold and Response Patterns of Auditory Neurons. Hearing Res., 4:325-333, 1981.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: On the Site of Pentylenetetrazol-Induced Enhancement of Auditory Responses of the Reticular Formation: Localized Cooling and Electrical Stimulation Studies. Neuropharmacology, 22:961-970, 1983.

Moore, M.J. and D.M. Caspary: Strychnine Blocks Binaural Inhibition in Lateral Superior Olivary Neurons. J. Neurosci., 3:237-242, 1983.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: Bicuculline-Induced Enhancement of Sensory Responses and Cross-Correlations between Reticular Formation and Cortical Neurons. Electroenceph. Clin. Neurophysiol., 55:301-313, 1983.

Caspary, D.M. and D.C. Havey: Effects of Acetylcholine on Cochlear Nucleus Neurons. Exp. Neurol., 82:491-498, 1983.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: Effects of Iontophoretic Application of Convulsants on the Sensory Responses of Neurons in the Brain Stem Reticular Formation. Electroenceph. Clin. Neurophysiol., 58:55-64, 1984.

Caspary, D.M., L. Rybak and C.L. Faingold: Baclofen Reduces Tone-Evoked and Spontaneous Activity of Cochlear Nucleus Neurons. Hearing Res., 13:113-122, 1984.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: Mechanisms of Sensory Seizures: Brain-Stem Neuronal Response Changes and Convulsant Drugs. Fed. Proc., 44:2436-2441, 1985.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: Comparative Effects of Convulsant Drugs on Sensory Responses of Neurons in the Amygdala and Reticular Formation. Neuropharmacology, 12:1221-1230, 1985.

Faingold, C.L., M.A. Travis, G. Gehlbach, W.E. Hoffmann, P.C. Jobe, H.E. Laird and D.M. Caspary: Neuronal Response Abnormalities in the Inferior Colliculus of the Genetically Epilepsy Prone Rat. Electroenceph. Clin. Neurophysiol., 63:296-305, 1986.

Faingold, C.L., G. Gehlbach and D.M. Caspary: Decreased Effectiveness of GABA-Mediated Inhibition in the Inferior Colliculus of the Genetically Epilepsy-Prone Rat. Exp. Neurol., 93:145-159, 1986.

Faingold, C.L., G. Gehlbach, M.A. Travis and D.M. Caspary: Inferior Colliculus Neuronal Response Abnormalities in Genetically Epilepsy-Prone Rats: Evidence for a Deficit of Inhibition. Life Sci., 39:869-878, 1986.

Caspary, D.M., K.E. Pazara, M. Kössl and C.L. Faingold: Strychnine Alters the Fusiform Cell Output from the Dorsal Cochlear Nucleus. Brain Res., 417:273-282, 1987.

Finlayson, P.G. and D.M. Caspary: Synaptic Potentials of the Principal Cells of the Chinchilla Lateral Superior Olivary Nucleus. Hearing Res., 38:221-228, 1989.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: Effects of Iontophoresis of Agents Affecting the Action of Excitant Amino Acids on the Acoustic Responses of Neurons in the Inferior Colliculus. Hearing Res., 40:127-136, 1989.

Gates, G.A., Caspary, D.M., Clark, W.,Pillsbury, H.C., Browm, H.C., Dobie, R.A.: Presbycusis, Invitational Geriatric Otorhinolaryngology Workshop, Otolaryngology, Head and Neck Surgery, 100:266-271, 1989.

Caspary, D.M. and C.L. Faingold: Non-NMDA Receptors May Mediate Ipsilateral Excitation at LSO Principal Cell Synapses. Brain Res., 503(1):83-90, 1989.

Faingold, C. L., G. Gehlbach and D.M. Caspary: On the Role of GABA as an Inhibitory Neurotransmitter in Inferior Colliculus Neurons: Iontophoretic Studies. Brain Res., 500(1):302-312, 1989.

Caspary, D.M., A. Raza, B.A. Lawhorn Armour, J. Pippen and S.P. Arneri: Immunocytochemical and Neurochemical Evidence for Age-related Loss of GABA in the Inferior Colliculus: Implications for Neural Presbycusis. J. Neurosci., 10(7):2363-2372, 1990.

Faingold, C.L., C. Boersma Anderson, and D.M. Caspary: Involvement of GABA in Acoustically-Evoked Inhibition in Inferior Colliculus Neurons. Hearing Res., 52:201-216, 1991.

Finlayson, P.G. and D.M. Caspary: Low Frequency Neurons in the Lateral Superior Olive Exhibit Phase-Sensitive Binaural Inhibition. J. Neurophysiol., 65(3):598-605, 1991.

Palombi, P.S. and D.M. Caspary: GABAA Receptor Antagonist Bicuculline Alters Response Properties of Posteroventral Cochlear Nucleus Neurons. J. Neurophysiol., 67:738-746, 1992.

Finlayson, P.G. and D.M. Caspary: Excitatory and Inhibitory Response Properties In Young and Old Fisher-344 Rat Lateral Superior Olivary Nucleus. Neurobiol. of Aging, 14:127-139, 1993.

Backoff, P.M. and D.M. Caspary: Age-Related Changes in Auditory Brainstem Responses in F-344 Rats: Effects of Rate and Intensity. Hearing Res., 73:163-172, 1994.

Palombi, P.S., P.M. Backoff and D.M. Caspary: Paired Tone Facilitation in Dorsal Cochlear Nucleus Neurons: A Short Term Potentiation Model Testable In Vivo. Hearing Res., 75:175-183, 1994.

Raza, A., S.P. Arneric, J. Milbrandt and D.M. Caspary: Age-Related Changes in Brainstem Auditory Neurotransmitters: Measures of GABA and Acetylcholine Function. Hearing Res., 77:221-230, 1994.

Evans, M.S., K.E. Viola-McCabe, D.M. Caspary and C.L. Faingold: Loss of Synaptic Inhibition During Repetitive Stimulation in Genetically Epilepsy-Prone Rats (GEPR). Epilepsy Res., 18:97-105, 1994.

