FAQ's -The best treatments for Prostate Cancer when first discovered?

1. Q: Do you feel that a radical prostatectomy offers the best chance for a "cure" of prostate cancer?

A: Yes, we do. That belief is based upon my our published results, the research literature, our own prostate cancer screening studies, and our collective professional experience.

2. Q: How can the Urologists at SIU be reached?

A: Our telephone number for scheduling surgeries is: 217-545-8000.

3. Q: What is the recovery time following a radical prostatectomy?

A: Usually, the patient is in the hospital for 1 to 2 days. The catheter remains for 10 days. No vigorous exercise should be performed for 6 weeks. The patient can return to work after 3 or 4 weeks, but he usually tires easily for the first 6-8 weeks.

4. Q: What is the survival rate of prostate cancer patients treated with radical prostatectomy?

A: In the most recent tabulation of surgical patients, now including more than 4,400 men, the 10-year prostate cancer-specific survival rate is 96%. This statistic means that whether or not there has been a recurrence of the prostate cancer, only 4% of men died of prostate cancer before 10 years after surgery. 5.

Q: How can I go about finding a good surgeon?

A: We cannot recommend specific surgeons in particular areas of the country in this forum, but we recommend that you ask physicians in your community whom they would recommend and also that you check at some of the high-volume prostate cancer centers for information about their surgeons. You want to know how frequently they perform nerve-sparing surgery and how many surgeries they’ve performed. Most doctors do not keep statistics on their operations, but we think it is reasonable to ask to talk with 10 previous patients of that doctor. Most surgeons should have a list of patients who have given their consent to be contacted by potential patients.

6. Q: Once prostate cancer is diagnosed, how long is it safe to wait before having surgery to remove the prostate?

A: It is impossible to tell how long is safe. Obviously, it is best to have treatment as soon as convenient. Some patients delay for 3 to 4 months for various reasons. Hormonal therapy may be indicated for longer delays; however, hormonal therapy can make it more difficult to perform nerve-sparing surgery because it causes scarring around the prostate gland.

7. Q: Is there any benefit beginning Kegel exercises prior to radical prostatectomy?

A: The short answer is “yes.” We believe that it will pay dividends to strengthen the muscles before surgery.

8. Q: What is nerve-sparing surgery? And which patients are candidates?

A: The nerves are like railroad tracks with the prostate being like a boxcar on top of the tracks. In this surgery, doctors try to gently lift the “box car” off the railroad tracks without damaging the “tracks.” If the cancer is detected early, then the prostate can sometimes be removed very nicely without disturbing the nerves. The nerves usually get bruised and stretched somewhat during the operation, which is why it can take 3 to 6 months for erections to begin to return after surgery. But with time, the nerves regenerate so it’s very important to detect the cancer while still on the inside of the prostate before it grows out into those nerves. Once it’s grown out into the nerves, it’s not possible to spare the nerves. Patients who have good erections preoperatively and desire to remain potent are reasonable candidates for nerve-sparing surgery if their PSA is low, their Gleason grade is not too high, and their prostate examination does not suggest that the cancer has spread beyond the prostate gland. The final decision to do nerve-sparing surgery is usually made by the surgeon during the operation.

9. Q: Is a CAT scan (CT) of the pelvis necessary before surgery?

A: Many surgeons say a CT is not necessary; however, we sometimes like to have a CT before surgery to ensure that no other important medical conditions are present that might affect the planned operation.

10. Q: Can surgery spread the prostate cancer?

A: Usually, a surgeon does not cut into the prostate gland during removal of the prostate. Although it is theoretically possible that cutting into the prostate could encourage cancer cells to spread, prostate cancer is not a type of cancer that “implants” easily into other tissues. This worry would be much greater with some other types of cancers.

11. Q: What is follow-up radiation (post-operative radiotherapy) and why would it be needed after a RRP?

A: Sometimes, it is strongly advised when the pathology report shows positive surgical margins or extension of the tumor beyond the prostate gland. Also, it is often advised when the PSA begins to rise after surgery. There are two types of follow-up radiotherapy.

1. Adjuvant radiotherapy is given as a precautionary measure in patients who have adverse features in their pathology report. This radiotherapy is usually given 3 to 4 months after the operation when urinary continence has returned. It may be delayed further if continence has not yet returned.

