Curriculum Vitae

Larry F. Hughes, Professor

Education

Southern Illinois University, Carbondale, IL. B.A. 1968 Psychology
Tulane University, New Orleans, La. M.S. 1971 Exp. Psychology
Tulane University, New Orleans, La. Ph.D. 1972 Exp. Psychology

Professional Experience

• 1972-1976 Assistant Professor
  
• 1976-1983 Associate Professor
  
• 1983-1986 Professor, Department of Otorhinolaryngology and Biocommunications, Kresge Hearing Research Laboratory of the South, Louisiana State University Medical Center New Orleans, Louisiana, with joint appointments in the Department of Audiology and Speech Pathology, School of Allied Health Professions, and the Department of Psychology, University of New Orleans, New Orleans, Louisiana.
  
• 1987-1989 Professor, Department of Psychology, MacMurray College, Jacksonville, Illinois with a joint appointment in the Department of Educational Administration, Sangamon State University, Springfield, Illinois.
  
• 1990 - Research Professor, Southern Illinois University School of Medicine, Department of Surgery/Otolaryngology, Neurology, Psychiatry, and Center for Alzheimer Disease and Related Disorders with a joint appointment at the Department of Psychology, University of Illinois at Springfield, Springfield, Illinois and MacMurray College Jacksonville, Illinois.
  

Research Support

Ongoing Research Support

• R01 DC00151 Caspary (PI) 7/1/02 - 6/30/07
  NIH/NIDCD Coding in Auditory Neurons: Effects of Amino Acids
  The objectives of this project are to determine how inhibitory amino acids function within known brainstem auditory circuits to encode acoustic information, and the impact of aging on inhibitory amino acid neurotransmission in the auditory brainstem.
  Role: Co-Investigator
• R01 DC00151 Rybak (PI) 4/1/99 - 3/31/04
  NIH/NIDCD Endogenous Modulation of Cisplatin Ototoxicity
  The objectives of this project are to determine the impact of endogenous antioxidants upon ototoxicity in the cochlea.
  Role: Co-Investigator
• R01 NS-40220 Toth (PI) 5/1/02 - 4/30/07
  NIH Influenza induced changes in Somnolence
  The objectives of this project are to identify the gene(s) that effect influenza induced changes in the pattern of sleep in genetically inbred strains of mice.
  Role: Co-Investigator
• Excellence in Academic Medicine Award Hughes (PI) 01/01/04 – 12/31/05
  IDPH Aging and Acoustic Coding across layers of Auditory Cortex.
  The objectives of this project are to characterize age-related layer-specific changes in response properties of the auditory cortex.
  Role: Principal Investigator
  

Selected Recent Bibliograph.

Selected peer-reviewed publications (36 of 72).