Milbrandt, J. C., R. L. Albin and D.M. Caspary. Age-related Decrease in GABAB Receptor Binding in the Fischer-344 Rat Inferior Colliculus. Neurobio. Aging, 15(6):699-703, 1994.

Nakayama, M., R.H. Helfert, H.R. Konrad and D.M. Caspary: Scanning Electron Microscopic Evaluation of Age-Related Changes in the Rat Vestibular Epithelium. Otolaryngol. Head and Neck Surg, 111:799-806, 1994.

Caspary, D.M., P.M. Backoff, P.G. Finlayson and P.S. Palombi: Inhibitory Inputs Modulate Discharge Rate within Frequency Receptive Fields of Anteroventral Cochlear Nucleus Neurons. J. Neurophysiol, 72(5):2124-2133, 1994.

Milbrandt, J. C., and D.M. Caspary. Age-Related Reduction of [3H]Strychnine Binding Sites in the Cochlear Nucleus of the Fisher 344 Rat. Neuroscience, 67(3):713-719, 1995.

Caspary, D.M., J.C. Milbrandt and R.H. Helfert. Central Auditory Aging: GABA Changes in the Inferior Colliculus. Experimental Gerontology, 30 (3/4):349-360, 1995.

Palombi, P.S. and D.M. Caspary. GABA Inputs Control Discharge Rate Primarily Within Frequency Receptive Fields of Inferior Colliculus Neurons, J. Neurophysiol., 75(6):2211-2219, 1996.

Milbrandt, J.C., R. L. Albin, S. M. Turgeon and D. M. Caspary. GABAA Receptor Binding in the Aging Rat Inferior Colliculus, Neuroscience, 73 (2) 449-458, 1996.

N'Gouemo, P., D.M. Caspary, and C.L. Faingold, Decreased GABA effectiveness in inferior colliculus neurons during ethanol withdrawal in rats susceptible to audiogenic seizures, Brain Res., 724(2):200-204, 1996.

Palombi, P.S. and D.M. Caspary. Physiology of the Aging Fisher 344 Rat Inferior Colliculus: Responses to Contralateral Monaural Stimuli, J. Neurophysiol., 76(5):3114-3125, 1996.

Palombi, P.S. and D.M. Caspary. Physiology of the Young Adult Fisher 344 Rat Inferior Colliculus: Responses to Contralateral Monaural Stimuli, Hearing Res., 100:41-58, 1996.

Palombi, P.S. and D.M. Caspary. Responses of Young and Aged Fischer 344 Rat Inferior Colliculus Neurons to Binaural Tonal Stimuli,Hearing Res., 100:59-67, 1996.

Milbrandt, J.C., C. Hunter and D.M. Caspary. Alterations of GABAA Receptor Subunit mRNAs levels in the Aged Fischer 344 Rat Inferior Colliculus. J. Comp. Neurol. 379:455-465, 1997.

Willott, J.F., J.C. Milbrandt, L. Seegers Bross and D.M. Caspary. Glycine Immunoreactivity and Receptor Binding in the Cochlear Nucleus of C57BL/6J and CBA/CaJ Mice: Effects of Cochlear Impairment and Aging.J. Comp. Neurol. 385:405-414, 1997.

Backoff, P.M., P.S. Palombi, and D.M. Caspary. Glycinergic and GABAergic Inputs Affect Short-term Suppression in the Cochlear Nucleus Hearing Res.110(1-2):155-163, 1997.

Krenning, J., L.F. Hughes, D.M. Caspary, and R.H. Helfert. Age-Related Subunit Changes in the Cochlear Nucleus of Fischer-344 Rats.Laryngoscope 108(1):26-31, 1998.

Nakayama, M., D.M. Caspary, H.R. Konrad, J.C. Milbrandt, and R.H. Helfert. Age-related Changes in [3H]Strychnine Binding in the Vestibular Nuclei of Rats. Hearing Res. 127:103-107, 1999.

Caspary, D.M., T.M. Holder, J.C. Milbrandt, R. McKernan, D.K. Naritoku. Age-Related Changes in GABAA Receptor Subunit Composition and Function in the Rat Auditory System. Neuroscience. 93(1):307-312, 1999.

Abbott, S. D., L.F. Hughes, C.A. Bauer, R.J. Salvi and D.M. Caspary. Detection of Glutamic Acid Decarboxylase Isoforms in Rat Inferior Colliculus Following Acoustic Exposure. Neuroscience. 93:1375-1381, 1999.

Backoff, P.M., P.S. Palombi, and D. M. Caspary. GABA- and Glycinergic Inputs Shape Coding of AM in Chinchilla Cochlear Nucleus.Hearing Res. 134:77-88, 1999.

Wang, J., D.M. Caspary, R.J. Salvi. GABAA Antagonist Causes Dramatic Expansion of Tuning in Primary Auditory Cortex. Neuroreport 57:1137-1139, 2000.

Mossop, J.E., M. Wilson, D.M. Caspary and D.R. Moore. Down-regulation of Inhibition Following Unilateral Deafening. , Hearing Res. 147:183-187, 2000.

Milbrandt, J.C., T.M. Holder, M.C. Wilson, R.J. Salvi, D.M. Caspary. GAD Levels and Muscimol Binding in Rat Inferior Colliculus Following Acoustic Trauma., Hearing Res. 147:251-260, 2000.

Bauer, C.A, T.J. Brozoski, T.M. Holder and D.M. Caspary. The Effects of Chronic Salicylate on GABAergic Activity in the Inferior Colliculus of Long-Evans Rats. Hearing Res. 147:175-182, 2000.

Palombi, P.S, P.M. Backoff and D.M. Caspary. Responses of Young and Aged Fischer 344 Rat Inferior Colliculus Neurons to Sinusoidally Amplitude Modulated Tonal Stimuli. Hearing Res. 153:174-180, 2001.