2. Salvage radiotherapy is for a rising PSA, which means a recurrence of the cancer. This radiotherapy should be given before the PSA level rises above 1ng/ml.

12. Q: Can other medical conditions affect the option of a radical prostatectomy for treatment of prostate cancer?

A: Yes. Some serious ailments make a patient too great a risk for surgery. Even though I believe that surgery might be the best treatment for a tumor, it is not always the best treatment for the patient. This decision is best made in consultation with the surgeon and other physicians of the patient.

13. Q: Is "watchful waiting" a treatment option after a diagnosis of prostate cancer?

A: In our opinion, the answer is no for some and probably OK for others (older men with low-grade tumors that are not very threatening). For the vast majority of men with prostate cancer, especially those less than 60 years old, early definitive treatment is indicated. Some of the public information about prostate cancer is misleading. It suggests that prostate cancer is a toothless lion, i.e., that more men die with it than of it. There is a difference between a dead man whose prostate is found to contain cancer when it is extensively examined at autopsy and a living man whose cancer has been found because of an elevated PSA or abnormal digital examination. And the younger a man is, the more likely he will benefit from being cured. It is most likely that a clinically detected prostate cancer will progress with time. For example, waiting for a PSA to get up to 6-7 risks a 30% chance that the cancer would have escaped from the prostate at the time of treatment. Currently, there are watchful waiting studies of young men. It is called “active monitoring.” If the PSA rises or repeated biopsies show more cancer or high-grade cancer, then treatment is initiated. The downside of this approach is that for men whose cancer ultimately requires treatment, it is treated at a later time and the repeated biopsies can me it more difficult to perform nerve-sparing surgery.

14. Q: What do you think about brachytherapy (seed implantation) compared to standard surgery?

A: We do not believe it is as effective as surgery. (Use the search engine in this website to find comparisons and studies for brachytherapy.)

15. Q: What do you think about cryoablation as a treatment for prostate cancer?

A: We do not believe that cryoablation (controlled freezing of the prostate gland in order to destroy cancerous cells) is an effective primary treatment for localized prostate cancer. Some advocate it for men who have failed radiation therapy. It almost always results in impotency. Also, a major concern is that if cancer cells are near the urethra, the warming of the urethra (as a protection against freezing and a consequence of the thawing process after the freezing) allows the cancer cells to survive. Frankly, I do not recommend cryoablation to any of our patients.

16. Q: Is it a good idea to use hormone therapy before or in conjunction with surgery? What does it do in this situation?

A: Hormonal therapy is used by some doctors to shrink the cancer before surgery. Available evidence suggests that while hormonal therapy makes it more likely that the surgical margins will be “clear,” no convincing evidence exists to show it reduces tumor recurrence rates. A possible disadvantage of hormonal therapy before surgery is that it may cause scarring around the prostate gland that sometimes makes it more difficult to perform nerve-sparing surgery.

17. Q: What are treatment options for a diagnosis with a high PSA and a high Gleason score?

A: With “high risk” prostate cancer, it is unlikely that the cancer can be cured by surgery or radiation alone. Options would include something as conservative as intermittent or continuous hormonal therapy or aggressive treatment with combinations of surgery, radiotherapy, hormonal therapy and/or chemotherapy.

18. Q: How far off do you think gene therapy is for the treatment of prostate cancer?

A: We are often asked this question by patients. We believe that gene therapy will be developed first as a potential treatment for patients with the most advanced stages of prostate cancer for whom no other effective therapy is available. Then if gene therapy works in these patients, it will be moved into the realm of treating earlier stages of the disease. Although exciting research is underway in gene therapy and other experimental treatment approaches for prostate cancer, we do not believe it is overly conservative to state that practical application of these new techniques is probably several years away.

19. Q: What is external beam radiotherapy and how are treatment results different from those of a radical prostatectomy?

A: In this method, x-ray treatments are given with a machine that sends high-energy x-rays through the patient’s body, aimed at the prostate gland and sometimes the pelvic lymph nodes. External beam radiotherapy is a totally non-invasive treatment used as an option for men who are considered too old or too ill for a prostatectomy or who just don’t want surgery. It is difficult to determine whether external beam radiation actually eradicates all of the prostate cancer because many patients in whom progression of the tumor is slowed or halted have persistent tumor on repeat rebiopsy. The best results are obtained when tumors are less than 2 centimeters in size at the time of therapy.