1. Hughes, L.F. Effects of varied response modes upon dichotic consonant-vowel identification latency. Brain and Language, 5:301-309, 1978.
2. Mouney, D.F., Berlin, C.I., Cullen, J.K.,Jr., and Hughes, L.F. Changes in human eighth nerve action potential as a function of stimulation rate. Archives of Otolaryngology, 104:551-554, 1978.
3. Mirabile, P.J., Porter, R.J., Jr., Hughes, L.F., and Berlin, C.I. Dichotic lag effect in children 7 to 15. Developmental Psychology, 14(3):277-285, 1979.
4. Hughes, L.F. and Holtzapple, P. Temporal-order judgments of speech and noise stimuli by normal and brain-injured subjects. Speech Communication Papers. Acoustical Society of America: New York, New York, Pp 583-586, 1979.
5. Hughes, L.F., Tobey, E.A., and Miller, C.J. Temporal aspects of dichotic listening in brain-damaged subjects. Ear and Hearing, 4:306-310, 1984.
6. Hughes, L.F., and Miller, C.J. The measurement of Performance Asymmetries with Dichotic Stimulus Presentation. Ear and Hearing,5(3):175-177, 1984.
7. Meyers, S.C., Hughes, L.F., and Zahrl, S.G. Temporal-phonemic processing skills in adult stutterers and nonstutterers. Journal of Speech and Hearing Research, 32:274-280, 1989.
8. Santos, P.M., Hall, R.A., Hughes, L.F., Snyder, J.M., Dobie, R.A. Diuretic and Diet effect on Meniere's Disease, evaluated by the 1985 Committee on Hearing and Equilibrium Guidelines. Otolaryngology - Head and Neck Surgery, 109(4): 680-689,1993.
9. Brilliant, M., Hughes L.F., Anderson D., Ghobrial M., Elble R. Rarefied White Matter in patients with Alzheimer Disease. Alzheimer Disease and Associated Disorders 9(1): 39-46, 1995.
10. Struble, R.G., Hughes, L.F., and Clark, B.R. Olfactory Bulb Degeneration in Aging and Alzheimer Disease. In: Development Growth and Senescence in the Chemical Senses. 1996.
11. Wortsman, J., and Hughes, L.F. Olfactory Function in a Fertile Eunuch with Kallmann Syndrome. American Journal of the Medical Sciences. 311:(3),1996.
12. Campbell, K.C.M., Naritoku, D.K., Evans, M.S., Hughes, L.F., Rybak, L.P. Is valproic acid ototoxic? American Journal of Audiology,5,7-10,1996.
13. Campbell, K.C.M., Rybak, L.P., Meech, R.P., Hughes, L.F., D-Methionine Provides Excellent Protection from Cisplatin Ototoxicity in the Rat. Hearing Research ,102,90-98,1996.
14. Krenning, J., Hughes, L., Caspary, D., Helfert, R., (1998). Age-Related Glycine Receptor Subunit Changes in the Cochlear Nucleus of Fischer-344 Rats. The Laryngoscope , 108: 26-31.
15. Meech, R.P., Campbell, K.C.M., Hughes, L.F., Rybak, L.P., (1998). A Semiquantitative Analysis of the Effects of Cisplatin on the Rat Stria Vascularis. Hearing Research , 124: 44-59.
16. Helfert, R.H., Sommer, T.J., Meeks, J., Hofstetter, P., Hughes, L.F., (1999). Age-Related Synaptic Changes in the Central Nucleus of the Inferior Colliculus of Fischer-344 Rats. Journal of Comparative Neurology, 406:285-298.
17. Caspary, D.M., Holder, T., Hughes, L.F., Milbrant, J., McKernan, R., Naritoku, D.K., (1999). Age-related changes in GABAA receptor subunit composition and function in the rat auditory system. Neuroscience, 93:307-312.
18. Abbot,S., Hughes, L.F., Bauer, C.A., Salvi, R., Caspary, D.M., (1999) Detection of glutamate decarboxylase isoforms in rat inferior colliculus following acoustic exposure. Neuroscience, 93:1375-1381.
19. Campbell, K.C.M., Meech, R.P., Rybak, L.P., Hughes, L.F. (1999) D-Methionine protects against cisplatin damage to the stria vascularis. Hearing Research, 138:13-28.
20. Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. (2001) Pentagon copying is more impaired in dementia with Lewy bodies than in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 70(4):483-8.
21. Sato T, Wilson TS, Hughes LF, Konrad HR, Nakayama M, Helfert RH. (2001) Age-related changes in levels of tyrosine kinase B receptor and fibroblast growth factor receptor 2 in the rat inferior colliculus: implications for neural senescence. Neuroscience 103,(3):695-702.
22. Hughes, Larry F., Struble, Robert G., Shaffer, Carla L. (2001) Olfaction in elderly and Alzheimer patients: differing feedback conditions. Journal of Alzheimer’s Disease 3,(4):367-375.
23. Caspary DM, Palombi PS, Hughes LF. (2002) GABAergic inputs shape responses to sinusoidally amplitude modulated stimuli in the chinchilla inferior colliculus. Hearing Research 168(1-2):163-73.
24. Lange R, Donathan CL, Hughes LF. (2002) Assessing Olfactory Abilities with the University of Pennsylvania Smell Identification Test: A Rasch Scaling Approach. Journal of Alzheimer’s Disease;4(2):77-91.
25. Hughes LF, Donathan CL, Smith T, McAsey ME, Conney PJ, Struble RG. (2002) Effects of HRT on olfactory sensitivity: cross-sectional and longitudinal studies. Climacteric;5:122-134.
26. Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. (2002) The Mini-Mental State exam helps in the differentiation of Alzheimer and Lewy body dementias. International Journal of Geratrics and Psychiatry;17:503-509.
27. Helfert RH, Glatz FR III, Wilson TS, Ramkumar V, Hughes LF. (2002) Hsp70 in the Inferior Colliculus of Fisher-344 Rats: Effects of Age and Noise Exposure. Hearing Research; 170(1-2):155-65.
28. Le Prell CG, Shore SE, Hughes LF, Bledsoe, SC Jr. Disruption of lateral efferent pathways: Functional changes in auditory evoked responses. Journal of the Association for Research in Otolaryngology 2003;4(2):276-290.
29. Klemens JJ, Campbell KCM, Meech RP, Hughes LF, Somani S. Anti-oxidant Levels Inversely Co-vary with HearingLoss After Amikacin Treatment. Journal of the AmericanAcademy of Audiology: Special Edition on Ototoxicity 2003;14(3):134-143.
30. Campbell KCM, Larsen DL, Meech RP, Rybak LP, Hughes LF. Glutathione Ester But Not Glutathione Protects Against Cisplatin-Induced Ototoxicity in a Rat Model. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 2003;14(3):124-133.
31. Campbell KCM, Kelly E, Targovnik N, Hughes LF, Van Saders C, Gottleib AB, Dorr MB, Leighton A. Audiologic Monitoring for Potential Ototoxicity in a Phase I Clinical Trial of a New Glycopeptide Antibiotic. Journal of theAmerican Academy of Audiology: Special Edition on Ototoxicity 2003;14(3):157-169.
32. Campbell KCM, Meech RP, Rybak LP, Hughes LF. The Effect of D-Methionine on Cochlear Oxidative State with and without Cisplatin Administration: Mechanisms of Otoprotection. Journal of the American Academy of Audiology: Special Edition on Ototoxicity 2003;14(3):144-156.
33. Helfert R, Krenning J, Wilson TS, Hughes LF. Age-related synaptic changes in the anteroventral cochlearnucleus of Fischer-344 rats. Hearing Research 2003;183(1-2):18-28.
34. Krishna S, Hughes LF, Lin SY. Postoperative Hemorrhage With Nonsteroidal Anti-inflammatory Drug Use After Tonsillectomy: A Meta-analysis. Arch Otolaryngol Head Neck Surg. 2003;129(10):1086-9.
35. Hughes LF, Perkins K, Wright BD, Westrick H. Using a Rasch scale to characterize the clinical features of patients with a clinical diagnosis of uncertain, probable, or possible Alzheimer disease at intake. Journal of Alzheimer’s Disease 2003;5(5):367-373.
36. Ramkumar V, Whitworth CA, Pingle SC, Hughes LF, Rybak LP. Noise induces A(1) adenosine receptor expression in the chinchilla cochlea. Hear Res. 2004 Feb;188(1-2):47-56.