Brozoski, T.J, C.A. Bauer, D.M. Caspary: Elevated Fusiform Cell Activity in the Dorsal Cochlear Nucleus of Chinchillas with Psychophysical Evidence of Tinnitus. J.Neurosci. 22(6):2383-90, 2002.

Wang, J., S.L. McFadden, D.M. Caspary, R.J. Salvi: Gamma-Aminobutyric Acid Circuits Shape Response Properties of Auditory Cortex Neurons. Brain Res. 944:219-231, 2002

Caspary, D.M, P.S. Palombi, L.F. Hughes: GABAergic Inputs Shape Responses to Sinusoidally Amplitude Modulated Stimuli in the Chinchilla Inferior Colliculus. Hearing Res. 168:163-173, 2002

Turner, J.G., L.F. Hughes, D.M. Caspary: Divergent Response Properties of Layer V Neurons in Rat Primary Auditory Cortex. Hearing Res. 202:129-140, 2005.

Turner, J.G., J.L. Parrish, L.F. Hughes, L.A. Toth, D.M. Caspary: Hearing in Laboratory Animals: Strain Differences and Non-Auditory Affects of Noise. Comparative Medicine 55:12-23, 2005.

Ling, L.L., L.F. Hughes, D.M. Caspary: Aged-Related Loss of the GABA Synthetic Enzyme in Rat Primary Auditory Cortex. Neurosci. 132:1103-1113, 2005.

Turner, J.G., L.F. Hughes, D.M. Caspary: Effects of Aging on Receptive Fields in Rat Primary Auditory Cortex Layer V Neurons. J.Neurophysiol. 94:2738-2747, 2005.

Caspary, D.M., T.A. Schatteman, L.F. Hughes: Age-Related Loss of Response Inhibition in Rat Dorsal Cochlear Nucleus. J. Neurosci. 23;25(47):10952-10959, 2005.

Brozoski, T.J., D.M. Caspary, C.A. Bauer: Marking multi-channel silicon-substrate electrode recording sites using radiofrequency lesions. J. Neurosci. Methods 150:185-191, 2006.

Turner, J.G., T.J. Brozoski, C.A. Bauer, J.L. Parrish, K. Myers, L.F. Hughes, D.M. Caspary: Rapid Tinnitus Screening in Rats Behavioral Neurosci. 120:188-195, 2006.

Caspary, D.M., L.F. Hughes, T.A. Schatteman, J.G. Turner: Age-Related Changes in the Response Properties of Cartwheel Cells in Rat Dorsal Cochlear Nucleus. Hearing Res. 217:207-215. 2006.

LETTERS TO THE EDITOR

Walling A. and D.M.Caspary : Effects of Benzodiazepines After Procedures in Elderly Patients; Am. Fam. Physician. 2002. http://www.aafp.org/afp/20020501/lettersonline.html

BOOK CHAPTERS

Caspary, D.M., L.P. Rybak and C.L. Faingold: The Effects of Inhibitory and Excitatory Amino Acid Neurotransmitters on the Response Properties of Brain Stem Auditory Neurons. In: Auditory Biochemistry (Dennis Drescher, Ed.), Charles C. Thomas Publisher, Springfield, IL, pp. 198-226, 1985.

Caspary, D.M.: Neurotransmitter Studies of the Cochlear Nucleus: Iontophoretic Methods. Health Sciences Consortium, North Carolina, 1985.

Caspary, D.M.: Cochlear Nuclei: Functional Neuropharmacology of the Principal Cell Types. In: Neurobiology of Hearing. (Rick Altschuler, Richard Bobbin and Douglas Hoffman, Eds.), Raven Press, New York, pp. 303-332, 1986.

Faingold, C.L. and D.M. Caspary: Reticular Formation Recording Studies. In: Convulsions and the Reticular Formation. (G.H. Fromm, W.M. Burnham, C.L. Faingold and R.A. Browning, Eds.), A.R. Liss, New Jersey, pp. 39-80, 1987.

Caspary, D.M.: Electrophysiologic Studies of Glycine Mechanisms in the Auditory Brainstem Structures. In: Glycine Neurotransmission. (O.P. Ottersen and J. Storm-Mathisen, Eds.), Sussex: John Wiley and Sons, pp. 453-483, 1990.

Caspary, D.M. and P.G. Finlayson: Superior Olivary Complex: Functional Neuropharmacology of the Principal Cell Types. In: Neurobiology of Hearing Vol. II: The Central Auditory System. (R.A. Altschuler, D.W. Hoffman, R.P. Bobbin and B. Clopton, Eds.), Raven Press, New York, pp. 141-162, 1991.

Faingold, C.L., G. Gehlbach and D.M. Caspary: Functional Pharmacology of Inferior Colliculus Neurons. In: Neurobiology of Hearing, Vol. II: The Central Auditory System. (R.A. Altschuler, D.W. Hoffman, R.P. Bobbin, B.M. Clopton, and D.W. Hoffman Eds.), Raven Press, New York, pp. 223-251, 1991.

Caspary, D.M., P.S. Palombi, P.M. Backoff, R.H. Helfert and P.G. Finlayson: GABA and Glycine Inputs Control Near-CF Discharge Rate of AVCN Neurons Displaying Primarylike and Phase-locked Response Properties. In: The Mammalian Cochlear Nuclei: Organization and Function. (M. A. Merchan, J. Juiz, D.G. Godfrey, Eds), Plenum Press, New York, pp. 239-252, 1993.

Caspary, D.M.: Fusiform Cell Response Properties are Shaped by Inputs Acting on Glycine I and GABAB Receptors. In: Advances in Speech, Hearing and Language Processing: The Cochlear Nucleus: Structure and Function in Relation to Modeling. (W. Ainsworth, T.S. Evans, and C.M. Hackney, Eds.), JAI Press LTD, London, pp. 273-292, 1996.

