Curriculum Vitae

Joseph C. Milbrandt, Ph.D.
Research Associate Professor
Email: jmilbrandt@siumed.edu

Southern Illinois University School of Medicine
Department of Surgery, PO Box 19638
Springfield, IL 62794-9638
Phone: (217) 545-7811

EDUCATION

• 1996-1998 Clinical Research Fellowship, Clinical Pharmacology
  University of Illinois College of Medicine, Peoria, IL
• 1991-1995 Doctorate of Philosophy, Pharmacology
  Southern Illinois University School of Medicine, Springfield, IL
• 1987-1991 Bachelor of Science, Zoology/Chemistry (minor)
  Eastern Illinois University, Charleston, IL

FACULTY APPOINTMENTS

• 2005-Present Research Associate Professor, Surgery
  Southern Illinois University School of Medicine, Springfield, IL
• 1998 – Present Adjunct Assistant Professor, Clinical Pharmacology and Clinical Assistant Professor, Neurology.
  University of Illinois College of Medicine, Peoria, IL

PROFESSIONAL EXPERIENCE

• 2005- Present Research Associate Professor,
  Department of Surgery
  Southern Illinois University School of Medicine, Springfield, IL
• 2000 – 2005 Director, Clinical Investigation
  OSF Saint Francis Medical Center, Peoria, IL
• 2002 – 2005 Co-Leader for Research, Research Education and Innovation Team
  Member, Implementation Team.
  Peoria NEXT, Peoria, IL
• 1998 – 2000 Neuroscience Research Coordinator
  OSF Saint Francis Medical Center, Peoria, IL
• 1996 – 1998 Clinical Pharmacology Fellowship
  Department of Biomedical and Therapeutic Sciences
  University of Illinois College of Medicine at Peoria, Peoria, IL
• 1995 – 1996 Research Associate, Department of Pharmacology
  Southern Illinois University School of Medicine, Springfield, IL
  

CLINICAL RESEARCH EXPERIENCE

• Oversight, facilitation, and management of Clinical Research Office and Department.
• Supervision of research staff coordination and activities for more than 30 clinical research projects.
• Co-Investigator on more than 30 clinical research studies.
• Clinical trial contracts review and facilitation for more than 100 studies.
• Statistical analysis and study design support for multiple Medical Center and University Departments.
• Formal training and experience in clinical trial protocol design, FDA and IRB rules and regulations, and IRB submissions. Course work:
• Clinical Trial Methodology, Advanced Pharmacokinetics, Statistics, Phamacogenetics, Research Techniques in Cellular Pharmacology, and Short Course in Clinical Trials.
• Data Safety Monitoring Committee.
• Collaboration, development, and conduct of clinical studies involving head trauma, dementia, hypertension, lipid disorders, MS, stroke, immune suppression, wound healing.
  

PROFESSIONAL SERVICE

• Surgery Research Committee
• Reviewer - UICOM-P Children’s Miracle Network Grant Review Committee
• Reviewer - UICOM-P Resident Research Review Committee
• Member, Peoria Community Institutional Review Board, 1999-2005
• IRB Liaison Committee, 2003-2005
• Organization of Annual OSF SFMC/UICOM-P Resident Research Day, 2004-present
• Medical Student Candidate Interviewer, 2001-present
• Member, Grant Procurement Team, OSF SFMC, 2002-2005
• Ad hoc reviewer, STROKE
• HIPAA Implementation Team, 2002-2003
• Clinical Effectiveness Team, OSF SFMC, 2001-2002
• Clinical Process Improvement, Stroke Team, OSF SFMC, 1999-2000
  

PROFESSIONAL ASSOCIATIONS AND MEMBERSHIPS

• Member/Consultant, The Council of Healthcare Advisors, 2003-present
  
  º Drug/Device development and technology consulting for investment organizations.
• Association of Clinical Research Professionals, 2000-present
• Stroke Council, American Heart Association, 1999-present
• Association for Research in Otolaryngology (ARO), 1994-present
• Society for Neuroscience, 1993-present
  

