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Eric C. Niederhoffer, Ph.D.

Associate Professor of Biochemistry and Molecular Biology

Southern Illinois University School of Medicine
600 Agriculture Drive, Carbondale, IL 62901-6503
Rm 112 Lindegren, 618-453-6467
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Open (1ig8) and closed (1hkg) forms of hexokinase from Saccharomyces cerevisiae

The open form allows binding of glucopyranose and ATP while the closed form excludes water from the active site in preparation for the catalytic reaction.

Kuser, P. R., S. Krauchenco, O. A. Antunes, and I. Polikarpov. 2000. The high resolution crystal structure of yeast hexokinase Pii with the correct primary sequence provides new insights into its mechanism of action. J. Biol. Chem. 275:20814-20821.

Steitz, T. A., M. Shoham, and W. S. Bennett Jr. 1981. Structural dynamics of yeast hexokinase during catalysis. Philos. Trans. R. Soc. Lond. B Biol. Sci. 293:43-52.

Hexokinase open form (1ig8)

Hexokinase closed form (1hkg)


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