Caspary, D.M., R.H. Helfert and P.S. Palombi: The Role of GABA in Shaping Frequency Response Properties in the Chinchilla Inferior Colliculus. In: Acoustical Signal Processing in the Central Auditory System. (J. Syka, Ed.), Plenum Press, New York, 1997. pp. 227-238.

Caspary D.M.: GABA and Glycine Neurotransmission in Mouse Auditory Brainstem Structures. In: Mouse Auditory Research: From Behavior to Molecular Biology. (J.F. Willott), CRC Press, LLC,Boca Raton, FL, 2001. pp. 317-320.

Caspary, D.M., R.J. Salvi, R.H. Helfert, T.J. Brozoski, C.A. Bauer: Neuropharmacology of Noise Induced Hearing Loss in Brainstem Auditory Structures. In: Noise Induced Hearing Loss: Mechanisms of Damage and Means of Prevention. (D. Henderson, D. Prasher, R. Kopke, R.J. Salvi and R. Hamernik Ed.), NRN Publications, London. 2002. pp. 169-186.

Kelly, J.B. and D.M. Caspary: Pharmacology of the Inferior Colliculus. In: The Inferior Colliculus, J.A. Winer and C.E. Schreiner (Eds.), Springer-Verlag: New York. 2005. pp. 248-281.

Turner J.G. and D.M. Caspary: Comparison of Two Rat Strains of Aging: Peripheral Pathology and GABA Changes in the Inferior Colliculus. In: Auditory Plasticity, Prague Symposium Proceedings, Syka J. and Merzanich M. (Eds), 2005. pp 217-225.

Salvi R.J., J. Wang, D.C. Caspary: Funtional Changes in the Central Auditory System After Noise Induced Cochlear Damage. In: Noise, Luxon (Eds.), John Wiley & Sons, Ltd. West Sussex. in press

SYMPOSIA AND WORKSHOPS (INVITED)

Caspary, D.M., M.J. Moore and C.L. Faingold: Role of Inhibitory and Excitatory Amino Acid Neurotransmitters in the Generation of Response Patterns in Brainstem Auditory Neurons. International Symposium on Auditory Biochemistry, Assoc. Res. Otolaryngol., St. Petersburg, FL, February, 1984.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: Epilepsy: Brainstem Seizure Mechanisms and Drug Action. FASEB (Chairman and Presenter), St. Louis, MO, April, 1984.

Faingold, C.L., G. Gehlbach, M.A. Travis and D.M. Caspary: Neuroanatomical and Electrophysiological Manifestations of Seizure Predisposition of the Genetically Epilepsy Prone Rat. ASPET, Boston, MA, August, 1985.

Caspary, D.M., D.W. Hoffmann, E.J. Walsh, J. McGee and C.L. Faingold: Neurotransmitter Mediated Coding of Acoustic Information. Midwest Neurobiology Meeting, Springfield, IL, April, 1986.

Caspary, D.M.: Invited Speaker. The Role of Central Auditory Neurotransmitters in Processing Acoustic Information. XVIIIth International Congress of Audiology, Prague, Czechoslovakia, August, 1986.

Caspary, D.M.: Invited presenter/panel member consultant to the National Institutes of Health-NINCDS Workshop on Pharmacology of Hearing, Bethesda, MD, September, 1987.

Caspary, D.M.: Invited panel member consultant to the National Institute on Aging and the American Academy of Otorhinolaryngology-Workshop on Geriatric Otolaryngology, Washington, D.C., April, 1988.

Caspary, D.M.: Invited Speaker. Association for Research in Otolaryngology symposium on Neurotransmitters, St. Petersburg, FL, February, 1990.

Caspary, D.M.: Invited Speaker. Cochlear Nucleus: Structure and Function in Relation to Modeling. University of Keele, U.K. September, 1990.

Caspary, D.M.: Invited Speaker. National Academy of Science, Committee on Hearing and Bioacoustics, and Biomechanics Symposium on Presbycusis. Washington, D.C., October, 1990.

Caspary, D.M.: Invited Speaker. The Mammalian Cochlear Nuclei: Organization and Function. Salamanca, Spain. 1991.

Caspary, D.M.: Invited Speaker. Progress in Otology, Bordeaux, France December 1992.

Caspary, D.M.: Invited speaker. Human Olfaction and Audition: Parallels and Emerging Research Strategies. Sponsored by the Wellcome Trust, London, UK. May 1994

Caspary, D.M.: Invited speaker. International Symposium on Neurobiology and Neuroendocrinology of Aging. Bregenz Austria, July 1994.

Caspary, D.M.: Invited speaker. International Symposium on Auditory Signal Processing in the Central Auditory Pathway. Prague, Czech Republic, 1996.

Caspary, D. M.: Invited speaker. Molecular Mechanisms of Central Auditory Plasticity, Satellite Symposium to the 26th Annual Meeting of the Society for Neuroscience. Washington, D. C., 1996.

Caspary, D.M.: Invited speaker. Plasticity in Central Auditory Pathways, Park City, Utah, June 1999.

Caspary, D.M.: Invited speaker. Noise Induced Hearing Loss, Cambridge England, July 2000.

Caspary, D.M.: Invited Speaker. Inferior Colliculus From Past to Future, Salamanca Spain, May 2001.

Caspary, D.M.: Invited Speaker. International Conference on Ageing and Hearing Loss- International Society of Audiology, Tarento Italy, June 2001.

Caspary, D.M., L.Ling, L.F. Hughes. Age-related Changes in the Subunit Makeup of the GABAA Receptor in Rat Primary Auditory Cortex. Twelth Neuropharmacology Conference: GABAA Receptors in Cellular and Network Excitability, Orlando Florida, October 2002.

Caspary, D.M.: Invited Speaker. Plasticity Of The Central Auditory System And Processing Of Complex Acoustic Signals, Prague CZ. June 2003.

Caspary, D.M.: Invited Speaker. Workshop on “Understanding Tinnitus ”Peter Wall Institute for Advanced Studies, Vancouver, Canada. November 2003.

