Curriculum Vitae

José A. Espinosa, M.D.
Associate Professor Division of Neurosurgery
E-mail: jespinosa@siumed.edu

Brief Bio

Research Interests/Areas of Expertise

• Epilepsy
• Digital imaging to access difficult areas of the brain

Dr. José Espinosa is a neurosurgeon and Assistant Professor in the Department of Surgery at the Southern Illinois University School of Medicine.
Dr. Espinosa completed his residency training at McGill University, Montreal Neurological Institute in 1994. During his residency he was awarded the Penfield Award in Neurosurgery and the Francis McNaughton Scholarship.
Dr. Espinosa has a special interest and surgical expertise in the treatment of epilepsy. His research interests include utilizing state-of-the-art imaging techniques to access difficult areas in the brain. He is also interested in laboratory techniques that improve neuronal survival following injuries to the central nervous system.
During his career at SIU School of Medicine, Dr. Espinosa has been awarded the J. Kiffin Penry Eagle Award for pioneering new therapies in the treatment of epilepsy. He is a life member of the National Registry of Who’s Who.
Dr. Espinosa is a fellow of the Royal College of Surgeons of Canada and is board certified in neurosurgery.

For more information or to make an appointment with Dr. Espinosa, please call 217-545-8000.

Education

1978 - 1984 M.D. Faculty of Medicine University of Panama
1988 - 1989 General Surgery McGill University Montreal General Hospital Montreal, Canada
1989 - 1994 Neurosurgery McGill University Montreal Neurological Institute Montreal, Canada

Languages

Fluent in English and Spanish with a working knowledge of French

Present Position

1994 to present Assistant Professor, Division of Neurosurgery
Southern Illinois University School of Medicine, Springfield, Illinois

Board Certification

• Board Certified American Board of Neurological Surgeons

Achievements

1996 Fellow of the Royal College of Physicians
1993 - 1994 Jeanne Timmins Costello Fellowship Award in Neurosurgery McGill University Montreal Neurological Institute
1993 Penfield-McNaughton Award in Neurosurgery McGill University
Montreal Neurological Institute
1992 - 1993 President of Fellows Society
Montreal Neurological Institute
1978 - 1984 Member of the Faculty Council University of Panama Faculty of Medicine

Licensure

• 1994 -- State of Illinois

Certificates

1992 FLEX The Federation of State Medical Boards
1988 E.C.F.M.G.Educational Commission for Foreign Medical Graduates Standard Certificate
1987 Medical Council of Canada Evaluating Examination for graduates of foreign medical schools.

Affiliations

1995 Interurban Neurosurgical Society
1994 Resident Member - American Association of Neurological Surgeons
1994 Resident Member - Congress of Neurological Surgeons
1995 Illinois Neurosurgical Society
1995 Sangamon County Medical Society
1995 Illinois State Medical Society
1992 - 1994 The Trauma Association of Canada
1992 - 1994 The Congress of Neurological Surgeons Resident Member

Grants Funded

• Activation of Vagus Nerve Fiber Subtypes in Humans and its Correlation with Antiepileptic Efficacy, October 1, 1998- September 30, 1999. $17,138
• A Randomized, Double-Blind Placebo-Controlled Study of Intravenous CI-1009 in Patients with Severe Head Injury, January 16, 1998 -- January 15, 1999. $119,781.
• Vagus Nerve Prosthesis Implant, September 1, 1990 -- December 30, 1996. $12,450
• A Phase III, Open-Label, Long-Term Safety and Efficacy Study of SNX-111 Administered Intrathecally to Patients Suffering from Chronic Pain Using the SynchroMed, May 22, 1996 -- Open. $20,625
• A Multicenter, Phase II/III, Placebo-Controlled Study of SNX-111 Administered Intrathecally to Patients with Chronic Malignant Pain, March 18, 1996 -- March 17, 1997. $112,875.
• Membrane and Synaptic Properties of Hippocampal Dentate Granule Cells in the Seizure-Sensitive Mongolian Gerbil, July 1, 1996 -- June 30, 1997. $3,317.
• Membrane and Synaptic Properties of Hippocampal Dentate Granule Cells in the Seizure-Sensitive Mongolian Gerbil, July 1, 1995 -- June 30, 1996. $1,363.
• Improving Neuron Survival Following Brain Lesion, Co-Investigator, SIU School of Medicine Central Research Committee, December 1, 1997 -- November 30, 1998.
• Efficacy and Safety of CERESTAT (aptiganel HCI) as a Neuroprotective Following Severe Traumatic Brain Injury, Investigator, SIU School of Medicine Central Research Committee, January 5, 1996 - July 4, 1998.
• Membrane and Synaptic Properties of Hippocampal Dentate Granule Cells in the Seizure Sensitive Mongolian Gerbil, Investigator, SIU School of Medicine Central Research Committee, July 1, 1995 - June 30, 1998.

