"Chime Square" Animations
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Eric C. Niederhoffer, Ph.D.
Associate Professor of Biochemistry
and Molecular Biology
- Southern Illinois University School
- 600 Agriculture Drive, Carbondale,
Rm 112 Lindegren, 618-453-6467
- Copyright 2000-
, E.C. Niederhoffer.
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Open (1ig8) and closed (1hkg)
forms of hexokinase from Saccharomyces cerevisiae
The open form allows binding
of glucopyranose and ATP while the closed form excludes water
from the active site in preparation for the catalytic reaction.
- What structural elements
are present in each molecule?
- What is the subunit composition?
- What gross comparisons can
be made with the two structures?
- Which residues participate
in the phosphorylation reaction?
- Which residues form a hydrophobic
Kuser, P. R., S. Krauchenco, O. A.
Antunes, and I. Polikarpov. 2000.
The high resolution crystal structure of yeast hexokinase Pii
with the correct primary sequence provides new insights into its
mechanism of action. J. Biol. Chem. 275:20814-20821.
Steitz, T. A., M. Shoham, and W. S.
Bennett Jr. 1981. Structural
dynamics of yeast hexokinase during catalysis. Philos. Trans.
R. Soc. Lond. B Biol. Sci. 293:43-52.
Hexokinase open form (1ig8)
Hexokinase closed form (1hkg)
Biochemistry and Molecular Biology Resources
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