Colon, mucosa, PAS stain for mucus
The mucosa of the colon is characterized by straight crypts with no villi.
This specimen has been stained with PAS (per-iodic acid, Schiff), so that mucus in goblet cells appears red. Note that epithelial nuclei are more numerous than the mucus blobs, indicating that absorptive cells remain the predominant cell type in colon epithelium (as also in the small intestine), even though they are crowded by goblets and hence inconspicuous.
In routine H&E preparations, the mucus in goblet cells appears as clear "bubbles" in crypt epithelium.
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Last updated: 3 June 2003 / dgk