Brunner's glands are compound, tubular, mucous glands in the submucosa of the duodenum. One mucous tubule is outlined in the image above. Cells lining these tubules secrete alkaline mucus into the crypts of the duodenal mucosa, and hence into the lumen of the duodenum where it serves to neutralize the acid contents entering from stomach.
Brunner's glands fill the submucosa of the duodenum so completely that the typical submucosal connective tissue is obscured.
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Last updated: 30 January 2002 / dgk