Caspary, D.M.: Invited Speaker. Pharmacology of Cochlear and Vestibular Systems
Tulane University health Sciences Center, New Orleans, LA. November 2003.

Caspary, D.M. Invited Speaker. Aging and Speech Communication: An International and Interdisciplinary Research Conference, Bloomington, IN. October 2005.

PAPERS AND PRESENTATIONS AT PROFESSIONAL MEETINGS:

Caspary, D.M.: Coding and Cytoarchitecture in the Kangaroo Rat Cochlear Nuclei. J. Acous. Soc. Amer., 50:118-119. Abstract, 1971.

Caspary, D.M.: The Ultrastructure of Synaptic Endings in the Globular and Multipolar Cell Areas of the Kangaroo Rat Ventral Cochlear Nucleus. Anat. Rec., 175:284-285. Abstract, 1973.

Caspary, D.M., A.L. Rupert and G. Moushegian: Response Characteristics of Neurons in the Cochlear Nuclei to Sinusoidal and Vowel-Sound Stimulation. J. Acous. Soc. Amer., 55: S85, 1974.

Rupert, A.L., D.M. Caspary and G. Moushegian: Neuronal Response Patterns in the Cochlear Nuclei: Effects of Vowel Position on Discharge Rate. J. Acous. Soc. Amer., 50: S85, 1974.

Caspary, D.M., A.L. Rupert and G. Moushegian: Processing of Simple and Complex Stimuli by the Globular and Multipolar Cell Areas of the Kangaroo Rat Cochlear Nuclei. Soc. Neurosci. Abstr., 1:163(#110), 1974.

Faingold, C.L. and D.M. Caspary: Differential Changes in Frequency Following and Evoked Responses in Some Primary Auditory and Reticular Structures. Soc. Neurosci. Abstr., 1:22, 1975.

Browner, R. and D.M. Caspary: The Neurobiology of the Acoustic Tubercle in Tupinambis Nigropuntatus. Soc. Neurosci. Abstr., 2:15, 1976.

Caspary, D.M. and D.C. Havey: Glycine Effects on Response Patterns of Neurons in the Cochlear Nuclei. Soc. Neurosci. Abstr., 3:4, 1977.

Caspary, D.M. and D.C. Havey: Effects of Putative Amino Acid Neurotransmitters on Response Patterns of Neurons in the Cochlear Nuclei. Soc. Neurosci. Abstr., 5:192, 1979.

Caspary, D.M. and D.C. Havey: Glutamate and Aspartate: Effects Threshold and Response Patterns in the Cochlear Nucleus. Soc. Neurosci. Abstr., 5:17, 1979.

Caspary, D.M.: Effects of Glutamate and Aspartate on Tone-Evoked and Spontaneous Activity in Posterior Ventral and Dorsal Cochlear Nucleus. J. Acous. Soc. Amer., 67:S89, 1980.

Caspary, D.M. and D.C. Havey: Effects of Acetylcholine on Dorsal Ventral Cochlear Nucleus Neurons. Assoc. Res. Otolaryngol., 4:85, 1981.

Caspary, D.M.: Differential Effects of Putative Neurotransmitters Cochlear Nucleus Neurons. The Pharmacologist, 225, 1981.

Moore, M., D.M. Caspary and D.C. Havey: Iontophoretic Application of Putative Inhibitory Neurotransmitters Onto Binaural Units in the Superior Olive. Soc. Neurosci. Abstr., 7:389, 1981.

Moore, M.J. and D.M. Caspary: Binaural Properties of Neurons in the Chinchilla Lateral Superior Olivary Nucleus. J. Acoust. Soc. Amer., 71:S99, 1982.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: Effects of Convulsants on the Sensory Responses of Neurons in Amygdala Stem Reticular Formation. Soc. Neurosci. Abstr., 8:1018, 1982.

Caspary, D.M., J. McGee and E. Walsh: Duration of Inhibition Seen For IE Neurons in Chinchilla Lateral Superior Olivary Nucleus. Soc. Neurosci. Abstr., 9:211, 1983.

Caspary, D.M., C.L. Faingold, D.C. Havey and M.J. Moore: Possible Roles of Central Auditory Neurotransmitters in Hearing Research. American Speech-Language-Hearing Assoc., p. 176, 1983.

Faingold, C.L., W.E. Hoffmann and D.M. Caspary: Lack of Neurotransmitter Specificity in the Action of Convulsant Drugs on Reticular Formation Neurons. 15th Epilepsy International Symposium, (Washington, D.C.), 358, 1983.

Caspary, D.M., M.J. Moore and C.L. Faingold: Role of Inhibitory and Excitatory Amino Acid Neurotransmitters in the Generation of Response Patterns in Brainstem Auditory Neurons. International Symposium on Auditory Biochemistry, Assoc. Res. Otolaryngol., St. Petersburg, FL, February, 1984.

Faingold, C.L., G. Gehlbach, W.E. Hoffmann and D.M. Caspary: Deficit of Inhibition and Reduced Effects of GABA and Flurazepam (FLU) and Inferior Colliculus (IC) Neurons in Audiogenic Seizures (AGS). IUPHAR 9th International Congress of Pharmacology, p. 775, 1984.

Caspary, D.M., K. Berry and C.L. Faingold: Effects of Amino Acid Neurotransmitters on Auditory Rate-Intensity Functions. IUPHAR 9th International Congress of Pharmacology, p. 723, 1984.

Faingold, C.L, W.E. Hoffmann and D.M. Caspary: Effects of Excitant Amino Acids on Inferior Colliculus Neuronal Responses to Acoustic Stimuli. Soc. Neurosci. Abstr., 10:1148, 1984.

Caspary, D.M. and K.P. Berry: Strychnine Alters Nonmonotonic Rate-Intensity Functions of DCN Neurons. Assoc. Res. Otolaryngol., 1985.

