The Laboratory for Tissue Engineering and Advanced Biomaterials at Southern Illinois University School of Medicine (SIU SOM) is headed by Dr. Saadiq El-Amin. Tissue engineering is emerging as a potential solution to many high demand tissue and organ transplantations as well as a multitude of other cutting edge applications including drug delivery and biomaterials formulation.
The Tissue Engineering Lab at SIU SOM has a dual focus on both regenerative medicine (tendon, bone and ligament) and tissue engineering projects. The Laboratory for Tissue Engineering and Advanced Biomaterials includes a polymer synthesis laboratory, a tissue culture laboratory, office space as well as a future imaging laboratory. Within the scope of the lab’s work, the improvement or replacement of biological functions is accomplished through the use of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors.
Current and future projects with which the lab is involved include collaborations with the Orthopaedics, OBGYN, Oncology, and Medical Microbiology, Immunology and Cell Biology departments.
Basic Science Research
Evaluation of non-functionalized single walled carbon nanotubes (SWCNT) composites for bone tissue engineering
This project incorporates SWCNT in poly-lactic-co-glycolic acid (PLAGA) to form SWCNT/PLAGA composites. Hypothesis: addition of SWCNT to PLAGA will increase the cell proliferation rate and mechanical strength of the composites, and the composites are non-toxic and biocompatible in-vivo (tested subcutaneously in rats).
Tissue engineered human anterior cruciate ligament derived cellular patch for partial ACL repair
The lab developed a protocol for the surgical retrieval, isolation and in-vitro expansion of the human ACL derived cells (hACL) obtained from discarded tissue. The lab then developed a patch using an engineered 2D matrix infused with hACL derived cells to augment a partial ACL repair and strengthen the torn ligament.
Tissue engineered meniscus
In this project the lab will develop a hydrogel based non-biodegradable tissue engineered meniscus for replacing meniscus.
Previous research projects conducted by orthopaedic residents
Stuart Blankenship MD
The relationship of the coracoid to the glenoid and humerus: an MRI study
Coracoid impingement is a well-described cause of anterior shoulder pain. However, there is some controversy about the diagnosis and treatment of patients with suspected coracoid impingement. The purpose of this study was to evaluate the normative values between the coracoid, glenoid and humerus; characterize coracoid shape and provide parameters to evaluate coracoid impingement and associated rotator cuff tears. This study characterized the morphology of the coracoid on MRI and evaluated parameters to predict subcoracoid impingement. Curved coracoids are more likely to have an anterosuperior rotator cuff tear, while flat coraoids are less likely to have an associated rotator cuff tear. This study can help guide surgery for anterosuperior rotator cuff tears and subcoracoid impingement.
Ryan Dabbs, MD
Driving under the influence of narcotics
Narcotic overuse has become a significant public health and safety concern. This review reports the incidence of narcotic intoxication in motor vehicle drivers of declared trauma activations at the Southern Illinois Trauma Center from 2008 to 2012. Over 26% of motor vehicle drivers arriving directly as declared traumas to the center tested positive for narcotics. As some patients received narcotic pain medication before urine or blood was collected for toxicology, only 14% of motor vehicle drivers could be confirmed as opioid positive at the time of injury. In comparison, a query of the trauma database during the same time period revealed a 20.5% incidence of alcohol intoxication with blood alcohol level greater than 0.08 in motor vehicle drivers of declared traumas. With the rising prevalence of narcotic use, awareness of driving under the influence of drugs is as critical as drunk driving awareness. We recommend further research on drugged driving as well as encourage renewed prescriber caution when dealing with opioid medications.
Brian Dahl, MD
Acetabular reconstruction in revision total hip arthroplasty: maximizing function and outcomes in protrusion and cavitary defects
The purpose of this study was to investigate the efficacy of ultrasonography to confirm Schanz pin placement in a cadaveric model, and the inter-observer repeatability of the ultrasound methodology. The investigation is a repeated measures cadaveric study with multiple examiners. Despite the statistical imparity of pin protrusion measurement via ultrasound compared to that of gross dissection, a consideration of the clinical relevance of ultrasound measurement bias during an austere operating theatre leads to the conclusion that ultrasonography is an adequate methodology for Schanz pin protrusion measurement.