PUBLICATIONS AND ABSTRACTS

PEER REVIEWED PUBLICATIONS:

1. Braun, RM, RE Bertino, JC Milbrandt, M Bray. Duplex Imaging of Carotid Artery Stenosis: An Analysis of the SRU Consensus Criteria. Ultrasound Quarterly (In press)
2. Duellman, TJ, C Gaffigan, JC Milbrandt, DG Allan. Multi-modal, Pre-emptive Analgesia Decreases the Length of Hospital Stay Following Total Joint Arthroplasty. orthopaedics (In press)
3. Kopec M, JC Milbrandt, N Kohut, B Kern, DG Allan. Effect of Cement Viscosity and Set Time on Cement Mantle in Total Knee Arthroplasty. Am. J. Ortho (In press).
4. Richardson, TD, SJ Pineda, KB Strenge, TA Van Fleet, M MacGregor, JC Milbrandt, JA Espinosa, P Freitag. (2008) Serum Titanium Levels after Instrumented Spinal Arthrodesis. Spine 33(7):792-6.
5. Allan, DG, R Trammell, B Dyrstad, B Barnhart, JC Milbrandt. (2007) Serum Cobalt and Chromium Elevations Following Hip Resurfacing with the Cormet 2000 Device. J. Surg Ortho Adv.16 (1):12-18.
6. Graumlich JF, Blough LS, McLaughlin RG, Milbrandt JC, Calderon CL, Agha SA, Scheibel LW. (2003) Healing Pressure Ulcers with Collagen or Hydrocolloid: A Randomized, Controlled Trial. Am Geriatr Soc. 51(2):147-154.
7. Milbrandt, JC, TM Holder, MC Wilson, RJ Salvi, DM Caspary. (2000) GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma. Hearing Research 147:251-260.
8. Wang, DZ, JA Rose, DS Honings, DJ Garwacki, JC Milbrandt. (2000) Treating acute stroke patients with intravenous TPA: The OSF Stroke Network Experience. Stroke 31(1): 77-81.
   
9. Caspary, DM, T Holder, LF Hughes, JC Milbrandt, R. McKernan, D.K. Naritoku. (1999) Age-related changes in GABAA receptor subunit composition and function in the rat auditory system. Neuroscience 93: 307-312.
   
10. Nakiyama, M, DM Caspary, HR Konrad, JC Milbrandt, RH Helfert. (1999) Age-related changes in [3H]strychnine binding in the vestibular nuclei of rats. Hearing Research 127:103-7.
11. Ryu, JR, PC Jobe, JC Milbrandt, PK Mishra, RW Clough, RA Browning, JW Dailey, DO Seo, KH Ko. (1999) Morphological noradrenergic deficits in GEPR-9s stem from abnormalities in both the locus coeruleus and its target tissues. Experimental Neurology 156: 84-91.
12. Dailey, JW, MEA Reith, KR Steidley, JC Milbrandt, P.C. Jobe. (1998) Carbamazepine-induced release of serotonin from rat hippocampus in vitro. Epilepsia 39(10):1054-63.
    
13. Milbrandt, JC, CH Hunter, DM Caspary. (1997) Alterations of GABAA Receptor Subunit mRNA Levels in the Aged Fischer 344 Rat Inferior Colliculus. J. Comp. Neurol. 379: 455-465.
    
14. Willott, JF, JC Milbrandt, DM Caspary, LS Bross. (1997) Glycine Immunoreactivity and Receptor Binding in the Cochlear Nucleus of C57BL/6J and CBA/CaJ Mice: Effects of Cochlear Impairment and Aging. J. Comp. Neurol. 385:405-414.
    
15. Milbrandt, JC, RL Albin, SM Turgeon, DM Caspary. (1996) GABAA Receptor Pharmacology in the Aging Rat Inferior Colliculus. Neuroscience 73:449-458.
    
16. Wright, SK, FJ Zhao, J Rardin, J Milbrandt, M Helton, NC Furumo (1995) Mechanistic Studies on MDH from Escherichia coli. Arch. Biochem. Biophys. 321:289-296.
    