Faingold, C.L., G. Gehlbach and D.M. Caspary: Effects of GABA on Inferior Colliculus Neuronal Responses to Acoustic Stimuli. Soc. Neurosci. Abstr., 11:247, 1985.

Caspary, D.M., C.L. Faingold and K.P. Berry: Synaptic Potentials of Neurons Recorded from the Chinchilla Lateral Superior Olivary Nucleus. Soc. Neurosci. Abstr., 11:1050, 1985.

Walsh, E.J., J. McGee and D.M. Caspary: Development of Neuronal Responses within the Caudal Cochlear Nucleus in Kittens. Assoc. Res. Otolaryngol., p. 86, 1986.

Caspary, D.M., D.W. Hoffmann, E.J. Walsh, J. McGee and C.L. Faingold: Neurotransmitter Mediated Coding of Acoustic Information. Midwest Neurobiology Meeting, Springfield, IL, April, 1986.

Caspary, D.M.: The Role of Central Auditory Neurotransmitters in Processing Acoustic Information. XVIIIth International Congress of Audiology, Prague, Czechoslovakia, August, 1986.

Walsh, E.J., J. McGee and D.M. Caspary: Development of Neuronal Responses within the Caudal Cochlear Nucleus in Kittens. Midwest Neurobiology Meeting, Springfield, IL, April, 1986.

Caspary, D.M.: The Pharmacology of IE Neurons in the LSO. Advances in Auditory Neuroscience, IUPS Satellite Symposium on Hearing, San Francisco, CA, July, p. 66, 1986.

Caspary, D.M. and C.L. Faingold: Excitant Amino Acid Receptor Types in the Lateral Superior Olivary Nucleus. Soc. Neurosci. Abstr., 12:1269, 1986.

Caspary, D.M. and B.A. Lawhorn: Loss of GABA-Immunoreactive Neurons in the Inferior Colliculus of the Aged Rat. Soc. Neurosci. Abstr., 13(1):545, 1987.

Caspary, D.M., S.D. Yuscius and P.G. Finlayson: Inhibitory Amino Acid Neurotransmitters and Noise/Tone Differences in the Ventral Cochlear Nucleus. Assoc. Res. Otolaryngol., 12:78, 1987.

Caspary, D.M., S.D. Yuscius, B.A. Lawhorn and P.G. Finlayson: Effects of Inhibitory Amino Acid Neurotransmitters on One Population of Ventral Cochlear Nucleus Neurons. Soc. Neurosci. Abstr., 14:649, 1988.

Finlayson, P.G., S.D. Yuscuis and D.M. Caspary: Responses of Ventral Cochlear Nucleus Neurons To Wide-Band Noise and Tone Combinations. Assoc. Res. Otolaryngol., 13:55, 1989.

Finlayson, P.G., S.D. Yuscius and D.M. Caspary: Matching of Excitation and Inhibition in the Lateral Superior Olivary Nucleus of the F-344 Rat. Soc. Neurosci. Abstr., 15:745, 1989.

Caspary, D.M., C.L. Faingold and P.G. Finlayson: Functional Pharmacology of the Cochlear Nucleus and Lateral Superior Olivary Nucleus. Assoc. Res. Otolaryngol., 13:124, 1990.

Finlayson, P.G. and D.M. Caspary: Physiology of Lateral Superior Olivary Neurons in Young and Old F-344 Rats. Assoc. Res. Otolaryngol., 13:266, 1990.

Caspary, D.M.: Selective New Excitant Amino Acid Neurotransmitter Antagonist (Quinoxaline Derivatives) Block Excitatory Responses at Acoustic Nerve Synapses. Assoc. Res. Otolaryngol., 13:60, 1990.

Evans, M.S., McCabe, K.F., Faingold, C.L. and Caspary, D.M., Repetitive synaptic stimulation evokes increased excitatory responses in genetically epilepsy-prone rat (GEPR) hippocampus. Epilepsia 32: 1991.

Finlayson, P.G. and D.M. Caspary: Phase-Sensitive Binaural Inhibition in Lateral Superior Olivary Neurons. Soc. Neurosci. Abstr., 16:875, 1990.

Raza, A. and D.M. Caspary: Age-Related Changes in GABA and ACh in the Brainstem Auditory Nuclei of Fischer-344 Rats. Soc. Neurosci. Abstr., 16:715, 1990.

Caspary, D.M. and P.S. Palombi: The GABAA Receptor Antagonist Bicuculline Alters Temporal Response Patterns and Isointensity Contours of PVCN Octopus Cells. Assoc. Res. Otolaryngol., 14:11, 1991.

Palombi, P.S., P.M. Backoff and D.M. Caspary: Do Dorsal Cochlear Nucleus Parallel Fibers Excite Fusiform Cells Via An Excitatory Amino Acid Neurotransmitter? Soc. Neurosci. Abstr., 17:305, 1991.

Backoff, P.M., C. Thompson and D.M. Caspary: Age-Related Changes in Auditory Brainstem Responses Observed in an Animal Model: Effects of Rate and Intensity. Assoc. Res. Otolaryngol., 15:451, 1992.

Caspary, D.M. and P.S. Palombi: Inputs Control Discharge Rate Within the Excitatory Response Area of Chinchilla Inferior Colliculus Neurons. Assoc. Res. Otolaryngol. 16:109, 1993

Backoff, P.M., F. Boettcher and D.M. Caspary: Response Suppression in a Paired-Click Masking Paradigm in Chinchilla Cochlear Nucleus: A Possible Role of Local Inhibition. Assoc. Res. Otolaryngol. 16:39, 1993.

Helfert, R.H., P.S. Palombi, B. Lawhorn Armour and D.M. Caspary: The Chinchilla Lateral Superior Olive Receives Descending Input from the Inferior Colliculus via the Ventral Nucleus of the Trapezoid Body. Assoc. Res. Otolaryngol. 16:126, 1993.