20. Q: What is the difference between a retropubic (RRP) and a perineal (RPP) prostatectomy?

A: Both approaches can yield good results if the surgeon is experienced and has expertise in performing the operation. In a radical perineal prostatectomy, the prostate gland is removed through an incision in the perineum, the area between the scrotum and the anus. In a radical retropubic prostatectomy, the surgeon makes an incision in the lower abdomen to remove the prostate, which is located retropubically, or behind the pubic bone. The principal advantage of the retropubic approach, in our opinion, is that the cavernosal (erection) nerves are more readily spared, because from the retropubic approach the prostate gland is lifted up off the nerves. In the perineal approach, the gland must be pulled down between the nerves. Another advantage of the retropubic approach is less chance for injuring the rectum during the surgery and less chance of postoperative rectal incontinence.

21. Q: What is IMRT radiation and is it an alternative to a radical prostatectomy?

A: IMRT (Intensity-Modulated Radiation Therapy) is one of the best forms of radiation therapy. It is computer-controlled radiation that delivers precise doses to malignant tumors or specific areas within a tumor with minimal effect on other tissue. The technology allows for higher and more effective doses to be delivered without damaging surrounding tissue. But there is a statistical issue about how the results are reported that make them appear 10% to 20% better than they really are. I do not believe that IMRT is as effective as surgery in appropriately selected patients.

22. Q: What information should I receive from my doctor when I’m diagnosed with prostate cancer?

A: You should be told the tumor stage (which tells how far it has spread) and the tumor or Gleason grade (which tells how aggressive it is or how fast it is growing). You should also be given treatment options for your particular tumor and then recommendations for the preferred treatment for that tumor. A list of treatments available to everyone is not particularly helpful to an individual patient. Good decisions are made based upon specific tumor characteristics.

23. Q: What do you think about the recent reports on the immunotherapy drug, Provenge and its use in treating advanced prostate cancer or any prostate cancer?

A: We are skeptical about the efficacy of Provenge. In the early studies, it only showed a benefit in patients with advanced, but low-grade prostate cancer. The great majority of prostate cancer patients with advanced disease have high-grade cancer. We would be surprised if Provenge has much to offer.

24.Q: Often the material about determining the incidence and severity of the side effects of a radical prostatectomy refers to the "experience" of the surgeon as the most important factor. How does a prospective patient interpret "experience?"

A: In our experience, most patients have three main priorities concerning their treatment outcomes, usually in the following order:

1) to survive prostate cancer

2) to recover urinary continence,

and 3) to recover erections. This threesome has been called “achieving the trifecta.” Of course, men have other secondary priorities, such as the discomforts associated with treatment, the time required for recovery, and the time to return to normal activities. All of these priorities are important, and different surgeons (and different treatments) vary in achieving them. Few surgeons keep accurate tabulations of their outcomes. Not surprisingly, studies have shown that high-volume surgeons generally (but not always) achieve better results. One practical solution for the prospective patient is to be diligent in finding out about the experience and reputation of the surgeon. He should also ask the surgeon to provide the contact information of 4 or 5 of his or her patients who have had good outcomes (We routinely ask my patients whether they are willing to be contacted by prospective future patients, and most are happy to do so and sign a HIPAA release form). If several patients are pleased with their outcomes, it shows that at least in these cases, the surgeon was able to achieve good results.

25.Q: Do men with prostate cancer ever have radiation prior to a radical prostatectomy?

A: Planned preoperative radiation therapy is not used in treating prostate cancer because radiation damages the blood supply to the tissues so they do not heal as well after high doses of radiation. Such radiation makes the complications and side effects of radical prostatectomy far more likely than if the tissues had not received radiation. Sometimes, so-called “salvage” radical prostatectomy is performed in patients who were treated initially with radiation and subsequently have a cancer recurrence. Salvage prostatectomy is associated with a far greater risk for complications and is substantially less likely to cure the cancer.