17. Caspary, DM, JC Milbrandt, RH Helfert (1995) Central Auditory Aging: GABA Changes in the Inferior Colliculus. Exp. Gerontology 30:349-360.
    
18. Milbrandt, JC and DM Caspary (1995) Age-Related Reduction of [3H]Strychnine Binding Sites in the Cochlear Nucleus of the Fischer 344 Rat. Neuroscience 67:713-719.
    
19. Milbrandt, JC, RL Albin, DM Caspary (1994) Age-Related Decrease in GABAB Receptor Binding in the Fischer 344 Rat Inferior Colliculus. Neurobiol. Aging, 15(6):699-703.
    
20. Raza, A, JC Milbrandt, SP Arneric, DM Caspary (1994) Age-Related Changes in Brainstem Auditory Neurotransmitters: Measures of GABA and Acetylcholine Function. Hearing Res., 77:221.

PUBLICATIONS FROM PARTICIPATION IN CLINICAL TRIALS:

1. Sacco, RL, JT DeRosa, EC Haley, B Levin, P Ordronneau, SJ Phillips, T Rundek, RG Snipes, JLP Thompson, and the GAIN Americas Investigators. (2001) Glycine Antagonist in Neuroprotection for Patients With Acute Stroke: GAIN Americas: A Randomized Controlled Trial. JAMA 285(13):1719.

INVITED COMMUNICATIONS:

1. Wang, DZ, JA Rose, DS Honings, JC Milbrandt. (2000) tPA: A Rural Network Experience. Stroke 31:1457. (Letter to the Editor)
2. Wang, DZ, JA Rose, JC Milbrandt. (1998) OSF Stroke Network, exploring the way of community stroke care. The Stroke Interventionist 1(4):11-13.

ABSTRACTS AT SCIENTIFIC MEETINGS:

1. Richardson T, S Pineda, JC Milbrandt, KB Strenge, T Van Fleet, J Espinosa, P Freitag. Serum Titanium Concentrations are Elevated in Patients Treated with Spinal Instrumentation. AOA-COA Combined Annual meeting. June 2008
   
2. Allan DG, BK Parsley, B Dyrstad, JC Milbrandt. Serum Cobalt and Chromium Concentrations in Bilateral versus Unilateral Hip Resurfacing. AOA-COA Combined Annual meeting. June 2008
   
3. Allan DG, L Rylander, A Wallace, JC Milbrandt. Clinical Outcome following Metal-On-Metal Hip Resurfacing Arthroplasty: A Single-Center Experience.Mid America Orthopeadic Association. April 2008.
   
4. Allan DG, BK Parsley, B Dyrstad, JC Milbrandt. Serum Cobalt and Chromium Levels in Patients with Bilateral versus Unilateral Hip Resurfacing. Mid America Orthopeadic Association. April 2008.
   
5. Allan DG, A Rainville, J Sams, J Bullard, JC Milbrandt. Emergent Versus Elective Revision Total Hip Arthroplasty. Mid America Orthopeadic Association. April 2008.
   
6. Allan, DG, JC Milbrandt, KK Trier, M Naughton. Metal-on-Metal Hip Resurfacing: Appropriate Patient Selection is Essential. AAHKS Annual Meeting, Dallas, TX. 2007.
   
7. T. Richardson, S. Pineda, K.B. Strenge, M. MacGregor, T. Van Fleet, J.C. Milbrandt, P. Freitag. Serum Titanium Levels after Instrumented Spinal Arthrodesis. North American Spine Society Annual Meeting, October 2007.
   
8. Allan DG, BK Parsley, B Dyrstad, JC Milbrandt. Serum Cobalt and Chromium Levels after Hip Resurfacing with the Cormet 2000: Gender and Head Size Differences. AOA Annual Meeting, Asheville, NC, June 2007.
   
9. Allan DG, B Dyrstad, BK Parsley, JC Milbrandt. Intra- and Post-operative Fractures following Revision surgery with the Biomet Orthopaedic Salvage System (OSS) and the Maxim Revision Knee System. COA Annual Meeting, Halifax, June 2007.
   
