Laboratory for Regenerative Medicine and Applied Sciences

  • Mission
  • Current Research Projects
  • Recent Publications
  • Community and Outreach
  • Research Staff and Faculty


The long term goal of The Laboratory for Regenerative Medicine and Applied Sciences is to develop a functional hybrid graft to heal full thickness skin defects and explore the potential of epithelial derived stem cells (LGR5+ and  LGR6+) for burns, neuropathic ulcers, and hair regeneration.

We are also exploring the potential of merging TRAIL therapy with conventional  breast reconstruction procedures to eliminate breast cancer recurrence after mastectomy.


  1. Bioenginnered  Skin: An Approach To Heal Full Thickness Skin Defects

    Goal: To develop a three dimensional (3-D) full thickness bioengineered skin to heal full thickness skin defects by providing complete closure and protection of wounds, with augmented wound healing and neovascularization at the injury site along with the development of nascent hair follicles.

  2. Human Hair Regeneration: A Cure for Male Pattern Baldness

    Goal: To produce de novo human hair follicles from LGR5 stem cells for a potential long term treatment for male pattern baldness.

  3. A Microbiologic Comparison of Acellular Dermal Matrices as an Aseptic Reconstructive Material and a Scaffold for Stem Cell In- growth

    Goal: To perform a microbiologic assessment of different Acellular Dermal Matrices (ADM) that are commonly used during reconstructive surgeries

  4. The TRAIL Flap: Bridging the Gap Between Breast Cancer Treatment and Reconstruction via a Gene Therapy Flap

    Goal: To determine if the TRAIL flap will be able to deliver anti-cancer therapy to a local tumor bed, which will limit systemic side effects.

  5. Development of a Chimeric Free Flap for Soft Tissue Coverage Following Burns, Trauma, Chronic Wounds and Cancer Resection

    Goal: To pursue clinical use of epithelial stem cells in chronic wounds, burns and poly-trauma and develop a method of soft tissue coverage utilizing chimeric free flap allografts.

  6. Therapeutic Fat Grafting: Breast Cancer Treatment and Reconstruction

    Goal: To determine the oncological safety of lipofilling/fat grafting.

  7. ADSC Potentiates Tissue Reorganization/Repair – Radiated Expansion

    Goal: To measure the effects of irradiation on tissue regeneration by evaluating ADSC differentiation into regenerative skin components and quantifying ADSC paracrine secretion of growth hormones.

Recent Publications

  1. Lough DM, Yang M, Blum A, Reichensperger JD, Cosenza NM, Wetter N, Cox LA, Harrison CE, Neumeister MW. Transplantation of the LGR6+ epithelial stem cell into full-thickness cutaneous wounds results in enhanced healing, nascent hair follicle development, and augmentation of angiogenic analytes. Plast Reconstr Surg. 2014 Mar;133(3):579-90. doi: 10.1097/PRS.0000000000000075.
  2. Lough D, Dai H, Yang M, Reichensperger J, Cox L, Harrison C, Neumeister MW. Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Hman Alpha Defensin 5 Results in Deceased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissue Devoid of Adnexal Structures. Plast Reconstr Surg 2013 Nov 132(5):1159-1171.
  3. Liu G, Neumeister MW, Reichensperger J, Yang RD. Therapeutic potential of human adipose stem cells in a cancer stem cell-like gastric cancer cell model. Int J Oncol 2013 oct;43($): 1301-9.
  4. Derby BM, Reichensperger J, Chambers C, Bueno RA, Suchy H, Neumeister MW. Early Growth Response Factor-1: Expression in a Rabbit Flexor Tendon Scar Model. Pla Reconstr Surg 2012 Mar;129(3):435e-442e.
  5. Roth V, Herron MS, Bueno RA, Chambers CB, Neumeister MW. Stimulating AAngiogenesis by Hyperbaric Oxygen in an Isolated Tissue Construct. Undersea Hyperb Med 2011 Nov-Dec 38(6):509-14.
  6. Cooney, DS, Chambers CB, Suchy H, Hornick MC, Reichensperger J, Neumeister MW. Transgene Expression in a Model of Composite Tissue Allotransplantation. Plast Reconstr Surg 2010 Mar: 125(3): 837-845.

Introduction to Microvascular Surgery
Elective for 4th year Medical Students

Microsurgery skills lab for Urology residents

High School/College Student Tours of Microsurgery Lab


Michael W. Neumeister, MD, FRCSC, FACS
Chief, Microsurgery & Research, SIUSOM
Director, Wound Care Center, Memorial Medical Center, Springfield, IL
Department of Surgery - Vice Chairman of Research, SIUSOM
Professor, SIUSOM
Chairman of Plastic Surgery, SIUSOM
Program Director – Hand/Micro Surgery Fellowship, SIUSOM
Director, Regional Burn Center, Memorial Medical Center, Springfield, IL
Medical Director – Baylis Outpatient Surgery Center, Springfield, IL
Chairman of Surgery, SIUSOM Microsurgery

1984- B.S. in Physiology/Pharmacology - University of Western Ontario, London, Ontario, Canada 1988- M.D. - University of Toronto, Ontario, Canada  
1996- Residency in Plastic Surgery - University of Manitoba, Winnipeg, Manitoba, Canada
1996- Fellowship in Microsurgery- Harvard University, Brigham and Women’s Hospital, Boston, MA
1997- Fellowship in Hand Surgery/Microsurgery - Southern Illinois University School of Medicine,  Springfield, IL  

Phone: 217.545.7018

Ashim Gupta, M.S., Ph.DAshim Gupta, M.S., Ph.D
Director Laboratory for Regenerative Medicine and Applied Sciences
Research Assistant Professor

2008- B.Pharm- Delhi Institute on Pharmaceutical Sciences and Research, University of Delhi, Delhi, India
2009- PDCR (Professional Diploma in Clinical Research)-Catalyst Clinical Services Pvt.Ltd., Delhi, India
2010- M.S. - SIU SOM
2014- Ph.D. – SIU SOM

Phone: 217.545.3862

Carrie Harrison, B.S.Carrie Harrison, B.S.
Research Laboratory Coordinator

Education: 1998- B.S. Clinical Laboratory Science- University of Illinois Springfield, Springfield, IL

Phone: 217.545.3862

Lisa Cox, B.S.Lisa Cox, B.S.
Researcher IV - Director of Animal Studies

Education: 1995 - B.S. in Life Sciences from Napier University in Edinburg, UK

Phone: 217.545.3862

Joel Reichensperger, B.S.Joel Reichensperger, B.S.
Researcher III - Cell Culture

Education: 1996- B.S. Biology from Illinois State University, Normal, IL

Phone: 217.545.7309




SIU School of Medicine
Laboratory for Regenerative Medicine and Applied Sciences
801 N. Rutledge
Room 3254
Springfield, IL 62794