26. Q: What is a man supposed to do who is diagnosed with prostate cancer but has no medical insurance and a low income?

A: The options are a Veterans Administration Hospital (if a veteran) or a public hospital, such as a county or city hospital. In addition, almost all private hospitals provide low-cost or free care to some patients who have no health insurance and a low income. Men in such a situation can call urology departments of private hospitals to see what options are available. Also, many private hospitals have social work departments and the staff there is trained to help with special needs. Men can ask to see someone in that department for advice.

27.Q: If I choose external beam radiation and the cancer does not go away, can I later have the prostate removed?

A: It is possible to remove the prostate gland after radiation therapy, but the complication rate is far higher (25% to 50% risk of incontinence, almost certain impotence, and a significant risk for rectal injury during surgery that might require a temporary or permanent colostomy). Accordingly, most surgeons, including myself (Catalona), do not perform salvage prostatectomy.

28.Q: Can IMRT (intensity modulated radiation therapy), the high-powered radiation that can be directed to very particular areas, be used as the sole treatment for prostate cancer? In other words, can I have IMRT and not have a radical prostatectomy?

A:IMRT can be used as the sole treatment for prostate cancer. In fact, it is one of the most effective forms of radiotherapy for treating prostate cancer. However, in our opinion, it is not as effective as surgery for treating organ-confined tumors that might be resistant to therapeutic doses of radiotherapy, and it does not prevent future new cancers from developing in the prostate gland.

29.Q: How many types of tests do you recommend taking prior to the decision to have surgery?. Whenever I read an article about prostate cancer, I learn about a new test.

A:How many tests are indicated before proceeding with treatment is a controversial subject. To some extent, it depends on the individual's risk for having cancer that has spread. For instance, if the patient has a low PSA, low Gleason grade and normal feeling prostate, some would argue that no further testing is indicated, including lymph node biopsy. On the other hand, if the PSA or Gleason grade are higher, further testing such as a bone scan and abdominal and pelvic CT or MRI scan might be indicated.Some of the tests currently available, such as Prostascint, ploidy, PAP, color endo-rectal MRI, complexed PSA, provide little additional useful information, in our opinion.We are usually comfortable if the patient has a bone scan with appropriate follow-up imaging studies of any abnormalities that might appear and an abdominal-pelvic CT scan.

30.Q: My understanding is that 72% of prostate cancer starts in the peripheral zone, 20% starts in transition zone and 8% in the central zone. Has there been any research which would indicate whether it is more difficult or any easier to treat prostate cancer which started in the transition zone or the apex zone as opposed to the peripheral zone?

A: In general, it is believed that prostate cancer that arises in the peripheral zone is more aggressive than that which arises in the transition or central zones. The apex includes the transition and peripheral zones.

31.Q: Is it always important to give my own blood in preparation for prostate cancer surgery?

A:The blood bank blood is now very safe, but nothing is safer than your own blood. We commonly have our patients store one pint of their own blood, which we may give back to them after surgery, and it is very unusual for them to have to receive blood from another person.

32.Q: As I wait over 3 months for surgery (grinding my teeth more each day), I am told that statistically my cancer has not moved out of the gland. What makes up such statistics and how much can I count on them?

A:Several tables called "nomograms" provide information on the probability that a tumor would be totally contained within the prostate and whether or not there will be a later recurrrence. These tables are called Partin tables, Kattan tables, or D'Amico tables, named after the authors who devised them.They contain an estimate of the probability, but there can be variation around these estimates.Factors to determine the likelihood that the tumor would be "contained" are: the Gleason grade, the PSA level, the rectal and ultrasound examination findings, the bone scan findings, and the number of biopsy cores involved with cancer, the percentage of the biopsy tissue involved with cancer, and whether or not the pathologist saw "perineural involvement" on the biopsy specimens.In general, I believe that these tables provide a slightly pessimistic estimate, because as time goes on, prostate cancer is discovered earlier and earlier.

33.Q: I was told by others that I will be asked to decide what I want the urologist to do if he finds evidence of prostate cancer in the lymph nodes. Is there only one kind of spread to the lymph nodes, and what is my best decision?