10. Allan DG, A Rainville, B Dyrstad, JC Milbrandt Acumatch Modular Femoral Stem in Primary and Revision Hip Arthroplasty in Patients over the Age of 75. COA Annual Meeting, Halifax, June 2007.
    
11. Allan DG, JC Milbrandt, M Naughton. Metal-on-Metal Hip Resurfacing: Patient Selection and Gender Impacts Failure Rates. COA Annual Meeting, Halifax, June 2007.
    
12. Allan DG, BK Parsley, B Dyrstad, JC Milbrandt. Serum Cobalt and Chromium Levels after Hip Resurfacing with the Cormet 2000: Effects of Gender and Femoral Head Size. COA Annual Meeting, Halifax, June 2007.
    
13. Allan DG, B Dyrstad, H Eltrevoog, D Harris, JC Milbrandt. Are Honors Received During Surgery Clerkships Useful in the Selection of Incoming Residents? AOA Annual Meeting, Asheville, NC, June 2007.
    
14. Richardson T, Pineda S, Strenge KB, MacGregor M, Van Fleet T, Milbrandt JC, Freitag P. Serum Titanium Levels in Patients Treated with Titanium Spinal Instrumentation. Mid-America Orthopaedic Association: Annual Meeting. Boca Raton, FL, April, 2007.
    
15. Allan, DG, Parsley, BK, Dyrstad, B, Milbrandt, JC. Serum Cobalt and Chromium Levels Following Hip Resurfacing with the Cormet 2000: Effects of Femoral Head Size. Mid-America Orthopaedic Association: Annual Meeting. Boca Raton, FL, April, 2007.
    
16. Allan DG, Dyrstad B, Eltrevoog H, Harris D, Milbrandt JC. Percentage of Honors Awarded in Surgery Clerkships. Mid-America Orthopaedic Association: Annual Meeting. Boca Raton, FL, April, 2007.
    
17. Allan, DG, Dyrstad, B, Parsley, BK, Milbrandt, JC. Evaluation of the Biomet Orthopaedic Salvage System (OSS) or Maxim Revision Knee System: Intra- and Post-operative Fracture Rates. Mid-America Orthopaedic Association: Annual Meeting. Boca Raton, FL, April, 2007.
    
18. Allan DG, Naughton, M, Milbrandt, JC. Metal-on-Metal Hip Resurfacing: Importance of Patient Selection. Mid-America Orthopaedic Association: Annual Meeting. Boca Raton, FL, April, 2007.
    
19. Allan DG, Dyrstad B, Milbrandt, JC. Effects of Femoral Head Size on Serum Cobalt and Chromium Levels Following Hip Resurfacing with the Cormet 2000. AAOS, San Diego, CA, February, 2007.
    
20. Allan DG, Dyrstad B, Payne, TJ, Milbrandt, JC. Clinical Experience with Selective Patellar Resurfacing with the NexGen Legacy Posterior Stabilized (LPS). AAOS, San Diego, CA, February, 2007.
    
21. Allan DG, Dyrstad B, Payne TJ, Milbrandt JC. Selective Patellar Resurfacing with the NexGen Legacy Posterior Stabilized (LPS). Mid-America Orthopaedic Association: Annual Meeting. Boca Raton, FL, April, 2007.
    
22. Allan DG, Parsley BK, Dyrstad B, Trammell, R, Milbrandt, JC. Elevation of Serum Cobalt and Chromium Levels in Patients with Metal-on-Metal Resurfacing Hip Prostheses: A 3 year follow-up. AAHKS Annual Meeting, Dallas, TX. 2006.
    
23. Fisk, HL, Milbrandt, JC, Zallek, SN. Increase in Physician Sleep Knowledge after an Interactive CME Program: Physician and Non-physician Sleep Knowledge do not differ at Baseline. Annual Meeting of the Associated Professional Sleep Societies, Denver, CO, June 2005.
    
