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Orthopaedic Research Program - Types of Research

SIU School of Medicine’s resident research falls under two types of categories:

microscope in the Tissue Engineering labBasic science research is where scientists study the cellular or molecular level of disease.
The Laboratory for Tissue Engineering and Advanced Biomaterials at Southern Illinois University School of Medicine (SIU SOM) is headed by Dr. Saadiq El-Amin.  Tissue engineering is emerging as a potential solution to many high demand tissue and organ transplantations as well as a multitude of other cutting edge applications including drug delivery and biomaterials formulation.  The Tissue Engineering Lab at SIU SOM has a dual focus on both regenerative medicine (tendon, bone and ligament) and tissue engineering projects.  The Laboratory for Tissue Engineering and Advanced Biomaterials includes a polymer synthesis laboratory, a tissue culture laboratory, office space as well as a future imaging laboratory.  Within the scope of the lab’s work, the improvement or replacement of biological functions is accomplished through the use of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors.  Current and future projects with which the lab is involved include collaborations with the Orthopedics, OBGYN, Oncology, and Medical Microbiology, Immunology and Cell Biology departments. 

Clinical & Translational

Under the guidance of Dr. Khaled J Saleh, both clinical and translational research occurs at SIU SOM.
Clinical research is patient-oriented research, in which the researcher interacts with human subjects directly. At SIU SOM, the main type of clinical research is completed through clinical trials. Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. ClinicalTrials.gov includes both interventional and observational types of studies. Interventional studies are those in which the research subjects are assigned by the investigator to a treatment or other intervention, and their outcomes are measured.  Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.


Translational research is patient-oriented research that encourages and embraces technological and biomedical innovation. As such, translational research incorporates two areas of research: apply the findings from the lab to clinical practice AND from clinical practice to the community.
For examples of SIU SOM clinical and translational research, click on the links below.
Research Accomplishments