• Activation of Vagus Nerve Fiber Subtypes in Humans and its Correlation to anti-epileptic efficacy, P.I., Excellence in Academic Medicine Award, CRC, 1999-2000, $49,000, Pending.
• Activation of Vagus Nerve Fiber Subtypes in Humans and its Correlation to anti-epileptic efficacy, P.I., Memorial Medical Center Foundaton, 1999-2000, $15,000, Pending.
• Long Term Alteration in Sleep-Awake Cycle by Exposure to Low Dose Sarin Combined With Pyridostigmine And Physical Stress, Co. Inv., Department of Defense, $919,861, Pending.
• Mechanism of Vagal Nerve Induced Inhibition of Epileptiform Activity, Cyberonics Inc., P.I., $46,000, Pending

Presentations

1993 "The Use of Fractionated Stereotactic Radiotherapy in Intracranial Meningiomas" (Oral)
Canadian Congress of Neurological SciencesToronto, Ontario
1992 "Hydromyelia Decompression with VP Shunt Revision in Patients with Chiari II Malformations" (Oral)
Quebec Association of Neurosurgeons Montreal
1991 Pediatric Section American Association of Neurological Surgeons Boston, Mass.
1991 "Dural Arteriovenous Malformations of the Anterior Cranial Fossa" (Oral) Quebec Association of Neurosurgeons Magog, Quebec

Posters

• Espinosa, Jose A., Olivier, F. Andermann, Dubeau, F., Savard, G., 1993. "Morbidity of Chronic Recording with Intracranial Depth Electrodes in 170 Patients." XIth Meeting of the World Society for Stereotactic and Functional Neurosurgery. Ixtapa, Mexico.
• Espinosa, Jose A., Salazar, Armando, del Carpio, Raquel,1993. "Limbic Encephalitis MRI as a Diagnostic Aid." Canadian Congress of Neurological Sciences, Toronto, Ontario.
• Espinosa, Jose A., Montes, Jose, Farmer, J-P, 1993. "Hydromyelia Decompression with VP Shunt Revision in Patients with Chiari II Malformations." Canadian Congress of Neurological Sciences. Toronto, Ontario.
• Espinosa, Jose A., Mohr, Gerald, Robert, Francoise, 1992. "Dural Arteriovenous Malformations of the Ethmoidal Region." International Cleveland-Montreal Cerebrovascular Symposium. Cleveland, Ohio.
• Espinosa, Jose A., Johnston, Karen, Giroux, Marc, Villemure, Jean-Guy, 1991."Abducens Palsy after Shunting for NPH." Canadian Congress of Neurological Sciences. Halifax, NS.
• Villemure, Jean-Guy, Espinosa, Jose A., 1991. "Stereotactic Craniotomy Using the Leksell Frame." Canadian Congress of Neurological Sciences. Halifax, NS.

1. Verma-Ahuja S, Husain K, Verhulst S, Espinosa J, and Somani S., Delayed Effects of Pyridostigmine and Exercise Training On Acetylcholinesterase and Muscle Tension in Mouse Lower Extremity, communicated to Canadian Journal of Physiology and Pharmacology 1999.
2. Espinosa, J.A., Aiello, M.A., Naritoku, D.K., Revision and removal of stimulating elecrodes following long-term therapy with the vagus nerve stimulator, Epilepsy Res. 1999 in Press.
3. Verma-Ahuja, Evans, M.S., and Espinosa, J.A., Evidence of increased excitability in GEPR hippocampus preceding development of seizure susceptibility, Epilepsy Res., 31 (1998) 161-173.
4. Verma-Ahuja, Evans, M.S., and Espinosa, J.A., Epileptiform bursting in the CA3 hippocampal area of seizure sensitive Mongolian gerbils, communicated to Seizures, 1998.
5. Reutens D, Dubeau F, Melanson D, Remillard G, Espinosa J, King M, Berkovic S, Andermann F. Intractable partial epilepsy following low-dose scalp irradiation in infancy. Annals of Neurology, 1995:38;951-954.
6. Preul M, Espinosa J, MD, Tampieri D, Carpenter S. Unusual evolution and computerized tompgraphic appearance of gliosarcoma. Canadian Journal of Neurological Sciences, 1994:21;141-5.
7. Espinosa J, Olivier A, Andermann F, Quesney F, Dubeau F, Savard G. Morbidity of chronic recording with intracranial depth electrodes in 170 patients. Stereotactic & Functional Neurosurgery, 1994:63;63-5.
8. Li M, Smith B, Espinosa J, Brown R, Richardson P, Ford R. Non penetrating trauma to the carotid artery: seven cases and a literature review. Journal of Trauma 1994:36;265-72.
9. Espinosa J, Mohr G, Robert F. Dural Arteriovenous Malformations of the Ethmoidal Region. British Journal of Neurosurgery 1994:7(4)431-45.
10. Espinosa J, Giroux M, Johnston K, Kirkham T, and Villemure J. Abducens Palsy Following Shunting for Hydrocephalus.Canadian Journal of Neurological Sciences 1993:20;123-5.