Nakayama, M., D.M. Caspary, H.R. Konrad and R.H. Helfert: Age-Related Changes in the Vestibular Endorgan of the Fischer-344 Rat: A Scanning Electron Microscopic Study. Assoc. Res. Otolaryngol. 16:466, 1993.

Caspary, D.M. and R.H. Helfert: Two Populations of Commissural Projections Connecting Like Regions of the Inferior Colliculus Immunostain for Different Amino Acid Transmitters. Soc. Neurosci. Abstr. 19:1425, 1993.

Helfert, R.H., T.J. Sommer, C. Jeffery, L.F. Hughes and D.M. Caspary: Age-related Changes in the Synaptic Organization of the Inferior Colliculus of the Fischer 344 Rat. Soc. Neurosci. Abstr. 19:1425, 1993.

Milbrandt, J.C., R.L. Albin and D.M. Caspary: Effects of Aging on GABAA and Glycine Receptor Binding in the Inferior Colliculus and Cochlear Nucleus of the Fischer 344 Rat: A Quantitative Autoradiographic Study. Soc. Neurosci. Abstr. 19:1425, 1993.

Milbrandt, J.C. and D.M. Caspary. Age-Related Decrease in GABAB Receptor Binding in the Inferior Colliculus of the Fischer 344 Rat. Assoc Res. Otolaryngol. 17:42 1994.

Helfert, R.H., T.J. Sommer, L.F. Hughes, C.M. Jeffery and D.M. Caspary. Age-Related Changes in the Synaptic Organization of the Central Nucleus of the Inferior Colliculus of the Fischer 344 Rat. Assoc Res. Otolaryngol. 17:43 1994.

Backoff, P.M. and D.M. Caspary. Pharmacologic Blockade of Glycine and GABA Inputs to CN Neurons Alters Envelope Coding for AM Tones. Assoc Res. Otolaryngol. 17:65 1994.

Nakayama, M., H.R. Konrad, D.M. Caspary and R.H. Helfert. Age-Related Changes at the Neuroepithelial Surface of the Crista of the Fischer-344 Rat. Assoc. Res. Otolaryngol., 17:612, 1994.

Cuadra, G., D.M. Caspary and E. Giacobini. Coadministration of Cholinesterase Inhibitors and Adrenergic Drugs: Effect on Acetylcholine and Biogenic Amine Levels in Rat Cortex: A Microdialysis Study. Soc. Neurosci. Abstr. 20:83, 1994.

Palombi, P.S. and D.M. Caspary. Response Properties of CIC Units of Young Adult Fischer 344 Rats. Assoc. Res. Otolaryngol., 18:516, 1995.

Palombi, P.S. and D.M. Caspary. Comparison of Response Properties of CIC and ECIC Units of Young Adult Fischer 344 Rats. Assoc. Res. Otolaryngol., 18:517, 1995.

Milbrandt, J.C. and D.M. Caspary. GABAA Receptor Modulation in the Aging Fischer 344 Rat Inferior Colliculus. Assoc. Res. Otolaryngol., 18:129, 1995.

Helfert, R.H., T.J.S. Blomquist, J.C. Milbrandt and D.M. Caspary. Excitant Amino Acid Binding and Aging in the Rat Auditory Brainstem. Soc. Neurosci. Abstr. 21:404, 1995.

Milbrandt, J.C., C. Hunter and D.M. Caspary. Distribution of GABAA Receptor Subunit mRNA in the Inferior Colliculus of Young Adult and Aged Fischer 344 Rats. Soc. Neurosci. Abstr. 21:404, 1995.

Palombi, P.S. and D.M. Caspary. Physiology of the Aging F344 Rat Inferior Colliculus. Soc. Neurosci. Abstr. 21:670, 1995.

Ford, M.S., S.B. Maggirwar, C. Whitworth, L.P. Rybak, D.M. Caspary and V. Ramkumar. P1 Purinoceptor Agonist Stimulates Antioxidant Enzymes in the Cochlea of Chinchilla. Soc. Neurosci. Abstr. 21:910, 1995.

Caspary, D.M., T.S. Blomquist, M.C. Wilson, R. Salvi and J.C. Milbrandt. GAD Immunoreactivity in the Inferior Colliculus Following Acute Sound Exposure: Loss of Inhibition? Assoc. Res. Otolaryngol.
19:361, 1996.

Wang, J., R.J. Salvi, D.M. Caspary and N. Powers. GABAergic Inhibition Profoundly Alters the Tuning and Discharge Rate of Neurons in the Primary Auditory Cortex of the Chinchilla.

Willott, J.F., J.C. Milbrandt and D.M. Caspary. Age-Related Changes in Strychnine-Sensitive Glycine Receptors of the Dorsal Cochlear Nucleus (DCN) Observed in C57BL/6 Mice but not in CBA Mice. Assoc. Res. Otolaryngol 19:653, 1996.

Milbrandt, J.C., T. Blomquist and D.M. Caspary. GABAA Receptor Subunit Changes in the Inferior Colliculus May Result in Enhanced Receptor Function in Aged Rats. Soc. Neurosci. Abstr. 22:1339, 1996.

Caspary, D.M., and P.S. Palombi. Possible role of GABAA Receptors in Coding Sinusoidally Amplitude Modulated Stimuli in the Chinchilla Inferior Colliculus Assoc. Res. Otolaryngol 20:189, 1997.

Holder, T.M., D.K. Naritoku, L.F. Hughes and D.M. Caspary. Age-Related Increase in Chloride Uptake Possibly Associated with GABAA Receptor Subunit Changes in Rat Inferior Colliculus. Soc. Neurosci. Abstr. 23:2068, 1997.

Abbott, S.D. and D.M. Caspary. Altered GAD levels in the rat inferior colliculus following acoustic exposure. Assoc. Res. Otolaryngol. 20:809, 1998.

