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SIU School of Medicine, Institute for Plastic Surgery supports Kidzeum of Health and Science with a $75,000 gift

(Springfield, IL) –Thanks to a $75,000 donation from the doctors of SIU School of Medicine Institute of Plastic Surgery, an interactive hand exhibit will be one of the 100 engagements that exist within the Healthy Body Gallery.
“SIU Plastic’s Quote”

The Interactive Hand Exhibit will be located within the 40-foot tall, 3-story child that makes up the Healthy Body Gallery.  The main message of the Interactive Hand Exhibit is to demonstrate how strong muscles and tendons work together with your bones to help your hand move.  Kidzeum visitors will use a series of levers and controls to move an oversized had and grasp a ball. Click on image for larger view

“Kidzeum is extremely grateful to SIU School of Medicine and the doctors of its Institute for Plastic Surgery for supporting the Interactive Hand. Our hands do so much for us. They are capable of a wide variety of functions: touching, grasping, feeling, holding, manipulating, caressing, and more. They are a vitally important part of who we are and how we see ourselves,” said Kidzeum Board President, Rachael Thomson.

Created in 1973, The Institute for Plastic Surgery is an academic surgical practice offering specialized medical and surgical care to adults and children in central and southern Illinois.  It is committed to achieving the highest standard of excellence in all areas of reconstructive and cosmetic surgery.  The Institute is known nationally and internationally for its work in many areas including microsurgery, hand surgery and therapy, reconstructive surgery, aesthetic surgery, and specialized care in the treatment of burns and problem wounds.

The Kidzeum of Health & Science will be located in the nationally registered, historic buildings at 412, 414 and 416 East Adams Street. The Kidzeum of Health and Science will be designed with a focus on fun and learning and upon completion of its Vital for Our Youth Campaign; Kidzeum will be a three story, 25,000 square foot children’s museum dedicated to teaching children of all abilities about health and science through discovery and play. The Kidzeum has raised $5.4 million of its $6.8 million dollar goal.  Slated to open in late fall 2015.

 

Dr. Tim Hargrove, Researcher III in the lab of Dr. Kathleen Campbell as being selected as the Professional Administrative Employee of the Quarter.

Tim, thank you for your continued exemplary service to the Department of Surgery.

 

 



August 21, 2014 Press Release

SIU Researcher Receives NIH Grant to Study Chili Pepper Component to Reduce Hearing Loss

A physician researcher at Southern Illinois University (SIU) School of Medicine in Springfield has been awarded a five-year federal grant from the National Institute of Deafness and Communication Disorders (NIDCD) of the National Institutes of Health to continue his studies of how to reduce hearing loss in cancer patients undergoing chemotherapy treatment. The current research project will examine whether capsaicin, a component of hot chili peppers, can reduce hearing loss and kidney damage if given prior to or after a dose of cisplatin, an anti-cancer drug frequently used for chemotherapy.

Dr. Leonard Rybak, professor emeritus of surgery in the Division of Otolaryngology Head and Neck Surgery and SIUC distinguished scholar, is the principal investigator for the project. The study is a continuation of an existing grant that has been funded for 17 years, to study the mechanisms and prevention of cisplatin ototoxicity. The grant has a total budget of $1,549,269.

“Cisplatin has been the most effective anti-tumor drug since the 1970’s,” Rybak said. “Through our research, we’re trying to make it less toxic without making it less effective.” Rybak’s previous research has shown that cisplatin causes reactive oxygen species (ROS) that damage the inner ear, causing permanent hearing loss. The research has identified several different pathways that can be targeted to decrease cisplatin induced hearing loss without compromising its tumor killing capacity.

Over the previous period of funding, Rybak studied several antioxidants and found that in animal models, these drugs protect against cisplatin-induced hearing loss and kidney damage. However, some experts are concerned that the antioxidants may interfere with cisplatin’s effectiveness as a cancer treatment. For that reason, Rybak’s laboratory is investigating potentially safer alternatives, such as capsaicin. Otolaryngology residents and pharmacology graduate students participated in these studies.

The study will determine the smallest doses of capsaicin possible that will prevent hearing loss yet still allow cisplatin to be effective in the treatment of tumors. The results of the research may lead to cancer treatment with fewer negative side effects, like hearing loss and kidney damage.

The importance of these findings underscores the use of readily available natural products in the prevention of toxic effects of chemotherapy. These findings could easily be translated to humans for clinical use in the near future.
Rybak’s research team at SIU includes Vickram Ramkumar, Ph.D., Debashree Mukherjea, Ph.D., Kelly Sheehan and Puspanjali Bhatta. He will also use a consultant, Sridar Chittur, Ph.D., director of the Center of Functional Genomics at the University of Albany, New York.

Rybak, who also is a member of the Simmons Cancer Institute, joined the SIU faculty in 1981. He completed his doctorate degree as well as a residency in otolaryngology at the University of Minnesota (1979). Rybak earned his medical degree at the Medical College of Wisconsin (1973). He earned his bachelor’s degree at the St. Louis College of Pharmacy (1969). He is board certified in otolaryngology. Since 1994, he's delivered 31 presentations and 40 published peer-reviewed journal articles on cisplatin-induced ototoxicity. Rybak has also mentored five medical students and one Ph.D. candidate who all performed research on cisplatin ototoxicity.


 

SIU Med School Hearing Loss Study Advances with DOD Grant

A Southern Illinois University School of Medicine patented drug aimed at preventing noise-induced hearing loss is in the final stages of research. A $2.5 million grant from the U.S. Department of Defense U.S. Army Research and Materiel Command Branch will support a Phase 3 clinical trial to determine if D-methionine (D-met) can prevent noise-induced hearing loss in soldiers. more...