1. Verma-Ahuja S., Husain K., Verhulst S., Espinosa J., and Somani S., Delayed Effects of Pyridostigmine and Exercise Training on Muscle Tension in Mouse Lower Extremity. Gulf War Veterans Illnesses Res., (1999) 81.
2. Verma-Ahuja S., Husain K., Verhulst S., Espinosa J., and Somani S., Delayed Effects of Pyridostigmine and Exercise Training on Muscle Tension in Mouse Lower Extremity. FASEBJ. 13:818.5, 1999.
3. Espinosa J., Aiello M., Naritoku D., Revision and Removal of Stimulating Electrodes After Long-Term Thereapy with Vagus Nerve Stimulation. Epilepsia, 39 (1998) 192.
4. Espinosa J., Evans M.S., and Verma-Ahuja S., Reduced Synaptic Inhibition in the CA3 Neurons of Seizure Sensitive Mongolian Gerbils, Epilepsia, 37 (1996) 68.
5. Espinosa J., Villemure J., Souhami L., Caron J., Olivier A., Bahary J., and Podgorsak E, The Use of Fractionated Stereotacticc Radiotherapy in Intracranial Meningiomas. Canadian Journal of Neurological Sciences. 20 (1993) S26.
6. Espinosa J., Salazar A., and Del Carpio R, Limbic Encephalitis: MRI as a Diagnostic Aid. Canadian Journal of Neurological Sciences. 20 (1993) S58.
7. Espinosa J., Farmer J., and Montes L, Communicating Syringomyelia: Resolution after Shunt Revision. Canadian Journal of Neurological Sciences. 20 (1993) S63.
8. Li M., Pokrupa R., and Espinosa J, Syringomyelia Secondary to Impeded CSF Flow in the Thoracic Spinal Subarachnoid Space Caused by an Idiopathic Arachnoid Membrane. Canadian Journal of Neurological Sciences. 20 (1993) S68.
9. Espinosa J., Gircoux M., Johnston K., Kirkham T., and Villemure J.G. Transient Abducens Palsy Following Shunting for Hydrocephalus. Canadian Journal of Neurological Sciences18 (1991) 243.
10. Villemure J.G., and Espinosa J. Stereotactic Craniotomy Using the Leksell System: Illustration with 2 Cases. Canadian Journal of Neurological Sciences. 18 (1991) 243.

1997 AANS Course, "Neurosurgical Critical Care" Philadelphia, Pennsylvania
1996 American Epilepsy Society Annual Meeting San Francisco, California
1996 "22nd Annual Review Course in Neurological Surgery" The National Center for Advanced Medical Education
Chicago, IL
1995 "Microsurgical Techniques for Epilepsy and Intrinsic Brain Tumors" St. Louis University School of Medicine
St. Louis, MO
1995 Attendance at the Annual Meeting of the Interurgan Neurosurgical Society and The American Association of Neurological Surgeons, Chicago, with credit toward Continuing Education Award in Neurosurgery
1993 "Techniques in Aneurysm Surgery" Congress of Neurological Surgeons 43rd Annual Meeting Vancouver
1993 "Treatment of Occult Vascular Lesions" Congress of Neurological Surgeons, 43rd Annual Meeting
Vancouver
1993 "Instability of the Cervical Spine" Congress of Neurological Surgeons, 43rd Annual Meeting Vancouver
1993 "Tumors of the Cavernous Sinus" Annual Meeting of the American Association of Neurological Surgeons
Boston
1993 "Cranio-Cervical Junction" Annual Meeting of the American Association of Neurological Surgeons Boston 1993 "Intraoperative Monitoring" Annual Meeting of the American Association of Neurological Surgeons
Boston
1992 "Brain Tumors" Harvard Medical School, Department of Continuing Education Boston
1992 "W. Lougheed Microsurgical Course" University of Toronto, Toronto