24. Wang, DZ, et al. An Open-Label Prospective Study to Evaluate the Efficacy and Safety of Double or Triple Concentrated Intravenous Nicardipine for Treatment of Hypertension in Patients with Ischemic Stroke, Intracerebral Hemorrhage or Subarachnoid Hemorrhage. American Stroke Association International Stroke Conference Annual Meeting, New Orleans, LA Feb, 2005.
    
25. Wang, H, D Wang, W Olivero, G Lanzino, D Honings, M Rodde, J Burnham, J Milbrandt, J Rose. Selective Brain Hypothermia Can Be Achieved with a Cooling Helmet: Preliminary Findings of the COOL BRAIN–Stroke Trial. American Stroke Association International Stroke Conference Annual Meeting, San Diego, CA Feb, 2004.
    
26. Wang DZ, H Wang, G Lanzino, JA Rose, DS Honings, ML Rodde, JC Milbrandt. Cooling Helmet for Patients with Brain Ischemic and Hemorrhagic Infarctions-the COOL BRAIN-STROKE Trial. Clinical Trial Poster.. American Stroke Association International Stroke Conference Annual Meeting, Phoenix, AZ Feb, 2003.
27. Wang, DZ, K Fraser, B Smouse, J Kumar, M Rodde, D Honings, J Rose, D Garwacki, JC Milbrandt, G Lanzino. Outcome of Intra-arterial TPA for Patients with Acute Middle Cerebral Artery Occlusion-The OSF Stroke Center Experience. Annual Conference of the American Academy of Neurology. Honolulu, Hawaii, 2003.
28. Wang, DZ, JA Rose, JC Milbrandt, M Rodde, DS Honings, J Burhnam, J Jahnel. Three month outcome and cost review of TIA patients discharged from the ER with normal MRI/MRA of Brain. American Stroke Association International Stroke Conference Annual Meeting, Phoenix, AZ, 2003
    
29. JF Graumlich, LS Blough, RG McLaughlin, JC Milbrandt, CL Calderon, SA Agha, LW Scheibel. Collagen Versus Hydrocolloid For Pressure Ulcers: Randomized, Controlled Trial. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Atlanta, Georgia, 2002.
    
30. Wang DZ, JA Rose, JC Milbrandt, DS Honings, ML Rodde. Four years of rural stroke care, the OSF Stroke Network experience. American Stroke Association International Stroke Conference Annual Meeting. San Antonio, TX, 2002.
    
31. O Bukhari, JC Milbrandt, MA Husain. A Prospective Evaluation of a Novel MRSA Susceptibility Reporting Method and its Implication on Treatment. Infectious Diseases Society of America Meeting, Chicago, IL 2002.
    
32. Wang, DZ, JA Rose, A Durocher, DS Honings, PJ Tolson, JC Milbrandt. The Predictive Value of NIH Stroke Scale on Discharge Disposition, Length of Stay and Direct Cost for Ischemic Stroke. American Stroke Association International Stroke Conference Annual Meeting, New Orleans, LA, 2000.
    
33. Rose, JA, JC Milbrandt, DS Honings, PJ Tolson, DZ Wang. Impact of an Organized Stroke Team. North American Stroke Conference, Snowmass, CO, 1999.
    
34. Rose, JA, DZ Wang, DS Honings, JC Milbrandt. A model of community stroke network serving 1.5 million people in central Illinois. American Academy of Neurology Abstr. Toronto, Ontario, Canada, 1999.
    
35. . Clough, RW, SR Eaton, MA Merrill, RA Browning, KR Steidley, JC Milbrandt, PK Mishra, PC Jobe, JW Dailey. Primary cell cultures of serotonin and norepinephrine neurons from fetal genetically epilepsy-prone rats (GEPR-3) reveal different arborization capacity. Society for Neuroscience Abstr. Los Angeles, CA, 1998.
    
36. Wang, DZ, JM McLean, JA Rose, D Honings, JC Milbrandt. The outcome of administering r-TPA for acute strokes at OSF comprehensive stroke center. American Stroke Association International Stroke Conference, Orlando, FL, 1998.
    