A: Now that we are detecting prostate cancer much earlier due to PSA testing, it is rare to find lymph node metastases.Predictors of lymph node involvement are high PSA level (greater than 20), Gleason grade higher than 7, many biopsy cores containing cancer, and a very abnormal feeling prostate on digital rectal examination.Lymph node biopsy is not mandatory in the absence of any of these features. Our policy is to remove a small tissue packet containing 1-3 of the so-called "first echelon" lymph nodes near the prostate. Lymph node involvement is an unfavorable prognostic sign. However, two small case-control studies from Johns Hopkins and the Mayo Clinic suggest that the outcome is better if the prostate is removed in patients with minimal lymph node involvement. About 95% of our patients elect to proceed with removal of the prostate even if the lymph nodes are involved.

34.Q: My father is 72 years old and in good health. He visited a urologist because he had trouble urinating. The diagnosis was prostate cancer. My father says that he has a good life. Why destroy everything by taking all of the treatments? Is 72 years old too old for surgery?

A: At age 72, your father still has a 10-year life expectancy that could be shortened by prostate cancer. Age 72 is "borderline" for a radical prostatectomy, but if he were otherwise healthy, he would be a legitimate candidate for the operation.There is no reason to believe that surgery would "destroy everything," if he chooses a good, experienced surgeon. His other option for cure would be radiotherapy. Hormonal therapy would almost certainly slow the progression of the cancer, perhaps for the rest of his natural life, but that result could not be guaranteed.

35.Q: Can a person wait as long as six months to decide whether or not to have surgery for prostate cancer that is low Gleason score and low volume?

A: Yes and No.If the biopsy suggests the cancer is low volume and low grade, the final prostatectomy specimen will confirm this impression 80-85% of the time. However, the biopsy is only a sample, and in 15-20% of cases, there will be significantly more cancer or cancer at or beyond the margin of the prostate gland or higher Gleason grade cancer. Therefore, we advise out patients to wait only 6 weeks after the biopsy to let the inflammation subside and then schedule surgery as soon as they conveniently can schedule it.

36. Q: Are there potential methods for predicting aggressive prostate cancer?

A: Many good ones are in use every day including free and total PSA, PSA velocity, PSA density, Gleason grade, amount of cancer in biopsy specimens, findings on prostate exam, ultrasound, CT or MRI scans. Other new tests include the [-2] ProPSA test (waiting for approval by the FDA). These tests all are useful in predicting the aggressiveness of a prostate cancer.Where the real problem lies is in patients who appear to have low-risk tumors (Gleason of 6 or less, low amounts of cancer in the biopsy specimens, and PSA less than 10). One-third or more of these tumors will ultimately prove to behave aggressively. How can we better identify the wolves masquerading as lambs? This answer is perhaps the holy grail of current prostate cancer research.(See page 1 article in the Winter 2010 Quest: Which Prostate Cancers Are Aggressive and Which Aren’t?)

37. Q: Before performing a radical prostatectomy, is it an acceptable practice for one hospital/surgeon to use another hospital’s biopsy report and not do their own?

A: Our hospital requires that our pathologists confirm the diagnosis.

38. Q: What is your opinion on attempting to shrink the prostate before having a prostatectomy as soon as possible?

A: We do not advise this practice. Trying to shrink the prostate with hormone therapy sometimes causes scarring around the prostate that makes it difficult to perform a nice clean nerve sparing operation. Also some prostate cancer cells are resistant to hormone therapy and if they are present, they could continue to grow and perhaps spread during the six months. In my opinion, one should be wary of using drugs that are not approved for prostate cancer treatment unless the reason is very compelling.

39. Q: I have heard that one should wait two months after a biopsy before having a radical prostatectomy? Is that correct and if so, why? And wouldn’t the cancer have a chance to spread in those two months?

A: We usually recommend waiting for six weeks to allow the inflammation from the biopsy procedure to subside. This time increases the chances that the surgeon can perform a nice, clean operation. If the prostate gland and the surrounding tissues are inflamed, it can compromise complete removal of the entire tumor with clean margins and the ability to perform nerve-sparing surgery. A risk is present that the cancer might spread in the interval, but it is unlikely and is just another example of life’s tradeoffs.