Bauer, C.A., T.J. Brozoski, D.M. Caspary, R. Rojas, J. Boley, M. Wyder, A. Hindes. The effects of salicylate on conditioned suppression behavior and receptor pharmacology in the inferior colliculus of the Long-Evans rat. Assoc. Res. Otolaryngol. 20:811, 1998.

Schatteman, T.S., L.F. Hughes, K.E. Hancock, D.L. Larsen and D.M. Caspary. SAM coding in DCN output neurons of young adult FBN1 rats: Effects of different modulation depths and background noise. Assoc. Res. Otolaryngol. 21:141, 1999.

Holder, T.M. and D.M. Caspary. Age-related changes in selective benzodiazepine binding in the inferior colliculus. Assoc. Res. Otolaryngol. 21:222, 1999.

Caspary, D.M., T.M. Holder, L.F. Hughes, T.A. Schatteman, S. A. Leroy and R. A. Browning. Aging-related changes in thresholds and GABA neurochemistry: Comparison between two rat strains. Assoc. Res. Otolaryngol. 23:81-82, 2000.

Holder, T.M., L.F. Hughes and D. M. Caspary. Benzodiazepine modulation of GABA-mediated chloride uptake with age. Assoc. Res. Otolaryngol. 23:82, 2000.

Schatteman, T.S., L.F. Hughes and D.M. Caspary. Evidence of an Age-related Loss of Inhibitory Function in Rat DCN Output Neurons: Rate Responses. Soc. Neurosci. Abstr. 30:957, 2000.

Caspary, D.M and, L.F. Hughes, Age-related Changes in the Subunit Makeup of the GABAA Receptor in Rat Primary Auditory Cortex. Assoc. Res. Otolaryngol. 25:188, 2002.

Turner, J.G., L.F. Hughes and D.M. Caspary. Response Characteristics of Layer V Neurons in Rat Primary Auditory Cortex. Assoc. Res. Otolaryngol. 26:203, 2003.

Caspary, D.M. and L.F. Hughes, Layer-Specific Age-related Changes in GAD Protein Levels in Rat Primary Auditory Cortex. Assoc. Res. Otolaryngol. 26:720, 2003

Ling, L., L.F. Hughes and D.M. Caspary, Altered GABAA Receptor Binding in Aged Rat Primary Auditory Cortex Assoc. Res. Otolaryngol. 27:218, 2004

Turner, J.G., L.F. Hughes and D.M. Caspary, Age-Related Changes in Response Properties of Rat A1 Layer V Neurons Assoc. Res. Otolaryngol. 27:218, 2004

Hughes L.F., Turner J.G., Helfert R.H. and Caspary D.M., Central Auditory Plasticity in Response to Aging;The Proceedings 7th International Symposium on the Neurobiology and Neuroendocrinology of Aging, Experimental Gerontology, 2004; 39(11-12):1772-1773.

Ling, L, L.F. Hughes and D.M.Caspary, Altered GABA neurochemistry in aged rat primary auditory cortex. Soc. Neurosci. Abstr. 34:625.5, 2004

Brozoski, T.J. C.A. Bauer, J.G. Turner and D.M. Caspary: Patterns of Cochlear Pathology, Neural Activity in the Inferior Colliculus, and Psychophysical Evidence of Tinnitus in Chinchillas Assoc. Res. Otolaryngol. 28:319, 2005

Turner, J.G., J. Parrish, L.F. Hughes, H.N. Wang, T.J. Brozoski, C.A. Bauer, and D.M. Caspary: Behavioral Gap Detection Deficits in the Fischer Brown Norway (FBN) Rat Model of Presbycusis Assoc. Res. Otolaryngol. 28:152, 2005

Turner, J.G., T.J. Brozoski, C.A. Bauer, J.L. Parrish, K. Myers, L.F. Hughes and D.M. Caspary. Gap Detection Deficits and Startle Habituation Changes In Rats With Psychophysical Evidence Of Tinnitus. Soc. Neurosci. Abstr. 35:163.13, 2005

Wang, H.N., L. Ling, L.F. Hughes, C.A. Bauer, T.J. Brozoski and D.M. Caspary. Altered Markers of Glycinergic function in the DCN of a Rat Model of Tinnitus Soc. Neurosci. Abstr. 35:163.12, 2005

Turner, J.G, J.L. Parrish, B. Canlon, S. Dure, L.F. Hughes and D.M. Caspary. Affects of Exposure to an Augmented Acoustic Environment in Aged CBA Mice: Cochleograms, ABR Thresholds and Behavior. Assoc. Res. Otolaryngol. 29:147, 2006

Hughes, L.F., J.G. Turner, D.L. Larsen, J.L. Parrish and D.M. Caspary. Sinusoidal Amplitude-Modulated Signal Processing Across AI Layers in Young and Aged Rats. Assoc. Res. Otolaryngol. 29:326, 2006

Helfert, R.H. L. Ling, A.Weberg, D L. Larsen, L.F. Hughes and D.M. Caspary. Age-Related Changes in GAD-67 Punctate Immunolabeling in Layer V of Rat Primary Auditory Cortex. Assoc. Res. Otolaryngol. 29:326, 2006

Hughes, L.F., L. Zuiderveld, J.G. Turner, J.L. Parrish and D. M. Caspary Gap Processing Across A1 Layers in Young and Aged Rats Assoc. Res. Otolaryngol. 30:290, 2007

Caspary, D.M., D. Martin, L. Ling, H.N.Wang, P. Hutson, J.G.Turner, E. Reuschel and L.F. Hughes. Receptor Subunit Changes in a Noise-Exposure Model of Tinnitus: Rat Medial Geniculate Body Assoc. Res. Otolaryngol. 30:295, 2007

Turner,J.G., J.L. Parrish, L. Zuiderveld, S. Darr, L.F. Hughes, D.M. Caspary. Exposure to an Augmented Acoustic Environment Alters GABA (GAD67) Levels in the IC and AI of Aged Mice with Presbycusis. Assoc. Res. Otolaryngol. 30:260, 2007