37. Milbrandt, JC, JL Steenbergen, KR Steidley, RW Clough, PK Mishra, JW Dailey, PC Jobe. Growth of noradrenergic neurons from fetal GEPR locus coeruleus can be influenced by the target tissue: an in vitro study. Society for Neuroscience Abstr. New Orleans, LA, 1997.
    
38. Dailey, JW, KR Steidley, JC Milbrandt, MEA Reith, PC Jobe. Carbamazepine-induced serotonin (5-HT) release from hippocampal slices: mechanism studies. ASPET, 1997 Milbrandt, JC, T Blomquist, DM Caspary. GABAA receptor subunit changes in the inferior colliculus may result in enhanced receptor function in aged rats. Society for Neuroscience Abstr. 531.9 Washington D.C., 1996.
39. . Caspary, DM and JC Milbrandt. Age-related changes in markers of GABA transmission in the rat inferior colliculus. Molecular Mechanisms of Central Auditory Plasticity: Transmitters, Receptors, and Channels, Satellite Symposium, Washington Convention Center, Washington D.C., 1996.
    
40. Caspary, DM, TS Blomquist, MC Wilson, R Salvi, JC Milbrandt. GAD immunoreactivity in the inferior colliculus following acute sound exposure: Loss of inhibition? Association for Research in Otolarygology Abstr., 361, St. Petersburg FL, 1996.
    
41. Willott, JF, JC Milbrandt, DM Caspary. Age related changes in strychnine-sensitive glycine receptors of the dorsal cochlear nucleus (DCN) observed in C57BL/6 mice but not in CBA mice. Association for Research in Otolarygology Abstr., 653, St. Petersburg FL, 1996.
    
42. Helfert, RH, TJS Blomquist, JC Milbrandt, DM Caspary. Excitant amino acid binding and aging in the rat auditory brainstem. Society for Neuroscience Abstr., 166.12, San Diego, CA, 1995.
    
43. Milbrandt JC, C Hunter, DM Caspary. Distribution of GABAA receptor subunit mRNAs in the inferior colliculus of young adult and aged Fischer 344 rats. Society for Neuroscience Abstr., 166.14, San Diego, CA, 1995.
    
44. Nakiyama, M, JC Milbrandt, RH Helfert, HR Konrad, LF Hughes. Age-related changes in [3H]-strychnine binding in the vestibular nuclei of the Fischer-344 rats. Association for Research in Otolarygology Abstr., 285, St. Petersburg FL, 1995.
    
45. Milbrandt JC and DM Caspary. GABAA receptor modulation in the aging Fischer 344 rat inferior colliculus. Association for Research in Otolarygology Abstr., 129, St. Petersburg FL, 1995.
    
46. Caspary, DM and JC Milbrandt. Neurochemical basis of auditory dysfunction with aging. Second International Symposium on Neurobiology and Neuroendocrinology of Aging. Bregenz, Austria 1994.
    
47. Milbrandt JC and DM Caspary. Effects of aging on GABAA and GABAB receptor binding in the inferior colliculus of the Fischer 344 rat. Midwest Neurobiologists, Springfield IL, 1994.
    
48. Milbrandt JC and DM Caspary. Age-related decrease in GABAB receptor binding in the inferior colliculus of the F344 rat. Association for Research in Otolaryngology (ARO), St. Petersburg FL, 1994.
    
49. Milbrandt JC, RL Albin, DM Caspary. Effects of aging on GABAA and glycine receptor binding in the inferior colliculus and cochlear nucleus of the Fischer 344 rat: A quantitative autoradiographic study. Society for Neuroscience, 19:1425, Washington D.C., 1993.
    
50. Milbrandt JC and DM Caspary. Age-related changes of [3H]strychnine binding sites in the cochlear nucleus of the Fischer 344 rat. Midwest Neurobiologists, Chicago IL, 1993.
    
51. Milbrandt JC and NC Furumo. Reinvestigation of the kinetics of malate dehydrogenase from Escherichia Coli. American Chemical Society: Great Lakes Regional Meeting, Indianapolis IN, 1991.